Dr Ryan West
Neuroscience, School of Medicine and Population Health
Dementia Research Leader Fellow
+44 114 222 2239
Full contact details
Neuroscience, School of Medicine and Population Health
91直播 Institute for Translational Neuroscience (SITraN)
385a Glossop Road
91直播
S10 2HQ
- Profile
-
2023 鈥 present: Alzheimer鈥檚 Society Dementia Research Leader Fellow (SITraN, University of 91直播)
2019 鈥 2023: SITraN Fellow and Alzheimer鈥檚 Society Fellow (SITraN, University of 91直播)
2018 鈥 2019: Alzheimer鈥檚 Society Junior Fellow (University of Manchester)
2015 鈥 2018: Postdoctoral Research Associate (University of York)
2013-2015: Centre for Chronic Diseases and Disorders Wellcome Trust funded 鈥淒iscipline hopping鈥 Fellow (University of York)
2010 - 2013: PhD, The University of York
- Research interests
-
My research looks to use Drosophila melanogaster (fruit flies) as a powerful genetic model organism to dissect the molecular mechanisms contributing to neurodegenerative diseases including dementia, motor neurone disease and Parkinson鈥檚 disease. My primary research focuses on two overlapping neurodegenerative disorders, Frontotemporal Dementia (FTD) and Motor Neurone Disease (MND). I am particularly interested in how dipeptide-repeats associated with the disease causing hexanucleotide expansion within the C9orf72 gene contribute towards neurodegeneration. In the lab we have a number of Drosophila models of both FTD and MND including C9orf72 related DPRs, C9orf72 pure repeat models and models of CHMP2B, VCP and TDP-43 related disease. I am also interested in how we can use Drosophila as part of a translational pipeline both to understand the molecular mechanisms of disease and as part of a drug-screening strategy.
- Publications
-
Journal articles
- . Life Science Alliance, 8(2), e202402757-e202402757.
- . Acta Neuropathologica Communications, 11(1).
- . Bio-protocol, 12(10).
- . Neurobiology of Disease, 147.
- . Acta Neuropathologica Communications, 8.
- . Neurobiology of Disease, 144.
- . Scientific Reports, 10(1).
- . Proceedings of the Royal Society B: Biological Sciences, 285(1893).
- . Journal of Comparative Neurology, 526(13), 1995-2009.
- . Journal of Neurophysiology, 119(3), 957-970.
- . Human Molecular Genetics, 27(8), 1382-1395.
- . Movement Disorders, 33(2), 248-248.
- . Human Molecular Genetics, 24(24), 6899-6909.
- . Scientific Reports, 5(1).
- . Future Neurology, 10(6), 507-510.
- . Journal of Cell Science, 128(18), 3386-3397.
- . Journal of Cell Biology, 208(7), 931-947.
- . Parkinson's Disease, 2015, 1-11.
- . Autophagy, 8(2), 284-285.
- . Frontiers in Cellular Neuroscience, 15.
- . eLife, 7.
Preprints
- Research group
-
PhD Students
- Duncan Garner
- Charlotte Gale
- Ergita Balli
- Abbie Stretch
Postdoctoral Research Associates
- Debarati Bhattacharya
- Kriti Gupta
- Professional activities and memberships
-
- Member of NC3Rs Studentship Grant Panel, January 2023 - present
- Current Funding Sources
- Alzheimer鈥檚 Society
- ARUK
- Motor Neurone Disease Association
- My Name鈥5 Doddie Foundation