Dr James Alix

BSc(Hons), MBChB, MRCP, PhD, FRCP

Neuroscience, School of Medicine and Population Health

Senior Clinical Lecturer in Neurophysiology

Honorary Consultant Clinical Neurophysiologist, 91Ö±²¥ Teaching Hospitals NHS Foundation Trust

James Alix
Profile picture of James Alix
j.alix@sheffield.ac.uk
+44 114 215 9100/222 2234

Full contact details

Dr James Alix
Neuroscience, School of Medicine and Population Health
Room B35
91Ö±²¥ Institute for Translational Neuroscience (SITraN)
385a Glossop Road
91Ö±²¥
S10 2HQ
Profile

2018 – Present

Senior Clinical Lecturer in Neurophysiology, University of 91Ö±²¥

Honorary Consultant Clinical Neurophysiologist, 91Ö±²¥ Teaching Hospitals NHS Foundation Trust

2015 – 2018:

NIHR Academic Clinical Lecturer in Neurophysiology, University of 91Ö±²¥

2012 – 2014:

Specialty Registrar in Clinical Neurophysiology, Yorkshire and the Humber Deanery

2010 – 2012:

NIHR Academic Clinical Fellowship in Core Medical Training/Neurology, University of 91Ö±²¥

2008 – 2010:

Academic Foundation Programme, Imperial College, London

2000 – 2008:

MB/PhD programme, University of Leicester Medical School

I studied medicine at Leicester Medical School, undertaking an intercalated BSc in neuroscience (1st class Hons). I then entered the MB/PhD programme, completing a PhD on the molecular mechanisms of perinatal white matter injury. After graduating I completed academic foundation programme training in London before coming to 91Ö±²¥ to take up an NIHR academic clinical fellowship in neurology. I subsequently moved into clinical neurophysiology and completed the final part of my training as an NIHR clinical lecturer.

Research interests

My research focuses on the development of new techniques to diagnose and monitor neuromuscular disorders. I use electrophysiology and different forms of spectroscopy in both pre-clinical and clinical settings in order to better understand how these diseases start and change over time.          

Current projects:

  • Use of electrical impedance myography in neuromuscular disease
  • Use of Raman spectroscopy in neuromuscular disease
  • Phenotyping preclinical models of MND

Funding                            

My work is or has been supported by the following:

Medical Research Council

Academy of Medical Sciences

Motor Neurone Disease Association

Engineering and Physical Sciences Research Council

Ryder Briggs Neuroscience Research Fund/Neurocare

Compound muscle action potentials, surface EMG recordings
novel electrical impedance spectroscopy device.

Compound muscle action potentials, surface EMG recordings and a novel electrical impedance spectroscopy device.

Publications

Journal articles

  • Qiang Z, Barnett L, Bingham G, Han O, Walsh A, Conwill M, McDonough HE, McDermott CJ, Shaw PJ & Alix JJP (2024) . J Neurol, 272(1), 35. RIS download Bibtex download
  • Alix JJP, Plesia M, Schooling CN, Dudgeon AP, Kendall CA, Kadirkamanathan V, McDermott CJ, Gorman GS, Taylor RW, Mead RJ , Shaw PJ et al (2022) . Journal of Raman Spectroscopy. RIS download Bibtex download
  • Alix JJP, Verber NS, Schooling CN, Kadirkamanathan V, Turner MR, Malaspina A, Day JCC & Shaw PJ (2022) . The Analyst, 147(22), 5113-5120. RIS download Bibtex download
  • Paterson TE, Hagis N, Boufidis D, Wang Q, Moore SR, Da Silva AC, Mitchell RL, Alix JJP & Minev I (2022) . Flexible and Printed Electronics, 7(3). RIS download Bibtex download
  • Alix JJP, Plesia M, Hool SA, Coldicott I, Kendall CA, Shaw PJ, Mead RJ & Day JC (2022) . Muscle and Nerve. RIS download Bibtex download
  • Schooling CN, Healey TJ, McDonough HE, French SJ, McDermott CJ, Shaw PJ, Kadirkamanathan V & Alix JJP (2022) . Clinical Neurophysiology, 139, 69-75. RIS download Bibtex download
  • Alix J, Plesia M, Lloyd GR, Dudgeon A, Kendall CA, Hewamadduma C, Hadjivassiliou M, McDermott C, Gorman G, Taylor R , Shaw PJ et al (2022) . Analyst. RIS download Bibtex download
  • Chan Y, Alix JJP, Neuwirth C, Barkhaus PE, Castro Tech J, Jenkins TM, McDermott CJ, Shaw PJ, Carvalho M, Nandedkar S , StÃ¥lberg E et al (2021) . Muscle & Nerve. RIS download Bibtex download
  • Sassani M, Alix J, Mcdermott C, Baster K, Hoggard N, Wild J, Mortiboys H, Shaw P, Wilkinson I & Jenkins T (2021) . Journal of the Neurological Sciences, 429, 119412. RIS download Bibtex download
  • Jamie Healey T, Billinge DER, Alix DJJP, Kadirkamanathan PV & Kemp CR (2021) . IEEE Sensors Journal. RIS download Bibtex download
  • Keerie A, Brown-Wright H, Kirkland I, Grierson A, Alix JJP, Holscher C & Mead RJ (2021) . Scientific Reports, 11(1), 17027. RIS download Bibtex download
  • Watkins JA, Alix JJP, Shaw PJ & Mead RJ (2021) . Scientific Reports, 11(1). RIS download Bibtex download
  • Watkins J, Ghosh A, Keerie AFA, Alix JJP, Mead RJ & Sreedharan J (2021) . Scientific Reports, 11(1). RIS download Bibtex download
  • Plesia M, Stevens OA, Lloyd GR, Kendall CA, Coldicott I, Kennerley AJ, Miller G, Shaw PJ, Mead RJ, Day JCC & Alix JJP (2021) . ACS Chem Neurosci. RIS download Bibtex download
  • Butler E, Mills N, J P Alix J & Hart AR (2021) . Developmental Medicine & Child Neurology. RIS download Bibtex download
  • Schooling CN, Gyenge N, Kadirkamanthan V & Alix JJP (2021) . Disaster Medicine and Public Health Preparedness. RIS download Bibtex download
  • Watkins J, Ghosh A, Keerie AFA, Alix JJP, Mead RJ & Sreedharan J (2020) . Scientific Reports, 10(1). RIS download Bibtex download
  • Alix JJP, McDonough HE, Sonbas B, French SJ, Rao DG, Kadirkamanathan V, McDermott CJ, Healey TJ & Shaw PJ (2020) . Clinical Neurophysiology. RIS download Bibtex download
  • Gossling L, Alix JJP, Stavroulakis T & Hart AR (2020) . BMC Pediatrics, 20(1). RIS download Bibtex download
  • Jenkins TM, Alix JJP, Fingret J, Esmail T, Hoggard N, Baster K, McDermott CJ, Wilkinson ID & Shaw PJ (2020) . Journal of Neurology, 267(1), 257-258. RIS download Bibtex download
  • Alix JJP, Neuwirth C, Gelder L, Burkhardt C, Castro J, de Carvalho M, Gawel M, Goedee S, Grosskreutz J, Lenglet T , Moglia C et al (2019) . Clinical Neurophysiology, 130(5), 666-674. RIS download Bibtex download
  • Henderson D, Alix JJP & Sinha S (2019) . Journal of Surgical Case Reports, 2019(4). RIS download Bibtex download
  • Verber NS, Shepheard SR, Sassani M, McDonough HE, Moore SA, Alix JJP, Wilkinson ID, Jenkins TM & Shaw PJ (2019) . Frontiers in Neurology, 10. RIS download Bibtex download
  • Alix JJP, Kandler RH, Pang C, Stavroulakis T & Catania S (2019) . Developmental Medicine & Child Neurology, 61(2), 181-185. RIS download Bibtex download
  • Carlson S, Kandler RH, Moorhouse D, Ponnusamy A, Mordekar SR & Alix JJP (2018) . Seizure, 61, 209-213. RIS download Bibtex download
  • Jenkins T, Alix J, David C, Pearson E, Ganesh Rao D, Hoggard N, O'Brien E, Baster K, Bradburn M, Bigley J , McDermott C et al (2018) . Journal of Neurology, Neurosurgery, and Psychiatry, 89, 248-255. RIS download Bibtex download
  • Hart AR & Alix JJP (2018) . Archives of Disease in Childhood - Fetal and Neonatal Edition, 103(2), F190-F190. RIS download Bibtex download
  • Alix JJP, Ponnusamy A, Pilling E & Hart AR (2016) . Paediatrics and Child Health. RIS download Bibtex download
  • Hart AR, Ponnusamy A, Pilling E & Alix JJP (2016) . Paediatrics and Child Health. RIS download Bibtex download
  • Jenkins TM, Alix JJP, Kandler RH, Shaw PJ & McDermott CJ (2016) . Muscle & Nerve, 54(3), 378-385. RIS download Bibtex download
  • Alix JJ, Alam T, Garrard K, Martindale J, Shanmugarajah P, Rao DG & Hadjivassiliou M (2016) . Muscle Nerve. RIS download Bibtex download
  • Alam T, Alix JJ, Rao DG & Hadjivassiliou M (2016) . Muscle Nerve. RIS download Bibtex download
  • Neuwirth C, Burkhardt C, Alix J, Castro J, de Carvalho M, Gawel M, Goedee S, Grosskreutz J, Lenglet T, Moglia C , Omer T et al (2016) . PLoS ONE, 11(5). RIS download Bibtex download
  • Alam T, Barker ASE, Alix JJP, Hadjivassiliou M & Rao DG (2016) . Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 43(3), 385-389. RIS download Bibtex download
  • Alix JJP, Ponnusamy A & Hart AR (2015) . Epileptic Disorders, 17(3), 349-349. RIS download Bibtex download
  • Hart AR, Pilling EL & Alix JJP (2015) . Archives of disease in childhood - Education & practice edition, 100(4), 170-175. RIS download Bibtex download
  • Hart AR, Pilling EL & Alix JJP (2015) . Archives of disease in childhood - Education & practice edition, 100(5), 226-232. RIS download Bibtex download
  • Alix JJP, Hadjivassiliou M, Ali R, Slater D, Messenger AG & Rao DG (2015) . Muscle & Nerve, 51(2), 296-301. RIS download Bibtex download
  • Alix JJP, Kandler RH & Mordekar SR (2014) . Seizure, 23(8), 662-665. RIS download Bibtex download
  • Alix JJP & Shaw PJ (2014) , 329-350. RIS download Bibtex download
  • Goodwin E, Kandler RH & Alix JJP (2014) . Seizure, 23(6), 480-482. RIS download Bibtex download
  • Blackburn DJ, Alix JJP, Sarrigiannis P, Hoggard N & Bandmann O (2013) . Practical Neurology, 13(2), 114-119. RIS download Bibtex download
  • Alix JJP, Blackburn DJ, Sokhi D, Craven I, Sharrack B & Snowden JA (2013) . Journal of Neurology, 260(3), 914-916. RIS download Bibtex download
  • Alix JJP, Zammit C, Riddle A, Meshul CK, Back SA, Valentino M & Fern R (2012) . Annals of Neurology, 72(6), 936-951. RIS download Bibtex download
  • Alix JJP, Ponnusamy A, Bhattacharyya D, Hoggard N & Grünewald RA (2012) . Seizure, 21(10), 820-822. RIS download Bibtex download
  • Alix JJP, Blackburn DJ, Bhattacharyya D & Ponnusamy A (2012) . The Spine Journal, 12(7), 629-630. RIS download Bibtex download
  • Alix JJP & de Jesus Domingues AM (2011) . Neurology, 76(4), 397-404. RIS download Bibtex download
  • Alix JJP (2009) . Multiple Sclerosis Journal, 15(2), 278-278. RIS download Bibtex download
  • Alix JJP & Fern R (2009) . Annals of Neurology, 66(5), 682-693. RIS download Bibtex download
  • Arranz AM, Hussein A, Alix JJP, Pérez-Cerdá F, Allcock N, Matute C & Fern R (2008) . Glia, 56(12), 1353-1367. RIS download Bibtex download
  • Alix JJP, Dolphin AC & Fern R (2008) . The Journal of Physiology, 586(17), 4069-4089. RIS download Bibtex download
  • Alix JJP (2006) . European Neurology, 56(2), 74-77. RIS download Bibtex download
  • Alix JJP (2006) The pathophysiology of ischemic injury to developing white matter. McGill Journal of Medicine, 9(2), 134-140. RIS download Bibtex download
  • Alix JJP, Plesia M, Stockholm D, Shaw PJ, Mead RJ & Day JCC () . Analytical Chemistry. RIS download Bibtex download
  • Conwill MT, Alix JJP & Shaw PJ () . Muscle & Nerve. RIS download Bibtex download
  • Alix JJP, Plesia M, Dudgeon AP, Kendall CA, Hewamadduma C, Hadjivassiliou M, Gorman GS, Taylor RW, McDermott CJ, Shaw PJ , Mead RJ et al () . The Analyst. RIS download Bibtex download
  • Alix JJP, Plesia M, Shaw PJ, Mead RJ & Day JCC () . Muscle & Nerve. RIS download Bibtex download
  • Schooling CN, Healey TJ, McDonough HE, French SJ, McDermott CJ, Shaw PJ, Kadirkamanathan V & Alix JJP () . Physiological Measurement. RIS download Bibtex download
  • Ghahremani Nezhad H, Franklin JP, Alix JJP, Moll T, Pattrick M, Cooper-Knock J, Shanmugarajah P, Beauchamp NJ, Hadjivissiliou M, Paling D , Mcdermott C et al () . Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 1-3. RIS download Bibtex download
  • Schooling C, Healey TJ, McDonough H, French S, McDermott C, Shaw P, Kadirkamanathan V & Alix J () . Physiological Measurement. RIS download Bibtex download
  • Schooling CN, Gyenge N, Kadirkamanathan V & Alix JJP () . RIS download Bibtex download
  • Alix JJP () . Annals of Neurology, 68(1), 119-120. RIS download Bibtex download
  • Jenkins TM, Alix JJP, Fingret J, Esmail T, Hoggard N, Baster K, McDermott CJ, Wilkinson ID & Shaw PJ () . Journal of Neurology. RIS download Bibtex download
  • Sassani M, Alix J, McDermott C, Baster K, Hoggard N, Wild J, Mortiboys H, Shaw P, Wilkinson I & Jenkins T () Magnetic resonance spectroscopy reveals mitochondrial dysfunction in amyotrophic lateral sclerosis. Brain. RIS download Bibtex download
  • Alix JJP, Plesia M, Lloyd GR, Dudgeon AP, Kendall CA, McDermott CJ, Gorman GS, Taylor RW, Shaw PJ & Day JC () . Journal of Raman Spectroscopy. RIS download Bibtex download

Chapters

  • Vucic S, de Carvalho M, Bashford J & Alix JJP (2024) , International Review of Neurobiology (pp. 87-118). Elsevier RIS download Bibtex download
  • Abrams GM, Albers GW, Alix JJP, Aminoff MJ, Bharucha AE, Batla A, Benson CM, Betjemann JP, Brosch JR, Camilleri M , Chen R et al (2014) , Aminoff's Neurology and General Medicine (pp. vii-xii). Elsevier RIS download Bibtex download
  • Alix JJP & Salter MG (2011) Highlights in understanding white matter ischemia, Brain Mapping and Diseases (pp. 61-80). RIS download Bibtex download
  • Alix JJP (2009) Organisation of the node of ranvier in myelinated central axons, Handbook on White Matter: Structure, Function and Changes (pp. 317-334). RIS download Bibtex download

Conference proceedings papers

  • Jenkins T, Alix J, Rao G, Hoggard N, O'Brien E, Baster K, Bradburn M, Bigley J, McDermott C, Wilkinson I & Shaw P (2017) . Journal of the Neurological Sciences, Vol. 381 (pp 102-102) RIS download Bibtex download
  • Rao DG, Alix J, Ali R, Slater D, Messenger A & Hadjivassiliou M (2014) A RARE CAUSE FOR DORSAL ROOT GANGLIONOPATHY WITH RESPONSE TO IMMUNOMODULATION. MUSCLE & NERVE, Vol. 50(4) (pp 646-646) RIS download Bibtex download
  • Blackburn D, Alix JP & Bandmann O (2012) . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 83(Suppl 2) (pp A16.2-A16) RIS download Bibtex download
  • Alix J, Blackburn D, Sokhi D, Dalley C, Jessop H, Sharrack B & Snowden J (2012) Pulse high-dose cyclophosphamide in malignant multiple sclerosis may result in successful functional recovery and stem cell mobilisation to enable safe delivery of AHSCT. BONE MARROW TRANSPLANTATION, Vol. 47 (pp S227-S228) RIS download Bibtex download

Preprints

  • Weinreich M, McDonough H, Yacovzada N, Magen I, Cohen Y, Harvey C, Gornall S, Boddy S, Alix J, Mohseni N , Kurz JM et al (2024) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • McKinnon S, Qiang Z, Keerie A, Wells T, Shaw PJ, Alix JJP & Mead RJ (2024) , Cold Spring Harbor Laboratory. RIS download Bibtex download
Research group

PhD students

Nicholas Hagis (Primary supervisor)

Scott McKinnon (co-supervisor; Primary supervisor Dr Richard Mead)

Postdoc:

Dr Ali Awan

Teaching interests

I am module leader for the Applied Neuroanatomy & Clinical Neuroscience module on the MSc Neurology course.

I regularly give neurophysiology lectures to medical and postgraduate students. I also provide research supervision to PhD students, intercalating medical students, MSc students and supervise students on SSC attachments. I am also a personal and academic (PATS) tutor for medical students. I am also the training programme director for clinical neurophysiology (Yorkshire and the Humber).

I am particularly keen to encourage medical students to undertake research during their time at medical school and welcome any enquiries regarding potential projects.

Professional activities and memberships

Module Leader, Applied Neuroanatomy & Clinical Neuroscience module, MSc Neurology course, University of 91Ö±²¥.

Ad hoc peer review for journals, including Clinical Neurophysiology, Muscle and Nerve,  European Journal of Neurology.

Grant reviewer for Medical Research Council, NIHR, Motor Neurone Disease Association, MND Scotland, Academy of Medical Sciences, Royal Society.

Awards

Lord Adrian Prize, British Society for Clinical Neurophysiology, 2017

Distinction, Final Professional Examination, University of Leicester, 2008

Wellcome Trust Elective Prize, 2008

Physiological Society Studentship, 2005

Leicester Medical Research Foundation (Medisearch) Studentship, 2004

Charles Lawson Award for Intercalated Studies, University of Leicester, 2004

Examples of prizes awarded to my students:

British Society of Clinical Neurophysiology intercalation award (Mr H. McDonough, 2017; Mr Y. Chan, 2019; Ms A Hodgson, 2023)

British Society of Clinical Neurophysiology Medical Student Essay Prize (Mr Z. Qiang, 2023)

Clinical Research Poster Prize (29th International Symposium on ALS/MND, Mr H. McDonough, 2018)

Bio91Ö±²¥ Poster Prize (Mr N. Hagis, 2022)

University of 91Ö±²¥ Summer Research Scholarships (Mr. Z Qiang, Ms H. Ji, 2022; Ms. C Kelly 2023)