Dr Martin Zeidler
School of Biosciences
Reader in Cell Signalling
+44 114 222 6093
Full contact details
School of Biosciences
Firth Court
Western Bank
91Ö±²¥
S10 2TN
- Profile
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Brief career history
- 2007-present: Reader, University of 91Ö±²¥, UK.
- 2006-2007: Senior Lecturer, University of 91Ö±²¥, UK.
- 2001-2006: Emmy Noether Independent Group Leader, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
- 1996-2001: Postdoctoral Fellow, Department of Genetics, Harvard Medical School, Boston, MA, USA
- 1991-1996: Pre-doctoral student at the European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
- 1987-1991: BSc in Biology with European Studies (German), The University of Sussex, Brighton, UK.
- Research interests
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Research interests
My lab is interested in identifying and analysing regulators of the JAK/STAT pathway– a signaling cascade frequently misactivated in haematopoietic malignancies.
We use both high throughput RNAi screening technologies and developmental genetic assays in Drosophila to determine the mechanisms of action of pathway regulators and their interactions in vivo.
JAK/STAT signalling in development and disease
My lab studies the regulators and roles of the JAK/STAT signal transduction cascade using a combination of human cell based approaches, Drosophila-based genetic screening and in vivo biology.
This work is aimed at generating insights into human inflammatory and haematopoietic disease.
The JAK/STAT pathway transduces the signals provided by multiple cytokines, growth factors and interferons. As a consequence, it plays a central role in development, cellular proliferation, stem cell maintenance, haematopoiesis and immunity.
In addition, inappropriate pathway activation is also linked to a wide range of human diseases including cancers, leukaemias, myeloproliferative neoplasms (MPNs) and inflammatory diseases such as rheumatoid arthritis.
Conserved throughout evolution, the pathways biological roles have also been largely maintained and as a result, many of the findings made in low complexity model systems such as Drosophila are applicable to humans.
The Zeidler lab has collaborations with a number of high profile groups including that of Tony Green (Cambridge) and Stefan Constantinescu (Brussels).
I have also collaborated and co-supervised joint PhD students with the Strutt and Smythe labs (BMS) and the Bellantuono lab (Human Metabolism).
In the future, I anticipate working more closely on Drosophila haematopoiesis (with lab of Iwan Evans) and on inflammatory aspects of JAK/STAT signalling humans.
In addition, we are also developing Zebrafish models of human myeloproliferative neoplasms in collaboration with the laboratory of Dr Rob Wilkinson (Cardiovascular Science). Insights gained from this work will also inform analysis using patient material which will be undertaken with Sally Thomas and John Snowden (NHS, Haematology).
Finally, ‘drug repurposing’ relating to our discovery of Methotrexate as a potent inhibitor of JAK/STAT pathway signalling will also be pursued.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
All publications
Journal articles
- . Frontiers in Medicine, 11.
- . Frontiers in Immunology, 14.
- . International Journal of Molecular Sciences, 24(16).
- . Elife, 10.
- . Journal of Cell Science, 133.
- . Biochemical Society Transactions, 48(2), 559-567.
- . Journal of Leukocyte Biology, 106(5), 1063-1068.
- . British Journal of Haematology, 187(3).
- . Innovation in Aging, 2(suppl_1), 545-545.
- . Journal of Cell Science, 131(13).
- . The Journal of Biological Chemistry, 293, 9570-9579.
- . Haematologica, 102, e336-e339.
- . Molecular Biology of the Cell, 27(3), 421-598.
- . British Journal of Cancer, 113(3), 365-371.
- . PLOS ONE, 10(7).
- . The Lancet, 385, S98-S98.
- . Development, 141(3), e308-e308.
- . Mol Biol Cell, 24(18), 3000-3009.
- . Development, 140(18), 3858-3868.
- . PLoS One, 8(5), e65076.
- The Drosophila JAK-STAT pathway. JAK-STAT, 2(3).
- Gα73Β is a downstream effector of JAK/STAT signaling and a regulator of Rho1 in Drosophila hematopoiesis. J Cell Sci.
- . BMC Genomics, 13, 506.
- Matters of the heart. JAK-STAT, 1(3), 208-210.
- . G3 (Bethesda), 2(5), 551-553.
- Modulation of human JAK-STAT pathway signaling by functionally conserved regulators. JAK-STAT, 1(1), 34-43.
- . J Signal Transduct, 2011, 894510.
- . Cell Signal, 23(5), 920-927.
- . Cellular Signalling, 23(5), 920-927.
- . Development, 137(21), e2107-e2107.
- . J Cell Sci, 123(Pt 20), 3457-3466.
- . EMBO Rep, 11(3), 201-207.
- . EMBO Rep, 9(11), 1114-1120.
- . Curr Opin Genet Dev, 18(5), 455-460.
- . Insect Mol Biol, 17(5), 475-483.
- . Semin Cell Dev Biol, 19(4), 360-369.
- . Development, 133(14), 2605-2616.
- . Cell Signal, 18(6), 819-829.
- . Dev Dyn, 235(4), 958-966.
- . Genetics, 172(3), 1683-1697.
- . Curr Biol, 16(1), 80-88.
- . Dev Biol, 288(2), 420-433.
- . Nature, 436(7052), 871-875.
- . Oncogene, 24(15), 2503-2511.
- . Nat Biotechnol, 22(7), 871-876.
- A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway.. Genetics, 165(3), 1149-1166.
- . Mech Dev, 117(1-2), 343-346.
- . Dev Biol, 228(2), 181-196.
- . Curr Biol, 10(18), R682-R684.
- . Oncogene, 19(21), 2598-2606.
- . Curr Biol, 9(23), 1363-1372.
- . Genes Dev, 13(10), 1342-1353.
- . Biol Chem, 378(10), 1119-1124.
- . Genes Dev, 10(1), 50-59.
- . Genes Dev, 8(19), 2313-2323.
- . J Comp Neurol, 347(4), 553-569.
- . The Journals of Gerontology: Series A.
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Chapters
Conference proceedings papers
- . Blood, Vol. 124(21) (pp 4577-4577)
- . MECHANISMS OF DEVELOPMENT, Vol. 126 (pp S176-S176)
- . MECHANISMS OF DEVELOPMENT, Vol. 126 (pp S290-S290)
Preprints
- Grants
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Funding
- CR-UK Fellowship
- UoS Schemes
- Cancer Research UK
- Wellcome Trust
- Teaching activities
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Undergraduate
- BMS109 Lab Skills & Skills Sessions
- BMS242/243 Principles of Developmental Biology
- BMS301 Membrane Receptors
- BMS356 Biomedical Technology & Drug Discovery (Co-ordinator)
Masters (MSc)
- BMS6083 Practical Developmental Genetics
- Professional activities and memberships
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- CR-UK Senior Cancer Research Fellow
- Former Emmy Noether Career Development Fellow and CRUK Senior Cancer Research Fellow
- Founder and academic director of the (SRSF)
- Supervised 13x PhD students
- Journal Editor and reviewer for many journals and grant awarding bodies
- Fellow of the Higher Education Academy (FHEA)
- Teaching at all Undergraduate levels