Professor Simon Heller
Clinical Medicine, School of Medicine and Population Health
Professor of Clinical Diabetes
+44 114 215 9009
Full contact details
Clinical Medicine, School of Medicine and Population Health
Room EU38, E Floor
The Medical School
Beech Hill Road
91直播
S10 2RX
- Profile
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For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
- Research interests
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Our groups interests concern clinical research, focussing on clinical investigation involving varied topics with the common theme of immediate relevance to patients with diabetes.
These include aspects of the pathophysiology of hypoglycaemia in diabetes, the contribution of hypoglycaemia to the increased risk of sudden death in young people with Type 1 diabetes (the 'dead in bed' syndrome), the clinical benefits of insulin analogues and trials of complex interventions to enable more effective self-management in people with diabetes.
Our observation that hypoglycaemia unawareness is caused by repeated episodes of hypoglycaemia has led to programmes of unawareness reversal and restoration of hypoglycaemic symptoms in patients with Type 1 diabetes.
Recent research on profound bradycardia during hypoglycaemia in patients with type 2 diabetes and ischaemic heart disease has commanded international attention (Chow et al, Diabetes 2014) and a collaboration between the pharmaceutical industry and our research group has led to recently published guidance to advise the FDA and other agencies of important issue when assessing cardiac electrophysical safety of therapeutic agents in diabetes (Heller et al Am Heart J 2015).
We were the principal investigators for the multi-centre DAFNE trial and lead a national programme of research exploring different facets of the DAFNE education programme.
This has directly led to funded roll-out of the approach by the Department of Health, an appraisal by NICE and recent NICE recommendations that training programmes be available to all patients throughout England and Wales. NIHR awarded a ?1.7m 5 year NIHR programme grant, using the DAFNE collaborative (with >30,000 UK trained adults with type 1 diabetes) as a research test-bed.
Following its successful completion (Heller et al, NIHR Journals Lib 2014), the NIHR has recently provided ?2..7m programme funding over 5.5 years to continue this work, which has led to improved diabetes care with national and international impact.
Other research has also explored the potential of technology to improve blood glucose control and reduce hypoglycaemia in diabetes and work with the pharmaceutical industry in evaluating the benefit of new insulins (Heller et al Diabetes Care 1999, Heller et al Lancet 2012) and participated in multi-centre trials evaluating technology (Little et al Diabetes Care 2014) and closed loop devices (Thabit et al Lancet Diabetes Endocrinol 2014). Designed and subsequently led the recently completed REPOSE Trial, a multi-centre.?2m HTA funded RCT conducted in England and Scotland, measuring the effectiveness of insulin pump therapy in adults with type 1 diabetes."
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . Diabetologia, 64(4), 727-736.
- . Diabetic Medicine.
- . Critical Care Medicine, 49(4), 636-649.
- . BMJ Open, 11(1).
- . Diabetologia, 63(12), 2501-2520.
- . Journal of Clinical Epidemiology.
- . Diabetes, Obesity and Metabolism.
- . Diabetologia, 63(4), 698-710.
- . Diabetic Medicine, 37(4), 545-554.
- . Diabetic Medicine.
- . Health Research Policy and Systems, 17(1).
- . Diabetes Care.
- . Diabetic Medicine.
- . Diabetes Care, 42(8), 1593-1603.
- . The Lancet Diabetes & Endocrinology, 7(5), 385-396.
- . Journal of Clinical Endocrinology and Metabolism, 104(4), 1187-1199.
- . Diabetes Care, 41(12), 2625-2633.
- . Diabetic Medicine, 35(11), 1531-1537.
- . The Lancet Diabetes & Endocrinology, 5(9), 677-679.
- . Diabetes, Obesity and Metabolism.
- . Diabetologia.
- . BMJ, 356, ---.
- . Diabetologia, 60(1), 3-6.
- . Diabetes Care, 40(1), 155-157.
- . Diabetes, Obesity and Metabolism, 17(8), 742-750.
- . New England Journal of Medicine, 371(15), 1392-1406.
- . Diabetes, 63(5), 1738-1747.
- . Diabetes Care, dc172682-dc172682.
- . Programme Grants for Applied Research, 2(5), 1-188.
Conference proceedings papers
- Reduced risk of hypoglycaemia and lower HbA(1c) with degludec compared to glargine U300 in insulin-treated patients with type 2 diabetes. DIABETOLOGIA, Vol. 62 (pp S47-S47)
- Hypoglycaemia is associated with increased risk of cardiovascular events: results from the EXAMINE trial. DIABETOLOGIA, Vol. 59 (pp S44-S44)
- . The Lancet, Vol. 385 (pp S96-S96)
- Cardiac autonomic regulation during acute experimental hypoglycaemia in type 2 diabetes. DIABETOLOGIA, Vol. 57 (pp S260-S261)
All publications
Journal articles
- . Health and Quality of Life Outcomes, 22(1), 70.
- . Diabetes Care, 47(10), 1769-1777.
- . Canadian Journal of Diabetes.
- . Diabetes, 73(Supplement_1).
- . Diabetes, 73(Supplement_1).
- . Diabetic Medicine, 41(7).
- . Diabetes, Obesity and Metabolism.
- . BMJ Open Diabetes Research & Care, 12(3), e003930-e003930.
- . Diabetes Research and Clinical Practice, 210, 111642-111642.
- . Canadian Journal of Diabetes, 48(3), 204-210.e1.
- . International Journal of Epidemiology.
- . The Lancet Respiratory Medicine, 11(11), e93-e94.
- . The Lancet Respiratory Medicine, 11(11), 1003-1019.
- . Diabetes, 72(Supplement_1).
- . Diabetes, 72(Supplement_1).
- . PLoS ONE, 18(3).
- . PLoS Medicine, 20(2).
- . Diabetes, Obesity and Metabolism.
- . Endocrine Reviews, 44(2), 254-280.
- . Diabetes Care, 45(12), 2799-2805.
- . Journal of Diabetes and its Complications.
- . Diabet Med, e14892.
- . American Journal of Respiratory and Critical Care Medicine, 206(7), 874-882.
- . Nat Commun, 13(1), 2229.
- . The Lancet Respiratory Medicine.
- . Thorax, 77(7), 717-720.
- . Diabetologia.
- . Diabetes Care.
- . Medicine.
- . PLoS ONE, 16(12).
- . The Lancet, 398(10313), 1785-1786.
- Hypoglycaemia combined with mild hypokalaemia reduces the heart rate and causes abnormal pacemaker activity in a computational model of a human sinoatrial cell.. Journal of the Royal Society Interface, 18(184).
- . Diabetes, Obesity and Metabolism.
- . Diabetic Medicine.
- . The Lancet Respiratory Medicine, 9(11), 1275-1287.
- . BMJ Open Diabetes Research & Care, 9(1), e002322-e002322.
- . Diabetes, 70(Supplement_1).
- . Diabetes, 70(Supplement_1).
- . Diabetes Care.
- . Diabetologia, 64, 935-938.
- . Diabetologia, 64(4), 727-736.
- . The Lancet Diabetes and Endocrinology, 9(4), 212-224.
- . Diabetes Research and Clinical Practice, 174, 108752-108752.
- . Diabetic Medicine.
- . Critical Care Medicine, 49(4), 636-649.
- . Diabetologia.
- . Diabetes & Metabolism, 101237-101237.
- . Diabetes, Obesity and Metabolism, 23(2), 549-560.
- . BMJ Open, 11(1).
- . Diabetologia, 63(12), 2501-2520.
- . BMJ Open, 10(9), e040201-e040201.
- . Diabetes and Vascular Disease Research, 17(5).
- . BMJ Open Diabetes Research & Care, 8(1).
- . Health Technology Assessment, 24(28).
- . Diabetes, 69(Supplement_1).
- . Journal of Clinical Epidemiology.
- . BMJ Open Diabetes Research & Care, 8(1).
- . Diabetes, Obesity and Metabolism.
- . Diabetologia, 63(4), 698-710.
- . Diabetes, Obesity and Metabolism.
- . Diabetic Medicine, 37(4), 545-554.
- . Diabetologia.
- . Diabetic Medicine.
- . Diabetic Medicine.
- . Diabetes, Obesity and Metabolism.
- . Diabetic Medicine, 37(5), 752-759.
- . Diabetes Care, 43(1), 44-52.
- . Diabetes, Obesity and Metabolism, 22(12), 2248-2256.
- . Health Research Policy and Systems, 17(1).
- . Diabetes Care.
- . Diabetic Medicine.
- . Diabetes Technology & Therapeutics, 21(11), 619-626.
- . Diabetes Care, 42(8), 1593-1603.
- . The Lancet Diabetes & Endocrinology, 7(7), 515-527.
- . Diabetes, Obesity and Metabolism, 21(7), 1634-1641.
- . Diabetes, Obesity and Metabolism, 21(7), 1706-1714.
- . BMJ Open, 9(6), e030356-e030356.
- . Diabetes Care, 42(6), 1005-1008.
- . The Lancet Diabetes & Endocrinology, 7(5), 385-396.
- . Sociology of Health & Illness, 41(7), 1289-1304.
- . Journal of Clinical Endocrinology and Metabolism, 104(4), 1187-1199.
- . Diabetes Obesity and Metabolism.
- . Diabetes Care, 42(6), 1147-1154.
- . Medicine, 47(1), 52-58.
- . Diabetes Therapy, 10(1), 177-188.
- . Current Medical Research and Opinion, 35(3), 525-533.
- . Diabetes Care, 41(12), 2625-2633.
- . BMC Health Services Research, 18.
- . Diabetes, Obesity and Metabolism.
- . Diabetic Medicine, 35(11), 1531-1537.
- . Journal of the American Heart Association, 7(20).
- . Diabetic Medicine, 35(9), 1273-1278.
- . Diabetic Medicine, 35(9), 1264-1272.
- . Diabetes, 67(Supplement_1).
- . Diabetes, Obesity and Metabolism, 20(11), 2565-2573.
- . Journal of Diabetes Science and Technology, 12(6), 1184-1191.
- . Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 11, 217-226.
- . Diabetes and Metabolism Journal, 42(2), 177-177.
- . Clinical Cardiology.
- . BMJ Open, 8(4).
- . The American Journal of Medicine, 131(7), 813-819.e5.
- . The Lancet Diabetes & Endocrinology, 6(2), 91-92.
- . Diabetes and Metabolism Journal, 42(1), 3-18.
- . The Lancet Diabetes & Endocrinology, 6(2), 130-142.
- . Diabetes Care, 40(12), 1631-1640.
- . Diabetes, Obesity and Metabolism.
- . Diabetologia.
- . The Lancet Diabetes & Endocrinology, 5(9), 677-679.
- . Diabetes, Obesity and Metabolism.
- . The Journal of Clinical Endocrinology & Metabolism, 102(11), 3953-3960.
- . Diabetologia.
- . Journal of Diabetes and its Complications, 31(6), 1047-1052.
- . Diabetes Care, 40(5), 655-662.
- . Diabetes, Obesity and Metabolism.
- . Diabetes Care.
- . Health Technology Assessment, 21(20), 1-278.
- . BMJ, 356, ---.
- . Diabetes, Obesity and Metabolism.
- . Trials, 18.
- . Diabetologia, 60(1), 3-6.
- . Diabetes Care, 40(1), 155-157.
- . Value in Health, 19(7), A671-A671.
- . Diabetologia, 59(12), 2603-2612.
- . Diabetes Care, 39(8), 1318-1328.
- . Best Practice & Research Clinical Endocrinology & Metabolism, 30(3), 413-430.
- . Diabetes Care, 39(7), 1267-1273.
- . Clinical Pharmacokinetics, 55(11), 1457-1463.
- . Diabetes Care, 39(5), 694-700.
- . Diabetes Care, 39(4), e56-e58.
- . Diabetic Medicine, 33(4), 471-477.
- . Diabetic Medicine, 33(4), 478-487.
- . Diabetes & Metabolism, 42, A31-A31.
- . Diabetes Technology & Therapeutics, 18(S1).
- . Evidence Based Medicine, 21(1), 20-20.
- . Diabetic Medicine, 33(2), 243-251.
- . Diabetic Medicine, 33(2), 192-203.
- . Diabetic Medicine, 33(3), 376-385.
- . Trials, 16(1).
- Accuracy and Performance of continuous Glucose Monitoring with three Closed-Loop Studies with Home Phase under normal Living Conditions. WIENER KLINISCHE WOCHENSCHRIFT, 127, S145-S146.
- . Diabetes Research and Clinical Practice, 110(2), 229-232.
- . Journal of Diabetes Science and Technology, 9(6), 1346-1347.
- . Diabetes Technology & Therapeutics, 17(11), 801-807.
- . Medical Decision Making, 35(7), 872-887.
- . Diabetes Therapy, 6(3), 389-393.
- . Diabetes Care, 38(8), 1583-1591.
- . Family Practice, 32(5), 596-602.
- . Diabetic Medicine, 32(12), 1541-1545.
- . Journal of Behavioral Medicine, 38(5), 817-829.
- . BMJ Open Diabetes Research & Care, 3(1).
- . Diabetes, Obesity and Metabolism, 17(5), 452-458.
- . Diabetes, Obesity and Metabolism, 17(8), 742-750.
- . Journal of Diabetes Science and Technology, 9(4), 932-933.
- . Diabetic Medicine, 32(3), 414-422.
- . Diabetic Medicine, 32(3), 391-398.
- . Psychology & Health, 30(1), 85-103.
- . Diabetic Medicine, 32(5), 601-608.
- . British Journal of Health Psychology, 20(2), 428-446.
- . Circulation, 130(suppl_2).
- . Diabetic Medicine, 31(11), 1431-1438.
- . New England Journal of Medicine, 371(15), 1392-1406.
- . Diabetes Research and Clinical Practice, 106(3), 443-450.
- . Diabetes Care, 37(10), e226-e227.
- . Diabetologia, 57(12), 2465-2474.
- . BMJ Open, 4(9), e006204-e006204.
- . The Lancet Diabetes & Endocrinology, 2(9), 701-709.
- . Medicine, 42(12), 727-731.
- . Diabetic Medicine, 31(7), 847-853.
- . Endocrine Practice, 20(7), 722-736.
- . Trials, 15(1).
- . Diabetes Care, 37(8), 2114-2122.
- . Diabetes, 63(5), 1738-1747.
- . SAGE Open Medicine, 2.
- . Diabetic Medicine, 31(4), 477-486.
- . Diabetes & Metabolism, 40, A101-A101.
- . Diabetes Care, 37(3), 863-866.
- . Trials, 15(1).
- Alogliptin after acute coronary syndrome in patients with type 2 diabetes. Austrian Journal of Clinical Endocrinology and Metabolism, 7(2), 77.
- WICKED: The development and evaluation of a psycho-education programme for young people with type 1 diabetes. Journal of Diabetes Nursing, 18(6), 233-237.
- . Diabetic Medicine, 31(10), 1260-1263.
- . Diabetologia, 57(1), 40-49.
- . Journal of Clinical Nursing, 23(19-20), 2919-2927.
- . Diabetes Care, 37(1), 109-115.
- . Chronic Illness, 10(3), 180-191.
- . Diabetes/Metabolism Research and Reviews, 30(3), 175-190.
- . Diabetic Medicine, 31(2), 227-231.
- . Diabetes, Obesity and Metabolism, 16(5), 426-432.
- . Diabetic Medicine, 31(1), 55-60.
- . Diabetes Care, 36(12), 4063-4070.
- . Journal of Diabetes, 5(4), 482-491.
- Liraglutide in Combination with Insulin in Type-1-Diabetes: glycemic Effect and Safety in a randomized, double bind Crossover-Study. WIENER KLINISCHE WOCHENSCHRIFT, 125, S14-S14.
- . New England Journal of Medicine, 369(14), 1327-1335.
- . Diabetes Technology & Therapeutics, 15(S1).
- . Diabetic Medicine, 30(6), 724-730.
- . Diabetes Care, 36(5), 1368-1376.
- . Diabetes Care, 36(5), 1117-1125.
- . Diabetic Medicine, 30(6), e223-e228.
- . Diabetic Medicine, 30(10), 1236-1244.
- . Diabetes Care, 36(2), 270-272.
- . BMJ Open, 3(1).
- . Diabetic Medicine, 30(11), 1293-1297.
- . Annals of Internal Medicine, 158(6), 500-500.
- . Diabetes Research and Clinical Practice, 100(1), 29-38.
- . Diabetic Medicine, 30(2), 209-215.
- . Diabetic Medicine, 30(2), 189-198.
- . Diabetic Medicine, 30(2), 199-208.
- Morphological analysis of T-wave in vectorcardiographic leads system by a bi-Gaussian approach in patients under effect of salbutamol.. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 5494-5497.
- . BMC Endocrine Disorders, 12(1).
- . BMC Endocrine Disorders, 12(1).
- . BMC Public Health, 12.
- . Diabetes Care, 35(8), 1638-1642.
- . BMJ, 344(apr26 2), e2333-e2333.
- . The Lancet, 379(9825), 1489-1497.
- . Diabetic Medicine, 29(8), 1079-1084.
- . BMC Family Practice, 13.
- . Diabetic Medicine, 29(5), 677-681.
- . Diabetes, Obesity and Metabolism, 14(2), 163-173.
- . Cardiovascular Diabetology, 11(1), 56-56.
- . 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.
- . Diabetes Research and Clinical Practice, 98(2), 236-242.
- . Diabetologia, 55(3), 636-643.
- Does duration of type 1 diabetes affect the outcomes of structured education?. DIABETOLOGIA, 55, S100-S100.
- . Diabetes Care, 34(12), 2491-2495.
- . Diabetes Technology & Therapeutics, 13(11), 1121-1127.
- . Journal of Hypertension, 29(7), 1439-1447.
- Impaired hypoglycemia awareness. Diabetic Hypoglycemia, 4(1), 1-2.
- Impaired awareness of hypoglycemia: Commentary. Diabetic Hypoglycemia, 4(1), 15.
- . Diabetic Medicine, 28(5), 532-538.
- . Diabetes Care, 34(Supplement_2), S132-S137.
- . BMJ, 342(apr13 5), d1855-d1855.
- Diabetic hypoglycemia and pregnancy. Diabetic Hypoglycemia, 3(3), 1-2.
- . Psychology & Health, 26(3), 321-335.
- . European Journal of Cardiovascular Prevention & Rehabilitation, 18(3), 393-398.
- . Diabetes Research and Clinical Practice, 91(1), 87-93.
- . Clinical Therapeutics, 33(9), 1258-1267.
- . Patient Education and Counseling, 83(1), 87-91.
- EXamination of CArdiovascular OutcoMes with AlogliptIN versus Standard of CarE in Patients with Type 2 Diabetes Mellitus and Acute Coronary Syndrome (EXAMINE). A cardiovascular safety study of the dipeptidyl peptidase 4 inhibitor alogliptin in patients with type 2 diabetes with acute coronary syndrome. American Heart Journal.
- . American Heart Journal, 162(4), 620-626.e1.
- Commentary. Diabetic Hypoglycemia, 3(2), 17.
- . Diabetes Research and Clinical Practice, 89(1), 22-29.
- . BIOMED ENG ONLINE, 9.
- Prospects for an artificial pancreas. Diabetic Hypoglycemia, 3(1), 1-2.
- . EP Europace, 12(4), 553-560.
- . Diabetes Care, 33(3), 473-477.
- . New England Journal of Medicine, 363(15), 1410-1418.
- . Diabetologia, 53(5), 821-831.
- . BMJ, 341(aug20 1), c4093-c4093.
- . Diabetes Care, 32(11), 2068-2074.
- . Diabetologia, 52(11), 2328-2336.
- . Diabetes Care, 32(suppl_2), S357-S361.
- . Clinical Therapeutics, 31(10), 2086-2097.
- . Diabetes Research and Clinical Practice, 85(2), 183-188.
- . Diabetic Medicine, 26(7), 665-672.
- . The Journal of Clinical Endocrinology & Metabolism, 94(3), 709-728.
- . The British Journal of Diabetes & Vascular Disease, 9(6), 269-272.
- . Diabetes Research and Clinical Practice, 82, S108-S111.
- . Diabetes, 57(12), 3177-3183.
- . Archives of Disease in Childhood, 93(11), 927-931.
- Can spectral analysis of heart rate variability detect subclinical autonomic dysfunction as reliably as spontaneous baroreceptor sensitivity?. DIABETOLOGIA, 51, S500-S500.
- . Clinical Endocrinology, 68(6), 912-918.
- . BMJ, 336(7642), 491-495.
- . Diabetic Medicine, 25(12), 1454-1461.
- . Chronic Illness, 4(1), 38-40.
- . New England Journal of Medicine, 358(24), 2560-2572.
- An approach to the assessment of diabetic neuropathy based on dynamic pupillometry.. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 557-560.
- . Diabetes Research and Clinical Practice, 78(2), 149-158.
- . Regenerative Medicine, 2(6), 887-902.
- . BMJ, 335(7611), 105-106.
- . Diabetologia, 50(6), 1140-1147.
- . Diabetes Care, 30(5), 1044-1048.
- . Diabetes Care, 30(4), 771-776.
- A prospective study of the prevalence of gastrointestinal symptoms in patients with Type 1 diabetes and correlation with diabetes control and quality of life. DIABETIC MEDICINE, 24, 65-65.
- . Health and Quality of Life Outcomes, 5(1), 21-21.
- . Obstetrics, Gynaecology & Reproductive Medicine, 17(12), 345-348.
- . 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.
- . Patient Education and Counseling, 64(1-3), 369-377.
- . Pediatric Diabetes, 7(6), 322-328.
- . Diabetic Medicine, 23(7), 729-735.
- Aircrew and type 1 diabetes mellitus. Aviation Space and Environmental Medicine, 77(4), 456-458.
- A knowledge-based electrocardiogram-monitoring system for detection of the onset of nocturnal hypoglycaemia in type 1 diabetic patients. Computers in Cardiology, 33, 5-8.
- . Medicine, 34(3), 107-110.
- . Medicine, 34(2), 80-82.
- . Diabetes, Obesity and Metabolism, 7(5), 504-516.
- . Diabetic Medicine, 22(s3), 11-13.
- . Diabetologia, 48(7), 1269-1272.
- . Child: Care, Health and Development, 31(3), 283-289.
- . Diabetic Medicine, 21(12), 1261-1262.
- . Diabetes/Metabolism Research and Reviews, 20(6), 479-486.
- . Diabetologia, 47(11), 1940-1947.
- . Diabetic Medicine, 21(10), 1061-1063.
- . Diabetes, Obesity and Metabolism, 6(5), 344-352.
- . Metabolism, 53(9), 1227-1232.
- . Diabetes Research and Clinical Practice, 65, S23-S27.
- . Diabetic Medicine, 21(7), 786-789.
- . Diabetic Medicine, 21(7), 769-775.
- . Diabetes, 53(6), 1535-1542.
- . Diabetologia, 47(2), 312-315.
- . Diabetic Medicine, 21(5), 460-467.
- Clinical evaluation of a plasma polymer surface for culture and transfer of keratinocytes for chronic wounds. Transactions - 7th World Biomaterials Congress, 1068.
- . Nuklearmedizin, 42(06), 234-239.
- . Expert Opinion on Pharmacotherapy, 4(8), 1407-1416.
- . Diabetes, 52(6), 1469-1474.
- . Evidence-Based Medicine, 8(3), 80-80.
- . Diabetic Medicine, 20(3), 173-174.
- . European Journal of Clinical Investigation, 33(2), 93-98.
- Cardiac arrhythmias in hypoglycaemia. Diabetes, Nutrition and Metabolism - Clinical and Experimental, 15(6), 461-467.
- . BMJ, 325(7367), 746-746.
- What we know about counterregulation in Type 2 diabetes. Diabetes, Nutrition and Metabolism - Clinical and Experimental, 15(5), 372-376.
- . International Journal of Obesity, 26(S3), S31-S36.
- Abnormalities of the electrocardiogram during hypoglycaemia: The cause of the dead in bed syndrome?. International Journal of Clinical Practice, Supplement(129), 27-32.
- . Journal of Clinical Endocrinology and Metabolism, 87(7), 3324-3329.
- . Journal of Clinical Endocrinology & Metabolism, 87(7), 3324-3329.
- . Diabetic Medicine, 19(4), 263-264.
- . Diabetes, Obesity and Metabolism, 4(2), 106-112.
- . Expert Opinion on Pharmacotherapy, 3(2), 183-195.
- . Medicine, 30(2), 66-67.
- . Medicine, 30(2), 54-57.
- . Current Medical Research and Opinion, 18(sup1), s40-s47.
- . Diabetic Medicine, 18(9), 689-689.
- Acute hypoglycemia suppresses parathyroid hormone and bone turnover markers: An insulin clamp study.. JOURNAL OF BONE AND MINERAL RESEARCH, 16, S403-S403.
- . Clinica Chimica Acta, 308(1-2), 91-98.
- . Practical Diabetes International, 18(SUPPL.).
- . Diabetic Medicine, 17(12), 819-819.
- Effect of intravenous adrenaline on cardiac repolarization in healthy males - Increases in corrected QT duration occur independently of hypokalaemia. JOURNAL OF PHYSIOLOGY-LONDON, 528P, 42P-42P.
- . Diabetic Medicine, 17(9), 684-685.
- Severe hypoglycaemia in unselected patients with type 1 diabetes: A cross-sectional multicentre survey. DIABETOLOGIA, 43, A194-A194.
- . Diabetes Care, 23(7), 1022-1023.
- . Diabetic Medicine, 17(6), 413-413.
- . Diabetic Medicine, 17(5), 335-335.
- . Physiological Measurement, 21(2), 295-303.
- . Diabetes, Obesity and Metabolism, 2(2), 75-82.
- . Diabetic Medicine, 17(1), 1-1.
- . Clinical Endocrinology, 52(2), 187-187.
- Sudden cardiac death in young people with diabetes. CME Bulletin Endocrinology and Diabetes, 3(1), 4-7.
- . Diabetes Care, 22(10), 1607-1611.
- Dead in bed. Diabetic Medicine, 16(9), 782-785.
- . Diabetic Medicine, 16(8), 623-625.
- A comparison of the metabolic and cardiac electrophysiophysiological changes during experimental and clinical hypoglycaemia.. DIABETOLOGIA, 42, A71-A71.
- Soluble insulin and the rapid -acting analogue insulin aspart have similar effects upon ventricular repolarization.. DIABETOLOGIA, 42, A237-A237.
- . Journal of Trace Elements in Medicine and Biology, 13(1-2), 57-61.
- . Best Practice & Research Clinical Endocrinology & Metabolism, 13(2), 279-294.
- . Health Informatics Journal, 5(4), 200-204.
- , 4-26.
- Population-based modeling to demonstrate extrapancreatic effects of tolbutamide. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 274(4), E758-E771.
- . American Journal of Physiology-Endocrinology and Metabolism, 274(4), E758-E771.
- . QJM, 90(9), 577-585.
- . Diabetic Medicine, 14(8), 648-654.
- . Diabetes Care, 20(8), 1293-1298.
- . Diabetic Medicine, 14(6), 442-448.
- . Diabetic Medicine, 14(4), 275-278.
- . Journal of Clinical Endocrinology & Metabolism, 82(5), 1458-1461.
- The insulinergic effect of tolbutamide during euglycaemic clamp in non-diabetic subjects: Pharmacokinetic-pharmacodynamic modelling. British Journal of Clinical Pharmacology, 41(5).
- . Journal of Medical Engineering & Technology, 20(6), 196-202.
- Training and professional development in diabetes care. Diabetic Medicine, 13(SUPPL. 4).
- Training and professional development in diabetes care.. Diabet Med, 13(9 Suppl 4), S65-S76.
- Abnormalities on the ECG during spontaneous overnight hypoglycaemia in patients with type 1 diabetes. DIABETOLOGIA, 39, 824-824.
- In search of a hypoglycaemic alarm. DIABETOLOGIA, 39, 832-832.
- Impaired peripheral physiological responses to hypoglycaemia in insulin treated type II diabetes. DIABETOLOGIA, 39, 243-243.
- Fasting insulin predicts the acute insulinergic effect of tolbutamide, which is not related to hypoglycaemic effect.. DIABETOLOGIA, 39, 870-870.
- Tolbutamide enhances glucose effectiveness following acute administration in non-diabetic subjects.. DIABETOLOGIA, 39, 869-869.
- . The Lancet, 348(9019), 60-61.
- . Diabetic Medicine, 13(7), 634-641.
- . Diabetic Medicine, 13(7), 607-615.
- . Journal of Clinical Endocrinology & Metabolism, 81(3), 1160-1163.
- . Diabetologia, 38(10), 1183-1190.
- . Diabetologia, 38(10), 1183-1190.
- QTC INTERVAL PROLONGATION DURING HYPOGLYCEMIA IN PATIENTS WITH IDDM - A POSSIBLE MECHANISM OF SUDDEN-DEATH. DIABETOLOGIA, 38, A18-A18.
- PHYSIOLOGICAL-RESPONSES TO HYPOGLYCEMIA ARE NOT REDUCED 2 DAYS AFTER ANTECEDENT HYPOGLYCEMIA IN IDDM. DIABETOLOGIA, 38, A18-A18.
- . BMJ, 310(6977), 440-440.
- HYPOGLYCEMIA ATTENUATES PHYSIOLOGICAL-RESPONSES TO FURTHER HYPOGLYCEMIA UP TO ONE, WEEK LATER. DIABETOLOGIA, 37, A165-A165.
- Neurologic consequences of hypoglycemia and pathogenic mechanisms involved in diabetic neuropathy. Current Opinion in Neurology and Neurosurgery, 6(3), 423-428.
- Brittle diabetes in the young. Practitioner, 236(1521), 1126-1129.
- . Diabetologia, 35(10), 1009-1010.
- A multicentre trial of the aldose-reductase inhibitor tolrestat, in patients with symptomatic diabetic peripheral neuropathy. Diabete et Metabolisme, 18(1), 14-20.
- . American Journal of Physiology-Endocrinology and Metabolism, 261(1), E41-E48.
- . Clinical Science, 81(1), 1-9.
- . Clinical Science, 80(6), 583-586.
- . BMJ, 302(6787), 1240-1243.
- . Diabetes, 40(2), 223-226.
- . Diabetes, 40(2), 223-226.
- . Diabetes Care, 14(4), 342-344.
- . British Journal of Clinical Pharmacology, 29(6), 685-693.
- . Diabetologia, 33(4), 216-221.
- . Diabetic Medicine, 5(6), 552-556.
- . Diabetic Medicine, 4(3), 260-264.
- . Diabetologia, 30(12), 924-929.
- . The Lancet, 330(8555), 359-363.
- . JAMA, 256(7), 877-877.
- . JAMA: The Journal of the American Medical Association, 256(7), 877-880.
- . BMJ, 292(6520), 583-586.
- . European Journal of Clinical Pharmacology, 31(1), 27-31.
- . The Lancet, 326(8448), 212-212.
- . Diabetic Medicine, 2(3), 167-172.
- . Journal of Chemical Information and Modeling, 25(3), 224-231.
- . Diabetic Medicine, 2(5), 395-397.
- . Diabetic Medicine, 1(3), 199-204.
- . BMJ, 285(6336), 167-168.
- . Diabetologia.
- . Diabetic Medicine.
- . Diabetologia.
- . Diabetologia.
- . Diabetic Medicine.
- . Diabetic Medicine.
- . Diabetologia.
- . Diabetologia.
- . Diabetic Medicine.
- . Diabetic Medicine.
- . Diabetes Technology & Therapeutics.
- . Diabetes Technology & Therapeutics.
- . Diabetic Medicine.
- . Diabetes Technology & Therapeutics.
- . Acta Diabetologica.
- . Diabetic Medicine.
- . JMIR Diabetes, 8, e42100-e42100.
- . Diabetic Medicine.
- . Diabetes Technology & Therapeutics.
- . Diabetes Care.
- . Diabetic Medicine.
- . Clinical Diabetes.
- . Diabetes Care.
- . Diabetologia.
- . Pediatric Diabetes.
- . Diabetologia.
- . Diabetic Medicine.
- . Diabetic Medicine.
- . Diabetic Medicine.
- . Pediatric Diabetes.
- . Diabetic Medicine.
- . Diabetes Care, dc172682-dc172682.
- . Programme Grants for Applied Research, 2(5), 1-188.
- . Diabetic Medicine, 27(6), 666-672.
- . Diabetic Medicine, 27(8), 965-967.
- . Diabetic Medicine, 25(9), 1117-1120.
- . Diabetic Medicine, 21(9), 961-961.
- . 2004 IEEE Africon. 7th Africon Conference in Africa (IEEE Cat. No.04CH37590).
- . British Journal of Clinical Pharmacology, 55(3), 246-251.
- . Diabetes Care, dc200277-dc200277.
- . Diabet Med.
- . Frontiers in Immunology, 12.
- . Diabetes, Obesity and Metabolism.
- . Diabetic Medicine.
- . Diabetic Medicine.
Chapters
- (pp. 579-601). Wiley
- , Metabolic Syndrome (pp. 597-608). Elsevier
- , Metabolic Syndrome (pp. 597-608). Elsevier
- , Endocrinology and Diabetes (pp. 375-386). Springer International Publishing
- , Endocrinology and Diabetes (pp. 429-443). Springer New York
- In Frier B, Heller S & McCrimmon R (Ed.), Hypoglycaemia in Clinical Diabetes, (pp. x-xi). Wiley
- Pathophysiology of the effects of hypoglycemia on the cardiovascular system (pp. 3-8).
- Does diabetic control matter? (pp. 553-563).
- CRC Press
- , Advanced Nutrition and Dietetics in Diabetes (pp. 60-66). John Wiley & Sons, Ltd
- , Hypoglycaemia in Clinical Diabetes (pp. 263-284). John Wiley & Sons, Ltd
- , Hypoglycaemia in Clinical Diabetes (pp. 96-113). John Wiley & Sons, Ltd
- , Difficult Diabetes (pp. 168-187). Blackwell Science Ltd
- , Hypoglycaemia in Clinical Diabetes (pp. 265-283). John Wiley & Sons, Ltd
- , Hypoglycaemia in Clinical Diabetes (pp. 83-99). John Wiley & Sons, Ltd
Conference proceedings papers
- . Diabetes, Vol. 71(Supplement_1)
- . Value in Health, Vol. 22 (pp S584-S584)
- Reduced risk of hypoglycaemia and lower HbA(1c) with degludec compared to glargine U300 in insulin-treated patients with type 2 diabetes. DIABETOLOGIA, Vol. 62 (pp S47-S47)
- Non-severe hypoglycaemia predicts increased risk of subsequent severe events in patients with type 2 diabetes. DIABETOLOGIA, Vol. 62 (pp S418-S418)
- Analysis of patients in the dapagliflozin DEPICT-1 and-2 trials in type 1 diabetes according to HbA(1c) subgroup. DIABETOLOGIA, Vol. 62 (pp S347-S347)
- Can computational modelling explain the dead in bed syndrome?. DIABETOLOGIA, Vol. 62 (pp S46-S46)
- An audit on multidisciplinary team-lead 'Impaired Awareness of Hypoglycaemia' clinic: Outcomes, challenges and experience from 91直播. DIABETIC MEDICINE, Vol. 36 (pp 79-79)
- Design and implementation of a hypoglycaemia toolkit for use in primary care settings. DIABETIC MEDICINE, Vol. 36 (pp 95-95)
- . C103. CRITICAL CARE: THE LONG WALK - ELUCIDATING OUTCOMES: DEATH, FUNCTIONAL STATUS AND COGNITION
- . ?Wissenschaft und klinischer Fortschritt – gemeinsam in die Zukunft“ – www.diabeteskongress.de, 9 May 2018 - 12 May 2018.
- Pharmacological autonomic blockade during experimental hypoglycaemia exacerbates cardiac repolarisation abnormalities. DIABETOLOGIA, Vol. 60 (pp S74-S74)
- Risk of cardiac arrhythmias and electrophysiological responses during spontaneous hyperglycaemia in young people with type 1 diabetes. DIABETOLOGIA, Vol. 60 (pp S534-S534)
- Satisfaction with insulin delivery and glucose monitoring modalities among adults with long-standing Type 1 diabetes and problematic hypoglycaemia: results from the HypoCOMPaSS study. DIABETIC MEDICINE, Vol. 34 (pp 30-30)
- Sustained improvement in diabetes-specific quality of life in adults with long-standing Type 1 diabetes and problematic hypoglycaemia: two year results from the HypoCOMPaSS study. DIABETIC MEDICINE, Vol. 34 (pp 13-13)
- . Diabetes, Obesity and Metabolism, Vol. 19(12) (pp 1773-1780)
- Psychometric properties of a new scale assessing the impact of acute postprandial hyperglycaemia: the aPPHG-Q. QUALITY OF LIFE RESEARCH, Vol. 25 (pp 132-133)
- Comparison of two treatment approaches in older patients with type 2 diabetes (IMPERIUM). DIABETOLOGIA, Vol. 59 (pp S395-S396)
- Effect of once-weekly semaglutide on the counter-regulatory response to hypoglycaemia in subjects with type 2 diabetes. DIABETOLOGIA, Vol. 59 (pp S363-S364)
- Hypoglycaemia is associated with increased risk of cardiovascular events: results from the EXAMINE trial. DIABETOLOGIA, Vol. 59 (pp S44-S44)
- Effects of antecedent hypoglycaemia on gastric and cardiac responses to subsequent hypoglycaemia in health. DIABETOLOGIA, Vol. 59 (pp S405-S405)
- Cardiac autonomic regulation during experimental hypoglycaemia in type 1 diabetes with impaired awareness of hypoglycaemia. DIABETOLOGIA, Vol. 58 (pp S63-S63)
- Major cardiovascular outcomes in the EXAMINE trial according to ACE inhibitor use. DIABETOLOGIA, Vol. 58 (pp S395-S396)
- Hypoglycaemia avoidance training improves glucose variability in Type 1 diabetes (HypoCOMPaSS Study). DIABETIC MEDICINE, Vol. 32 (pp 7-7)
- Nocturnal confirmed hypoglycaemia with insulin degludec vs insulin glargine: rate ratios for different definitions. DIABETIC MEDICINE, Vol. 32 (pp 67-67)
- Associations with hyperglycaemia avoidance among adults with long-standing Type 1 diabetes and impaired awareness of hypoglycaemia: baseline characteristics from the HypoCOMPaSS Study. DIABETIC MEDICINE, Vol. 32 (pp 186-186)
- Effect of sleep on cardiac autonomic tone during nocturnal hypoglycaemia in adults with Type 1 diabetes. DIABETIC MEDICINE, Vol. 32 (pp 21-21)
- Cardiac autonomic regulation during experimental hypoglycaemia in Type 1 diabetes with impaired awareness of hypoglycaemia (IAH). DIABETIC MEDICINE, Vol. 32 (pp 61-61)
- . The Lancet, Vol. 385 (pp S96-S96)
- PERFORMANCE DURING UNSUPERVISED CLOSED LOOP IN CHILDREN AND ADULTS WITH TYPE 1 DIABETES: WHAT MAKES THE DIFFERENCE?. DIABETES TECHNOLOGY & THERAPEUTICS, Vol. 17 (pp A100-A101)
- Accuracy of Continuous Glucose Monitoring (CGM) under free-living conditions during three home closed loop studies. DIABETOLOGIA, Vol. 57 (pp S406-S407)
- Effects of baseline glycaemic HbA1c on CV outcomes and blood glucose control during the EXAMINE trial in patients with type 2 diabetes and recent acute coronary syndrome. DIABETOLOGIA, Vol. 57 (pp S357-S357)
- Factors predictive of overnight closed loop performance during free living in children and adults with type 1 diabetes. DIABETOLOGIA, Vol. 57 (pp S414-S414)
- Severe hypoglycaemia often results in hospital visits and ambulance calls regardless of insulin regimen. DIABETOLOGIA, Vol. 57 (pp S204-S204)
- Cardiac autonomic regulation during acute experimental hypoglycaemia in type 2 diabetes. DIABETOLOGIA, Vol. 57 (pp S260-S261)
- Three to four weeks of overnight closed loop insulin delivery during free living: analysis of randomised crossover studies in adults and adolescents with type 1 diabetes. DIABETOLOGIA, Vol. 57 (pp S89-S89)
- Psychosocial impact of closed loop therapy for adults with Type 1 diabetes: overnight closed loop at home study. DIABETIC MEDICINE, Vol. 31 (pp 151-151)
- . The Lancet, Vol. 383 (pp S35-S35)
- PSYCHOSOCIAL IMPACT OF CLOSED LOOP THERAPY - ADULTS WITH TYPE 1 DIABETES: OVERNIGHT CLOSED LOOP AT HOME STUDY. DIABETES TECHNOLOGY & THERAPEUTICS, Vol. 16 (pp A102-A102)
- Positive effects of liraglutide as adjunct to insulin in type 1 diabetes: glycaemic control and safety in a randomised, double blind, placebo controlled crossover trial. DIABETOLOGIA, Vol. 56 (pp S7-S8)
- Treatment with liraglutide as adjunct to insulin in type 1 diabetes; effects on counter regulatory response to hypoglycaemia: a randomised, double blind, crossover trial. DIABETOLOGIA, Vol. 56 (pp S404-S405)
- A cross country qualitative investigation of structured education programmes for adults with type 1 diabetes. DIABETOLOGIA, Vol. 56 (pp S452-S453)
- Experimental hypoglycaemia decreases cardiac vagal function for between 7 to 30 days in patients with type 2 diabetes. DIABETOLOGIA, Vol. 56 (pp S243-S243)
- Hypoglycaemia promotes thrombosis and inflammation for at least one week in patients with type 2 diabetes. DIABETOLOGIA, Vol. 56 (pp S243-S243)
- . Diabetic Medicine, Vol. 30(8) (pp 914-917)
- A higher counter-regulatory hormone response is seen with insulin degludec than insulin glargine in response to induced hypoglycaemia in type 1 diabetes. DIABETOLOGIA, Vol. 54 (pp S261-S261)
- Basal-bolus therapy with insulin degludec improves long-term glycaemic control with less nocturnal hypoglycaemia compared with insulin. DIABETOLOGIA, Vol. 54 (pp S425-S425)
- Impaired awareness of hypoglycemia: Commentary. Diabetic Hypoglycemia, Vol. 3(3) (pp 9)
- . Journal of Diabetes Science and Technology, Vol. 5(6) (pp 1352-1362)
- Hypoglycemia and clinical islet transplantation. Diabetic Hypoglycemia, Vol. 3(2) (pp 11-12)
- Nature of association between severe hypoglycaemia and risks of vascular events and death in ADVANCE. DIABETOLOGIA, Vol. 53
- Overnight closed-loop glucose control following consumption of alcohol in adults with type 1 diabetes. DIABETOLOGIA, Vol. 53 (pp S25-S26)
- . Diabetes Research and Clinical Practice, Vol. 78(3) (pp S40-S46)
- Do high fasting glucose levels suggest nocturnal hypoglycaemia? The Somogyi effect - fact or fiction?. DIABETOLOGIA, Vol. 50 (pp S335-S336)
- Frequency and motives of blood glucose self-monitoring in type I diabetes: association with glycaemic control, complications, and patient characteristics. DIABETOLOGIA, Vol. 49 (pp 494-494)
- Maternal hypoglycaemia and glycaemic control in pregnancy: a randomised trial comparing insulin aspart with human insulin in 322 subjects with type 1 diabetes. DIABETOLOGIA, Vol. 49 (pp 576-577)
- Sensitivity and specificity of CGMS for identifying clinially relevant symptomatic hypoglycaemia. DIABETOLOGIA, Vol. 49 (pp 507-508)
- . Diabetic Medicine, Vol. 23(3) (pp 285-292)
- . Computers in Cardiology, 2003, 24 September 2003 - 24 September 2003.
- Effect of atenolol on QTc interval lengthening during hypoglycaemia in Type 1 diabetes. DIABETOLOGIA, Vol. 45 (pp A78-A78)
- A pharmacokinetic-pharmacodynamic model to explain the biphasic insulinergic effect of tolbutamide and the suppressive role of lowering blood glucose on this effect. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol. 42(5) (pp P675-P676)
- . Computers in Cardiology 2000. Vol.27 (Cat. 00CH37163)
- . Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286)
Reports
Posters
- The Cost-Effectiveness of 5-week versus 1-week DAFNE Structured Education in Type 1 Diabetes: A Preliminary Evaluation Using the 91直播 Type 1 Diabetes Policy Model (Diabetes UK Professional Conference 13-15 March 2013).
- The Cost-Effectiveness of Dose Adjustment For Normal Eating (DAFNE) Structured Education in Type 1 Diabetes: An Update using the 91直播 Type 1 Diabetes Policy Model (Diabetes UK Professional Conference 13-15 March 2013).
Other
- . Diabetologia.
- . Diabetes Care, 41(4), e65-e66.
- . Diabetes Care, 37(12), e272-e273.
- . The Lancet Diabetes & Endocrinology, 2(3), 194-195.
- . Diabetologia, 57(5), 847-849.
- . Diabetic Medicine, 29(12), 1600-1601.
- . Diabetes/Metabolism Research and Reviews, 28(1), 50-61.
- . Practical Diabetes International, 28(5), 227-232.
- . The British Journal of Diabetes & Vascular Disease, 11(1_suppl), 6-9.
- . Medicine, 38(12), 671-675.
- Self-destructive behavior - A case of recurrent severe hypoglycemia. Diabetic Hypoglycemia, 2(3), 17-18.
Preprints
- Grants
-
National Institute of Health Research, Programme Grant October 2007-April 2013. Improving management of Type 1 diabetes in the UK: the DAFNE programme as a research test-bed. Principal
Investigator in collaboration with Dr J Lawton, Dr M Clarke, Ms G Thompson, Prof S Amiel, Prof M Campbell, Dr P Mansell, Dr I Lawrence, Ms C Taylor, Ms L Oliver (Chief Investigator) ?1.8m
Diabetes UK. Jan 2009-July 2013. KICk-OFF: A multi-centre, randomised controlled trial comparing intensive structured education with standard education in 11-16 year olds on intensive insulin therapy.
Dr K Price, Prof C Eiser Dr J Wales, Dr J Freeman (co-investigator) ?1.35m
Diabetes UK. April 2008-March 2011. Overnight hypoglycaemia prevention in adult subjects with type 1 diabetes: Closing the loop
Dr R Hovorka, Prof S Amiel Dr M Evans, (co-investigator) ?750k
Diabetes UK. Sep 2009-March 2012. Prevention of recurrent severe hypoglycaemia: a definitive RCT comparing optimised MDI and CSII with or without adjunctive real-time continuous glucose monitoring
Dr J Shaw, Prof D Kerr, Dr D Flanagan, Dr M Evans, Dr J Speight (co-investigator) ?1.4m
South Yorkshire Research Collaborations for Leadership in Applied Health Research and Care October 2008- September 2013 Diabetes Theme Adolescent Project to develop a structured training programme and other interventions to improve outcomes in young people with Type 1 diabetes aged 16-21years.
Prof C Eiser, Dr A Scott, (Chief Investigator) ?900k
Health Technology Assessment Grant. June 2011-Dec 2015 The REPOSE (Relative Effectiveness of Pumps Or Structured Education) Trial.
Prof N Waugh, Dr C Cooper, Prof M Campbell, Prof S Amiel, Dr P Hammond, Ms C Taylor, Dr R Lindsay, Dr J Lawton, Dr K Barnard, Dr M Evans, Dr F Green, Dr A Jaap, Ms C Taylor, Prof S Dixon, (Chief Investigator). ?2.0m
Health Technology Assessment Grant. 14/213/10 January 2016 – June 2017 A systematic review of psychological interventions to improve motivation for self-management in people with type 1 and type 2 diabetes
Dr K Winkley, Prof Khalida Ismail, Prof A Brennan (co-investigator) ?176.74k
National Institute of Health Research, Programme Grant March 2016- September 2021. Developing and trialling the DAFNEplus (Dose for Adjustment for Normal Eating) intervention. A lifelong approach to promote effective self-management in adults with type 1 diabetes.
Chief Investigator in collaboration with Professor J Lawton, Professor S Michie, Ms G Thompson, Prof S Amiel, Prof M Campbell, Dr P Mansell, Dr D Hopkins, Ms C Taylor, Dr J Elliott, Mr S Fisher, Prof L Yardley, Prof A Brennan, Dr J Cohen, Dr D Cooke, Prof W Baird. (Chief Investigator) ?2.75m
- Professional activities and memberships
-
Activities and Distinctions
- Diabetes UK Research Committee 2005 – 2015. Professional Advisory Council 2003-2008. Scientific and Research Advisory Group. 2009- present, Arnold Bloom Lecture, Diabetes UK, 2012
- Member of NICE/RCP working groups developing national guidelines for the management of adult Type 1 (2002) and Type 2 diabetes (2000).
- Deputy Chair Joint DoH/MRC Research Advisory Committee on Diabetes 2002
- Member of MRC College of Experts 2005-2009
- Acting Portfolio Director in Diabetes, Dept of Health, Sept – Dec 2004
- I chaired the Clinical Studies Advisory Group (2008-2014) and sit on the Management Committee of the UK Diabetes Clinical Research Network. I am currently the acting National Speciality Lead for Diabetes in the NIHR Clinical Research Network.
- NIHR Senior Investigator (since 2012)
- Regional Diabetes Specialty Lead, Yorks/Humber CRN, 2014 to present
- National Diabetes Speciality Lead, NIHR CRN, 2015 to present