El-Khamisy, Sherif, Professor

Professor Sherif El-Khamisy

School of Biosciences

Professor of Molecular Medicine

Deputy Director of the Healthy Lifespan Institute

Chair in Molecular Medicine, Sherif El-Khamisy

S.El-Khamisy@sheffield.ac.uk
+44 114 222 2791

Firth Court

Full contact details

Professor Sherif El-Khamisy
School of Biosciences
Firth Court
Western Bank
91ֱ��
S10 2TN

Profile

Career history

2015 - present: Director of Research and Innovation
2014 - present: Chair of Molecular Medicine, Krebs Institute, University of 91ֱ��
2014 - present: Wellcome Trust Investigator, Krebs Institute, University of 91ֱ��
2014 - present: Lister Research Fellow, Krebs Institute, University of 91ֱ��
2013 - 2015: Wellcome Trust Group Leader, Genome Center, University of Sussex
2013 - 2014: Reader, Krebs Institute, University of 91ֱ��
2008 - 2013: Wellcome Trust Fellow, Genome Center, University of Sussex
2007 - 2008: MRC Post-doctoral Fellow, Genome Center, University of Sussex, UK
2006: Post-doctoral Fellow, Dept. of Genetics, St Jude Children’s Research Hospital, USA
2005: Lecturer, Dept. of Biochemistry, Ain Shams University, Egypt
2002 - 2005: PhD in Biochemistry, University of Sussex, UK

Video animations summarising recent research discoveries

This video describes how DNA repair guards us against ALS, in particular the most common genetic cause for ALS and frontotemporal dementia caused by expansion in a gene called C9orf72. It summarises the work published in Nature Neuroscience on 17 July 2017.

How can the cells' powerhouse - mitochondria - protect their DNA? This video summarises a recent publication in Science Advances.

Major scientific accomplishments

Discovery of the mechanism of genomic instability and neural cell death in C9orf72 ALS (Nature Neuroscience 2017)
Discovery of protein-linked chromosomal break repair in the mitochondria (Science Advances 2017)
Discovery of a novel therapeutic strategy for ALS by inhibiting nuclear export (Nature communications 2017)
Elucidation of an epigenetic mechanism underlying irinotecan resistance in colorectal cancer (Nucleic Acids Research 2016)
Development of a nano-genomic technology to diagnose nucleic acid based infections (Biosensors 2016)
Discovery of the first human diseases resulting from accumulation of Top2-linked DNA breaks (Nature Genetics 2014)
Elucidation of the mechanisms underlying temozolomide therapy in brain tumors (Nucleic Acids Research 2014)
Development of techniques to measure protein-linked chromosomal breaks (Plos One 2013)
Identification of the molecular role of SUMOylation during single-strand break repair (Nature Communications 2012)
Identification of the role of XRCC1 during neural development and maintenance (Nature Neuroscience 2010)
Discovery of the enzyme that disjoins abortive topoisomerase 2 DNA breaks (Nature 2009)
Discovery of the function of the neuroprotective enzyme aprataxin (Nature 2006)
Identification of the first human disease with defects in chromosomal single-strand break repair (Nature 2005)
Elucidation of the role of CK2 in chromosomal single-strand break repair (Cell 2003)

Qualifications

Honours and distinctions

Wellcome Trust Investigator Award
Fellow of the Royal Society of Chemistry
Fellow of the Royal Society of Biology
Fellow of the Lister Institute of Preventative Medicine
Shoman Award for Medical Sciences
Sir Richard Stapley Award, UK
Lorne Duncan Award, UK

Research interests

The intertwined nature of the DNA double helix creates topological barriers that need to be resolved during all types of DNA transactions, in all forms of life from plant to man.

DNA topoisomerases achieve this by breaking and sealing the double helix, allowing the DNA to become untangled or unwound. During their normal catalytic cycle DNA topoisomerases become covalently attached to the DNA 3’-end (Top1) or to the 5’-end (Top2) via a reversible covalent phosphotyrosyl bond.

The presence of nearby oxidative DNA breaks (red circles) or collision with elongating RNA polymerases (RNA POL) during transcription results in ‘trapping’ of topoisomerases on DNA, causing protein-linked DNA breaks (PDBs), which are potent blocks to transcription and cell viability.

PDBs are repaired by a nucleolytic cleavage of DNA releasing the stalled Top and a fragment of DNA. Since this process results in an inevitable loss of genetic material, it is inherently error-prone.

Alternatively, PDBs can be repaired by an error-free mechanism in which the covalent phosphotyrosyl bond linking DNA to the stalled Top is cleaved by specific enzymes, such as tyrosyl DNA phosphodiesterases (TDP1 and TDP2). Interestingly, defects in TDPs cause neurological disease in man (see Fig.2).

In addition to maintaining genetic integrity in post-mitotic non cycling cells, accumulation of PDBs in cycling cells has been widely exploited to treat cancer (e.g. topoisomerase poisons such as Irinotecan and Topotecan), and therefore small molecule inhibitors of TDPs are emerging as attractive strategies to improve cancer therapy.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Karyka E, Berrueta Ramirez N, Webster CP, Marchi PM, Graves EJ, Godena VK, Marrone L, Bhargava A, Ray S, Ning K , Crane H et al (2022) . Life Science Alliance, 5(8), e202101145-e202101145.
Palminha NM, Dos Santos Souza C, Griffin J, Liao C, Ferraiuolo L & El-Khamisy SF (2022) . Cellular and Molecular Life Sciences, 79(3).
Elserafy M, El-Shiekh I, Fleifel D, Atteya R, AlOkda A, Abdrabbou MM, Nasr M & El-Khamisy SF (2021) . Life Science Alliance, 4(10), e202000966-e202000966.
Jurga M, Abugable AA, Goldman ASH & El-Khamisy SF (2021) . Nature Communications, 12.
Ramachandran S, Ma TS, Griffin J, Ng N, Foskolou IP, Hwang M-S, Victori P, Cheng W-C, Buffa FM, Leszczynska KB , El-Khamisy SF et al (2021) . Nature Communications, 12(1).
Ashour ME, Allam W, Elsayed W, Atteya R, Elserafy M, Magdeldin S, Hassan MK & El-Khamisy SF (2021) . Cancers, 13(10).
Zaksauskaite R, Thomas RC, van Eeden F & El-Khamisy SF (2021) . Science Advances, 7(5), eabc4165-eabc4165.
Kim HR, Santhakumar K, Markham E, Baldera D, Greenald D, Bryant HE, El-Khamisy SF & van Eeden FJ (2020) . Oncotarget, 11(13), 1109-1130.
Fielden J, Wiseman K, Torrecilla I, Li S, Hume S, Chiang S-C, Ruggiano A, Narayan Singh A, Freire R, Hassanieh S , Domingo E et al (2020) . Nature Communications, 11(1).
Osman DI, El-Sheikh SM, Sheta SM, Ali OI, Salem AM, Shousha WG, EL-Khamisy SF & Shawky SM (2019) . Biosensors and Bioelectronics, 141, 111451-111451.
Hegazy MT, Allam WR, Hussein MA, Zoheir N, Quartuccio L, El-Khamisy SF & Ragab G (2018) . EBioMedicine, 35, 106-113.
Elserafy M, Abugable AA, Atteya R & El-Khamisy SF (2018) . Trends in Genetics, 34(8), 574-577.
Kassouf N, Kay CWM, Volkov A, Chiang S-C, Birch-Machin MA, El-Khamisy SF & Haywood RM (2018) . Free Radical Biology and Medicine, 126, 153-165.
Mohamed Z, Hassan MK, Okasha S, Mitamura T, Keshk S, Konno Y, Kato T, EL-khamisy SF, Ohba Y & Watari H (2018) . Oncotarget, 9(53), 30053-30065.
Liao C, Beveridge R, Hudson JJR, Parker JD, Chiang S-C, Ray S, Ashour ME, Sudbery I, Dickman MJ & El-Khamisy SF (2018) . Cell Reports, 23(11), 3352-3365.
Samir N, Matboli M, El-Tayeb H, El-Tawdi A, Hassan MK, Waly A, EL-Akkad HAE, Ramadan MG, Al-Belkini TN, El-Khamisy S & El-Asmar F (2018) . Journal of Cellular Biochemistry, 119(8), 6869-6881.
Walker C & El-Khamisy SF (2018) . Brain, 141(5), 1247-1262.
Elserafy M & El-Khamisy SF (2018) . Nature Reviews Molecular Cell Biology, 19(6), 343-344.
Walker C, Herranz-Martin S, Karyka E, Liao C, Lewis K, Lukashchuk V, Chiang S-C, Ray S, Mulcahy PJ, Jurga M , Tsagakis I et al (2017) . Nature Neuroscience, 20, 1225-1235.
Hautbergue GM, Castelli LM, Ferraiuolo L, Sanchez-Martinez A, Cooper-Knock J, Higginbottom A, Lin YH, Bauer CS, Dodd JE, myszczynska MA , Alam SM et al (2017) . Nature Communications, 8.
Chiang S-C, Meagher M, Kassouf N, Hafezparast M, McKinnon PJ, Haywood R & El-Khamisy SF (2017) . Science Advances, 3(4).
Meisenberg C, Ashour ME, El-Shafie L, Liao C, Hodgson A, Pilborough A, Khurram SA, Downs JA, Ward SE & El-Khamisy SF (2017) . Nucleic Acids Research, 45(3), 1159-1176.
Shawky SM, Awad AM, Allam W, Alkordi MH & EL-Khamisy SF (2016) . Biosensors and Bioelectronics.
Atteya R, Ashour ME, Ibrahim EE, Farag MA & El-Khamisy SF (2016) . Mechanisms of Ageing and Development.
Elsayed W, El-Shafie L, Hassan MK, Farag MA & El-Khamisy SF (2016) . Scientific Reports, 6, 26626-26626.
Mazouzi A, Stukalov A, Müller AC, Chen D, Wiedner M, Prochazkova J, Chiang S-C, Schuster M, Breitwieser FP, Pichlmair A , El-Khamisy SF et al (2016) . Cell Reports, 15(4), 893-908.
Ashour ME, Atteya R & El-Khamisy SF (2015) . Nature Reviews Cancer, 15(3), 137-151.
Carroll J, Page TKW, Chiang S-C, Kalmar B, Bode D, Greensmith L, Mckinnon PJ, Thorpe JR, Hafezparast M & El-Khamisy SF (2015) . Human Molecular Genetics, 24(3), 828-840.
Meisenberg C, Gilbert DC, Chalmers A, Haley V, Gollins S, Ward SE & El-Khamisy SF (2015) . Molecular Cancer Therapeutics, 14(2), 575-585.
Gómez-Herreros F, Schuurs-Hoeijmakers JHM, McCormack M, Greally MT, Rulten S, Romero-Granados R, Counihan TJ, Chaila E, Conroy J, Ennis S , Delanty N et al (2014) . Nature Genetics, 46(5), 516-521.
Alagoz M, Wells OS & El-Khamisy SF (2014) . Nucleic Acids Research, 42(5), 3089-3103.
Alagoz M, Chiang S-C, Sharma A & El-Khamisy SF (2013) . PLoS One, 8(4), e58239.
Zeng Z, Sharma A, Ju L, Murai J, Umans L, Vermeire L, Pommier Y, Takeda S, Huylebroeck D, Caldecott KW & El-Khamisy SF (2012) . Nucleic Acids Res, 40(17), 8371-8380.
Hudson JJR, Chiang S-C, Wells OS, Rookyard C & El-Khamisy SF (2012) . Nat Commun, 3, 733.
El-Khamisy SF (2011) . EMBO Mol Med, 3(2), 78-88.
Zeng Z, Cortés-Ledesma F, El Khamisy SF & Caldecott KW (2011) . J Biol Chem, 286(1), 403-409.
Kerzendorfer C, Whibley A, Carpenter G, Outwin E, Chiang S-C, Turner G, Schwartz C, El-Khamisy S, Raymond FL & O'Driscoll M (2010) . Hum Mol Genet, 19(7), 1324-1334.
Cortes Ledesma F, El Khamisy SF, Zuma MC, Osborn K & Caldecott KW (2009) . Nature, 461(7264), 674-678.
Lee Y, Katyal S, Li Y, El-Khamisy SF, Russell HR, Caldecott KW & McKinnon PJ (2009) . Nat Neurosci, 12(8), 973-980.
Katyal S, el-Khamisy SF, Russell HR, Li Y, Ju L, Caldecott KW & McKinnon PJ (2007) . EMBO J, 26(22), 4720-4731.
Ahel I, Rass U, El-Khamisy SF, Katyal S, Clements PM, McKinnon PJ, Caldecott KW & West SC (2006) . Nature, 443(7112), 713-716.
El-Khamisy SF, Saifi GM, Weinfeld M, Johansson F, Helleday T, Lupski JR & Caldecott KW (2005) . NATURE, 434(7029), 108-113.
Loizou JI, El-Khamisy SF, Zlatanou A, Moore DJ, Chan DW, Qin J, Sarno S, Meggio F, Pinna LA & Caldecott KW (2004) . Cell, 117(1), 17-28.
El-Khamisy SF, Masutani M, Suzuki H & Caldecott KW (2003) . Nucleic Acids Res, 31(19), 5526-5533.

All publications

Journal articles

Alaswad Z, Attallah NE, Aboalazm B, Elmeslhy ES, Mekawy AS, Afify FA, Mahrous HK, Abdalla A, Rahmoon MA, Mohamed AA , Shata AH et al (2024) . Journal of Genetic Engineering and Biotechnology, 22(4), 100427-100427.
Edwards H, Morton J, Moseley J, Marshall T, Berry A, Igwesi-Chidobe C, El-Khamisy S, Jones H & Farrow M (2024) . Neuromuscular Disorders, 43, 104441.131-104441.131.
Stevenson LK, Page AJ, Dowson M, ElBadry SK, Barnieh FM, Falconer RA & El-Khamisy SF (2024) . Frontiers in Cell and Developmental Biology, 12.
Abugable AA, Antar S & El-Khamisy SF (2024) . DNA Repair, 103629-103629.
Rahmoon MA, Elghaish RA, Ibrahim AA, Alaswad Z, Gad MZ, El-Khamisy SF & Elserafy M (2024) . Cancer Research, 84(1_Supplement), A023-A023.
Barnieh FM, Galuska SP, Loadman PM, Ward S, Falconer RA & El-Khamisy SF (2023) . iScience, 26(11), 108219-108219.
Edwards H, Jones H, Moseley J, Marshall T, El-Khamisy SF, Aung MN & Farrow M (2023) . Nutrition Today, 58(3), 105-118.
El-Khamisy SF (2023) . Trends in Cell Biology.
Rahmoon MA, Elghaish RA, Ibrahim AA, Alaswad Z, Gad MZ, El-Khamisy SF & Elserafy M (2023) . Genes, 14(1).
Elghzaly AA, Sun C, Looger LL, Hirose M, Salama M, Khalil NM, Behiry ME, Hegazy MT, Hussein MA, Salem MN , Eltoraby E et al (2022) . Frontiers in Genetics, 13.
Ray S, Abugable AA, Parker J, Liversidge K, Palminha NM, Liao C, Acosta-Martin AE, Souza CDS, Jurga M, Sudbery I & El-Khamisy SF (2022) . Nature, 609(7929), 1038-1047.
Chaturvedi S, Naseem Z, El-Khamisy SF & Wahajuddin M (2022) . Seminars in Cancer Biology.
Al Saeedy D, Abuhijjleh RK, Gouda A, El-Khamisy SF & Al-Abd AM (2022) . Cancer Research, 82(12_Supplement), 1049-1049.
Fuchs J, Schwer B & El-Khamisy SF (2022) . Frontiers in Aging Neuroscience, 14.
Karyka E, Berrueta Ramirez N, Webster CP, Marchi PM, Graves EJ, Godena VK, Marrone L, Bhargava A, Ray S, Ning K , Crane H et al (2022) . Life Science Alliance, 5(8), e202101145-e202101145.
Palminha NM, Dos Santos Souza C, Griffin J, Liao C, Ferraiuolo L & El-Khamisy SF (2022) . Cellular and Molecular Life Sciences, 79(3).
Matboli M, Hassan MK, Ali MA, Mansour MT, Elsayed W, Atteya R, Aly HS, Meteini ME, Elghazaly H, El-Khamisy S & Agwa SHA (2022) . Pharmaceutics, 14(1).
Elserafy M, El-Shiekh I, Fleifel D, Atteya R, AlOkda A, Abdrabbou MM, Nasr M & El-Khamisy SF (2021) . Life Science Alliance, 4(10), e202000966-e202000966.
Jurga M, Abugable AA, Goldman ASH & El-Khamisy SF (2021) . Nature Communications, 12.
Chaudhari S, Ware AP, Jayaram P, Gorthi SP, El-Khamisy SF & Satyamoorthy K (2021) . Biochimie, 190, 70-90.
Crane H, Foran B, Tahir F, Joyce H, El-Khamisy S & Hunter K (2021) . Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 132(1), e15-e15.
Ramachandran S, Ma TS, Griffin J, Ng N, Foskolou IP, Hwang M-S, Victori P, Cheng W-C, Buffa FM, Leszczynska KB , El-Khamisy SF et al (2021) . Nature Communications, 12(1).
Boughey H, Jurga M & El-Khamisy SF (2021) . International Journal of Molecular Sciences, 22(11).
Ashour ME, Allam W, Elsayed W, Atteya R, Elserafy M, Magdeldin S, Hassan MK & El-Khamisy SF (2021) . Cancers, 13(10).
Hassan MK, Waly AA, Elsayed W, Keshk S, Allam WR & El-khamisy SF (2021) . Scientific Reports, 11(1).
Zaksauskaite R, Thomas RC, van Eeden F & El-Khamisy SF (2021) . Science Advances, 7(5), eabc4165-eabc4165.
Halliwell JA, Frith TJR, Laing O, Price CJ, Bower OJ, Stavish D, Gokhale PJ, Hewitt Z, El-Khamisy SF, Barbaric I & Andrews PW (2020) . Stem Cell Reports, 14(6), 1009-1017.
Kim HR, Santhakumar K, Markham E, Baldera D, Greenald D, Bryant HE, El-Khamisy SF & van Eeden FJ (2020) . Oncotarget, 11(13), 1109-1130.
Fielden J, Wiseman K, Torrecilla I, Li S, Hume S, Chiang S-C, Ruggiano A, Narayan Singh A, Freire R, Hassanieh S , Domingo E et al (2020) . Nature Communications, 11(1).
Ibler AEM, ElGhazaly M, Naylor KL, Bulgakova NA, F. El-Khamisy S & Humphreys D (2019) . Nature Communications, 10(1).
Osman DI, El-Sheikh SM, Sheta SM, Ali OI, Salem AM, Shousha WG, EL-Khamisy SF & Shawky SM (2019) . Biosensors and Bioelectronics, 141, 111451-111451.
Abugable AA, Morris JLM, Palminha NM, Zaksauskaite R, Ray S & El-Khamisy SF (2019) . DNA Repair, 81, 102669-102669.
Ghoneimy M, Nabil E, Badr A & El-Khamisy SF (2019) A new filter-based Gene selection method based on dragonfly optimization and correlation-based feature selection. BIOSCIENCE RESEARCH, 16(3), 3139-3154.
Moradzadeh M, Ghorbani A, Erfanian S, Mohaddes ST, Rahimi H, karimiani EG, Mashkani B, Chiang S, El‐Khamisy SF, Tabarraei A & Sadeghnia HR (2019) . Journal of Cellular Biochemistry, 120(2), 1943-1957.
Fleifel D, Rahmoon MA, AlOkda A, Nasr M, Elserafy M & El-Khamisy SF (2018) . Journal of Genetic Engineering and Biotechnology, 16(2), 427-432.
Shawky SM, Awad AM, Abugable AA & El-Khamisy SF (2018) . International Journal of Nanomedicine, 13, 8137-8151.
Hegazy MT, Allam WR, Hussein MA, Zoheir N, Quartuccio L, El-Khamisy SF & Ragab G (2018) . EBioMedicine, 35, 106-113.
Southam HM, Smith TW, Lyon RL, Liao C, Trevitt CR, Middlemiss LA, Cox FL, Chapman JA, El-Khamisy SF, Hippler M , Williamson MP et al (2018) . Redox Biology, 18, 114-123.
Elserafy M, Abugable AA, Atteya R & El-Khamisy SF (2018) . Trends in Genetics, 34(8), 574-577.
Kassouf N, Kay CWM, Volkov A, Chiang S-C, Birch-Machin MA, El-Khamisy SF & Haywood RM (2018) . Free Radical Biology and Medicine, 126, 153-165.
Mohamed Z, Hassan MK, Okasha S, Mitamura T, Keshk S, Konno Y, Kato T, EL-khamisy SF, Ohba Y & Watari H (2018) . Oncotarget, 9(53), 30053-30065.
Liao C, Beveridge R, Hudson JJR, Parker JD, Chiang S-C, Ray S, Ashour ME, Sudbery I, Dickman MJ & El-Khamisy SF (2018) . Cell Reports, 23(11), 3352-3365.
Samir N, Matboli M, El-Tayeb H, El-Tawdi A, Hassan MK, Waly A, EL-Akkad HAE, Ramadan MG, Al-Belkini TN, El-Khamisy S & El-Asmar F (2018) . Journal of Cellular Biochemistry, 119(8), 6869-6881.
Walker C & El-Khamisy SF (2018) . Brain, 141(5), 1247-1262.
Elserafy M & El-Khamisy SF (2018) . Nature Reviews Molecular Cell Biology, 19(6), 343-344.
Chiang S-C, Liversidge K & El-Khamisy SF (2018) , 173-181.
Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al’Absi M, Arain F, Arango-Lasprilla JC, Atasoy D , Avila J et al (2017) . Neuron, 96(4), 730-735.
Walker C, Herranz-Martin S, Karyka E, Liao C, Lewis K, Lukashchuk V, Chiang S-C, Ray S, Mulcahy PJ, Jurga M , Tsagakis I et al (2017) . Nature Neuroscience, 20, 1225-1235.
Herranz-Martin S, Chandran J, Lewis K, Mulcahy P, Higginbottom A, Walker C, Valenzuela IM-PY, Jones RA, Coldicott I, Iannitti T , Akaaboune M et al (2017) . Disease Models & Mechanisms, 10, 859-868.
Hautbergue GM, Castelli LM, Ferraiuolo L, Sanchez-Martinez A, Cooper-Knock J, Higginbottom A, Lin YH, Bauer CS, Dodd JE, myszczynska MA , Alam SM et al (2017) . Nature Communications, 8.
Chiang S-C, Meagher M, Kassouf N, Hafezparast M, McKinnon PJ, Haywood R & El-Khamisy SF (2017) . Science Advances, 3(4).
Meisenberg C, Ashour ME, El-Shafie L, Liao C, Hodgson A, Pilborough A, Khurram SA, Downs JA, Ward SE & El-Khamisy SF (2017) . Nucleic Acids Research, 45(3), 1159-1176.
Allam WR, Ashour ME, Waly AA & El-Khamisy S (2017) , 41-58.
Shawky SM, Awad AM, Allam W, Alkordi MH & EL-Khamisy SF (2016) . Biosensors and Bioelectronics.
Atteya R, Ashour ME, Ibrahim EE, Farag MA & El-Khamisy SF (2016) . Mechanisms of Ageing and Development.
Elsayed W, El-Shafie L, Hassan MK, Farag MA & El-Khamisy SF (2016) . Scientific Reports, 6, 26626-26626.
Mazouzi A, Stukalov A, Müller AC, Chen D, Wiedner M, Prochazkova J, Chiang S-C, Schuster M, Breitwieser FP, Pichlmair A , El-Khamisy SF et al (2016) . Cell Reports, 15(4), 893-908.
Hassan MK, Watari H, Mitamura T, Mohamed Z, EL-khamisy SF, Ohba Y & Sakuragi N (2015) . Oncoscience, 2(3), 294-308.
Ashour ME, Atteya R & El-Khamisy SF (2015) . Nature Reviews Cancer, 15(3), 137-151.
Carroll J, Page TKW, Chiang S-C, Kalmar B, Bode D, Greensmith L, Mckinnon PJ, Thorpe JR, Hafezparast M & El-Khamisy SF (2015) . Human Molecular Genetics, 24(3), 828-840.
Ashour ME, El-Shafie L & El-Khamisy SF (2015) , 39-74.
Meisenberg C, Gilbert DC, Chalmers A, Haley V, Gollins S, Ward SE & El-Khamisy SF (2015) . Molecular Cancer Therapeutics, 14(2), 575-585.
Gómez-Herreros F, Schuurs-Hoeijmakers JHM, McCormack M, Greally MT, Rulten S, Romero-Granados R, Counihan TJ, Chaila E, Conroy J, Ennis S , Delanty N et al (2014) . Nature Genetics, 46(5), 516-521.
Walker S, Meisenberg C, Bibby RA, Askwith T, Williams G, Rininsland FH, Pearl LH, Oliver AW, El-Khamisy S, Ward S & Atack JR (2014) . Analytical Biochemistry, 454, 17-22.
Alagoz M, Wells OS & El-Khamisy SF (2014) . Nucleic Acids Research, 42(5), 3089-3103.
Alagoz M, Chiang S-C, Sharma A & El-Khamisy SF (2013) . PLoS One, 8(4), e58239.
Zeng Z, Sharma A, Ju L, Murai J, Umans L, Vermeire L, Pommier Y, Takeda S, Huylebroeck D, Caldecott KW & El-Khamisy SF (2012) . Nucleic Acids Res, 40(17), 8371-8380.
Lebedeva NA, Rechkunova NI, El-Khamisy SF & Lavrik OI (2012) . Biochimie, 94(8), 1749-1753.
Hudson JJR, Chiang S-C, Wells OS, Rookyard C & El-Khamisy SF (2012) . Nat Commun, 3, 733.
Gilbert DC, Chalmers AJ & El-Khamisy SF (2012) . Br J Cancer, 106(1), 18-24.
Alagoz M, Gilbert DC, El-Khamisy S & Chalmers AJ (2012) . Curr Med Chem, 19(23), 3874-3885.
El-Khamisy SF (2011) . EMBO Mol Med, 3(2), 78-88.
Zeng Z, Cortés-Ledesma F, El Khamisy SF & Caldecott KW (2011) . J Biol Chem, 286(1), 403-409.
Kerzendorfer C, Whibley A, Carpenter G, Outwin E, Chiang S-C, Turner G, Schwartz C, El-Khamisy S, Raymond FL & O'Driscoll M (2010) . Hum Mol Genet, 19(7), 1324-1334.
Chiang S-C, Carroll J & El-Khamisy SF (2010) . Cell Cycle, 9(3), 588-595.
Cortes Ledesma F, El Khamisy SF, Zuma MC, Osborn K & Caldecott KW (2009) . Nature, 461(7264), 674-678.
Lee Y, Katyal S, Li Y, El-Khamisy SF, Russell HR, Caldecott KW & McKinnon PJ (2009) . Nat Neurosci, 12(8), 973-980.
El-Khamisy SF, Katyal S, Patel P, Ju L, McKinnon PJ & Caldecott KW (2009) . DNA Repair (Amst), 8(6), 760-766.
Reynolds JJ, El-Khamisy SF & Caldecott KW (2009) . Biochem Soc Trans, 37(Pt 3), 577-581.
Reynolds JJ, El-Khamisy SF, Katyal S, Clements P, McKinnon PJ & Caldecott KW (2009) . Mol Cell Biol, 29(5), 1354-1362.
El-Khamisy S & Caldecott K (2009) REPAIR OF DNA SINGLE-STRAND BREAKS IN NEURONS: IMPLICATIONS ON HUMAN HEALTH. CELLULAR ONCOLOGY, 31(2), 131-131.
Iles N, Rulten S, El-Khamisy SF & Caldecott KW (2008) . Molecular and Cellular Biology, 28(10), 3561.
Katyal S, el-Khamisy SF, Russell HR, Li Y, Ju L, Caldecott KW & McKinnon PJ (2007) . EMBO J, 26(22), 4720-4731.
Rulten SL, Iles N, El-Khamisy SF & Caldecott KW (2007) Characterisation of aprataxin- and PNK-like factor: a novel FHA-domain protein involved in single and double-strand break repair. MUTAGENESIS, 22(6), 449-450.
El-Khamisy SF, Hartsuiker E & Caldecott KW (2007) . DNA Repair (Amst), 6(10), 1485-1495.
Iles N, Rulten S, El-Khamisy SF & Caldecott KW (2007) . Mol Cell Biol, 27(10), 3793-3803.
el-Khamisy SF & Caldecott KW (2007) . Neuroscience, 145(4), 1260-1266.
Ahel I, Rass U, El-Khamisy SF, Katyal S, Clements PM, McKinnon PJ, Caldecott KW & West SC (2006) . Nature, 443(7112), 713-716.
El-Khamisy SF & Caldecott KW (2006) . Mutagenesis, 21(4), 219-224.
Breslin C, Clements PM, El-Khamisy SF, Petermann E, Iles N & Caldecott KW (2006) . Methods Enzymol, 409, 410-425.
El-Khamisy SF, Saifi GM, Weinfeld M, Johansson F, Helleday T, Lupski JR & Caldecott KW (2005) . NATURE, 434(7029), 108-113.
Loizou JI, El-Khamisy SF, Zlatanou A, Moore DJ, Chan DW, Qin J, Sarno S, Meggio F, Pinna LA & Caldecott KW (2004) . Cell, 117(1), 17-28.
El-Khamisy SF, Masutani M, Suzuki H & Caldecott KW (2003) . Nucleic Acids Res, 31(19), 5526-5533.
Thomas RC, Zaksauskaite R, Al-Kandari NY, Hyde AC, Abugable AA, El-Khamisy SF & van Eeden FJ () . Nucleic Acids Research.
Kassem PH, Montasser IF, Mahmoud RM, Ghorab RA, AbdelHakam DA, Fathi MELSA, Wahed MAA, Mohey K, Ibrahim M, Hadidi ME , Masssoud YM et al () . BMC Medical Genomics, 17(1).
Barnieh FM, Morais GR, Loadman PM, Falconer RA & El‐Khamisy SF () . Advanced Science.
Allam WR, Hegazy MT, Hussein MA, Zoheir N, Quartuccio L, El-Khamisy SF & Ragab G () . Scientific Reports, 14(1), 11840.
Edwards HR, Jones H, Moseley J, Marshall T, El-Khamisy S, Aung MN & Farrow M () . Physical & Occupational Therapy In Geriatrics, 1-24.
Lyon RF, Southam HM, Trevitt C, Liao C, El-Khamisy S, Poole RK & Williamson MP () . Biochemical Journal.
M. Shawky S, A. Abo-AlHassan A, Lill H, Bald D, F.EL-Khamisy S & M. Ebeid E-Z () . Journal of Nanosciences: Current Research, 01(01).
Meisenberg C () . Journal of Cancer Science & Therapy, 06(07).
Carmell N, Rominiyi O, Myers KN, McGarrity-Cottrell C, Vanderlinden A, Lad N, Perroux-David E, El-Khamisy SF, Fernando M, Finegan KG , Brown S et al () . Cancers, 13(5), 944-944.
Kok JR, Palminha NM, Dos Santos Souza C, El-Khamisy SF & Ferraiuolo L () . Cellular and Molecular Life Sciences.
Griffin J, Chen Y, Catto JWF & El-Khamisy S () . Journal of Clinical Pathology.

Chapters

Shnyder SD, Chatterji SK & El-Khamisy S (2022) , Paraproteinemia and Related Disorders (pp. 57-77). Springer International Publishing
Chandran JS, Scarrott JM, Shaw P & Azzouz M (2017) Gene Therapy in the Nervous System: Failures and Successes In El-Khamisy S (Ed.), Personalised Medicine Lessons from Neurodegeneration to Cancer Springer
Allen C, Shaw PJ & Ferraiuolo L (2017) In El-Khamisy (Ed.), Personalised Medicine
El-Khamisy S (2017) Personalised Medicine Lessons from Neurodegeneration to Cancer Preface, PERSONALISED MEDICINE: LESSONS FROM NEURODEGENERATION TO CANCER (pp. V-V).
Abugable AA, Awwad DA, Fleifel D, Ali MM, El-Khamisy S & Elserafy M (2017) , Advances in Experimental Medicine and Biology (pp. 157-178). Springer International Publishing
Wells OS & El-Khamisy SF (2015) , Movement Disorders (pp. 1033-1041). Elsevier
Wells OS & El-Khamisy SF (2015) , Movement Disorders: Genetics and Models: Second Edition (pp. 1033-1041).

Conference proceedings papers

Crane H, Hunter K & El-Khamisy S (2023) The Role of R-loops in the Development of Cisplatin Resistance in Oropharyngeal Squamous Cell Carcinoma (OPSCC). JOURNAL OF PATHOLOGY, Vol. 261(SUPPL1) (pp S62-S62)
Crane H, Hunter K & El-Khamisy SF (2022) Exploration of the transcriptomic landscape of HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma upon development of cisplatin resistance. VIRCHOWS ARCHIV, Vol. 481(SUPPL 1) (pp S73-S73)
Al Saeedy D, Abuhijjleh RK, Gouda A, El-Khamisy SF & Al-Abd AM (2022) Modulating the polymorphic UGT1A1 gene to enhance camptothecin anti-colorectal effect. CANCER RESEARCH, Vol. 82(12)
Loutfy SA, Fattah NFA, Barakat AB, Alfarouk OR, Hashem TM, Osman AM, Metwally SA, Abo-Shadi MA, Helal AM, Habib SA , Sherif AAE et al (2021) . Molecular and Cellular Biology/Genetics
Loutfy SA, Fattah NFA, Barakat AB, Alfarouk OR, Hashem TM, Osman AM, Metwally SA, Abo-Shadi MA, Helal AM, Habib SA , El Sherif AA et al (2021) BRCA1 and BRCA2 mutations and its clinical relevance among egyptian breast cancer women.. CANCER RESEARCH, Vol. 81(13)
Crane H, Hunter K & El-Khamisy S (2020) The effect of E6 and E7 knockdown and PARP inhibition on cisplatin sensitivity in oropharyngeal squamous cell carcinoma. VIRCHOWS ARCHIV, Vol. 477 (pp S76-S76)
Samer SE, Maghraby AA, Zook Y, Haiba A, Lazem S, Shawky SM & Elkhamisy SF (2018) . ACM International Conference Proceeding Series (pp 391-396)
Hegazy MT, Allam W, Hussein MA, Zoheir N, Quartuccio L, Cacoub P, Doss W, Ellawindi MI, Fawzy M, Guillevin L , El Ray A et al (2018) DNA Damage and Repair in Patients with Cryoglobulinemic Vasculitis Treated with Direct Anti-HCV Drugs. ARTHRITIS & RHEUMATOLOGY, Vol. 70
Hassan M, Mohamed Z, Okasha S, Watari H & EL-Khamisy S (2017) COMPARATIVE MIRNA MICROARRAY PROFILING INDICATES MIR-363 PROMOTES CHEMORESISTANCE IN OVARIAN CANCER CELLS BY TARGETING THE HIPPO MEMBER, LATS2. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol. 27 (pp 1952-1952)
Sakuragi N, Farah MK, Mohamed Z, Okasha S, Watari H, Mitamura T, Khamisy SE & Ohba Y (2017) . Molecular and Cellular Biology, Genetics
Hegazy MT, Hussein MA, Quartuccio L, Fawzy M, Zoheir N, Ellawindi MI, Bond M, Mazzaro C, El Ray A, El Raziky MES , El Serafy M et al (2016) Treatment of Cryoglobulinemic Vasculitis with Sofosbuvir in Four Combination Protocols. ARTHRITIS & RHEUMATOLOGY, Vol. 68
Lebedeva N, Rechkunova N, El-Khamisy S & Lavrik O (2013) Tyrosyl-DNA phosphodiesterase 1-a new player in base excision repair. FEBS JOURNAL, Vol. 280 (pp 63-64)

Preprints

Crane H, Carr I, Hunter KD & El-Khamisy SF (2024) , Cold Spring Harbor Laboratory.
Edwards HR, Jones H, Mosely J, Marshall T, El-Khamisy SF, Aung MN & Farrow M () , Research Square Platform LLC.
Halliwell JA, Frith TJR, Laing O, Price CJ, Bower OJ, Stavish D, Gokhale PJ, Hewitt Z, El-Khamisy SF, Barbaric I & Andrews PW () , Cold Spring Harbor Laboratory.
Kim HR, Santhakumar K, Markham E, Baldera D, Bryant HE, El-Khamisy SF & van Eeden FJ () , Cold Spring Harbor Laboratory.
Shafei AE-S, Matboli M, Ali MA, Nagy Z, Reda M, Salah M, Hamdy A, Abdelgawad M, Ashry A, Tarek M , Saber O et al () , Cold Spring Harbor Laboratory.

Research group

I welcome applications from self-funded prospective home and international PhD students; see examples of possible projects below.

You can apply for a PhD position in MBB here.

Contact me at S.El-Khamisy@sheffield.ac.uk for further information.

Teaching activities

Level 3 Modules

MBB313 Genome Stability and Genetic Change

Level 2 Modules

MBB262 Genetics 2

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School of Biosciences

School of Biosciences

Professor Sherif El-Khamisy

Career history

Video animations summarising recent research discoveries

Major scientific accomplishments

Honours and distinctions

Featured publications

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Journal articles

Chapters

Conference proceedings papers

Preprints

Level 3 Modules

Level 2 Modules

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