Current trials and studies
An alphabetical list of all trials and studies currently being undertaken by the Clinical Trials Research Unit.
A
AWARE-IBD
Putting people with inflammatory bowel disease (IBD) in control of their care.
- Chief investigator: Professor Alan Lobo, 91Ö±²¥ Teaching Hospitals
- Funding body: The Health Foundation
- Status: Follow-up
B
BASIS
Bracing Adolescent Idiopathic Scolio-SIS
- Chief investigator: Mr. Ashley Cole, 91Ö±²¥ Children’s NHS Foundation Trust
- Funding body: Health Technology Assessment
- Status: Recruitment
D
DAFNEplus
Developing and trialling the DAFNEplus (Dose for Adjustment for Normal Eating) intervention. A lifelong approach to promote effective self-management in adults with type 1 diabetes
- Chief investigator: Professor Simon Heller, 91Ö±²¥ Teaching Hospitals NHS Foundation Trust / University of 91Ö±²¥
- Funding body: NIHR Programme Grant for Applied Research
- Status: Follow-up
DETECT-CRC
Early DETECTion of ColoRectal Cancer in Yorkshire (DETECT-CRC): Feasibility study assessing active case finding of colorectal cancer in socio-economically deprived areas.
- Chief investigator: Matthew Kurien, University of 91Ö±²¥
- Funding body: Yorkshire Cancer Research
- Status: Recruitment
E
Evaluating the intervention fidelity of computer therapy for aphasia post-stroke (PhD project)
- Chief investigator: Professor Simon Heller, 91Ö±²¥ Teaching Hospitals NHS Foundation Trust / University of 91Ö±²¥
- CTRU supervisor: Professor Cindy Cooper
- Funding body: NIHR Programme Grant for Applied Research
EXPERTS-ALS
EXPErimental medicine Route To Success in Amyotrophic Lateral Sclerosis
- Chief investigators: Professor Christopher McDermott, University of 91Ö±²¥ and Professor Martin Turner, University of Oxford
- Funding body: National Institute for Health Research, Efficacy and Mechanism Evaluation (EME) programme
- Status: Set-up
F
FIRST
Flexor Injury Rehabilitation Splint Trial: A pragmatic multi-centre randomised control trial (RCT) comparing splints following repair of finger flexor tendons.
- Chief investigator: Emma Bamford, Hand Therapist, Extended Scope Practitioner, Pulvertaft Hand Centre, Derby
- Funding body: National Institute for Health Research, Health Technology Assessment
- Status: Recruitment
H
Healthy weight management - grant development work
We plan to apply for research funding in January 2024. This work will inform the application.
- Chief investigator: TBC
- Status: Recruitment
HELP Fertility?
What is the clinical and cost-effectiveness of hysteroscopic removal of submucosal fibroids and polyps in women presenting with infertility and recurrent miscarriage?
- Chief investigator: Mostafa Metwally, 91Ö±²¥ Teaching Hospitals
- Funding body: National Institute for Health Research, Health Technology Assessment
- Status: Follow-up
I
ILAT (PhD project)
Pilot trial of Intensive Language Action Therapy
- Chief investigator: Mostafa Metwally, 91Ö±²¥ Teaching Hospitals
- CTRU supervisor: Dr Daniel Hind
- Funding body: National Institute for Health Research, Health Technology Assessment
Implementation and acceptability of a Minimum Intervention Care pathway for children with carious permanent teeth attending NHS dental practice – a feasibility study (PhD project)
- Chief investigator: Bhupinder Dawett
- CTRU supervisor: Diana Papaioannou
- Funding body: National Institute for Health Research
M
MATTS
Major Trauma Triage Tool Study
- Chief investigator: Gordon Fuller, University of 91Ö±²¥
- Funding body: Health Technology Assessment
- Status: Analysis
MEErKAT
MEsenteric Excision and Kono-S Anastomosis Trial (MEErKAT).
- Chief investigator: Steven Brown, 91Ö±²¥ Teaching Hospitals NHS Foundation Trust
- Funding body: National Institute for Health Research, Efficacy and Mechanism Evaluation (EME) programme
- Status: Recruitment
MIND
MedIcal studeNt mental health stuDy
- Chief investigator: Elena Sheldon, University of 91Ö±²¥
- Funding body: British Medical Association
- Status: Reporting
MissionEB
Double-blinded placebo control study of Mesenchymal Intravenous Stromal cell Infusions in children with recessive dystrophic Epidermolysis Bullosa.
- Chief investigator: Dr Anna Martinez, Great Ormond Street Hospital
- Funding body: The Efficacy and Mechanism Evaluation (EME) Programme, NHS England and Cure EB
- Status: Recruitment
O
OptiCALS
A programme to develop and evaluate a complex intervention to improve nutritional management for people with Amyotrophic Lateral Sclerosis (ALS)
- Chief investigator: Professor Christopher McDermott, 91Ö±²¥ Teaching Hospitals NHS Foundation Trust / University of 91Ö±²¥
- Funding body: National Institute for Health Research
- Status: Recruitment
ORION
RadiO fRequency ablatION for haemorrhoids
- Chief investigator: Professor Steven Brown, 91Ö±²¥ Teaching Hospitals
- Funding body: NIHR Health Technology Assessment (HTA)
- Status: Follow-up
P
PRAISE
Pain Relief After Instrumented Spinal surgEry trial
- Chief investigator: Professor Matthew Wilson, University of 91Ö±²¥
- Funding body: NIHR Health Technology Assessment (HTA)
S
STAR MS
Autologous stem cell transplantation versus alemtuzumab or ocrelizumab in relapsing-remitting multiple sclerosis
- Chief investigator: Professor John Snowden, 91Ö±²¥ Teaching Hospitals NHS Foundation Trust
- Funding body: EME Programme
- Status: Recruitment
STOP-OHSS
Shaping and Trialling Outpatient Protocols for Ovarian HyperStimulation Syndrome
- Chief investigator: Mostafa Metwally, 91Ö±²¥ Teaching Hospitals NHS Foundation Trust
- Funding body: NIHR Health Technology Assessment
- Status: Recruitment
T
TRICEPS
TRanscutaneous lImb reCovEry Post-Stroke
- Chief investigator: Professor Arshad Majid, University of 91Ö±²¥
- Funding body: NIHR Efficacy and Mechanism Evaluation (EME) Programme
- Status: Recruitment