Dr Emily No毛l
School of Biosciences
Lecturer
+44 114 222 2311
Full contact details
School of Biosciences
C21
Firth Court
Western Bank
91直播
S10 2TN
- Profile
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Brief career history
- 2017-Present: British Heart Foundation Intermediate Basic Science Research Fellow, University of 91直播, UK
- 2015-2017: Independent Research Fellow, University of 91直播, UK
- 2009-2015: Postdoctoral Research Scientist, Bakkers Lab, Hubrecht Institute, Utrecht, NL
- 2005-2009: PhD Student, Ober Lab, National Institute for Medical Research, London, UK
- 2001-2004: BSc Biochemistry, University of Warwick
- Research interests
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The heart is a highly complex organ that forms very early during embryonic development from a simple linear tube. Problems with heart development often result in babies being born with congenital heart defects, a spectrum of structural heart malformations which affect around 1% of live births. Studying how hearts form when an organism is developing helps us better understand why this process sometimes goes wrong.
Our lab uses zebrafish to understand how the developing heart undergoes complex morphological rearrangements. We are particularly interested in how cells interact with their cellular neighbours or the extracellular matrix in different regions of the heart, and how these regionalised interactions support heart form and function as the embryo develops.
We use a variety of genetic and imaging techniques in zebrafish to link cellular processes/signalling, extracellular matrix composition, and heart morphology and function. These include establishing genetic models through targeted gene editing using CRISPR-Cas9, live light-sheet imaging of transgenic lines with fluorescent tissues or reporters, and quantitative image analyses.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
All publications
Journal articles
- . Development, 151(13), dev202482.
- . Development.
- . British Journal of Pharmacology.
- . Development, 148(5), dev191320-dev191320.
- . Cardiovascular Research.
- . Philosophical Transactions of the Royal Society B: Biological Sciences, 375(1809).
- . eLife, 6.
- . Biol Open, 5, 1461-1472.
- . Human Mutation, 37(2), 194-200.
- . Developmental Cell, 36(1), 36-49.
- . Developmental Cell, 32(5), 631-639.
- . Cell, 159(3), 662-675.
- . Development, 141(9), 1961-1970.
- . Nature Communications, 4(1).
- . PLoS Genetics, 7(9).
- , 401-428.
- . Gene Expression Patterns, 10(6), 237-243.
- . Developmental Biology, 322(2), 237-250.
- . Scientific Reports, 14(1).
Chapters
Conference proceedings papers
- morphoHeart: A novel tool to capture, quantify and link 3D asymmetric heart morphogenesis with spatiotemporal extracellular matrix dynamics in zebrafish cardiac development. JOURNAL OF ANATOMY, Vol. 240(4) (pp 785-786)
- Laminins regulate cardiac growth through restricting second heart field addition. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 102(2) (pp 126-126)
- . C49. TICKET TO RIDE: EXPERIMENTAL MODELS OF PAH
Preprints
- Research group
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- Research theme: Development, stem cells and regenerative medicine
- Research assistant: Eric Pollitt
- PhD students: Juliana S谩nchez Posada, Emma Armitage
- Grants
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- British Heart Foundation
- Academy of Medical Sciences/Wellcome Trust
- Rosetrees Trust
- Teaching activities
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- BMS110 Research Topics in Biomedicine
- BMS242/3 Advanced Concepts in Developmental Biology
- BMS356 Biomedical Technology & Drug Discovery
- BMS336 Modelling Human Disease
- BMS397 Laboratory Research Project
- L4/MSc Dissertation and Laboratory Research Supervision
Links