Dr Matthew Livesey

PhD

Neuroscience, School of Medicine and Population Health

Research Fellow

Matt Livesey
Profile picture of Matt Livesey
M.R.Livesey@91Ö±²¥.ac.uk
+44 114 222 2233

Full contact details

Dr Matthew Livesey
Neuroscience, School of Medicine and Population Health
91Ö±²¥ Institute for Translational Neuroscience (SITraN)
385a Glossop Road
91Ö±²¥
S10 2HQ
Profile

I studied Pharmacology (B.Sc. Hons) at the University of Edinburgh between 2001 – 2005. In 2005, I joined the Department of Neuroscience, University of Dundee, to undertake a BBSRC-Case PhD studentship. Here, using patch-clamp electrophysiology techniques, I examined the structure-function of pentameric ligand-gated ion channels. My time in Dundee included a short post-doctoral position (JBC, 2008 and JBC, 2011).

I joined the University of Edinburgh at the start of 2011 and undertook a postdoctoral position to examine the functional capabilities and developmental properties of pluripotent stem cell-derived cortical neurons (J.Neurosci, 2014; J.Physiol, 2014 and PLoS One, 2014). In this time I became interested in using this technology in order to model disease, specifically amyotrophic lateral sclerosis and frontotemporal dementia, and was awarded a Royal Society of Edinburgh Fellowship (2015) in order to investigate synaptic impairments in ALS-FTD (Nature Neuroscience, 2016; Nature Communications, 2018; J.Pathology, 2020; Molecular Neurodegeneration, 2021). Furthermore, noting the increasing appreciation of the roles of non-neuronal cell types in healthy neuronal health and disease, I have also explored the functional properties of oligodendrocytes-derived from ALS patients (Stem Cells, 2016) and also began to examine the heavily underexplored area of oligodendrocyte physiology (Glia, 2019; Journal of Neuroscience, 2021).  

In March 2020, I arrived at SITraN as a principle investigator to lead work on neurophysiological perturbations and their mechanistic bases in ALS-FTD.

Research interests

In neurodegenerative disease, neuronal dysfunction precedes neuronal death. My research interests centre around understanding these functional disturbances in neurons. Furthermore, it is increasingly regarded that such diseases are not ‘purely’ neuronal and often include a role for their supporting cells called glia. Our research also therefore investigates the properties of glia; both their functional properties and their role on neuronal function.

To do this we combine multiple research specialisations; electrophysiology, human in vitro cell models and rodent models.

Current Projects

  •  Glutamatergic dysfunction in ALS patient-derived neurons and glia.
  •  Synaptic pathophysiology in cortical neurons derived from ALS patients.
  •  The physiological role of C9ORF72.
  •  The role of ion channels on oligodendrocyte-lineage cell function.
Publications

Journal articles

  • Zhang S, Cooper-Knock J, Weimer AK, Shi M, Moll T, Marshall JNG, Harvey C, Nezhad HG, Franklin J, Souza CDS , Ning K et al (2022) . Neuron. RIS download Bibtex download
  • Pasniceanu I-S, Atwal MS, Souza CDS, Ferraiuolo L & Livesey MR (2021) . Frontiers in Cellular Neuroscience, 15. RIS download Bibtex download
  • Barton SK, Magnani D, James OG, Livesey MR, Selvaraj BT, James OT, Perkins EM, Gregory JM, Cleary E, Ausems CRM , Carter R et al (2021) . Brain Communications, 3(4). RIS download Bibtex download
  • Castelli LM, Cutillo L, Souza CDS, Sanchez-Martinez A, Granata I, Lin Y-H, Myszczynska MA, Heath PR, Livesey MR, Ning K , Azzouz M et al (2021) . Molecular Neurodegeneration, 16(1). RIS download Bibtex download
  • Swire M, Assinck P, McNaughton PA, Lyons DA, ffrench-Constant C & Livesey MR (2021) . The Journal of Neuroscience. RIS download Bibtex download
  • Perkins EM, Burr K, Banerjee P, Mehta AR, Dando O, Selvaraj BT, Suminaite D, Nanda J, Henstridge CM, Gillingwater TH , Hardingham GE et al (2021) . Molecular Neurodegeneration, 16(1). RIS download Bibtex download
  • Das Sharma S, Pal R, Reddy BK, Selvaraj BT, Raj N, Samaga KK, Srinivasan DJ, Ornelas L, Sareen D, Livesey MR , Bassell GJ et al (2020) . Molecular Autism, 11(1). RIS download Bibtex download
  • Marshall-Phelps KLH, Kegel L, Baraban M, Ruhwedel T, Almeida RG, Rubio-Brotons M, Klingseisen A, Benito-Kwiecinski SK, Early JJ, Bin JM , Suminaite D et al (2020) . Journal of Cell Biology, 219(7). RIS download Bibtex download
  • Gregory JM, Livesey MR, McDade K, Selvaraj BT, Barton SK, Chandran S & Smith C (2020) . The Journal of Pathology, 250(1), 67-78. RIS download Bibtex download
  • Gregory JM, McDade K, Livesey MR, Croy I, Marion de Proce S, Aitman T, Chandran S & Smith C (2020) . Neuropathology and Applied Neurobiology, 46(5), 441-457. RIS download Bibtex download
  • Vasistha NA, Johnstone M, Barton SK, Mayerl SE, Thangaraj Selvaraj B, Thomson PA, Dando O, Grünewald E, Alloza C, Bastin ME , Livesey MR et al (2019) . Molecular Psychiatry, 24(11), 1567-1567. RIS download Bibtex download
  • Suminaite D, Lyons DA & Livesey MR (2019) . Glia, 67(11), 2050-2062. RIS download Bibtex download
  • Vasistha NA, Johnstone M, Barton SK, Mayerl SE, Thangaraj Selvaraj B, Thomson PA, Dando O, Grünewald E, Alloza C, Bastin ME , Livesey MR et al (2019) . Molecular Psychiatry, 24(11), 1641-1654. RIS download Bibtex download
  • Johnstone M, Vasistha NA, Barbu MC, Dando O, Burr K, Christopher E, Glen S, Robert C, Fetit R, Macleod KG , Livesey MR et al (2019) . Molecular Psychiatry, 24(2), 294-311. RIS download Bibtex download
  • Selvaraj BT, Livesey MR, Zhao C, Gregory JM, James OT, Cleary EM, Chouhan AK, Gane AB, Perkins EM, Dando O , Lillico SG et al (2018) . Nature Communications, 9(1). RIS download Bibtex download
  • Etherington L-A, Mihalik B, Pálvölgyi A, Ling I, Pallagi K, Kertész S, Varga P, Gunn BG, Brown AR, Livesey MR , Monteiro O et al (2017) . Neuropharmacology, 125, 353-364. RIS download Bibtex download
  • Selvaraj BT, Livesey MR & Chandran S (2017) . Brain Pathology, 27(4), 518-524. RIS download Bibtex download
  • Johnstone M, Vasistha N, Livesey M, Burr K, Whalley H, Clair DS, Blackwood D, Wyllie D, Lawrie S, Johnstone EC , McIntosh AM et al (2017) . European Neuropsychopharmacology, 27, S509-S510. RIS download Bibtex download
  • Livesey MR, Magnani D, Hardingham GE, Chandran S & Wyllie DJA (2016) . The Journal of Physiology, 594(22), 6573-6582. RIS download Bibtex download
  • Qiu J, McQueen J, Bilican B, Dando O, Magnani D, Punovuori K, Selvaraj BT, Livesey M, Haghi G, Heron S , Burr K et al (2016) . RIS download Bibtex download
  • Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D , Sadegh C et al (2016) . Nature Neuroscience, 19(4), 542-553. RIS download Bibtex download
  • Livesey MR, Magnani D, Cleary EM, Vasistha NA, James OT, Selvaraj BT, Burr K, Story D, Shaw CE, Kind PC , Hardingham GE et al (2016) . STEM CELLS, 34(4), 1040-1053. RIS download Bibtex download
  • Rzechorzek NM, Connick P, Livesey MR, Borooah S, Patani R, Burr K, Story D, Wyllie DJA, Hardingham GE & Chandran S (2016) . The Lancet, 387, S88-S88. RIS download Bibtex download
  • Rzechorzek NM, Connick P, Livesey MR, Borooah S, Patani R, Burr K, Story D, Wyllie DJA, Hardingham GE & Chandran S (2016) . EBioMedicine, 3, 141-154. RIS download Bibtex download
  • James OT, Livesey MR, Qiu J, Dando O, Bilican B, Haghi G, Rajan R, Burr K, Hardingham GE, Chandran S , Kind PC et al (2014) . The Journal of Physiology, 592(19), 4353-4363. RIS download Bibtex download
  • Sharma R, Livesey MR, Wyllie DJA, Proudfoot C, Whitelaw CBA, Hay DC & Donadeu FX (2014) . Stem Cells and Development, 23(13), 1524-1534. RIS download Bibtex download
  • Livesey MR, Bilican B, Qiu J, Rzechorzek NM, Haghi G, Burr K, Hardingham GE, Chandran S & Wyllie DJA (2014) . Journal of Neuroscience, 34(11), 4070-4075. RIS download Bibtex download
  • Carland JE, Cooper MA, Livesey MR, Hales TG, Peters JA & Lambert JJ (2013) . Journal of Biological Chemistry, 288(44), 31592-31601. RIS download Bibtex download
  • Wyllie DJA, Livesey MR & Hardingham GE (2013) . Neuropharmacology, 74, 4-17. RIS download Bibtex download
  • Edman S, McKay S, MacDonald LJ, Samadi M, Livesey MR, Hardingham GE & Wyllie DJA (2012) . Neuropharmacology, 63(3), 441-449. RIS download Bibtex download
  • Chia PW, Livesey MR, Slawin AMZ, van Mourik T, Wyllie DJA & O'Hagan D (2012) . Chemistry - A European Journal, 18(28), 8813-8819. RIS download Bibtex download
  • Livesey MR, Cooper MA, Lambert JJ & Peters JA (2011) . Journal of Biological Chemistry, 286(18), 16008-16017. RIS download Bibtex download
  • Peters JA, Cooper MA, Carland JE, Livesey MR, Hales TG & Lambert JJ (2010) . The Journal of Physiology, 588(4), 587-596. RIS download Bibtex download
  • Livesey MR, Cooper MA, Deeb TZ, Carland JE, Kozuska J, Hales TG, Lambert JJ & Peters JA (2008) . Journal of Biological Chemistry, 283(28), 19301-19313. RIS download Bibtex download
  • Chen PE, Geballe MT, Katz E, Erreger K, Livesey MR, O'Toole KK, Le P, Lee CJ, Snyder JP, Traynelis SF & Wyllie DJA (2008) . The Journal of Physiology, 586(1), 227-245. RIS download Bibtex download
  • Deeb TZ, Carland JE, Cooper MA, Livesey MR, Lambert JJ, Peters JA & Hales TG (2007) . Journal of Biological Chemistry, 282(9), 6172-6182. RIS download Bibtex download
  • Peters JA, Carland JE, Cooper MA, Livesey MR, Deeb TZ, Hales TG & Lambert JJ (2006) . Biochemical Society Transactions, 34(5), 882-886. RIS download Bibtex download
  • Bin J, Suminaite D, Benito-Kwiecinski S, Kegel L, Rubio-Brotons M, Early J, Soong D, Livesey M, Poole R & Lyons D () Importin 13-dependent axon diameter growth regulates conduction speeds along myelinated CNS axons. Nature Communications. RIS download Bibtex download
  • Bauer CS, Cohen RN, Sironi F, Livesey MR, Gillingwater TH, Highley JR, Fillingham DJ, Coldicott I, Smith EF, Gibson YB , Webster CP et al () . Acta Neuropathologica. RIS download Bibtex download
  • Marrone L, Marchi PM, Webster CP, Marroccella R, Coldicott I, Reynolds S, Alves-Cruzeiro J, Yang Z-L, Higginbottom A, Khundadze M , Shaw PJ et al () . Human Molecular Genetics. RIS download Bibtex download
  • Madden ME, Suminaite D, Ortiz E, Early JE, Koudelka S, Livesey MR, Bianco IH, Granato M & Lyons DA () . The Journal of Neuroscience. RIS download Bibtex download
  • Bilican B, Livesey MR, Haghi G, Qiu J, Burr K, Siller R, Hardingham GE, Wyllie DJA & Chandran S () . PLoS ONE, 9(1), e85932-e85932. RIS download Bibtex download
  • Vasistha NA, Johnstone M, Barton SK, Mayerl S, Selvaraj BT, Thomson PA, Dando O, Grünewald E, Alloza C, Bastin ME , Livesey MR et al () . RIS download Bibtex download
  • Qiu J, McQueen J, Bilican B, Dando O, Magnani D, Punovuori K, Selvaraj BT, Livesey M, Haghi G, Heron S , Burr K et al () . eLife, 5. RIS download Bibtex download

Chapters

  • Magnani D, Chandran S, Wyllie DJA & Livesey MR (2019) , Oligodendrocytes (pp. 65-77). Springer New York RIS download Bibtex download

Preprints

  • Chen H-JC, Yang A, Mazzaferro S, Mali I, Cahn O, Kentistou K, Rowley C, Stewart N, Seah JWE, Pisupati V , Kirwan P et al (2023) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Bin JM, Suminaite D, Benito-Kwiecinski SK, Kegel L, Rubio-Brotons M, Early JJ, Soong D, Livesey MR, Poole RJ & Lyons DA (2023) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Madden ME, Suminaite D, Ortiz E, Early JJ, Koudelka S, Livesey MR, Bianco IH, Granato M & Lyons DA () , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Castelli LM, Cutillo L, Souza CDS, Sanchez-Martinez A, Granata I, Myszczynska MA, Heath PR, Livesey MR, Ning K, Azzouz M , Shaw PJ et al () , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Kegel L, Marshall-Phelps KLH, Baraban M, Almeida RG, Rubio-Brotons M, Klingseisen A, Benito-Kwiecinski S, Early JJ, Bin J, Livesey MR , Poole RJ et al () , Cold Spring Harbor Laboratory. RIS download Bibtex download
Research group
  • Ms Iris Pasniceanu (PhD student)
  • Mr Manpreet Atwal (PhD student)
  • Ms Marilina Douloudi (PhD Student)
  • Research Lab Alumni (including current position where known)
  • Ms Niamh Conway (MSc student)
  • Ms Zahra Shather (MSc student, Research assistant at Samsara Therapeutics)
  • Ms Ergita Bali (Technician, PhD student at University of 91Ö±²¥)
  • Ms Amelia Potter (MSc student)
Grants

The lab is currently funded by the following sources;

  • Motor Neurone Disease Association
  • MRC
  • Industrial collaboration with MSD

Previous funders

  • ARUK
  • Royal Society
  • Rosetrees Trust
Professional activities and memberships

Internal:

  • Post-graduate research tutor
  • MSc teaching

External:

  • Peer reviewer for journals including Nature Communications, Cell Reports, Journal of Neuroscience and Journal of Physiology.
  • Peer reviewer for grant funding bodies including MRC, BBSRC, NC3Rs, MNDA and ARUK.