Dr Robert Fagan

School of Biosciences

Senior Lecturer

Rob Fagan
Profile picture of Rob Fagan
r.fagan@sheffield.ac.uk
+44 114 222 4182

Full contact details

Dr Robert Fagan
School of Biosciences
Firth Court
Western Bank
91Ö±²¥
S10 2TN
Profile

Career history

  • 2018-present: Senior Lecturer, School of Biosciences, University of 91Ö±²¥, UK
  • 2013 - 2017: Lecturer, Dept. of Molecular Biology and Biotechnology, University of 91Ö±²¥, UK
  • 2008 - 2012: Senior Research Associate, Centre for Molecular Microbiology and Infection, Imperial College London, UK
  • 2005 - 2008: Research Associate, Centre for Molecular Microbiology and Infection, Imperial College London, UK
  • 2001 - 2005: PhD, Moyne Institute of Preventive Medicine, Trinity College, University of Dublin, Ireland
Research interests

Clostridium difficile is the most common cause of antibiotic-associated diarrhea. It’s a highly antibiotic resistant pathogen that can cause severe disease following antibiotic-mediated disruption of the protective gut microbiota.

The aim of our research is to understand the molecular basis of interactions between the bacterium and its host. We study the outermost layer of the C. difficile cell envelope, the surface- or S-layer, a 2-dimensional proteinaceous crystal that completely coats the surface of the bacterium.

The S-layer has been implicated in adhesion and induction of innate immunity. Our work combines molecular microbiology and structural biology to study S-layer biogenesis and function.

Publications

Show: Featured publications All publications

Journal articles

  • Buddle JE, Thompson LM, Williams AS, Wright RCT, Durham WM, Turner CE, Chaudhuri RR, Brockhurst MA & Fagan RP (2024) . PLOS Biology, 22(8). RIS download Bibtex download
  • Lanzoni-Mangutchi P, Banerji O, Wilson J, Barwinska-Sendra A, Kirk JA, Vaz F, O'Beirne S, Baslé A, El Omari K, Wagner A , Fairweather NF et al (2022) . Nat Commun, 13(1), 970. RIS download Bibtex download
  • Fuchs M, Lamm-Schmidt V, Sulzer J, Ponath F, Jenniches L, Kirk JA, Fagan RP, Barquist L, Vogel J & Faber F (2021) . Proceedings of the National Academy of Sciences of the United States of America, 118(25). RIS download Bibtex download
  • Kirk JA, Gebhart D, Buckley AM, Lok S, Scholl D, Douce GR, Govoni GR & Fagan RP (2017) . Science Translational Medicine, 9(406). RIS download Bibtex download
  • Dembek M, Barquist L, Boinett CJ, Cain AK, Mayho M, Lawley TD, Fairweather NF & Fagan RP (2015) . MBIO, 6(2). RIS download Bibtex download

All publications

Journal articles

  • Buddle JE, Thompson LM, Williams AS, Wright RCT, Durham WM, Turner CE, Chaudhuri RR, Brockhurst MA & Fagan RP (2024) . PLOS Biology, 22(8). RIS download Bibtex download
  • Phothichaisri W, Phetruen T, Chankhamhaengdecha S, Janvilisri T, Ounjai P, Fagan RP & Chanarat S (2024) , 245-262. RIS download Bibtex download
  • Galley NF, Greetham D, Alamán-Zárate MG, Williamson MP, Evans CA, Spittal WD, Buddle JE, Freeman J, Davis GL, Dickman MJ , Wilcox MH et al (2023) . Journal of Biological Chemistry, 105529-105529. RIS download Bibtex download
  • Ormsby MJ, Vaz F, Kirk JA, Barwinska-Sendra A, Hallam JC, Lanzoni-Mangutchi P, Cole J, Chaudhuri RR, Salgado PS, Fagan RP & Douce GR (2023) . PLOS Pathogens, 19(6). RIS download Bibtex download
  • Royer ALM, Umansky AA, Allen M-M, Garneau JR, Ospina-Bedoya M, Kirk JA, Govoni G, Fagan RP, Soutourina O & Fortier L-C (2023) . Microbiol Spectr, 11(2), e0389422. RIS download Bibtex download
  • Buddle JE & Fagan RP (2023) . Virulence, 14(1), 2150452. RIS download Bibtex download
  • Phothichaisri W, Chankhamhaengdecha S, Janvilisri T, Nuadthaisong J, Phetruen T, Fagan RP & Chanarat S (2022) . Microbiol Spectr, 10(2), e0236121. RIS download Bibtex download
  • Lanzoni-Mangutchi P, Banerji O, Wilson J, Barwinska-Sendra A, Kirk JA, Vaz F, O'Beirne S, Baslé A, El Omari K, Wagner A , Fairweather NF et al (2022) . Nat Commun, 13(1), 970. RIS download Bibtex download
  • Alabdali YAJ, Oatley P, Kirk JA & Fagan RP (2021) . Anaerobe, 70. RIS download Bibtex download
  • Fuchs M, Lamm-Schmidt V, Sulzer J, Ponath F, Jenniches L, Kirk JA, Fagan RP, Barquist L, Vogel J & Faber F (2021) . Proceedings of the National Academy of Sciences of the United States of America, 118(25). RIS download Bibtex download
  • Oatley P, Kirk JA, Ma S, Jones S & Fagan RP (2020) . Scientific Reports, 10(1). RIS download Bibtex download
  • Janganan TK, Mullin N, Dafis-Sagarmendi A, Brunt J, Tzokov SB, Stringer S, Moir A, Chaudhuri RR, Fagan RP, Hobbs JK & Bullougha PA (2020) . mSphere, 5(4). RIS download Bibtex download
  • de Lussy-Kubisa L, Chaudhuri R & Fagan R (2019) . Access Microbiology, 1(1A). RIS download Bibtex download
  • Vaz F, Wilson G, Kirk J, Salgado P, Fagan R & Douce G (2019) . Access Microbiology, 1(1A). RIS download Bibtex download
  • O’Beirne S, Kirk JA & Fagan RP (2019) . Access Microbiology, 1(1A). RIS download Bibtex download
  • Fagan R, McBride SM & Shen A (2018) . Anaerobe, 53, 1-1. RIS download Bibtex download
  • McHale TM, Garciarena CD, Fagan RP, Smith SGJ, Martin-Loches I, Curley GF, Fitzpatrick F & Kerrigan SW (2018) . Critical care medicine, 46(8), e805-e810. RIS download Bibtex download
  • Kirk JA, Gebhart D, Buckley AM, Lok S, Scholl D, Douce GR, Govoni GR & Fagan RP (2017) . Science Translational Medicine, 9(406). RIS download Bibtex download
  • Kirk JA, Banerji O & Fagan RP (2017) . Microbial Biotechnology, 10(1), 76-90. RIS download Bibtex download
  • Kirk JA & Fagan RP (2016) . Anaerobe, 42, 1-5. RIS download Bibtex download
  • Janganan TK, Mullin N, Tzokov SB, Stringer S, Fagan RP, Hobbs JK, Moir A & Bullough PA (2016) . Food Microbiology, 59, 205-212. RIS download Bibtex download
  • Buckley AM, Jukes C, Candlish D, Irvine JJ, Spencer J, Fagan RP, Roe AJ, Christie JM, Fairweather NF & Douce GR (2016) . Scientific Reports, 6. RIS download Bibtex download
  • Willing SE, Candela T, Shaw HA, Seager Z, Mesnage S, Fagan RP & Fairweather NF (2015) . Molecular Microbiology, 96(3), 596-608. RIS download Bibtex download
  • Dembek M, Barquist L, Boinett CJ, Cain AK, Mayho M, Lawley TD, Fairweather NF & Fagan RP (2015) . MBIO, 6(2). RIS download Bibtex download
  • Pettit LJ, Browne HP, Yu L, Smits WK, Fagan RP, Barquist L, Martin MJ, Goulding D, Duncan SH, Flint HJ , Dougan G et al (2014) . BMC Genomics, 15(1). RIS download Bibtex download
  • Fagan RP & Fairweather NF (2014) . Nature Reviews Microbiology, 12(3), 211-222. RIS download Bibtex download
  • Mahon V, Fagan RP & Smith SGJ (2012) . Biochimie, 94(9), 2058-2061. RIS download Bibtex download
  • Deakin LJ, Clare S, Fagan RP, Dawson LF, Pickard DJ, West MR, Wren BW, Fairweather NF, Dougan G & Lawley TD (2012) . Infect Immun, 80(8), 2704-2711. RIS download Bibtex download
  • Tam Dang TH, Fagan RP, Fairweather NF & Tate EW (2012) . Bioorg Med Chem, 20(2), 614-621. RIS download Bibtex download
  • Fagan RP & Fairweather NF (2011) . J Biol Chem, 286(31), 27483-27493. RIS download Bibtex download
  • Fagan RP, Janoir C, Collignon A, Mastrantonio P, Poxton IR & Fairweather NF (2011) . J Med Microbiol, 60(Pt 8), 1225-1228. RIS download Bibtex download
  • Reynolds CB, Emerson JE, de la Riva L, Fagan RP & Fairweather NF (2011) . PLoS Pathog, 7(4), e1002024. RIS download Bibtex download
  • Dang THT, de la Riva L, Fagan RP, Storck EM, Heal WP, Janoir C, Fairweather NF & Tate EW (2010) . ACS Chem Biol, 5(3), 279-285. RIS download Bibtex download
  • Fagan R & Fairweather N (2010) . Methods Mol Biol, 646, 117-134. RIS download Bibtex download
  • Emerson JE, Reynolds CB, Fagan RP, Shaw HA, Goulding D & Fairweather NF (2009) . Mol Microbiol, 74(3), 541-556. RIS download Bibtex download
  • Fagan RP, Albesa-Jové D, Qazi O, Svergun DI, Brown KA & Fairweather NF (2009) . Mol Microbiol, 71(5), 1308-1322. RIS download Bibtex download
  • Fagan RP, Lambert MA & Smith SGJ (2008) . Infect Immun, 76(3), 1135-1142. RIS download Bibtex download
  • Smith SGJ, Mahon V, Lambert MA & Fagan RP (2007) . FEMS Microbiol Lett, 273(1), 1-11. RIS download Bibtex download
  • Fagan RP & Smith SGJ (2007) . FEMS Microbiol Lett, 269(2), 248-255. RIS download Bibtex download

Preprints

  • Buddle JE, Wright RCT, Turner CE, Chaudhuri RR, Brockhurst MA & Fagan RP (2023) . RIS download Bibtex download
  • Wilson JS, Fortier L-C, Fagan RP & Bullough PA (2023) . RIS download Bibtex download
  • Ormsby MJ, Vaz F, Kirk JA, Barwinska-Sendra A, Hallam JC, Lanzoni-Mangutchi P, Cole J, Chaudhuri RR, Salgado PS, Fagan RP & Douce GR (2022) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Royer ALM, Umansky AA, Allen M-M, Garneau JR, Bedoya MO, Kirk JA, Govoni G, Fagan RP, Soutourina O & Fortier L-C (2022) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Oatley P, Kirk J, Ma S, Jones S & Fagan R (2018) . RIS download Bibtex download
  • Banerji O, Lanzoni-Mangutchi P, Vaz F, Barwinska-Sendra A, Wilson J, Kirk J, O'Beirne S, Basle A, Omari KE, Wagner A , Fairweather N et al () . RIS download Bibtex download
  • Janganan TK, Mullin N, Dafis-Sagarmendi A, Brunt J, Tzokov SB, Stringer S, Moir A, Chaudhuri R, Fagan RP, Hobbs JK & Bullough PA () . RIS download Bibtex download
  • Alabdali YAJ, Oatley P, Kirk JA & Fagan RP () . RIS download Bibtex download
Teaching activities

Level 3 modules

  • MBB328 The Organisation of Bacterial Cells (Module Coordinator)
  • MBB335 Bacterial Pathogenicity (Module Coordinator)