Professor Stephen B Wharton
Neuroscience, School of Medicine and Population Health
Professor and Honorary Consultant in Neuropathology
Full contact details
Neuroscience, School of Medicine and Population Health
91直播 Institute for Translational Neuroscience (SITraN)
385a Glossop Road
91直播
S10 2HQ
- Profile
-
- 2014 - present: Professor in Neuropathology, 91直播
- 2001-2014: Senior Lecturer / Reader in Neuropathology, 91直播
- 2001 鈥 present: honorary consultant in neuropathology, 91直播 Teaching Hospitals
- 1997 - 2001: Senior lecturer / honorary consultant in Neuropathology, Edinburgh University
- 1994 鈥 1997: Senior registrar in Neuropathology, Addenbrookes Hospital, Cambridge
- Qualifications
-
- PhD, University of 91直播, 2013
- FRCPath awarded 2005
- MRCPath in Neuropathology 1997
- DipRCPath Histopathology 1995
- MSc University of Cambridge 1995
- MBBS London University 1988
- BSc (Hons) University of London 1985
- Research interests
-
Professor Wharton鈥檚 research interest are focused on the cellular and molecular pathology of dementia and brain ageing. His major areas of interest are in:
- Lead in neuropathology for the which takes a population-based approach to understanding the pathological basis of late-life dementia.
- Investigating the cellular and molecular pathology of astrocytes, neurones and endothelium as components of the neurovascular unit in brain ageing and in the pathogenesis of dementia.
- The pathogenesis of white matter pathology in brain ageing and its contribution to dementia.
- The pathology of motor neurone diseases and tissue banking.
External collaborations
- Prof Fiona Matthews (University of Newcastle) and Prof Carol Brayne (University of Cambridge). The Cognitive Function and Ageing Study.
- Publications
-
Journal articles
- . Nature Communications, 15.
- . Brain Communications, 6(2).
- . Brain Pathol, e13247.
- . Neuroscience Research.
- . Brain and Spine, 4, 102819-102819.
- . Alzheimer鈥檚 Research & Therapy, 15.
- . The Lancet Healthy Longevity, 4(3), e115-e125.
- . Alzheimer's & Dementia, 18(S5).
- . Cell Reports, 40(5), 111162-111162.
- . Brain Pathology.
- . Acta Neuropathologica, 144(1), 27-44.
- . Translational Stroke Research.
- . Journal of Neuroinflammation, 18(1).
- . Journal of Neurochemistry.
- . Brain Communications, 3(4).
- . European Journal of Neuroscience.
- . Brain Pathology, 31(3).
- . Neuropathol Appl Neurobiol.
- . Journal of Cachexia, Sarcopenia and Muscle, 12(2), 308-318.
- . Acta Neuropathologica Communications, 9(1).
- . Bio-protocol, 11(1).
- . Neuro-Oncology, 22(Supplement_3), iii408-iii408.
- . Neuro-Oncology, 22(Supplement_3), iii405-iii406.
- . Alzheimer's & Dementia, 16(S4).
- MBRS-60. THE ACTIONABLE GENOMIC LANDSCAPE OF RELAPSED MEDULLOBLASTOMA IS DEFINED BY MAINTENANCE AND ACQUISITION OF DRIVER EVENTS. Neuro-oncology, 22(Suppl 3), iii408-iii408.
- MBRS-44. TIME, PATTERN AND OUTCOME OF MEDULLOBLASTOMA RELAPSE ARE ASSOCIATED WITH TUMOUR BIOLOGY AT DIAGNOSIS AND UPFRONT THERAPY: A COHORT STUDY. Neuro-oncology, 22(Suppl 3), iii405-iii406.
- . International Journal of Molecular Sciences, 21(21).
- . International Journal of Molecular Sciences, 21(21).
- . The Lancet Child & Adolescent Health.
- . Current Alzheimer Research, 17.
- . Neuropathology and Applied Neurobiology.
- . Acta Neuropathologica Communications, 8(1).
- . Journal of Neuropathology & Experimental Neurology, 79(9), 950-958.
- . Scientific Reports, 10(1).
- . Frontiers in Immunology, 11.
- . Neuropathology.
- . Journal of Alzheimer's Disease.
- . International Journal of Molecular Sciences, 21(1).
- . The British Journal of Psychiatry, 216(1), 49-54.
- . Acta Neuropathologica Communications, 7(1), 1-12.
- . Journal of Cerebral Blood Flow and Metabolism.
- . International Journal of Molecular Sciences, 20(20).
- . Alzheimer's & Dementia, 15, P1232-P1232.
- . International Journal of Molecular Sciences, 20(12).
- . Neuropathology and Applied Neurobiology.
- . Journal of Alzheimer's disease : JAD.
- . Neuropathology and Applied Neurobiology.
- . Glia, 66(11), 2316-2323.
- . British Journal of Neurosurgery.
- . Neuroscience, 390, 46-59.
- . European Journal of Neuroscience, 47(12), 1444-1456.
- . Alzheimer's & Dementia, 14(7S_Part_31), P1624-P1624.
- . Alzheimer's & Dementia, 14(7S_Part_27), P1455-P1455.
- . Neuro-Oncology, 20(suppl_2), i123-i123.
- MBCL-30. SUBGROUP-DIRECTED CLINICAL AND MOLECULAR STRATIFICATION OF DISEASE RISK IN INFANT MEDULLOBLASTOMA.. Neuro-oncology, 20(Suppl 2), i123-i123.
- . Neuropathology and Applied Neurobiology, 44(3), 328-340.
- Genomic Analysis, Surgical Treatment and Outcomes of Lower-Grade Gliomas in a Single Institution.. Neuro-oncology, 20(Suppl 1), i20-i20.
- , 273-284.
- . Neuropathology and Applied Neurobiology, 43(7), 553-570.
- . The Lancet.
- . The Lancet Oncology, 18(7), 958-971.
- . Journal of Neuropathology and Experimental Neurology, 76(7), 605-619.
- . Neuropathology and Applied Neurobiology, 43(4), 281-298.
- . Neuro-Oncology, 19(suppl_4), iv41-iv41.
- . Neuro-Oncology, 19(suppl_4), iv39-iv39.
- . Neuro-Oncology, 19(suppl_4), iv38-iv38.
- MEDU-16. TIME, PATTERN AND OUTCOME OF MEDULLOBLASTOMA RELAPSE IS BIOLOGY AND THERAPY-DEPENDENT. Neuro-oncology, 19(Suppl 4), iv41-iv41.
- MEDU-06. NOVEL MOLECULAR SUBGROUPS IMPROVE CLINICAL CLASSIFICATION AND OUTCOME PREDICTION FOR CHILDHOOD MEDULLOBLASTOMA. Neuro-oncology, 19(Suppl 4), iv38-iv38.
- MEDU-09. SUBGROUP-DIRECTED STRATIFICATION OF DISEASE RISK IN INFANT MEDULLOBLASTOMA. Neuro-oncology, 19(Suppl 4), iv39-iv39.
- . World Neurosurgery.
- . British Journal of Radiology.
- . Journal of Neuroimmunology, 299, 139-146.
- . Neuropathol Appl Neurobiol.
- . BMC Medicine, 14(1).
- . Journal of Neuroscience Methods, 268, 125-130.
- . Neuro-Oncology, 18(suppl 3), iii111.2-iii111.
- . Neuro-Oncology, 18(suppl 3), iii115.1-iii115.
- MB-63SUBGROUP-DIRECTED STRATIFICATION OF RISK IN INFANT MEDULLOBLASTOMA. Neuro-oncology, 18(Suppl 3), iii111-iii111.
- MB-79CENTRALISED MOLECULAR PATHOLOGY FOR RARE TUMOURS: A NATIONAL FEASIBILITY STUDY OF REAL-TIME MEDULLOBLASTOMA DIAGNOSTICS. Neuro-oncology, 18(Suppl 3), iii115-iii115.
- . Neuropathology and Applied Neurobiology, 42(4), 377-389.
- . Nature Communications, 7, 11398-11398.
- . Practical Neurology, 16(2), 153-156.
- . Acta Neuropathologica Communications, 4(1).
- . Neuropathology and Applied Neurobiology, 42(2), 167-179.
- . Acta Neuropathologica, 131(1), 87-102.
- . Cerebellum & Ataxias, 2.
- . Molecular Brain, 8(1).
- . Neuroscience Letters, 609, 11-17.
- . Brain Pathology, 25(5), 565-574.
- . Brain Pathology, 26(3), 371-386.
- . Journal of Neural Transmission, 122(7), 973-974.
- . Acta Neuropathologica, 130(1), 63-75.
- . Journal of Neural Transmission, 122(7), 957-972.
- . Neuropathology and Applied Neurobiology, 41(4), 483-496.
- . Endocrinology, Diabetes & Metabolism Case Reports, 2015.
- . Brain Pathology, 25(1), 35-43.
- . Cancer Cell, 27(1), 72-84.
- . Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 16(3-4), 249-251.
- . Neuropathol Appl Neurobiol, 40(6), 670-685.
- . Brain, 137(Pt 7), 2040-2051.
- . GLIA.
- . Neuropathol Appl Neurobiol, 40(7), 802-814.
- . Neurology, 82(10_supplement).
- . Neurology, 82(10_supplement).
- . Acta Neuropathol, 127(3), 407-418.
- . Neuropathol Appl Neurobiol, 40(3), 258-269.
- . Neuro-Ophthalmology, 37(4), 146-156.
- . Plos One, 6(8), e68256-e68256.
- . Neuropathol Appl Neurobiol, 39(7), 788-799.
- . Journal of Alzheimer's Disease, 33(SUPPL. 1).
- . Acta Neuropathol, 125(1), 95-109.
- . Experimental Gerontology, 47(11), 825-833.
- . Neurodegenerative Disease Management, 2(5), 471-482.
- . Dement Geriatr Cogn Disord, 34(1), 15-24.
- . J Neurosci Methods, 208(2), 108-113.
- . Brain, 135(Pt 3), 751-764.
- . Advances in Alzheimer's Disease, 3, 385-396.
- . JOURNAL OF ALZHEIMERS DISEASE, 28(2), 485-493.
- . Acta Neuropathol, 122(6), 657-671.
- . NEUROBIOL AGING, 32(10), 1795-1807.
- . Neurosci Lett, 505(1), 25-30.
- . Alzheimer's & Dementia, 7, S566-S566.
- . Alzheimer's & Dementia, 7, S606-S607.
- . NEUROLOGY, 76(16), 1435-1436.
- . J Alzheimers Dis, 25(2), 359-372.
- . Brain, 134(Pt 2), 506-517.
- . Neuroscience Letters, 505(1), 25-30.
- . Neurosci Lett, 486(3), 246-251.
- . Neurology, 75(11), 1003-1008.
- . Pediatr Radiol, 40 Suppl 1, S145-S149.
- . Neurogenetics, 11(2), 217-225.
- . Neurobiol Aging, 31(4), 578-590.
- . Neuropathol Appl Neurobiol, 36(1), 25-40.
- . Neuroscience Letters, 486(3), 246-251.
- . PLoS One, 5(3), e9872.
- . PLOS MED, 6(11).
- . APMIS, 117(10), 768-772.
- Age, Neuropathology, and Dementia. NEW ENGL J MED, 360(22), 2302-2309.
- . Brain, 132(Pt 5), 1324-1334.
- . ACTA NEUROPATHOL, 117(3), 309-320.
- . Stroke, 40(2), 369-375.
- . BMC NEUROL, 9.
- . Dement Geriatr Cogn Disord, 27(5), 465-473.
- . J Neurochem, 110(1), 34-44.
- . BRAIN PATHOL, 18(4), 484-496.
- . Neuropathology and Applied Neurobiology, 34(1), 1-3.
- . Neuroradiology Journal, 21(SUPPL. 1), 47-66.
- . Neuropathol Appl Neurobiol, 33(6), 670-683.
- . Neuropathol Appl Neurobiol, 33(4), 410-419.
- . Muscle Nerve, 35(4), 443-450.
- . Clin Neuropathol, 26(2), 43-58.
- . Acta Neuropathol, 113(2), 119-127.
- . J Neurosurg, 106(2 Suppl), 143-146.
- . Neuropathology and Applied Neurobiology, 33(1), 1-1.
- . J Neurol Neurosurg Psychiatry, 77(11), 1262-1266.
- . Stroke, 37(6), 1391-1398.
- . J Neuropathol Exp Neurol, 65(1), 26-36.
- . MUSCLE NERVE, 32(4), 541-544.
- . Br J Neurosurg, 19(4), 348-351.
- . Neurosci Lett, 383(1-2), 33-38.
- . NEUROPATH APPL NEURO, 31(2), 191-202.
- Progressive loss of motor neuron function in wasted mice: Effects of a spontaneous null mutation in the gene for the eEF1A2 translation factor. J NEUROPATH EXP NEUR, 64(4), 295-303.
- A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas. CLIN CANCER RES, 11(1), 217-225.
- , 149-167.
- . Neuropathol Appl Neurobiol, 30(5), 427-446.
- . Br J Cancer, 91(2), 262-269.
- Morphological changes and stress responses in neurons in cerebral cortex infiltrated by diffuse astrocytoma. NEUROPATHOLOGY, 23(4), 262-270.
- . Ann Neurol, 54(6), 748-759.
- . J Neuropathol Exp Neurol, 62(11), 1166-1177.
- . Neuropathol Appl Neurobiol, 29(3), 254-261.
- . Neurology, 60(8), 1252-1258.
- . J Biol Chem, 278(8), 6371-6383.
- . The Journal of Pathology, 199(2), 271-271.
- . Brain Research, 965(1-2), 57-66.
- Glioma tumourgenicity is decreased by iNOS knockout: experimental studies using the C6 striatal implantation glioma model. BRIT J NEUROSURG, 16(6), 567-572.
- . PROSTAG LEUKOTR ESS, 67(5), 283-292.
- . Trends in Microbiology, 10(11), 496-501.
- . EYE, 16(5), 670-673.
- . ACTA NEUROPATHOL, 104(2), 215-215.
- Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasis - Reply. CLIN NEUROPATHOL, 21(4), 195-196.
- . J CLIN NEUROSCI, 9(2), 165-169.
- . Am J Ophthalmol, 133(1), 147-149.
- . Prostaglandins Leukot Essent Fatty Acids, 66(1), 19-29.
- Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasis [2] (multiple letters). Clinical Neuropathology, 21(4), 193-196.
- . Br J Neurosurg, 15(5), 416-418.
- Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasis.. Clin Neuropathol, 20(5), 212-218.
- . Neuropathol Appl Neurobiol, 27(4), 291-304.
- . Neuropathol Appl Neurobiol, 27(4), 305-313.
- . Eye (Lond), 15(Pt 3), 309-312.
- . Retina, 21(3), 247-251.
- . Acta Neuropathol, 100(6), 695-700.
- . Neuropathol Appl Neurobiol, 26(6), 528-535.
- . The Journal of Laryngology & Otology, 114(1), 17-23.
- . The Journal of Laryngology & Otology, 114(1), 67-69.
- Spontaneous acute scleritis and scleral necrosis in choroidal malignant melanoma. EYE, 13, 793-795.
- . J Neurosurg, 91(6), 989-996.
- . Clin Neurol Neurosurg, 101(4), 275-279.
- . Neuropathol Appl Neurobiol, 25(5), 400-407.
- . Arch Ophthalmol, 117(10), 1411-1413.
- . Eye (Lond), 13 ( Pt 2), 247-250.
- Neuropathological findings after intracerebral implantation of microdialysis catheters in sheep forebrain.. Neuroreport, 10(3).
- Systemic metastases of glioblastoma multiforme. CLIN ONCOL-UK, 11(3), 205-207.
- . Br J Neurosurg, 12(6), 539-546.
- . Journal of Neurology, Neurosurgery & Psychiatry, 65(5), 788-790.
- . Neuropathol Appl Neurobiol, 24(4), 302-308.
- Proliferation and cell death in oligodendrogliomas. NEUROPATH APPL NEURO, 24(1), 21-28.
- The natural history of a recurrent central neurocytoma-like tumor.. Clin Neuropathol, 17(3), 136-140.
- . The Journal of Laryngology & Otology, 111(4), 368-371.
- . Journal of Neurology, Neurosurgery & Psychiatry, 61(5), 461-465.
- . Neuropathology and Applied Neurobiology, 21(3), 228-237.
- . Current Opinion in Neurobiology, 3(5), 768-772.
- . International Journal of Molecular Sciences, 25(8), 4445-4445.
- . Neuropathology and Applied Neurobiology.
- . Brain Pathology.
- . International Journal of Molecular Sciences, 23(11), 5913-5913.
- . Neuro-Oncology.
- .
- .
- .
- .
- . Endocrine Abstracts.
- . PLoS ONE, 10(2).
- . eLife.
Chapters
- , Greenfield's Neuropathology 10e Set (pp. 875-906). CRC Press
- , Atlas of Adult Autopsy (pp. 297-330). Springer Nature Switzerland
- Motor neuron disorders In Love S, Budka H, Ironside JW & Perry A (Ed.), Greenfield's Neuropathology (pp. 817-848). Boca Raton: CRC Press.
- (pp. 89-119).
- , Motor Neuron Disorders (pp. 17-49). Elsevier
Conference proceedings papers
- The miRNA profile of neutrophil-derived microvesicles may impact blood-brain barrier integrity in Alzheimer's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
- Characterising the astrocyte response to oligomeric and fibrillary A beta 1-42 in Alzheimer's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
- Demystifying the gluten brain: Understanding the origin of gluten-related neurological disorders. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
- Microarray approach to identifying the role of microglia in the pathogenesis of age-associated deep-subcortical white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
- What happens to cells of the brain in people who develop dementia after stroke?. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 8-8)
- The effect of systemic atherosclerosis on the neurovascular unit. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 21-21)
- Effects of Type 2 Diabetes on Neuronal and Associated Neurovascular Unit Transcriptomes. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 8-8)
- Characterising the varying astrocyte response to oligomeric and fibrillar A beta(1-42). NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 18-19)
- Transcriptomic profile of the blood-brain barrier in age-associated white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 46 (pp 46-46)
- 121st Meeting of the British Neuropathological Society UCL Great Ormond Street Institute of Child Health, London. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 46 (pp 14-15)
- Characterising the varying astrocyte response to oligomeric and fibrillar A beta. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 46 (pp 25-25)
- Multiple sclerosis-like CNS inflammation following allogeneic haematopoietic stem cell transplantation treated with a 'domino' autologous haematopoietic stem cell transplantation. NEUROLOGY, Vol. 94(15)
- TIME, PATTERN AND OUTCOME OF MEDULLOBLASTOMA RELAPSE ARE ASSOCIATED WITH TUMOUR BIOLOGY AT DIAGNOSIS AND UPFRONT THERAPY: A COHORT STUDY. NEURO-ONCOLOGY, Vol. 22 (pp 405-406)
- THE ACTIONABLE GENOMIC LANDSCAPE OF RELAPSED MEDULLOBLASTOMA IS DEFINED BY MAINTENANCE AND ACQUISITION OF DRIVER EVENTS. NEURO-ONCOLOGY, Vol. 22 (pp 408-408)
- The Molecular Landscape and Clinical Experience in Infant Medulloblastoma. PEDIATRIC BLOOD & CANCER, Vol. 66 (pp S4-S4)
- A microarray analysis approach to identify mechanisms underlying the pathogenesis of age-associated periventricular white matter lesions. GLIA, Vol. 67 (pp E300-E300)
- SUBGROUP-DIRECTED CLINICAL AND MOLECULAR STRATIFICATION OF DISEASE RISK IN INFANT MEDULLOBLASTOMA. NEURO-ONCOLOGY, Vol. 20 (pp 123-123)
- Hypoxia-induced changes in astrocytes and their role in the formation of age-associated white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 17-18)
- Advanced glycosylated end products in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 12-12)
- Identification of miRNA and mRNA regulatory networks in the ageing blood-brain barrier: Comparative gene expression studies in human and mouse. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 36-36)
- . Neuro-Oncology, Vol. 20(suppl_1) (pp i20-i20)
- GENOMIC ANALYSIS, SURGICAL TREATMENT AND OUTCOMES OF LOWER-GRADE GLIOMAS IN A SINGLE INSTITUTION. NEURO-ONCOLOGY, Vol. 19 (pp 238-238)
- Time, Pattern and Outcome of Medulloblastoma Relapse is Biology and Therapy-Dependent. PEDIATRIC BLOOD & CANCER, Vol. 64 (pp S13-S14)
- SUBGROUP-DIRECTED STRATIFICATION OF DISEASE RISK IN INFANT MEDULLOBLASTOMA. NEURO-ONCOLOGY, Vol. 19 (pp 39-39)
- TIME, PATTERN AND OUTCOME OF MEDULLOBLASTOMA RELAPSE IS BIOLOGY AND THERAPY-DEPENDENT. NEURO-ONCOLOGY, Vol. 19 (pp 41-41)
- Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 43 (pp 43-43)
- Early cellular changes and cognitive decline in an Alzheimer's mouse model. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 43 (pp 42-43)
- CENTRALISED MOLECULAR PATHOLOGY FOR RARE TUMOURS: A NATIONAL FEASIBILITY STUDY OF REAL-TIME MEDULLOBLASTOMA DIAGNOSTICS. NEURO-ONCOLOGY, Vol. 18 (pp 115-115)
- SUBGROUP-DIRECTED STRATIFICATION OF RISK IN INFANT MEDULLOBLASTOMA. NEURO-ONCOLOGY, Vol. 18 (pp 111-111)
- Impairment of IGF1 signalling in human astrocytes and it's effect on astrocyte support for neurons. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42 (pp 51-52)
- Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42 (pp 27-28)
- Establishment of national real-time central pathology review (CPR) and molecular diagnostics for medulloblastoma (MB). NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42 (pp 19-20)
- Microinfarcts, Small Vessel Disease and Dementia in the population-representative CFAS brain donor cohort. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 41 (pp 22-23)
- Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 41 (pp 32-32)
- . Tumor Biology
- . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 85(10) (pp e4.130-e4)
- Oxidative stress and DNA damage in cerebral white matter lesions of the ageing human brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 40 (pp 33-34)
- A neuronal DNA damage response is detected at low Braak stages and correlates with cognitive impairment in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 40 (pp 31-32)
- A pathological basis for the association of parkinsonism and amyotrophic lateral sclerosis. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 39 (pp 51-51)
- A national feasibility study of real-time central pathology review (CPR) and molecular diagnostics for medulloblastoma. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 39 (pp 20-20)
- Oxidative stress and DNA damage in cerebral white matter lesions of the ageing human brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 39 (pp 36-37)
- Evidence for an ischemic origin of deep brain 'microbleeds'. CEREBROVASCULAR DISEASES, Vol. 35 (pp 42-42)
- Microarray analysis of the astrocyte transcriptome in normal appearing white matter in multiple sclerosis. JOURNAL OF NEUROIMMUNOLOGY, Vol. 253(1-2) (pp 54-54)
- A NATIONAL FEASIBILITY STUDY OF REAL-TIME CENTRAL PATHOLOGY REVIEW AND MOLECULAR DIAGNOSTICS FOR MEDULLOBLASTOMA. NEURO-ONCOLOGY, Vol. 14 (pp 44-44)
- . JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 83(3)
- SEMI-AUTOMATED VOLUMETRIC ANALYSIS OF LOW-GRADE GLIOMAS. NEURO-ONCOLOGY, Vol. 13 (pp 140-140)
- Oxidative nucleic acid damage in motor neuron disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 36-36)
- A feasibility study of real-time central pathology review (CPR) and molecular diagnostics for medulloblastoma in the United Kingdom. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 18-19)
- Microarray analysis of the astrocyte transcriptome in the ageing brain: relationship to Alzheimer's pathology and ApoE genotype. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 33-33)
- The development of the National Brain and CNS Tumour Registry. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 19-19)
- Microarray analysis of the astrocyte transcriptome in the ageing brain: relationship to Alzheimer's pathology and ApoE genotype. BRAIN PATHOLOGY, Vol. 20 (pp 46-46)
- ESTABLISHMENT OF REAL-TIME CENTRALISED PATHOLOGY REVIEW (CPR) AND MOLECULAR DIAGNOSTICS FOR MEDULLOBLASTOMA IN THE UNITED KINGDOM. NEURO-ONCOLOGY, Vol. 12 (pp 6-6)
- ESTABLISHMENT OF REAL-TIME CENTRALISED PATHOLOGY REVIEW (CPR) AND MOLECULAR DIAGNOSTICS FOR MEDULLOBLASTOMA IN THE UNITED KINGDOM. NEURO-ONCOLOGY, Vol. 12(6) (pp II58-II58)
- Presenilin 1 S170P Mutation with a Limbic Encephalitis like Presentation. NEUROLOGY, Vol. 74(9) (pp A244-A244)
- . JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 80(11)
- Evidence of an astrocytic DNA damage response to oxidative stress in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 35 (pp 18-19)
- Variation in 4R and 3R tau isoforms in the ageing population. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 35 (pp 19-19)
- Reproducibility in the assessment of Alzheimer's disease and Lewy body disease-related pathologies: a study by Brain Net Europe. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 35 (pp 12-13)
- DNA oxidative damage and repair mechanisms in astrocytes, and their relationship to Alzheimer-type pathology in the ageing brain. JOURNAL OF NEURAL TRANSMISSION, Vol. 115(12) (pp 1727-1727)
- Variation in 4R and 3R Tau isoforms in the ageing population. JOURNAL OF NEURAL TRANSMISSION, Vol. 115(12) (pp 1725-1726)
- Optic neuropathy and cerebellar degeneration. JOURNAL OF NEUROIMMUNOLOGY, Vol. 197(2) (pp 175-175)
- Characterisation of astrocytes in relation to Alzheimer-type pathology in the ageing brain using a population-based neuropathology cohort. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 34 (pp 31-31)
- Age effects on the relationship between pathology and cognitive impairment in a population cohort. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 34 (pp 10-10)
- Population variation in tau pathology in the MRC-CFAS neuropathology cohort. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 34 (pp 10-11)
- Microarray gene expression analysis of deep subcortical lesions in the ageing brain reveals changes in multiple functional pathways. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 34 (pp 30-31)
- Population variation in tau pathology in the aged hippocampus in the MRC-CFAS neuropathology cohort. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 263-263)
- Extra-motor manifestations of motor neurone disease and the role of TDP43 in ALS variants. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 264-265)
- Axonal number and myelin sheath degeneration in MRI hyperintense white matter lesions in the aging brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 266-267)
- Microarray gene expression profiling of deep subcortical lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 254-255)
- Microglial activation in white matter of the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 255-255)
- Cytogenetic subtypes of oligodendroglioma differ in their apoptotic index, while the population of replication-licensed, non-proliferating cells is higher in anaplastic tumors but does not differ according to 1p,19q status. NEURO-ONCOLOGY, Vol. 8(4) (pp 459-459)
- FISH for the detection of 1p and 19q deletions in oligodendrogioma paraffin wax sections - A retrospective study of 55 cases. JOURNAL OF MEDICAL GENETICS, Vol. 43 (pp S101-S101)
- Molecular markers of tissue hypoxia and glial pathology associated with incidental white matter lesions in the ageing brain. BRAIN PATHOLOGY, Vol. 16 (pp S92-S92)
- New pathological findings from the MRC-cognitive function and ageing study (CFAS) neuropathology cohort. BRAIN PATHOLOGY, Vol. 16 (pp S127-S127)
- Molecular markers of tissue hypoxia are associated with deep subcortical white matter lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 32(2) (pp 224-224)
- Glial cell pathology of periventricular and deep white matter lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 32(2) (pp 224-225)
- . International Journal of Molecular Sciences, Vol. 21(4) (pp 1225-1225)
Datasets
Preprints
- Research group
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Current PhD students:
- Harriet Brooke
Research team:
- Dr Bridget Ashford
- Dr Bridget Benson
- Mr Saif Ahamed
- Grants
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Current funding sources
- Alzheimer鈥檚 Society
- Alzheimer鈥檚 Research UK
- British Heart Foundation
- Teaching interests
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- Module leader: Neurodegeneration module, MSc Translational Neuroscience
- MSc lectures 鈥 Translational Neuroscience
- MBBS lectures 鈥 Preclinical neurosciences
- Neuroanatomy dissection teaching
- Supervisor SSC research projects
- Supervisor MSc research projects
- Seminars to postgraduate trainees in histopathology and clinical neurosciences
- Professional activities and memberships
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Editorial activities
- Consulting editor, Neuropathology and Applied Neurobiology (2014-7)
- Editor-in-Chief, Neuropathology and Applied Neurobiology (2007-13)
External professional activities 鈥 current and recent
- President of the British Neuropathological Society (2022 鈥 2024)
- Vice-president of the British Neuropathological Society (2020-2022)
- Member of the annual review panel for Brains for Dementia Research (2022 鈥 present)
- Member of the Alzheimer鈥檚 Research UK Grant Review Board 2016- 2022
- Chair of the specialist advisory committee in neuropathology, Royal College of Pathologists, 2020-2022
- Chief of panel of examiners in neuropathology for the Royal College of Pathologists (2018-21)
- Examiner in neuropathology for the Royal College of Pathologists (2005-21)
Membership of associations and societies - current
- International Society for Neuropathology
- British Neuropathological Society
- Current projects
Neuronal Senescence as a Contributory Mechanism to Dementia
Funded by Alzheimer's Research UK, this project aims to study the contribution of neuronal senescence to dementia. Markers of dementia, such as tangles and plaques that characterise Alzheimer鈥檚, do not explain all dementia, and treatments aimed at them have been unsuccessful. This suggests other processes contribute to dementia.
Senescent cells, sometimes called zombie cells, are persistently damaged cells, often because of damage to their DNA, which carries all the instructions for the cell. These cells remain alive, but they do not carry out their normal functions. Additionally, they produce factors that damage nearby cells and cause inflammation. Zombie cells are described in other tissues and diseases and there are drug treatments aimed at them. However, their role in dementia is not understood. Using brain tissue samples from the Cognitive Function and Ageing Study, we plan to identify senescent nerve cells in the brain and determine how they relate to dementia.
To determine how senescence causes damage, we will isolate nerve cells with and without markers of senescence from the same cases, and investigate effects on the cells by determining differences in the gene messages present. This will provide greater understanding of how senescence contributes to dementia and identify specific ways in which senescence affects nerve cells, which may lead us to new approaches to target zombie cells.
How does brain microvascular disease, especially pathological changes to capillaries, contribute to dementia?
Studies of blood vessel diseases, the second commonest cause of dementia, have focused mainly on large or small arteries. However, the contribution of pathology affecting the smallest vessels, the capillaries, is not understood. Brain capillaries are specialised to ensure that substances entering the brain from the blood are tightly-regulated and that blood supply is matched to the needs of nerve cells. This study, funded by the British Heart Foundation, will investigate the contribution of microvascular disease (MVD), affecting the capillaries, to dementia. Using donated human brain tissue, we will first characterise MVD using immunohistochemistry, a method that allows us to identify whether and where particular molecules are expressed and to measure them using a computer. Secondly, we will determine how these new MVD measures compare to other, existing measures of dementia-related pathologies. Thirdly, we will extend the assessment of the most informative MVD measures to all 550 donations, then determine how MVD contributes to dementia using advanced statistical methods. Lastly, we will identify potential new mechanisms of capillary damage by examining the expression of all the messages (mRNA) that code for protein production in the capillaries. Computer-based approaches will allow us to analyse this data to identify changes in cell processes that contribute to disease.
What is the Contribution of Basal Ganglia Pathology to Late-life Dementia and Frailty?
Most studies of dementia focused on the cerebral cortex, but other brain regions are also important. This PhD studentship, funded by the Alzheimer鈥檚 Society, aims to investigate how pathology in the basal ganglia contributes to dementia and frailty in late-life. The basal ganglia have many connections to the cortex and are involved in cognition as well as in motor control. They are affected by vascular disease and in the progression of Alzheimer鈥檚 disease. We plan to use human autopsy brain tissue samples donated as part of the Cognitive Function and Ageing Study. We will characterised vascular pathology and neurodegenerative pathology in basal ganglia using microscopy and immunohistochemistry. We will then determine the contribution that pathology in the basal ganglia makes to dementia and also to frailty. Finally, we will use gene expression analysis to determine new pathways by which pathology in basal ganglia might damage the function of this tissue.