Suman De
Neuroscience, School of Medicine and Population Health
Research Fellow
UKRI Future Leaders Fellow
+44 114 21 59107
Full contact details
Neuroscience, School of Medicine and Population Health
91Ö±²¥ Institute for Translational Neuroscience (SITraN)
385a Glossop Road
91Ö±²¥
S10 2HQ
- Research interests
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Identification and characterisation of protein complexes, aggregates and post-translational modifications in human is essential for understanding the underlying mechanism of a range of neurodegenerative disease including Alzheimer’s disease, Parkinson disease and Amyotrophic Lateral Sclerosis. In all these diseases, physiological form of proteins such as amyloid-β, α-synuclein, Tar DNA binding protein-43, under specific conditions, aggregate into a range of soluble complexes, and ultimately polymerising into insoluble fibrils to deposit in the specific parts of the central nervous system. These diseases associated proteins can potentially aggregate into many different forms, consisting of different numbers of peptides, with multiple possible post-translational modifications and co-aggregating species. Since the structural and compositional heterogeneities of these protein aggregate correlate with the disease type and severity, determination of specific molecular details of individual pathogenic aggregates is of vital importance.
In our group, we develop and apply novel imaging-based biophysical methodologies to identify and characterise these disease-associated protein aggregates at the single-molecule level with the goal of identifying the structural determinants of their pathogenicity, determining the primary molecular events that trigger their formation and finally, finding the right molecular approach to prevent their formation, block their neurotoxic effects or enhance their clearance. Single-molecule characterisation of these individual aggregates is crucial, especially in a scenario where toxicity may arise from a specific type of species, conformation, or pathways. By studying aggregation and propagation of disease-relevant proteins at the highest level of sensitivity, we aim to understand molecular mechanism underpinning various neurological disorders such as Alzheimer’s disease, Parkinson disease and Amyotrophic Lateral Sclerosis.
Current ProjectS
- Interaction of Amyloid-β and Apolipoprotein in Alzhimer’s disease
- Protein-aggregate membrane interaction in health and disease
- Misfolded and aggregated conformational strains in Neurodegenerative Diseases
- Identificaton and charecterisation of protein aggregates in human biofluids and post-mortem tissue
- Publications
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Featured publications
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All publications
Journal articles
- . Alzheimer's & Dementia, 19(S13).
- . Nature Communications, 13(1).
- . Nature Neuroscience, 25(9), 1134-1148.
- . Nature Communications, 13.
- . Brain Communications, 3(3).
- . Journal of Biological Chemistry, 296, 100631-100631.
- . Nature Structural & Molecular Biology, 27(-), 886-891.
- . Brain Communications.
- . Cell Death & Differentiation, 27(9), 2747-2747.
- . Cell Death & Differentiation.
- . Brain Communications, 2(1).
- . Biophysical Journal, 118(3), 217a-217a.
- . Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1867(10), 870-878.
- . Acta Neuropathologica Communications, 7(1).
- . Alzheimer's & Dementia, 15, P875-P876.
- . ACS Chemical Neuroscience, 10(5), 2374-2384.
- . Chemical Science, 10(17), 4588-4597.
- . Nature Communications, 10(1), ---.
- . Nano Letters, 18(12), 7494-7501.
- . ACS Nano, 12(11), 10855-10866.
- . ChemBioChem, 19(19), 2033-2038.
- . ChemBioChem, 19(19), 2001-2001.
- . Cell Reports, 23(12), 3492-3500.
- . Angewandte Chemie International Edition, 57(18), 4886-4890.
- . Angewandte Chemie, 130(18), 4980-4984.
- . ACS Chemical Biology, 13(3), 636-646.
- . Alzheimer's & Dementia, 14(7S_Part_3).
- . Alzheimer's & Dementia, 14(7S_Part_13).
- . Cell Reports, 21(11), 3310-3316.
- . Scientific Reports, 7(1).
- . Alzheimer's & Dementia, 13(7S_Part_20), P960-P960.
- . Angewandte Chemie, 129(27), 7858-7862.
- . Angewandte Chemie International Edition, 56(27), 7750-7754.
- . Chemical Physics Letters, 667, 247-253.
- . The Journal of Physical Chemistry B, 120(48), 12404-12415.
- . The Journal of Physical Chemistry B, 118(19), 5240-5249.
- . The Journal of Physical Chemistry B, 117(25), 7771-7782.
- . Applied Physics Letters, 101(12), 121919-121919.
- . Applied Physics Letters, 99(25), 251911-251911.
- . Advanced Functional Materials, 21(20), 3828-3835.
- . Advanced Functional Materials, 21(20), 3827-3827.
- . Journal of Applied Physics, 110(3), 033528-033528.
- . The Journal of Physical Chemistry Letters, 2(11), 1241-1247.
- Molecular determinants of protein pathogenicity at the single-aggregate level. Advanced Science.
- . Molecular Psychiatry.
- Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease. Nature Communications.
- . Nature Neuroscience.
- . Nature Chemistry.
- .
- . Cell Death & Differentiation.
- . Methods and Applications in Fluorescence, 5(1), 014003-014003.
- . Physical Review Letters, 110(26).
- Fast 3D imaging of giant unilamellar vesicles using re ected light-sheet microscopy with single molecule sensitivity. Journal of Microscopy.
Chapters
Preprints
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Research Square Platform LLC.
- , arXiv.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Research Square Platform LLC.
- , Research Square Platform LLC.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- Grants
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2022-2026: UKRI Future Leaders Fellowship
2021-2023: AMS Springboard Award
2019: Pilot Grant funded by Dementia Research Institute UK
2019: Pilot Grant funded Alzheimer’s Research UK
2016: Marie Curie Individual Fellowship funded by European Union