Dr Emily No毛l

School of Biosciences

Lecturer

British Heart Foundation Intermediate Basic Science Research Fellow, Emily No毛l
Profile picture of British Heart Foundation Intermediate Basic Science Research Fellow, Emily No毛l
e.s.noel@sheffield.ac.uk
+44 114 222 2311

Full contact details

Dr Emily No毛l
School of Biosciences
C21
Firth Court
Western Bank
91直播
S10 2TN
Profile

Brief career history

  • 2017-Present: British Heart Foundation Intermediate Basic Science Research Fellow, University of 91直播, UK
  • 2015-2017: Independent Research Fellow, University of 91直播, UK
  • 2009-2015: Postdoctoral Research Scientist, Bakkers Lab, Hubrecht Institute, Utrecht, NL
  • 2005-2009: PhD Student, Ober Lab, National Institute for Medical Research, London, UK
  • 2001-2004: BSc Biochemistry, University of Warwick
Research interests

The heart is a highly complex organ that forms very early during embryonic development from a simple linear tube. Problems with heart development often result in babies being born with congenital heart defects, a spectrum of structural heart malformations which affect around 1% of live births. Studying how hearts form when an organism is developing helps us better understand why this process sometimes goes wrong.

Our lab uses zebrafish to understand how the developing heart undergoes complex morphological rearrangements. We are particularly interested in how cells interact with their cellular neighbours or the extracellular matrix in different regions of the heart, and how these regionalised interactions support heart form and function as the embryo develops.

We use a variety of genetic and imaging techniques in zebrafish to link cellular processes/signalling, extracellular matrix composition, and heart morphology and function. These include establishing genetic models through targeted gene editing using CRISPR-Cas9, live light-sheet imaging of transgenic lines with fluorescent tissues or reporters, and quantitative image analyses.

Publications

Show: Featured publications All publications

Journal articles

  • Derrick CJ, Pollitt EJG, Sevilla Uruchurtu AS, Hussein F, Grierson AJ & No毛l ES (2021) . Development. RIS download Bibtex download
  • Bowley G, Kugler E, Wilkinson R, Lawrie A, Eeden F, Chico TJA, Evans PC, No毛l ES & Serbanovic鈥怌anic J (2021) . British Journal of Pharmacology. RIS download Bibtex download
  • Derrick CJ & No毛l ES (2021) . Development, 148(5), dev191320-dev191320. RIS download Bibtex download
  • Derrick CJ, S谩nchez-Posada J, Hussein F, Tessadori F, Pollitt EJG, Savage AM, Wilkinson RN, Chico TJ, van Eeden FJ, Bakkers J & No毛l ES (2021) . Cardiovascular Research. RIS download Bibtex download
  • No毛l ES & Bakkers J (2017) . eLife, 6. RIS download Bibtex download
  • No毛l ES, Momenah TS, Al-Dagriri K, Al-Suwaid A, Al-Shahrani S, Jiang H, Willekers S, Oostveen YY, Chocron S, Postma AV , Bhuiyan ZA et al (2016) . Human Mutation, 37(2), 194-200. RIS download Bibtex download
  • Junker JP, No毛l ES, Guryev V, Peterson KA, Shah G, Huisken J, McMahon AP, Berezikov E, Bakkers J & van聽Oudenaarden A (2014) . Cell, 159(3), 662-675. RIS download Bibtex download
  • No毛l ES, Verhoeven M, Lagendijk AK, Tessadori F, Smith K, Choorapoikayil S, den Hertog J & Bakkers J (2013) . Nature Communications, 4(1). RIS download Bibtex download
  • Smith KA, No毛l E, Thurlings I, Rehmann H, Chocron S & Bakkers J (2011) . PLoS Genetics, 7(9). RIS download Bibtex download

All publications

Journal articles

  • Pollitt EJG, S谩nchez-Posada J, Snashall CM, Derrick CJ & No毛l ES (2024) . Development, 151(13), dev202482. RIS download Bibtex download
  • Derrick CJ, Pollitt EJG, Sevilla Uruchurtu AS, Hussein F, Grierson AJ & No毛l ES (2021) . Development. RIS download Bibtex download
  • Bowley G, Kugler E, Wilkinson R, Lawrie A, Eeden F, Chico TJA, Evans PC, No毛l ES & Serbanovic鈥怌anic J (2021) . British Journal of Pharmacology. RIS download Bibtex download
  • Derrick CJ & No毛l ES (2021) . Development, 148(5), dev191320-dev191320. RIS download Bibtex download
  • Derrick CJ, S谩nchez-Posada J, Hussein F, Tessadori F, Pollitt EJG, Savage AM, Wilkinson RN, Chico TJ, van Eeden FJ, Bakkers J & No毛l ES (2021) . Cardiovascular Research. RIS download Bibtex download
  • Campbell K, No毛l ES, Fletcher AG & Bulgakova NA (2020) . Philosophical Transactions of the Royal Society B: Biological Sciences, 375(1809). RIS download Bibtex download
  • No毛l ES & Bakkers J (2017) . eLife, 6. RIS download Bibtex download
  • Han MK, Hoijman E, N枚el E, Garric L, Bakkers J & de Rooij J (2016) . Biol Open, 5, 1461-1472. RIS download Bibtex download
  • No毛l ES, Momenah TS, Al-Dagriri K, Al-Suwaid A, Al-Shahrani S, Jiang H, Willekers S, Oostveen YY, Chocron S, Postma AV , Bhuiyan ZA et al (2016) . Human Mutation, 37(2), 194-200. RIS download Bibtex download
  • Wu C-C, Kruse F, Vasudevarao MD, Junker JP, Zebrowski DC, Fischer K, No毛l ES, Gr眉n D, Berezikov E, Engel FB , van聽Oudenaarden A et al (2016) . Developmental Cell, 36(1), 36-49. RIS download Bibtex download
  • Tessadori F, No毛l ES, Rens EG, Magliozzi R, Evers-van聽Gogh IJA, Guardavaccaro D, Merks RMH & Bakkers J (2015) . Developmental Cell, 32(5), 631-639. RIS download Bibtex download
  • Junker JP, No毛l ES, Guryev V, Peterson KA, Shah G, Huisken J, McMahon AP, Berezikov E, Bakkers J & van聽Oudenaarden A (2014) . Cell, 159(3), 662-675. RIS download Bibtex download
  • Bonetti M, Paardekooper Overman J, Tessadori F, No毛l E, Bakkers J & den Hertog J (2014) . Development, 141(9), 1961-1970. RIS download Bibtex download
  • No毛l ES, Verhoeven M, Lagendijk AK, Tessadori F, Smith K, Choorapoikayil S, den Hertog J & Bakkers J (2013) . Nature Communications, 4(1). RIS download Bibtex download
  • Smith KA, No毛l E, Thurlings I, Rehmann H, Chocron S & Bakkers J (2011) . PLoS Genetics, 7(9). RIS download Bibtex download
  • Mas JC, No毛l ES & Ober EA (2011) , 401-428. RIS download Bibtex download
  • No毛l ES, Reis MD, Arain Z & Ober EA (2010) . Gene Expression Patterns, 10(6), 237-243. RIS download Bibtex download
  • No毛l ES, Casal-Sueiro A, Busch-Nentwich E, Verkade H, Dong PDS, Stemple DL & Ober EA (2008) . Developmental Biology, 322(2), 237-250. RIS download Bibtex download
  • Bowley G, Irving S, Hoefer I, Wilkinson R, Pasterkamp G, Darwish HMS, White S, Francis SE, Chico T, Noel E , Serbanovic-Canic J et al () . Scientific Reports, 14(1). RIS download Bibtex download

Chapters

  • No毛l ES (2024) , Current Topics in Developmental Biology Elsevier RIS download Bibtex download

Conference proceedings papers

  • Sanchez-Posada J & Noel ES (2022) morphoHeart: A novel tool to capture, quantify and link 3D asymmetric heart morphogenesis with spatiotemporal extracellular matrix dynamics in zebrafish cardiac development. JOURNAL OF ANATOMY, Vol. 240(4) (pp 785-786) RIS download Bibtex download
  • Derrick CJ, Hussein F, Pollitt EJG & Noel ES (2021) Laminins regulate cardiac growth through restricting second heart field addition. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 102(2) (pp 126-126) RIS download Bibtex download
  • Carr PL, Jiang Z, Savage AM, No毛l ES, Wilkinson RN & Lawrie A (2019) . C49. TICKET TO RIDE: EXPERIMENTAL MODELS OF PAH RIS download Bibtex download

Preprints

  • S谩nchez-Posada J & No毛l ES (2024) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Pollitt EJG, Derrick CJ, S谩nchez-Posada J & No毛l ES (2023) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Derrick CJ, Pollitt EJG, Uruchurtu ASS, Hussein F & No褢l ES () . RIS download Bibtex download
  • Derrick CJ, S谩nchez-Posada J, Hussein F, Tessadori F, Pollitt EJG, Savage AM, Wilkinson RN, Chico TJ, van Eeden FJ, Bakkers J & No毛l ES () , Cold Spring Harbor Laboratory. RIS download Bibtex download
Research group
Grants
  • British Heart Foundation
  • Academy of Medical Sciences/Wellcome Trust
  • Rosetrees Trust
Teaching activities
  • BMS110 Research Topics in Biomedicine
  • BMS242/3 Advanced Concepts in Developmental Biology
  • BMS356 Biomedical Technology & Drug Discovery
  • BMS336 Modelling Human Disease
  • BMS397 Laboratory Research Project
  • L4/MSc Dissertation and Laboratory Research Supervision