Dr Hannes Maib

School of Biosciences

Research Fellow

Hannes Maib
Profile picture of Hannes Maib
h.maib@sheffield.ac.uk

Full contact details

Dr Hannes Maib
School of Biosciences
Addison Building
91Ö±²¥
S10 2TN
Profile

• 2023 – Present - Wellcome Trust Early Career Fellow, University of 91Ö±²¥

• 2019-2023 - Postdoctoral Research Assistant, University of Dundee, Cell and Developmental Biology, Supervisor: Dr. David Murray

• 2015-2019 - PhD University of 91Ö±²¥, Supervisor: Prof Elizabeth Smythe

• 2013-2015 - MSc, Life and Medical Sciences, University of Bonn, Germany Supervisor: Prof Thorsten Lang

• 2010-2013 -  Bsc, Molekulare Biomedizin, University of Bonn
 

Research interests

Membrane identity changes in control of contact site formation

Membrane identity is key to cellular function, with each organelle displaying distinct identity determinants. Among the main factors imposing this are phosphoinositides, a small family of phospholipids that act as signpost of membrane identity. Lipid kinases and phosphatases are capable of interconverting these lipids by addition or removal of phosphate groups, leading to 8 distinct phosphoinositides. Key interest of my lab is to understand how these conversion cascades are regulated and how these changes to membrane identity influence cellular processes. The recent realisation that almost all organelles are in constant communication with each other, through formation of dynamic membrane contact sites, has opened up new questions regarding the interplay of membrane identity and contact site formation. Importantly, these contact sites are essential for the intracellular transport of lipids and misregulation is associated with disease and hereditary disorders. Therefore, it is essential to gain a better understanding of the molecular mechanisms that regulate this fundamental aspect of cell biology in order to develop novel interventions.
 

Publications

Journal articles

  • Maib H, Adarska P, Hunton R, Vines JH, Strutt D, Bottanelli F & Murray DH (2024) . Journal of Cell Biology, 223(6). RIS download Bibtex download
  • Vines JH, Maib H, Buckley CM, Gueho A, Zhu Z, Soldati T, Murray DH & King JS (2023) . Journal of Cell Biology, 222(9). RIS download Bibtex download
  • Maib H & Murray DH (2022) . Current Biology, 32(13), 2821-2833.e6. RIS download Bibtex download
  • Gill MR, Jarman PJ, Hearnden V, Fairbanks SD, Bassetto M, Maib H, Palmer J, Ayscough KR, Thomas JA & Smythe C (2022) . Angew Chem Weinheim Bergstr Ger, 134(27), e202117449. RIS download Bibtex download
  • Maib H, Ferreira F, Vassilopoulos S & Smythe E (2018) . The Journal of Cell Biology, 217(12), 4253-4266. RIS download Bibtex download
  • Maib H, Smythe E & Ayscough KR (2017) . Molecular Biology of the Cell, 28(7), 843-847. RIS download Bibtex download
  • Edwards-Hicks J, Apostolova P, Buescher JM, Maib H, Stanczak MA, Corrado M, Klein Geltink RI, Maccari ME, Villa M, Carrizo GE , Sanin DE et al () . Nature Immunology. RIS download Bibtex download

Preprints

  • Maib H, Adarska P, Hunton R, Vines J, Strutt D, Bottanelli F & Murray DH (2023) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Alshahrani F, Zhu Z, Ferreira F, McComb A, Maib H, Pruzina S, Robinson D, Murray D & Smythe E (2023) , Cold Spring Harbor Laboratory. RIS download Bibtex download