Dr Anton Nikolaev
School of Biosciences
Lecturer in Neuroscience
+44 114 222 5113
Full contact details
School of Biosciences
B1 221b
Alfred Denny Building
Western Bank
91Ö±²¥
S10 2TN
- Profile
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Brief career history
- 2013 - present: Lecturer, School of Biosciences, the University of 91Ö±²¥
- 2008 - 2013: Postdoctoral Fellow, MRC Laboratory of Molecular Biology, Cambridge
- 2006 - 2008: Postdoctoral Fellow, University of 91Ö±²¥
- 2005 - 2006: Postdoctoral Fellow, University of Umea
- 2001 - 2005: PhD, Institute of Cytology, Russian Academy of Science, St.Petersburg
- 1994 - 2000: BSc, MSc, University of St.Petersburg.
- Research interests
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Our research is focused on investigating the neuronal circuits responsible for information processing in the visual system.
The vertebrate visual system is able to recognize a remarkable number of objects of different appearances but the mechanisms and neural circuits underlying this ability are not known. To tackle this problem we use in vivo imaging of neuronal activity in zebrafish and follow the processing of visual information in different brain areas.
Neuronal circuits involved in processing of visial information in zebrafish
To understand the organisation of neuronal circuits performing processing of visual information in zebrafish. Using a combination of behavioural and imaging techniques we study how the zebrafish visual system processes visual information. Our main goal is to understand how information about object identity is encoded in the activity of visual neurons.
The range of questions we ask includes: what features are extracted by the early visual system in order to make object recognition efficient? How do these features converge to form receptive fields of object recognising neurons? What is the role of adaptation in this process?
To answer these questions we image neuronal activity in zebrafish larvae. We are using zebrafish lines expressing calcium activity indicators in all or subset of visual neurons. These indicators change their brightness when neuron is active.
The advantage of this method is that it is non-invasive and allows for the simultaneous study of a large population of neurons - something that is currently unfeasible using other techniques.
To understand how memory is encoded in changes in synaptic strength. We are develop GFP based reporters of long-term potentiation and long-term depression. These reporters will be used in vivo to understand how simple forms of associative and non-associative memory are implemented in changes in synaptic strength.
To answer these questions we are developing behavioural paradigms that will allow us to combine evaluation of memory formation with in vivo imaging of synaptic strength.
Collaborators
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . Frontiers in Cell and Developmental Biology, 9.
- . Current Biology, 30(15), 2912-2926.e5.
- . Journal of Neuroscience, 39(36), 7132-7154.
- . BioTechniques, 65(1), 37-39.
- . Journal of Developmental Biology, 6(1).
- . PLoS Biology, 12(10).
- . Nature Neuroscience, 16(7), 934-941.
- . PLoS One, 4(1).
- Encoding of Luminance and Contrast by Linear and Nonlinear Synapses in the Retina. Neuron, 73(4), 758-773.
All publications
Journal articles
- . Frontiers in Cell and Developmental Biology, 9.
- . Current Biology, 30(15), 2912-2926.e5.
- . Journal of Neuroscience, 39(36), 7132-7154.
- . BioTechniques, 65(1), 37-39.
- . Journal of Developmental Biology, 6(1).
- . PLoS Biology, 12(10).
- . Nature Neuroscience, 16(7), 934-941.
- . PLoS One, 4(1).
- . PLoS One, 4(1).
- . Journal of Neuroscience, 28(29), 7250-7259.
- Impact of synaptic feedbacks from L2 neurones on the signaling performance of Drosophila photoreceptors. JOURNAL OF NEUROGENETICS, 20(3-4), 191-192.
- . Journal of Biological Chemistry, 280(17), 16790-16797.
- Homer family proteins regulate the activity of Imin channels in plasma membrane of HEK293 cells. Biologicheskie Membrany, 21(6), 466-472.
- I
min -channels in plasma membrane of human embryonic kidney cells. Biologicheskie Membrany, 21(3), 212-219.
- Phosphatidylinositol-4,5-bisphosphate modulates activity of receptor-induced calcium entry channels in A431 cells. Biologicheskie Membrany, 19(1), 23-31.
- . Journal of Biological Chemistry, 7(275), 4561-4564.
- . J Biol Chem, 274(37), 25983-25985.
- A study of the growth of stable clones of mouse fibroblast cell line C3H10T1/2 expressing the human retinoblastoma gene product. Tsitologiya, 40(2-3), 159-160.
- .
- Spikes in Retinal Bipolar Cells Phase-Lock to Visual Stimuli with Millisecond Precision. Current Biology, 21(22), 1859-1869.
- Encoding of Luminance and Contrast by Linear and Nonlinear Synapses in the Retina. Neuron, 73(4), 758-773.
Chapters
- In Detrich HW, Westerfield M & Zon LI (Ed.), The Zebrafish Cellular and Developmental Biology, Part B Developmental Biology (pp. 257-334).
Preprints
- , arXiv.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- . Frontiers in Cell and Developmental Biology, 9.
- Teaching activities
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Undergraduate taught modules
- BMS109-153 Neuroscience
- BMS109 Practical Classes
- BMS242 Advanced Concepts in Molecular Physiology (Co-ordinator)
Teaching experience
2015: Postgraduate Certificate in Learning and Teaching from the University of 91Ö±²¥ (Fellow of The Higher Education Academy, FHEA)
- Professional activities and memberships
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- Fellow of the Higher Education Academy (FHEA)