Dr Raman Vaidyanathan

School of Chemical, Materials and Biological Engineering

Senior Lecturer in Chemical Engineering

Course Director MSc (Eng) Biological and Bioprocess Engineering

Course Director MSc (Eng) Biochemical Engineering with Industrial Management

Dr Raman Vaidyanathan
Profile picture of Dr Raman Vaidyanathan
s.vaidyanathan@sheffield.ac.uk
+44 114 222 7526

Full contact details

Dr Raman Vaidyanathan
School of Chemical, Materials and Biological Engineering
Room G60
Sir Robert Hadfield Building
Mappin Street
91直播
S1 3JD
Profile

I joined the Department as a lecturer in 2007. I'm a chemical graduate with a Masters degree in Biotechnology (both from India) and completed my PhD in 2001 from the University of Strathclyde in Glasgow, where I investigated the application of near infrared spectroscopy to monitor industrially relevant bioprocesses involving filamentous microorganisms. This was work done in collaboration with Eli Lilly.

I have over five years of pre-doctoral industrial experience applying biotechnological solutions to environmental engineering problems.

Before joining 91直播 I was a research associate at the University of Manchester, where I investigated a) the application of secondary ion mass spectrometry with buckminsterfullerene (C60) cluster ions as primary ion sources to characterize biological surfaces, and b) laser desorption ionization mass spectrometry for metabolomic applications.

I also spent my post-doctoral years investigating the application of soft ionization mass spectrometry to characterize biological systems, at Aberystwyth in Wales.

Research interests

Algae Biotechnology
Systems and synthetic biology
Bioprocess Engineering
Bioenergy
Bioinformatics and use of machine learning
Metabolomics and Proteomics
Mass spectrometric imaging

Publications

Books

  • Vaidyanathan S, Harrigan GG & Goodacre R (2005) Metabolome Analyses:. Springer. RIS download Bibtex download

Journal articles

  • Shuhaili F, Segura-Noguera M, Mathumathy , Vijayaraghavan R, Thilagar S, Lakshmanan U, Prabaharan D & Vaidyanathan S (2023) . Chemical Engineering Journal, 458, 141433-141433. RIS download Bibtex download
  • Esther Elizabeth Grace C, Briget Mary M, Vaidyanathan S & Srisudha S (2022) . Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 270. RIS download Bibtex download
  • Butler TO, Padmaperuma G, Lizzul AM, McDonald J & Vaidyanathan S (2021) . Bioresource Technology. RIS download Bibtex download
  • Hadiyanto H, Khoironi A, Dianratri I, Suherman S, Muhammad F & Vaidyanathan S (2021) . Heliyon, 7(8), e07676-e07676. RIS download Bibtex download
  • Slocombe SP, Huete-Ortega M, Kapoore RV, Okurowska K, Mair A, Day JG, Stanley MS & Vaidyanathan S (2021) . iScience, 102743-102743. RIS download Bibtex download
  • Kapoore RV, Padmaperuma G, Maneein S & Vaidyanathan S (2021) . Critical Reviews in Biotechnology. RIS download Bibtex download
  • Butler TO, Acurio K, Mukherjee J, Dangasuk MM, Corona O & Vaidyanathan S (2021) . Separation and Purification Technology, 255. RIS download Bibtex download
  • Sethi D, Butler TO, Shuhaili F & Vaidyanathan S (2020) . Biology, 9(8). RIS download Bibtex download
  • Chen Y, Xu C & Vaidyanathan S (2020) . Applied Energy, 261. RIS download Bibtex download
  • Butler T, Kapoore RV & Vaidyanathan S (2020) . Trends in Biotechnology. RIS download Bibtex download
  • Grace CEE, Lakshmi PK, Meenakshi S, Vaidyanathan S, Srisudha S & Mary MB (2020) . Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 224. RIS download Bibtex download
  • Kapoore RV, Huete-Ortega M, Day JG, Okurowska K, Slocombe SP, Stanley MS & Vaidyanathan S (2019) . Scientific Reports, 9. RIS download Bibtex download
  • Kapoore RV & Vaidyanathan S (2018) . Metabolites, 8(4). RIS download Bibtex download
  • Sydney T, Marshall-Thompson J-A, Kapoore RV, Vaidyanathan S, Pandhal J & Fairclough JPA (2018) . Metabolites, 8(4). RIS download Bibtex download
  • Huete-Ortega M, Okurowska K, Kapoore RV, Johnson MP, Gilmour DJ & Vaidyanathan S (2018) . Biotechnology for Biofuels, 11(1), 60-60. RIS download Bibtex download
  • Chen Y, Xu C & Vaidyanathan S (2017) . Critical Reviews in Biotechnology. RIS download Bibtex download
  • Padmaperuma G, Kapoore RV, Gilmour DJ & Vaidyanathan S (2017) . Critical Reviews in Biotechnology, 38(5), 690-703. RIS download Bibtex download
  • Kapoore RV, Coyle R, Staton CA, Brown NJ & Vaidyanathan S (2017) . Analyst, 142(11), 2038-2049. RIS download Bibtex download
  • Kapoore RV & Vaidyanathan S (2016) . Philosophical transactions of the Royal Society of London. Series A: Mathematical and physical sciences, 374. RIS download Bibtex download
  • Vaidyanathan S, Longworth J, Wu D, Huete-Ortega M & Wright PC (2016) . Algal Research, 18, 213-224. RIS download Bibtex download
  • Hounslow E, Kapoore RV, Vaidyanathan S, Gilmour DJ & Wright PC (2016) . Current Biotechnology, 5(4), 305-313. RIS download Bibtex download
  • Chen Y, Zhang L, Xu C & Vaidyanathan S (2016) . Science of The Total Environment, 541, 1282-1295. RIS download Bibtex download
  • Kapoore RV, Coyle R, Staton CA, Brown NJ & Vaidyanathan S (2015) . Metabolomics, 11(6), 1743-1755. RIS download Bibtex download
  • Chen Y, Tang X, Kapoore RV, Xu C & Vaidyanathan S (2015) . Energy Conversion and Management, 106, 61-72. RIS download Bibtex download
  • Aram P, Shen L, Pugh J, Vaidyanathan S & Kadirkamanathan V (2014) . Bioinformatics, 31(5), 753-760. RIS download Bibtex download
  • Chen Y & Vaidyanathan S (2013) . Anal Chim Acta, 776, 31-40. RIS download Bibtex download
  • Longworth J, Noirel J, Pandhal J, Wright PC & Vaidyanathan S (2012) . J Proteome Res, 11(12), 5959-5971. RIS download Bibtex download
  • Salim M, Wright PC & Vaidyanathan S (2012) . Analyst, 137(10), 2350-2356. RIS download Bibtex download
  • Chen Y & Vaidyanathan S (2012) A simple, reproducible and sensitive spectrophotometric method to estimate microalgal lipids. Analytica Chimica Acta, 724, 67-72. RIS download Bibtex download
  • Salim M, Fowler GJS, Wright PC & Vaidyanathan S (2012) . Analytica Chimica Acta. RIS download Bibtex download
  • Chen Y & Vaidyanathan S (2012) . Analytica Chimica Acta. RIS download Bibtex download
  • Salim M, McArthur SL, Vaidyanathan S & Wright PC (2011) . Mol Biosyst, 7(1), 101-115. RIS download Bibtex download
  • Vaidyanathan S, Fletcher JS, Jarvis RM, Henderson A, Lockyer NP, Goodacre R & Vickerman JC (2009) . Analyst, 134(11), 2352-2360. RIS download Bibtex download
  • Vickerman J, Chandra S, Nygren H, Heeren R, Winograd N, Tyler D, Moon D, Walker D, Clode D, Breitenstein D , Peterson D et al (2008) . APPLIED SURFACE SCIENCE, 255(4), 1305-1306. RIS download Bibtex download
  • Vaidyanathan S (2008) . Molecular Biotechnology, 40(2), 214-215. RIS download Bibtex download
  • Vaidyanathan S, Fletcher JS, Goodacre R, Lockyer NP, Micklefield J & Vickerman JC (2008) . Anal Chem, 80(6), 1942-1951. RIS download Bibtex download
  • Fletcher JS, Lockyer NP, Vaidyanathan S & Vickerman JC (2007) . Anal Chem, 79(6), 2199-2206. RIS download Bibtex download
  • Vaidyanathan S, Lopez-Diez C & Goodacre R (2007) , 29-48. RIS download Bibtex download
  • Vaidyanathan S & Goodacre R (2007) . Rapid Commun Mass Spectrom, 21(13), 2072-2078. RIS download Bibtex download
  • Vaidyanathan S, Jones D, Ellis J, Jenkins T, Chong C, Anderson M & Goodacre R (2007) . Rapid Commun Mass Spectrom, 21(13), 2157-2166. RIS download Bibtex download
  • Vaidyanathan S (2006) Influence of instrumental conditions on the electrospray ionization mass spectrometry of peptides/proteins in mixtures. American Biotechnology Laboratory, 24(2), 32-33. RIS download Bibtex download
  • Vaidyanathan S, O'Hagan S & Goodacre R (2006) . Rapid Commun Mass Spectrom, 20(1), 21-30. RIS download Bibtex download
  • Vaidyanathan S, Gaskell S & Goodacre R (2006) . Rapid Commun Mass Spectrom, 20(8), 1192-1198. RIS download Bibtex download
  • Vaidyanathan S, Jones D, Broadhurst DI, Ellis J, Jenkins T, Dunn WB, Hayes A, Burton N, Oliver SG, Kell DB & Goodacre R (2005) . METABOLOMICS, 1(3), 243-250. RIS download Bibtex download
  • Vaidyanathan S (2005) . METABOLOMICS, 1(1), 17-28. RIS download Bibtex download
  • Vaidyanathan S, Harrigan GG & Goodacre R (2005) . Metabolome Analyses: Strategies for Systems Biology, 1-7. RIS download Bibtex download
  • Vaidyanathan S, Harrigan GG & Goodacre R (2005) . Metabolome Analyses: Strategies for Systems Biology, 1-390. RIS download Bibtex download
  • Vaidyanathan S & Goodacre R (2005) . Chemical Analysis, 169, 229-256. RIS download Bibtex download
  • Vaidyanathan S, Kell DB & Goodacre R (2004) . Anal Chem, 76(17), 5024-5032. RIS download Bibtex download
  • Goodacre R, Vaidyanathan S, Dunn WB, Harrigan GG & Kell DB (2004) . Trends Biotechnol, 22(5), 245-252. RIS download Bibtex download
  • Ellis DI, O'Hagan S, Dunn WB, Brown M & Vaidyanathan S (2004) . Genome Biol, 5(11), 354. RIS download Bibtex download
  • Vaidyanathan S, Broadhurst DI, Kell DB & Goodacre R (2003) . Anal Chem, 75(23), 6679-6686. RIS download Bibtex download
  • Vaidyanathan S, White S, Harvey LM & McNeil B (2003) . BIOTECHNOLOGY AND BIOENGINEERING, 82(6), 715-724. RIS download Bibtex download
  • Goodacre R, Vaidyanathan S, Bianchi G & Kell DB (2002) Metabolic profiling using direct infusion electrospray ionisation mass spectrometry for the characterisation of olive oils.. Analyst, 127(11), 1457-1462. RIS download Bibtex download
  • Vaidyanathan S, Kell DB & Goodacre R (2002) Flow-injection electrospray ionisation mass spectrometry of crude cell extracts for high-throughput bacterial identification.. Journal of the American Society for Mass Spectrometry, 13, 118-128. RIS download Bibtex download
  • Vaidyanathan S, Winder CL, Wade SC, Kell DB & Goodacre R (2002) Sample preparation in matrix鈥恆ssisted laser desorption/ionization mass spectrometry of whole bacterial cells and the detection of high mass (> 20 kDa) proteins.. Rapid Communications in Mass Spectrometry, 16(13), 1276-1286. RIS download Bibtex download
  • Vaidyanathan S, Arnold SA, Matheson L, Mohan P, McNeil B & Harvey LM (2001) . Biotechnol Bioeng, 74(5), 376-388. RIS download Bibtex download
  • Vaidyanathan S, Rowland JJ, Kell DB & Goodacre R (2001) . ANALYTICAL CHEMISTRY, 73(17), 4134-4144. RIS download Bibtex download
  • Vaidyanathan S, Macaloney G, Harvey LM & McNeil B (2001) . APPLIED SPECTROSCOPY, 55(4), 444-453. RIS download Bibtex download
  • Vaidyanathan S, Harvey LM & McNeil B (2001) . ANALYTICA CHIMICA ACTA, 428(1), 41-59. RIS download Bibtex download
  • Arnolda SA, Crowley J, Vaidyanathan S, Matheson L, Mohan P, Hall JW, Harvey LM & McNeil B (2000) . Enzyme Microb Technol, 27(9), 691-697. RIS download Bibtex download
  • Vaidyanathan S, Arnold A, Matheson L, Mohan P, Macaloney G, McNeil B & Harvey LM (2000) . Biotechnol Prog, 16(6), 1098-1105. RIS download Bibtex download
  • Vaidyanathan S, Macaloney G & McNeil B (1999) . ANALYST, 124(2), 157-162. RIS download Bibtex download
  • Vaidyanathan S, Macaloney G, Vaughn J, McNeil B & Harvey LM (1999) . CRITICAL REVIEWS IN BIOTECHNOLOGY, 19(4), 277-316. RIS download Bibtex download
  • Almalki W, Nwokeoji AO & Vaidyanathan S () . SynBio, 2(2), 190-205. RIS download Bibtex download
  • Hamed SM, Kapoore RV, Raut MP, Vaidyanathan S & Wright PC () . Applied Microbiology and Biotechnology. RIS download Bibtex download
  • Hamed SM, Kapoore RV, Raut MP, Vaidyanathan S & Wright PC () . Applied Microbiology and Biotechnology. RIS download Bibtex download
  • Remiezowicz E, Spooren J, Bay E, Cowan A, Ingram I, Abrantes P, Nunes da Ponte M, North M, Albo J, Styring P , Priestnall M et al () . Faraday Discuss., 183, 463-487. RIS download Bibtex download
  • Kapoore R, Butler T, Pandhal J & Vaidyanathan S () . Biology, 7(1). RIS download Bibtex download

Chapters

  • Padmaperuma G, Butler T, Shuhaili FAB, Almalki WJ & Vaidyanathan S (2020) Microbial Consortia: Concept and Application in Fruit Crop Management In Srivastava AK & Hu C (Ed.), Fruit Crops Diagnosis and Management of Nutrient Constraints (pp. 353-366). Elsevier RIS download Bibtex download
  • Padmaperuma G, Butler TO, Shuhaili FABA, Almalki WJ & Vaidyanathan S (2020) , Fruit Crops (pp. 353-366). Elsevier RIS download Bibtex download
  • Vaidyanathan S & Goodacre R (2005) Understanding the behaviour of pathogenic cells: proteome and metabolome analyses. In Griffiths M (Ed.), Understanding Pathogen Behaviour (pp. 3-52). CRC Press RIS download Bibtex download
  • Vaidyanathan S & Goodacre R (2003) Proteome and metabolome analyses for food authentication In Lees M (Ed.), Food authenticity and traceability [electronic resource] (pp. 71-100). Woodhead Publishing RIS download Bibtex download
  • Vaidyanathan S & Goodacre R (2003) , Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis (pp. 9-38). Springer US RIS download Bibtex download
  • Vaidyanathan S & Goodacre R (2003) Metabolome and proteome profiling for microbial characterization: Mass spectrometric applications. In Harrigan GG & Goodacre R (Ed.), Metabolic Profiling (pp. 9-38). Springer RIS download Bibtex download
  • Marmiroli N, Peano C, Maestri E, Lenstra JA, M盲rtlbauer E, Vaidyanathan S, Goodacre R, Benson I, Le Gall G, Colquhoun IJ , Kelly SD et al (2003) , Food Authenticity and Traceability (pp. xiii-xvii). Elsevier RIS download Bibtex download
  • Vaidyanathan S & Goodacre R (2003) , Food Authenticity and Traceability (pp. 71-100). RIS download Bibtex download

Conference proceedings papers

  • Vaidyanathan S, Salim M, Hurley C & Pugh J (2013) . SURFACE AND INTERFACE ANALYSIS, Vol. 45(1) (pp 290-293) RIS download Bibtex download
  • Vaidyanathan S (2013) . SURFACE AND INTERFACE ANALYSIS, Vol. 45(1) (pp 255-259) RIS download Bibtex download
  • Vaidyanathan S (2009) ANYL 380-Matrix effects in biomolecular imaging using ToF-SIMS. ABSTR PAP AM CHEM S, Vol. 238 RIS download Bibtex download
  • Vaidyanathan S & Longworth J (2009) BIOT 402-Seeking the message in the medium: Metabolic footprints of microalgal cultivations for bioenergy. ABSTR PAP AM CHEM S, Vol. 238 RIS download Bibtex download
  • Fletcher JS, Henderson A, Biddulph GX, Vaidyanathan S, Lockyer NP & Vickerman JC (2008) . APPLIED SURFACE SCIENCE, Vol. 255(4) (pp 1264-1270) RIS download Bibtex download
  • Vaidyanathan S, Fletcher JS, Lockyer NP & Vickerman JC (2008) . APPLIED SURFACE SCIENCE, Vol. 255(4) (pp 922-925) RIS download Bibtex download
  • Vaidyanathan S, Fletcher JS, Henderson A, Lockyer NP & Vickerman JC (2008) . APPL SURF SCI, Vol. 255(4) (pp 1599-1602) RIS download Bibtex download
  • Vaidyanathan S, Lopez-Diez C & Goodacre R (2007) Proteome and metabolome analyses for rapid authentication of food.. Rapid Methods Europe 2005 (pp 29-48). Noordwijk aan Zee, the Netherlands, 24 May 2005 - 25 May 2005. RIS download Bibtex download
  • Vaidyanathan S, Kell DB & Goodacre R (2005) Electrospray-ionization mass spectrometry of protein mixtures: Influence of instrumental settings and proteomic implications.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 229 (pp U185-U185) RIS download Bibtex download
  • Vaidyanathan S, Jones D, Jenkins T, Kell DB & Goodacre R (2005) Metabolomic investigations using laser desorption ionisation mass spectrometry on porous silicon. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 229 (pp U245-U245) RIS download Bibtex download
  • Vaidyanathan S & Goodacre R (2003) Metabolite and protein profiling of whole cells using soft-ionization mass spectrometry for rapid microbial characterization.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 225 (pp U199-U199) RIS download Bibtex download
  • Vaidyanathan S, Kell DB & Goodacre R (2002) Rapid, high-throughput microbial characterization by metabolite and protein profiling of whole cells using soft-ionization mass spectrometry.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 224 (pp U199-U199) RIS download Bibtex download
  • Vaidyanathan S, Macaloney G & McNeil B (2000) Measurement of mycelial biomass in a submerged bioprocess using near infrared spectroscopy.. NIRS-鈥99 - Proceedings of the 9th International conference on Near-infrared spectroscopy (pp 429-433). Chichester, UK RIS download Bibtex download

Preprints

  • Butler TO, Padmaperuma G, Lizzul AM, McDonald J & Vaidyanathan S () . RIS download Bibtex download
Research group

Our current research focus is in developing and establishing microalgae-based value chains and processes that can be carbon negative and offer environmentally sustainable solutions with wider impact in the chemicals, materials, energy, food and health sectors. We are working with a diverse group of microalgae, including Chalmydomonas sp., Chlorella sp., Dunaliella salina, Scenedesmus sp., Phaeodactylum tricornutum, Nannochloropsis oceanica, Porphyridium purpureum, etc. The investigations include molecular level understanding and identification of relevant metabolic pathways, metabolic modelling, systems level characterisations, chemical and biochemical process engineering, techno-economic assessments, resource utilisation towards a circular bio-economy. We have been funded by UKRI BBSRC and EPSRC o develop an understanding of lipid accumulation in microalgae towards sustainable biofuels production, and by EU H2020, through an MSCFA to study nutrient uptake by microalgae.

We have identified key delineating features suitable for lipid accumulation in marine microalgae that would help in selecting appropriate strains and process conditions suitable for oil production in microalgae []. We have studied nutrient uptake in the context of lipid accumulation in P. tricornutum and N. oceanica [], as well as in N. salina and D. salina [ and have reported on the differences in the capacity between species to respond to the supply of nitrogen and exposure to high intensity light towards increased lipid accumulation. We have reported on cryopreservation of Chlorella to preserve its lipid accumulating capacity []. We are working towards a better understanding of carbon uptake by microalgae [ to enable appropriate interventions for carbon capture and utilisation. Methods to characterise dissolved inorganic carbon [], intracellular biochemical compositions [,], proteomic and metabolomic data acquisition in microalgae [,,,] have been established. We are developing strategies for microalgae based microbial co-culture systems for better bioproduct formations [, ]. Accumulation of the health-promoting polyunsaturated fatty acids, such as EPA, in the diatom, P. tricornutum have been characterised in pilot-scale outdoor PBRs, as a part of BBSRC funded research (PHYCBIV-28), as well as cell lysis for extraction of products from microalgae (PHYCBIV-13). The development of a biorefinery concept with microalgal cultivations to sustainably sequester CO 2 and produce economically viable processes is being explored with the diatom P. tricornutum [, ]. These include downstream processing considerations [, ].

We wish to build on these findings and develop relevant microalgae-based value chains and materials to enable sustainable interventions in diverse sectors, including renewable energy generation [, ], agriculture [], aquaculture practice, food production, nutrition, health, bulk and fine chemical manufacture. These interventions are aimed at developing environmentally inclusive, economically impacting routes to future food security, chemical manufacturing, health and energy generation. We have wider expertise in microbial characterisations, omic analyses, mass spectrometric imaging, bioinformatics, bioprocess monitoring and microbial process engineering.

Grants

Teaching activities
  • CPE403/6030 - Environment: Gaseous Emissions
  • CPE401 - Research Project (MEng)
  • CPE6009 鈥 Bio-energy
  • CPE6016 鈥 Bioanalytical Techniques (MSc BBE)