Dr Claire Turner

School of Biosciences

Senior Research Fellow

Profile
  • 2017-present: Royal Society/ Wellcome Trust Sir Henry Dale Research Fellow, University of 91Ö±²¥
  • 2017-present: Florey Institute Research Fellow, University of 91Ö±²¥
  • 2013-2016: Imperial College Junior Research Fellow
  • 2009-2013: Research Associate, National Centre for Infection Prevention & Management, Imperial College London
  • 2005-2009: PhD, Imperial College London.
Research interests

My research focus is on trying to understand the mechanisms behind upsurges in disease caused by the human pathogen Streptococcus pyogenes (also known as group A Streptococcus). Upsurges occur frequently and can be associated with specific genotypes.

I use a combination of whole genome sequencing, epidemiology, clinical analysis and phenotypic work to try and identify what makes strains successful at causing disease and become suddenly more abundant.

One of my particular interests is recombination-related genome remodelling, which we identified to be the driving force behind a very recent shift in the population of the S. pyogenes genotype emm89. A new variant of emm89 emerged from the population having undergone six regions of recombination within the core genome.

This recombination-related genome remodelling led to substantial phenotype changes, including loss of the hyaluronic acid capsule and increase of toxin expression, altering the way this genotype interacted with the host.

The emergent variant has now become the dominant form of emm89 in the UK and globally, causing a high level of disease. Understanding how recombination occurs and what the impact of recombination is on the bacterium are part of my research aims.

Publications

Show: Featured publications All publications

Journal articles

  • Turner CE, Holden MTG, Blane B, Horner C, Peacock SJ & Sriskandan S (2019) . mBio, 10(6). RIS download Bibtex download
  • Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Marks M, Cerami C, Roca A, Antonio M , Turner CE et al (2019) . PLOS Neglected Tropical Diseases, 13(10). RIS download Bibtex download
  • Lynskey NN, Jauneikaite E, Li HK, Zhi X, Turner CE, Mosavie M, Pearson M, Asai M, Lobkowicz L, Chow JY , Parkhill J et al (2019) . The Lancet Infectious Diseases. RIS download Bibtex download
  • Reglinski M, Sriskandan S & Turner C (2019) . Journal of Infection. RIS download Bibtex download
  • Turner CE, Bedford L, Brown NM, Judge K, Török ME, Parkhill J & Peacock SJ (2017) . Scientific Reports, 7(1). RIS download Bibtex download
  • Afshar B, Turner CE, Lamagni T, Smith K, Al-Shahib A, Underwood A, Holden M, Efstratiou A & Sriskandan S (2017) . Virulence, 8(7), 1390-1400. RIS download Bibtex download
  • Turner CE, Pyzio M, Song B, Lamagni T, Meltzer M, Chow JY, Efstratiou A, Curtis S & Sriskandan S (2016) . Emerging Infectious Diseases, 22(6), 1075-1078. RIS download Bibtex download
  • Turner CE, Abbott J, Lamagni T, Holden MTG, David S, Jones MD, Game L, Efstratiou A & Sriskandan S () . mBio, 6(4). RIS download Bibtex download

All publications

Journal articles

  • Buddle JE, Thompson LM, Williams AS, Wright RCT, Durham WM, Turner CE, Chaudhuri RR, Brockhurst MA & Fagan RP (2024) . PLOS Biology, 22(8). RIS download Bibtex download
  • Hall JN, Bah SY, Khalid H, Brailey A, Coleman S, Kirk T, Hussain N, Tovey M, Chaudhuri RR, Davies S , Tilley L et al (2024) . Microbial Genomics, 10(8). RIS download Bibtex download
  • Armitage EP, de Crombrugghe G, Keeley AJ, Senghore E, Camara FE, Jammeh M, Bittaye A, Ceesay H, Ceesay I, Samateh B , Manneh M et al (2024) . The Lancet Microbe. RIS download Bibtex download
  • Hall J, Angyal A, Armitage E, Senghore E, Darboe S, Barry M, Camara J, Bah S, Keeley A, McCarthy J , Turner C et al (2023) . Clinical Infection in Practice, 20(Supplement 1). RIS download Bibtex download
  • Li HK, Zhi X, Vieira A, Whitwell HJ, Schricker A, Jauneikaite E, Li H, Yosef A, Andrew I, Game L , Turner CE et al (2023) . Microbial Genomics, 9(4). RIS download Bibtex download
  • Catton EA, Bonsor DA, Herrera C, StÃ¥lhammar-Carlemalm M, Lyndin M, Turner CE, Soden J, van Strijp JAG, Singer BB, van Sorge NM , Lindahl G et al (2023) . Nature Communications, 14. RIS download Bibtex download
  • Turner CE (2022) . The Lancet Infectious Diseases. RIS download Bibtex download
  • Jagne I, Keeley AJ, Bojang A, Camara B, Jallow E, Senghore E, Oluwalana C, Bah SY, Turner CE, Sesay AK , D’Alessandro U et al (2022) . BMC Infectious Diseases, 22(1). RIS download Bibtex download
  • Tan LKK, Reglinski M, Teo D, Reza N, Lamb LEM, Nageshwaran V, Turner CE, Wikstrom M, Frick IM, Bjorck L & Sriskandan S (2021) . npj Vaccines, 6(1). RIS download Bibtex download
  • Remmington A, Haywood S, Edgar J, Green LR, de Silva T & Turner CE (2021) . Microbial Genomics, 7(1). RIS download Bibtex download
  • Siggins MK, Lynskey NN, Lamb LE, Johnson LA, Huse KK, Pearson M, Banerji S, Turner CE, Woollard K, Jackson DG & Sriskandan S (2020) . Nature Communications, 11(1). RIS download Bibtex download
  • Turner CE, Holden MTG, Blane B, Horner C, Peacock SJ & Sriskandan S (2019) . mBio, 10(6). RIS download Bibtex download
  • Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Marks M, Cerami C, Roca A, Antonio M , Turner CE et al (2019) . PLOS Neglected Tropical Diseases, 13(10). RIS download Bibtex download
  • Sharma H, Turner CE, Siggins MK, El-Bahrawy M, Pichon B, Kearns A & Sriskandan S (2019) . mSphere, 4(5). RIS download Bibtex download
  • Lynskey NN, Jauneikaite E, Li HK, Zhi X, Turner CE, Mosavie M, Pearson M, Asai M, Lobkowicz L, Chow JY , Parkhill J et al (2019) . The Lancet Infectious Diseases. RIS download Bibtex download
  • Turner CE, Bubba L & Efstratiou A (2019) . Microbiology Spectrum, 7(3). RIS download Bibtex download
  • Davies FJ, Olme C, Lynskey NN, Turner CE & Sriskandan S (2019) . Clinical & Experimental Immunology. RIS download Bibtex download
  • Reglinski M, Sriskandan S & Turner C (2019) . Journal of Infection. RIS download Bibtex download
  • Davies F, Olme C, Lynskey N, Turner C & Sriskandan S (2018) . RIS download Bibtex download
  • Lamb LE, Siggins MK, Scudamore C, Macdonald W, Turner CE, Lynskey NN, Tan LKK & Sriskandan S (2018) . Virulence, 9(1), 1074-1084. RIS download Bibtex download
  • Edwards RJ, Pyzio M, Gierula M, Turner CE, Abdul-Salam VB & Sriskandan S (2018) . Scientific Reports, 8(1). RIS download Bibtex download
  • Remmington A & Turner CE (2018) . Microbiology, 164(3), 242-250. RIS download Bibtex download
  • Sharma H, Smith D, Turner CE, Game L, Pichon B, Hope R, Hill R, Kearns A & Sriskandan S (2018) . Emerging Infectious Diseases, 24(2). RIS download Bibtex download
  • Turner CE, Bedford L, Brown NM, Judge K, Török ME, Parkhill J & Peacock SJ (2017) . Scientific Reports, 7(1). RIS download Bibtex download
  • Afshar B, Turner CE, Lamagni T, Smith K, Al-Shahib A, Underwood A, Holden M, Efstratiou A & Sriskandan S (2017) . Virulence, 8(7), 1390-1400. RIS download Bibtex download
  • Al-Shahib A, Underwood A, Afshar B, Turner CE, Lamagni​ T, Sriskandan S & Efstratiou A (2016) . Microbial Genomics, 2(11). RIS download Bibtex download
  • Al-Shahib A, Underwood A, Afshar B, Turner CE, Lamagni T, Sriskandan S & Efstratiou A (2016) . Microbial Genomics, 2(6). RIS download Bibtex download
  • Turner CE, Pyzio M, Song B, Lamagni T, Meltzer M, Chow JY, Efstratiou A, Curtis S & Sriskandan S (2016) . Emerging Infectious Diseases, 22(6), 1075-1078. RIS download Bibtex download
  • Smith DS, Siggins MK, Gierula M, Pichon B, Turner CE, Lynskey NN, Mosavie M, Kearns AM, Edwards RJ & Sriskandan S (2016) . Microbial Genomics, 2(2). RIS download Bibtex download
  • Lamb L, MacDonald W, Scudamore C, Tan L, Lynskey N, Turner CE & Sriskandan S (2015) . Journal of Infection, 71(6), 686-686. RIS download Bibtex download
  • Turner CE & Sriskandan S (2015) . Journal of Infection, 71(3), 338-346. RIS download Bibtex download
  • Lynskey NN, Turner CE, Heng LS & Sriskandan S (2015) . Infection and Immunity, 83(4), 1732-1733. RIS download Bibtex download
  • Turner CE, Dryden M, Holden MTG, Davies FJ, Lawrenson RA, Farzaneh L, Bentley SD, Efstratiou A & Sriskandan S (2013) . Journal of Clinical Microbiology, 51(7), 2089-2095. RIS download Bibtex download
  • Al-Shahib A, Afshar B, Underwood A, Turner C, Sriskandan S, Holden M, Parkhill J & Efstratiou A (2013) . International Journal of Antimicrobial Agents, 42, S103-S104. RIS download Bibtex download
  • Davies F, Turner C, Boyle J & Sriskandan S (2010) . Journal of Infection, 61(6), 518-518. RIS download Bibtex download
  • (2009) . The Journal of Infectious Diseases, 200(8), 1353-1353. RIS download Bibtex download
  • Turner CE, Kurupati P, Jones MD, Edwards RJ & Sriskandan S (2009) . The Journal of Infectious Diseases, 200(4), 555-563. RIS download Bibtex download
  • Turner CE, Kurupati P, Wiles S, Edwards RJ & Sriskandan S (2009) . Vaccine, 27(36), 4923-4929. RIS download Bibtex download
  • Zinkernagel AS, Timmer AM, Pence MA, Locke JB, Buchanan JT, Turner CE, Mishalian I, Sriskandan S, Hanski E & Nizet V (2008) . Cell Host & Microbe, 4(2), 170-178. RIS download Bibtex download
  • Turner C & Sriskandan S (2007) . Nature Medicine, 13(8), 909-910. RIS download Bibtex download
  • Edwards RJ, Taylor GW, Ferguson M, Murray S, Rendell N, Wrigley A, Bai Z, Boyle J, Finney SJ, Jones A , Russell HH et al (2005) . The Journal of Infectious Diseases, 192(5), 783-790. RIS download Bibtex download
  • Hall JN, Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Keeley AJ, McCarthy JS, Smeesters P , Turner CE et al () . The Journal of Infectious Diseases. RIS download Bibtex download
  • Green LR, Issa R, Albaldi F, Urwin L, Thompson R, Khalid H, Turner CE, Ciani B, Partridge LJ & Monk PN () . mBio. RIS download Bibtex download
  • Keeley AJ, Groves D, Armitage EP, Senghore E, Jagne YJ, Sallah HJ, Drammeh S, Angyal A, Hornsby H, de Crombrugghe G , Smeesters P et al () . The Journal of Infectious Diseases. RIS download Bibtex download
  • Catton EA, Bonsor DA, Herrera C, StÃ¥lhammar-Carlemalm M, Lyndin M, Turner CE, Soden J, van Strijp JAG, Singer BB, van Sorge NM , Lindahl G et al () . Nature Communications, 14(1). RIS download Bibtex download
  • Carrilero L, Urwin L, Ward E, Choudhury NR, Monk IR, Turner CE, Stinear TP & Corrigan RM () . Microbiology Spectrum. RIS download Bibtex download
  • Bah S, Keeley A, Armitage E, Khalid H, Chaudhuri R, Senghore E, Manneh J, Tilley L, Marks M, Darboe S , Sesay A et al () Genomic characterisation of skin and soft tissue Streptococcus pyogenes isolates from a low-income and a high-income setting. mSphere. RIS download Bibtex download
  • Jabang S, Erhart A, Darboe S, Baldeh A-K, Delforge V, Watson G, Foster-Nyarko E, Salaudeen R, Lawal B, Mackenzie G , Botteaux A et al () . Vaccines, 9(2), 124-124. RIS download Bibtex download
  • Turner CE, Lamagni T, Holden MTG, David S, Jones MD, Game L, Efstratiou A & Sriskandan S () . mBio, 6(6). RIS download Bibtex download
  • Lynskey NN, Goulding D, Gierula M, Turner CE, Dougan G, Edwards RJ & Sriskandan S () . PLoS Pathogens, 9(12), e1003842-e1003842. RIS download Bibtex download
  • Alam FM, Bateman C, Turner CE, Wiles S & Sriskandan S () . PLoS ONE, 8(11), e82123-e82123. RIS download Bibtex download
  • Alam FM, Turner CE, Smith K, Wiles S & Sriskandan S () . PLoS ONE, 8(9). RIS download Bibtex download
  • Alam FM, Turner CE, Smith K, Wiles S & Sriskandan S () . PLoS ONE, 8(4), e61655-e61655. RIS download Bibtex download
  • Turner CE, Sommerlad M, McGregor K, Davies FJ, Pichon B, Chong DLW, Farzaneh L, Holden MTG, Spratt BG, Efstratiou A & Sriskandan S () . PLoS ONE, 7(10), e46376-e46376. RIS download Bibtex download
  • Kurupati P, Turner CE, Tziona I, Lawrenson RA, Alam FM, Nohadani M, Stamp GW, Zinkernagel AS, Nizet V, Edwards RJ & Sriskandan S () . Molecular Microbiology, 76(6), 1387-1397. RIS download Bibtex download
  • Siggins M, Lynskey NN, Lamb LE, Johnson LA, Huse KK, Pearson M, Banerji S, Turner CE, Woollard K, Jackson DG & Sriskandan S () . SSRN Electronic Journal. RIS download Bibtex download
  • Turner CE, Abbott J, Lamagni T, Holden MTG, David S, Jones MD, Game L, Efstratiou A & Sriskandan S () . mBio, 6(4). RIS download Bibtex download

Chapters

  • Efstratiou A, Lamagni T & Turner CE (2017) , Infectious Diseases (pp. 1523-1536.e2). Elsevier RIS download Bibtex download
  • Efstratiou A, Lamagni T & Turner CE (2017) , Infectious Diseases, 2-Volume Set (pp. 1523-1536.e2). RIS download Bibtex download
  • Efstratiou A, Lamagni T & Turner CE (2016) Streptococci and Enterococci In Cohen J, Powderly W & Opal S (Ed.), Infectious Diseases 4th edition Elsevier RIS download Bibtex download
  • Turner CE, Bubba L & Efstratiou A () , Gram-Positive Pathogens (pp. 264-274). ASM Press RIS download Bibtex download

Conference proceedings papers

  • Alam F, Bateman C, Turner C, Sriskandan S & Wiles S (2010) Bioluminescence imaging of a clinical isolate of Streptococcus pyogenes. LUMINESCENCE, Vol. 25(2) (pp 179-181) RIS download Bibtex download

Preprints

  • Hall JN, Bah SY, Khalid H, Brailey A, Coleman S, Kirk T, Hussain N, Tovey M, Chaudhuri RR, Davies S , Tilley L et al (2024) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Hall JN, Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Keeley AJ, McCarthy JS, Smeesters P , Turner CE et al (2024) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Buddle JE, Wright RCT, Turner CE, Chaudhuri RR, Brockhurst MA & Fagan RP (2023) . RIS download Bibtex download
  • Green LR, Issa R, Albaldi F, Urwin L, Khalid H, Turner CE, Ciani B, Partridge LJ & Monk PN (2023) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Li HK, Zhi X, Vieira A, Whitwell HJ, Schricker A, Jauneikaite E, Li H, Yosef A, Andrew I, Game L , Turner CE et al (2022) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Keeley AJ, Groves D, Armitage EP, Senghore E, Jagne YJ, Sallah HJ, Drammeh S, Angyal A, Hornsby H, de Crombrugghe G , Smeesters P et al (2022) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Marks M, Cerami C, Roca A, Antonio M , Turner CE et al (2019) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Lynskey NN, Jauneikaite E, Li HK, Zhi X, Turner CE, Mosavie M, Pearson M, Asai M, Lobkowicz L, Chow JY , Parkhill J et al (2019) , SSRN Electronic Journal. RIS download Bibtex download
  • Bah SY, Keeley AJ, Armitage EP, Khalid H, Chaudhuri RR, Senghore E, Manneh J, Tilley L, Marks M, Darboe S , Sesay AK et al () , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Jagne I, Keeley AJ, Bojang A, Camara B, Jallow E, Senghore E, Oluwalana C, Bah SY, Turner CE, Sesay AK , D’Alessandro U et al () , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Tan LKK, Reglinski M, Teo D, Reza N, Lamb LEM, Nageshwaran V, Turner CE, Wikstrom M, Frick I-M, Bjorck L & Sriskandan S () , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Remmington A, Haywood S, Edgar J & Turner CE () . RIS download Bibtex download
  • Turner CE, Holden MTG, Blane B, Horner C, Peacock SJ & Sriskandan S () . RIS download Bibtex download