Skerry, Tim, Professor

Professor Tim Skerry

BVet.Med, FRCVS, Cert.SAO, PhD

Clinical Medicine, School of Medicine and Population Health

Professor of Orthopaedic Biology

t.skerry@sheffield.ac.uk
+44 114 215 9026

FU19, F Floor, The Medical School

Full contact details

Professor Tim Skerry
Clinical Medicine, School of Medicine and Population Health
FU19, F Floor
The Medical School
Beech Hill Road
91ֱ��
S10 2RX

Profile

For enquiries please contact - ClinMed-Operational@sheffield.ac.uk

2005 – Present: Professor of Orthopaedic Biology University of 91ֱ��; (Head of Department 2011-17).
2003 - 2005: Vice Principal Research RVC;
2001 – 2003: Head of Veterinary Basic Sciences; RVC
1995 – 2001: Professor of Cellular and Molecular Biology University of York;
1987 – 1995: Lecturer in Surgery, then Anatomy University of Bristol;
1984 – 1987: PhD Functional adaptation in bone;
1980 – 1986: Mixed practice, small animal practice, specialist orthopaedic practice;
1980: Veterinary Graduate RVC London.

Research interests

After spending a considerable number of years researching the mechanisms behind the way that the skeleton responds to exercise, my interests have shifted substantially in recent years. Interest in the calcitonin family of hormones and receptors led to a project on understanding the roles of so-called receptor activity modifying proteins in bone (RAMPs). RAMPs are interesting accessory proteins that control the ligand selectivity of a small number of receptors. For example a calcitonin receptor (CTR) alone binds and responds primarily to the hormone calcitonin.

However, co-expression of the CTR with any of the 3 human RAMPs leads to the heteromeric receptor complex becoming a one of 3 distinct receptors for the hormone amylin. Similarly, the calcitonin like-receptor (CLR) which is an orphan becomes a CGRP receptor with RAMP1 and either an adrenomedullin 1 or 2 receptor with RAMPs 2 and 3 respectively.

We have studied the roles of the RAMPs in bone by assessing the skeletal phenotypes of RAMP KO mice and shown that there appears to be no overt phenotype in RAMP 1 KO mice, there is a haploid insufficiency phenotype in RAMP2 heterozygotes with delayed development and intracortical porosity. In RAMP3 mice though there is accelerated development and an increased response of the bones to mechanical loading.

Our work on RAMPs has taken us into other directions too. Exploration of the role of RAMPs with other receptors where there is no change in ligand selectivity but a role in trafficking the receptors to the cell surface resulted in a paper on the need for RAMP1 for trafficking of the calcium sensing-receptor in a cell line not engineered to overexpress the proteins.

However, the main focus of the lab is now on development of small molecule antagonists of the AM2 adrenomedullin receptor. AM is involved centrally in regulation of blood pressure but it is also a potent player in tumorigenesis, where it has innate tumour cell to tumour cell actions, and roles in which AM released by the tumour upregulates AM2R expression in host cells around the tumour.

As a broad spectrum AM antagonist would interfere with AM’s potent vasodilator effect, we cannot tractably use such an approach to block AM’s role in tumours. However, we have shown that the physiological roles of AM are maintained predominantly by the AM1 receptor (CLR+RAMP2) while the AM2 receptor (CLR+RAMP3) can be blocked without significant deleterious effects.

Our major research programme is now a Wellcome Trust funded drug discovery programme in which Dr Gareth Richards and I work with collaborators in Industry (Dr Karl Gibson, a modeller at Sandexis and Dr Matt Tozer formerly a medicinal chemist at Peakdale Molecular) and Professor Joe Harrity in the Department of Chemistry here in 91ֱ�� to develop and optimise small molecule AM2R antagonists for cancer treatment.

The success of the funded programme has led to the identification of a candidate AM receptor antagonist molecule (and backup) suitable for development in oncology applications. Tim, Dr Gareth Richards and Professor Joe Harrity have formed a spinout company with the University, the Wellcome Trust and specialist Oncology incubator specialists to progress development.

Developments of the Wellcome research programme have led to pilot data that provided proof of concept for the development of small molecule antagonists of the AM1 adrenomedullin receptor, and at reversing the catastrophic low blood pressure in septic shock. This has led to support from the (£250,000), an EPSRC studentship and a collaboration to screen huge compound libraries for novel AM1 binding molecules.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Wang N, Niger C, Li N, Richards GO & Skerry TM (2020) . Frontiers in Endocrinology, 11.
Avgoustou P, Jailani ABA, Zirimwabagabo J-O, Tozer MJ, Gibson KR, Glossop PA, Mills JEJ, Porter RA, Blaney P, Bungay P , WANG N et al (2020) . ACS Pharmacology & Translational Science, 3(4), 706-719.
Hillam RA, Goodship AE & Skerry TM (2015) . Journal of Biomechanics, 48(12), 3292-3298.
Desai AJ, Roberts DJ, Richards GO & Skerry TM (2014) . PLoS One, 9(1), e85237.
Kadmiel M, Fritz-Six K, Pacharne S, Richards GO, Li M, Skerry TM & Caron KM (2011) . Mol Endocrinol, 25(7), 1244-1253.
Gomez C, David V, Peet NM, Vico L, Chenu C, Malaval L & Skerry TM (2007) . J Anat, 210(3), 259-271.
Skerry TM (2006) One mechanostat or many? Modifications of the site-specific response of bone to mechanical loading by nature and nurture.. J Musculoskelet Neuronal Interact, 6(2), 122-127.
Skerry TM & Genever PG (2001) Glutamate signalling in non-neuronal tissues. Trends in pharmacological sciences, 22(4), 174-181.
Genever PG, Birch MA, Brown E & Skerry TM (1999) Osteoblast-derived acetylcholinesterase: a novel mediator of cell-matrix interactions in bone?. Bone, 24(4), 297-303.
Dallas DJ, Genever PG, Patton AJ, Millichip MI, McKie N & Skerry TM (1999) Localization of ADAM10 and Notch receptors in bone. Bone, 25(1), 9-15.
Genever PG, Wilkinson DJ, Patton AJ, Peet NM, Hong Y, Mathur A, Erusalimsky JD & Skerry TM (1999) Expression of a functional N-methyl-D-aspartate-type glutamate receptor by bone marrow megakaryocytes. Blood, 93(9), 2876-2883.
Genever PG, Maxfield SJ, Kennovin GD, Maltman J, Bowgen CJ, Raxworthy MJ & Skerry TM (1999) . The Journal of investigative dermatology, 112(3), 337-342.
Peet NM, Grabowski PS, Laketic-Ljubojevic I & Skerry TM (1999) . FASEB J, 13(15), 2179-2185.
Fermor B & Skerry TM (1995) . Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 10(12), 1935-1943.
Skerry TM, Bitensky L, Chayen J & Lanyon LE (1989) . Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 4(5), 783-788.

All publications

Books

(1998) . Springer Berlin Heidelberg.

Journal articles

Avgoustou P, Jailani ABA, Desai AJ, Roberts DJ, Lilley ER, Stothard GW, Skerry TM & Richards GO (2024) . Frontiers in Pharmacology, 15.
Krstic N, Bishop N, Curtis B, Cooper C, Harvey N, Lilycrop K, Murray R, Owen R, Reilly G, Skerry T & Borg S (2022) . Genes & Nutrition, 17(1).
Pacharne S, Livesey M, Kadmiel M, Wang N, Caron KM, Richards GO & Skerry TM (2022) . Frontiers in Endocrinology, 12.
Samvelyan HJ, Mathers JC & Skerry TM (2021) . The FASEB Journal, 35(10).
Ascolani G, Skerry TM, Lacroix D, Dall'Ara E & Shuaib A (2021) . Interface Focus, 11(1).
Wang N, Niger C, Li N, Richards GO & Skerry TM (2020) . Frontiers in Endocrinology, 11.
Avgoustou P, Jailani ABA, Zirimwabagabo J-O, Tozer MJ, Gibson KR, Glossop PA, Mills JEJ, Porter RA, Blaney P, Bungay P , WANG N et al (2020) . ACS Pharmacology & Translational Science, 3(4), 706-719.
Ascolani G, Skerry TM, Lacroix D, Dall’Ara E & Shuaib A (2020) . BMC Bioinformatics, 21(1).
Shuaib A, Motan D, Bhattacharya P, McNabb A, Skerry TM & Lacroix D (2019) . Scientific Reports, 9(1).
Prakash J, Herlin M, Kumar J, Garg G, Akesson KE, Grabowski PS, Skerry TM, Richards GO & McGuigan FEA (2019) . Gene, 721(Supplement).
Borg SA, Buckley H, Owen R, Marin AC, Lu Y, Eyles D, Lacroix D, Reilly GC, Skerry TM & Bishop NJ (2018) . PLoS ONE, 13(1).
Balasubramanian M, Hurst J, Brown S, Bishop NJ, Arundel P, DeVile C, Pollitt RC, Crooks L, Longman D, Caceres JF , Shackley F et al (2017) . BONE, 94, 65-74.
Hillam RA, Goodship AE & Skerry TM (2015) . Journal of Biomechanics, 48(12), 3292-3298.
Weston C, Lu J, Li N, Barkan K, Richards GO, Roberts DJ, Skerry TM, Poyner D, Pardamwar M, Reynolds CA , Dowell SJ et al (2015) . Journal of Biological Chemistry, 290(38), 23009-23022.
Kamal T, Green TN, Morel-Kopp M-C, Ward CM, McGregor AL, McGlashan SR, Bohlander SK, Browett PJ, Teague L, During MJ , Skerry TM et al (2015) . Cellular Signalling, 27(9), 1860-1872.
Notomi T, Kuno M, Hiyama A, Ohura K, Noda M & Skerry TM (2015) . Journal of Bone and Mineral Research, 30(9), 1618-1626.
Borg S, Buckley H, Nicholson K, Skerry T & Bishop N (2015) . Bone Abstracts.
Buckley H, Borg S, Nicholson K, Kinch M, Hughes D, Skerry T & Bishop N (2015) . Bone Abstracts.
Desai AJ, Roberts DJ, Richards GO & Skerry TM (2014) . PLoS One, 9(1), e85237.
(2013) . Proceedings of the National Academy of Sciences, 110(11), 4428-4428.
Wang N, Rumney RMH, Yang L, Robaye B, Boeynaems J-M, Skerry TM & Gartland A (2013) . J Bone Miner Res, 28(6), 1446-1456.
Wang N, Robaye B, Agrawal A, Skerry TM, Boeynaems J-M & Gartland A (2012) . Mol Endocrinol, 26(1), 142-152.
Kadmiel M, Fritz-Six K, Pacharne S, Richards GO, Li M, Skerry TM & Caron KM (2011) . Mol Endocrinol, 25(7), 1244-1253.
Whitehouse⁎ CA, Waters S, Marchbank K, Horner A, McGowan N, Richards G, Burford J, Sharpe P, Skerry T, Grigoriadis A & Solomon E (2010) . Bone, 47, S43-S43.
Whitehouse CA, Waters S, Marchbank K, Horner A, McGowan NWA, Jovanovic JV, Xavier GM, Kashima TG, Cobourne MT, Richards GO , Sharpe PT et al (2010) . Proc Natl Acad Sci U S A, 107(29), 12913-12918.
Skerry TM & Lanyon LE (2009) . J Bone Miner Res, 24(4), 753.
Perry MJ, Parry LK, Burton VJ, Gheduzzi S, Beresford JN, Humphrey VF & Skerry TM (2009) . Med Eng Phys, 31(1), 42-47.
Whitehouse CA, Waters S, Grigoriadis AE, Marchbank K, McGowan N, Skerry T, Sharpe PT & Solomon E (2009) . Bone, 44(2), S296-S296.
Skerry TM (2008) . Arch Biochem Biophys, 473(2), 117-123.
Skerry TM (2008) The role of glutamate in the regulation of bone mass and architecture.. J Musculoskelet Neuronal Interact, 8(2), 166-173.
Skerry T (2008) Mechanostat function during skeletal development. Journal of musculoskeletal & neuronal interactions, 8(1), 12.
Gomez C, David V, Peet NM, Vico L, Chenu C, Malaval L & Skerry TM (2007) . J Anat, 210(3), 259-271.
Skerry TM (2006) One mechanostat or many? Modifications of the site-specific response of bone to mechanical loading by nature and nurture.. J Musculoskelet Neuronal Interact, 6(2), 122-127.
Molloy TJ, Wang Y, Horner A, Skerry TM & Murrell GA (2006) . Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 24(4), 842-855.
Pead MJ, Skerry TM & Lanyon LE (2005) . JOURNAL OF BONE AND MINERAL RESEARCH, 20(1), 161-171.
Gomez C, Burt-Pichat B, Mallein-Gerin F, Merle B, Delmas PD, Skerry TM, Vico L, Malaval L & Chenu C (2005) Expression of Semaphorin-3A and its receptors in endochondral ossification: potential role in skeletal development and innervation. Developmental dynamics : an official publication of the American Association of Anatomists, 234(2), 393-403.
de Souza RL, Pitsillides AA, Lanyon LE, Skerry TM & Chenu C (2005) . Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 20(12), 2159-2168.
Inkson CA, Brabbs AC, Grewal TS, Skerry TM & Genever PG (2004) . Bone, 35(4), 819-827.
Noble BS, Peet N, Stevens HY, Brabbs A, Mosley JR, Reilly GC, Reeve J, Skerry TM & Lanyon LE (2003) . Am J Physiol Cell Physiol, 284(4), C934-C943.
Skerry TM & Suva LJ (2003) . Cell Biochem Funct, 21(3), 223-229.
Hitchcock IS, Skerry TM, Howard MR & Genever PG (2003) . Blood, 102(4), 1254-1259.
Skerry T (2002) Neurotransmitters in bone. Journal of Musculoskeletal Neuronal Interactions, 2(5), 401-403.
Gu Y, Genever PG, Skerry TM & Publicover SJ (2002) The NMDA type glutamate receptors expressed by primary rat osteoblasts have the same electrophysiological characteristics as neuronal receptors. Calcified tissue international, 70(3), 194-203.
Skerry TM (2002) Neurotransmitter functions in bone remodeling. Journal of musculoskeletal & neuronal interactions, 2(3), 281.
Skerry T (2002) Neurotransmitters in bone. Introduction. Journal of musculoskeletal & neuronal interactions, 2(5), 401-403.
Skerry T, Genever P, Taylor A, Dobson K, Mason D & Suva L (2001) Absence of evidence is not evidence of absence. The shortcomings of the GLAST knockout mouse.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 16(9), 1729-1731.
Grewal TS, Tolley RJ, Rawlinson SCF, Lanyon LE & Skerry TM (2001) Mechanical strain rapidly activates osteoblastic protein kinase B (PKB): An upstream modulator of eNOS activity.. JOURNAL OF BONE AND MINERAL RESEARCH, 16, S144-S144.
Genever PG & Skerry TM (2001) Autocrine glutamate signaling regulates osteoblast apoptosis.. JOURNAL OF BONE AND MINERAL RESEARCH, 16, S257-S257.
Hitchcock IS, Howard MR, Skerry TM & Genever PG (2001) Glutamatergic regulation of megakaryocyte function.. JOURNAL OF BONE AND MINERAL RESEARCH, 16, S477-S477.
Inkson CA, Grewal TS, Brabbs AC, Skerry TM & Genever PG (2001) Acetylcholinesterase: A secreted bone matrix protein regulated by osteogenic stimuli and mechanical loading.. JOURNAL OF BONE AND MINERAL RESEARCH, 16, S190-S190.
Spencer GJ, Grewal TS, Genever PG & Skerry TM (2001) Calcium dependent protein kinase II activity is obligate for bone formation in vitro. JOURNAL OF BONE AND MINERAL RESEARCH, 16(6), 1180-1180.
Grewal TS, Tolley RJ & Skerry TM (2001) Phosphorylation of protein kinase B by mechanical strain in osteoblasts - A mechanism for activation of nitric oxide synthase in the adaptive response. JOURNAL OF BONE AND MINERAL RESEARCH, 16(6), 1179-1179.
Bhangu PS, Genever PG & Skerry TM (2001) Differentiation-dependent regulation of presynaptic snare proteins implicated in glutamines signalling in osteoblasts. JOURNAL OF BONE AND MINERAL RESEARCH, 16(6), 1181-1181.
Dobson KR & Skerry TM (2001) The NMDA-type glutamate receptor antagonist MK801 regulates differentiation of non-adherent rat bone marrow osteoprogenitors.. BONE, 28(5), S75-S75.
Grewal TS, Tolley RJ & Skerry TM (2001) Activation of the protein kinase B (PKT/Akt) signalling pathway in osteoblasts by mechanical strain. BONE, 28(5), S92-S92.
Spencer GJ, Grewal TS, Genever PG & Skerry TM (2001) Long-term potentiation in bone: A cellular basis of memory in osteoblasts?. BONE, 28(5), S87-S87.
Bhangu PS, Genever PG, Grewal TS & Skerry T (2001) Expression and differentiation-dependent regulation of the 'brain-specific', sodium-dependent inorganic phosphate cotransporter (BNPI) in osteoblasts.. Journal of Bone and Mineral Research, 16, S490-S490.
Lanyon L & Skerry T (2001) Postmenopausal osteoporosis as a failure of bone's adaptation to functional loading: a hypothesis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 16(11), 1937-1947.
Genever PG & Skerry TM (2001) Regulation of spontaneous glutamate release activity in osteoblastic cells and its role in differentiation and survival: evidence for intrinsic glutamatergic signaling in bone. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 15(9), 1586-1588.
Bhangu PS, Genever PG, Spencer GJ, Grewal TS & Skerry TM (2001) Evidence for targeted vesicular glutamate exocytosis in osteoblasts. Bone, 29(1), 16-23.
Skerry TM & Genever PG (2001) Glutamate signalling in non-neuronal tissues. Trends in pharmacological sciences, 22(4), 174-181.
Skerry T, Genever P, Taylor A, Dobson K, Mason D & Suva L (2001) The shortcomings of the GLAST knockout mouse. Journal of Bone and Mineral Research, 16(9), 1729-1730.
Skerry TM & Taylor AF (2001) Glutamate signalling in bone. Current pharmaceutical design, 7(8), 737-750.
Croucher PI, Shipman CM, Lippitt J, Perry M, Asosingh K, Hijzen A, Brabbs AC, van Beek EJ, Holen I, Skerry TM , Dunstan CR et al (2001) . Blood, 98(13), 3534-3540.
Taylor AF, Brabbs AC, Peet NM, Laketic-Ljubojevic I, Dobson KR & Skerry TM (2000) Bone formation/resorption and osteoblast/adipocyte plasticity mediated by AMPA/kainate glutamate receptors in vitro and in vivo.. JOURNAL OF BONE AND MINERAL RESEARCH, 15, S275-S275.
Bhangu PS, Genever PG, Spencer GJ, Grewal TS & Skerry TM (2000) Mechanisms for regulated uptake and release of glutamate by osteoblasts.. JOURNAL OF BONE AND MINERAL RESEARCH, 15, S378-S378.
Dobson KR & Skerry TM (2000) The NMDA-type glutamate receptor antagonist MK801 regulates differentiation of rat bone marrow osteoprogenitors and influences adipogenesis.. JOURNAL OF BONE AND MINERAL RESEARCH, 15, S272-S272.
Genever PG & Skerry TM (2000) Regulated glutamate exocytosis is necessary for osteoblast differentiation and survival in vitro.. JOURNAL OF BONE AND MINERAL RESEARCH, 15, S378-S378.
Maxfield SJ, Wood EJ, Wolowacz R, Skerry TM & Genever PG (2000) . Biochemical Society Transactions, 28(3), A82-A82.
Gu Y, Genever PG, Skerry TM & Publicover SJ (2000) Expression of functional NMDA receptors in rat femoral osteoblasts in primary culture. JOURNAL OF PHYSIOLOGY-LONDON, 523, 155P-155P.
Genever PG & Skerry TM (2000) . Expert Opinion on Therapeutic Targets, 4(2), 207-218.
Skerry T & Currey J (2000) Bone to pick. New Scientist, 168(2263), 54.
Genever PG & Skerry TM (2000) . Expert Opinion on Therapeutic Targets, 4(3), 333-345.
Skerry T & Currey J (2000) Bone to pick. New Scientist, 168(2263), 64-64.
Grewal TS, Genever PG, Brabbs AC, Birch M & Skerry TM (2000) Best5: a novel interferon-inducible gene expressed during bone formation. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 14(3), 523-531.
Suva LJ & Skerry T (2000) Glutamate signaling in bone: A role in mechanosensing, bone formation and bone resorption.. Journal of Bone and Mineral Research, 15(4), 822-822.
Bettany JT, Peet NM, Wolowacz RG, Skerry TM & Grabowski PS (2000) . Bone, 27(1), 75-80.
Spencer GJ, Genever PG, Bhangu PS, Grewal TS & Skerry TM (1999) Subcellular distribution and membrane targeting of NMDA-Type glutamate receptors in osteoblasts.. JOURNAL OF BONE AND MINERAL RESEARCH, 14, S241-S241.
Dallas DJ, Birch MA, Peet NM, Murphy G & Skerry TM (1999) Stimulation of osteoblast differentiation and bone formation in vitro and in vivo by notch receptor-ligand interactions.. JOURNAL OF BONE AND MINERAL RESEARCH, 14, S172-S172.
Spencer GJ, Bhangu PS, Genever PG, Grewal TS & Skerry TM (1999) Functional GLAST; An essential molecular link in glutamatergic signalling during osteoblast differentiation. JOURNAL OF BONE AND MINERAL RESEARCH, 14(6), 1033-1033.
Skerry TM (1999) Ex vivo - the third way. JOURNAL OF BONE AND MINERAL RESEARCH, 14(6), 1057-1057.
Taylor AF, Birch MA & Skerry TM (1999) c-FOS dependent and independent AP-1 translocation induced by NMDA, AMPA and kainate glutamate receptors in bone. JOURNAL OF BONE AND MINERAL RESEARCH, 14(6), 1041-1041.
Genever PG, Wilkinson DJP, Patton AJ, Peet NM, Hong Y, Mathur A, Erusalimsky JD & Skerry TM (1999) . Blood, 93(9), 2876-2883.
Rainsford KD, Skerry TM, Chindemi P & Delaney K (1999) . Vet Res Commun, 23(2), 101-113.
Birch MA & Skerry TM (1999) Differential regulation of syndecan expression by osteosarcoma cell lines in response to cytokines but not osteotropic hormones. Bone, 24(6), 571-578.
Genever PG, Birch MA, Brown E & Skerry TM (1999) Osteoblast-derived acetylcholinesterase: a novel mediator of cell-matrix interactions in bone?. Bone, 24(4), 297-303.
Dallas DJ, Genever PG, Patton AJ, Millichip MI, McKie N & Skerry TM (1999) Localization of ADAM10 and Notch receptors in bone. Bone, 25(1), 9-15.
Genever PG, Wilkinson DJ, Patton AJ, Peet NM, Hong Y, Mathur A, Erusalimsky JD & Skerry TM (1999) Expression of a functional N-methyl-D-aspartate-type glutamate receptor by bone marrow megakaryocytes. Blood, 93(9), 2876-2883.
Genever PG, Maxfield SJ, Kennovin GD, Maltman J, Bowgen CJ, Raxworthy MJ & Skerry TM (1999) . The Journal of investigative dermatology, 112(3), 337-342.
Pitsillides AA, Skerry TM & Edwards JC (1999) Joint immobilization reduces synovial fluid hyaluronan concentration and is accompanied by changes in the synovial intimal cell populations. Rheumatology (Oxford, England), 38(11), 1108-1112.
Maxfield S, Maltman J, Kennovin G, Bowgen C, Raxworthy M, Wood E, Skerry T & Genever P (1999) Switching of keratinocyte phenotype by a novel glutamate signalling pathway analogous to synaptic transmission in the central nervous system. Journal of Investigative Dermatology, 112(4), 563-563.
Laketic-Ljubojevic I, Suva LJ, Maathuis FJ, Sanders D & Skerry TM (1999) Functional characterization of N-methyl-D-aspartic acid-gated channels in bone cells. Bone, 25(6), 631-637.
Skerry TM (1999) Identification of novel signaling pathways during functional adaptation of the skeleton to mechanical loading: the role of glutamate as a paracrine signaling agent in the skeleton. Journal of bone and mineral metabolism, 17(1), 66-70.
Peet NM, Grabowski PS, Laketic-Ljubojevic I & Skerry TM (1999) . FASEB J, 13(15), 2179-2185.
Grewal TS, Birch MA & Skerry TM (1998) Best5: A novel interferon stimulated gene (ISG) expressed during bone formation.. JOURNAL OF BONE AND MINERAL RESEARCH, 13(9), 1501-1501.
Genever PG, Bewick GS & Skerry TM (1998) Vesicular trafficking and release mechanisms in osteoblasts. Putative role in glutamate signalling?. JOURNAL OF BONE AND MINERAL RESEARCH, 13(9), 1501-1501.
Dallas DJ, Patton AJ, Birch MA, McKie GPG & Skerry TM (1998) Co-expression of ADAM10 and notch receptors suggests metalloproteinase activity in bone and cartilage.. JOURNAL OF BONE AND MINERAL RESEARCH, 13(9), 1504-1504.
Patton AJ, Genever PG, Birch MA, Suva LJ & Skerry TM (1998) Expression of an N-methyl-D-aspartate-type receptor by human and rat osteoblasts and osteoclasts suggests a novel glutamate signaling pathway in bone. Bone, 22(6), 645-649.
Bentolila V, Boyce TM, Fyhrie DP, Drumb R, Skerry TM & Schaffler MB (1998) Intracortical remodeling in adult rat long bones after fatigue loading. Bone, 23(3), 275-281.
Yellowley CE, Hancox JC, Skerry TM & Levi AJ (1998) Whole-cell membrane currents from human osteoblast-like cells. Calcified tissue international, 62(2), 122-132.
Birch MA & Skerry TM (1997) Syndecan expression by osteosarcoma cell lines is regulated by cytokines but not osteotropic hormones. JOURNAL OF BONE AND MINERAL RESEARCH, 12(9), P20-P20.
Birch MA, Genever PG, Laketic I, Patton AJ, Peet NM & Skerry TM (1997) Glutamate receptor activation is necessary for bone formation in vitro. JOURNAL OF BONE AND MINERAL RESEARCH, 12(9), O10-O10.
Skerry TM & Peet NM (1997) ''Unloading'' exercise increases bone formation in rats. JOURNAL OF BONE AND MINERAL RESEARCH, 12(9), O6-O6.
Birch MA, Patton AJ, Suva LJ & Skerry TM (1997) N-methyl-D-aspartate receptor (NMDAR1) transcript heterogeneity in bone cells. JOURNAL OF BONE AND MINERAL RESEARCH, 12, S235-S235.
Mason DJ, Suva LJ, Genever PG, Patton AJ, Steuckle S, Hillam RA & Skerry TM (1997) Mechanically regulated expression of a neural glutamate transporter in bone: a role for excitatory amino acids as osteotropic agents?. Bone, 20(3), 199-205.
Skerry TM (1997) Mechanical loading and bone: what sort of exercise is beneficial to the skeleton?. Bone, 20(3), 179-181.
Hillam RA, Jackson M, Goodship AE & Skerry TM (1996) . Bone, 19(6), 686-686.
Davies T, Hillam RA, Femor B, Wakley GK & Skerry TM (1996) . Bone, 19(6), 699-699.
Genever PG, Peet NM, Patton AJ & Skerry TM (1996) NMDA and AMPA type glutamate receptors in bone. JOURNAL OF BONE AND MINERAL RESEARCH, 11(11), P32-P32.
Arnott N, Clammer P, Skerry T & Beresford J (1996) . Biochemical Society Transactions, 24(4), 603s-603s.
Skerry TM, Mason DJ, Genever P, Peet NM & Patton AJ (1996) Regulation of gene expression in bone by mechanical loading. International Journal of Experimental Pathology, 77(6).
Thomas T, Vico L, Skerry TM, Caulin F, Lanyon LE, Alexandre C & Lafage MH (1996) Architectural modifications and cellular response during disuse-related bone loss in calcaneus of the sheep. Journal of applied physiology (Bethesda, Md : 1985), 80(1), 198-202.
Mason DJ, Hillam RA & Skerry TM (1996) . Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 11(3), 350-357.
Hillam RA, Breen SA & Skerry TM (1995) . Bone, 17(6), 581-581.
Fermor B & Skerry TM (1995) . Bone, 17(6), 562-562.
Mason DJ, Stueckle S, Hillam RA, Suva LJ & Skerry TM (1995) . Bone, 17(6), 568-568.
Dallas SL, Miyazono K, Skerry TM, Mundy GR & Bonewald LF (1995) Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein. The Journal of Cell Biology, 131(2), 539-549.
Mason DJ, Suva LJ, Stueckle S, Hillam RA & Skerry TM (1995) . Bone, 17(3), 319-319.
MASON DJ, STUECKLE S, HILLAM RA, SUVA LJ & SKERRY TM (1995) NOVEL GENES REGULATED BY MECHANICAL LOADING OF BONE IN-VIVO INCLUDE A GLUTAMATE ASPARTATE TRANSPORTER (GLAST) PROTEIN. JOURNAL OF BONE AND MINERAL RESEARCH, 10, S332-S332.
FERMOR B & SKERRY TM (1995) REGULATION OF PARATHYROID-HORMONE BINDING IN-VIVO BY BOTH DISUSE AND PARATHYROIDECTOMY. JOURNAL OF BONE AND MINERAL RESEARCH, 10, S482-S482.
HILLAM RA, JACKSON M, GOODSHIP AE & SKERRY TM (1995) REGIONAL DIFFERENCES IN HUMAN BONE STRAIN IN-VIVO. JOURNAL OF BONE AND MINERAL RESEARCH, 10, S443-S443.
Skerry TM (1995) . Bone, 16(6), 685-685.
Fermor B & Skerry TM (1995) . Bone, 16(6), 680-680.
Hillam RA & Skerry TM (1995) Inhibition of bone resorption and stimulation of formation by mechanical loading of the modeling rat ulna in vivo. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 10(5), 683-689.
Fermor B & Skerry TM (1995) . Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 10(12), 1935-1943.
Thomas T, Skerry TM, Vico L, Caulin F, Lanyon LE & Alexandre C (1995) Ineffectiveness of calcitonin on a local-disuse osteoporosis in the sheep: a histomorphometric study. Calcified tissue international, 57(3), 224-228.
Skerry TM & Lanyon LE (1995) Interruption of disuse by short duration walking exercise does not prevent bone loss in the sheep calcaneus. Bone, 16(2), 269-274.
Hillam RA & Skerry TM (1994) . Bone, 15(6), 731-731.
Skerry TM, Gowen M & Dodds RA (1994) . Bone, 15(4), 454-455.
Yellowley C, Levi AJ, Hancox J & Skerry TM (1994) . Bone, 15(4), 455-455.
YELLOWLEY CE, LEVI AJ, SKERRY TM & HANCOX JC (1994) THE MEMBRANE CURRENTS OF HUMAN OSTEOBLAST-LIKE CELLS FROM THE MG63 CELL-LINE. JOURNAL OF PHYSIOLOGY-LONDON, 476P, P59-P59.
Fermor B, Mason DJ, Gowen M & Skerry TM (1994) . Bone, 15(2), 235-236.
BUTTERWORTH SJ, GRIBBEN S, SKERRY TM, DENNY HR, BARR ARS & GREGORY SP (1994) . JOURNAL OF SMALL ANIMAL PRACTICE, 35(3), 139-143.
YELLOWLEY CE, LEVI AJ, SKERRY TM & HANCOX JC (1994) POTASSIUM AND CALCIUM CHANNELS IN CULTURED HUMAN OSTEOBLAST-LIKE CELLS. BIOPHYSICAL JOURNAL, 66(2), A325-A325.
Skerry TM (1994) The effects of the inflammatory response on bone growth. European journal of clinical nutrition, 48 Suppl 1, S190-S198.
Aaron JE & Skerry TM (1994) Intramembranous trabecular generation in normal bone. Bone and mineral, 25(3), 211-230.
FERMOR B, MASON DJ, LEE K, SEGRE GV, GOWEN M & SKERRY TM (1993) DIFFERENCES IN PERIOSTEAL AND TRABECULAR GENE-EXPRESSION IN GROWING BONE. JOURNAL OF BONE AND MINERAL RESEARCH, 8, S198-S198.
Skerry TM & Lanyon LE (1993) Immobilisation induced bone loss in the sheep is not modulated by calcitonin treatment. Bone, 14(3), 511-516.
AARON J & SKERRY TM (1992) TRABECULAR REGENERATION IN BONE DEFECTS. JOURNAL OF BONE AND MINERAL RESEARCH, 7, S176-S176.
Skerry TM & Lanyon LE (1992) . Bone, 13(5), A31-A31.
Skerry TM (1992) . Bone and Mineral, 17, 164-164.
Skerry TM (1992) . Bone, 13(1), 118-118.
Skerry TM, Pead MJ & Lanyon LE (1991) . Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 9(4), 600-608.
SPARKES AH & SKERRY TM (1990) SUCCESSFUL MANAGEMENT OF A PROLAPSED INTERVERTEBRAL-DISK IN A SIAMESE CAT. FELINE PRACTICE, 18(1), 7-9.
Skerry TM, Suswillo R, el Haj AJ, Ali NN, Dodds RA & Lanyon LE (1990) Load-induced proteoglycan orientation in bone tissue in vivo and in vitro. Calcified tissue international, 46(5), 318-326.
Ali NN, Dodds RA, Suswillo R, Skerry TM, Pead MJ & Lanyon LE (1989) . Bone, 10(2), 151-151.
Skerry TM, Bitensky L, Chayen J & Lanyon LE (1989) . Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 4(5), 783-788.
ELHAJ AJ, PEAD MJ, SKERRY TM, SUSWILLO R, MINTER SL, RAWLINSON SCF, ALI NN & LANYON LE (1988) . BONE, 9(4), 255-255.
SKERRY TM, SUSWILLO R, ELHAJ AJ, BITENSKY L, CHAYEN J & LANYON LE (1988) . BONE, 9(4), 264-264.
Pead MJ, Suswillo R, Skerry TM, Vedi S & Lanyon LE (1988) Increased 3H-uridine levels in osteocytes following a single short period of dynamic bone loading in vivo. Calcified tissue international, 43(2), 92-96.
Pead MJ, Skerry TM & Lanyon LE (1988) . Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 3(6), 647-656.
Skerry TM, Bitensky L, Chayen J & Lanyon LE (1988) Loading-related reorientation of bone proteoglycan in vivo. Strain memory in bone tissue?. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 6(4), 547-551.
Jailani ABA, Bigos KJA, Avgoustou P, Egan JL, Hathway RA, Skerry TM & Richards GO () . Expert Opinion on Drug Discovery, 1-10.
Zirimwabagabo J-O, Jailani ABA, Avgoustou P, Tozer MJ, Gibson KR, Glossop PA, Mills JEJ, Porter RA, Blaney P, Wang N , Skerry TM et al () . Journal of Medicinal Chemistry.
Livesey M, Pacharne S, Wang N, Grabowski P, Yang L, Richards G & Skerry T () . Bone Abstracts.
Pacharne S, Richards G, Wang N, Skerry T & Caron K () . Bone Abstracts.
T S () . Frontiers in Endocrinology, 2.
TM S () . Frontiers in Endocrinology, 2.
TM S () . Frontiers in Endocrinology, 2.
Acey , Grabowski & Skerry () . International Journal of Experimental Pathology, 81(1), A17-A17.

Chapters

Skerry T (2011) , Mechanosensing Biology (pp. 181-191). Springer Japan
Skerry T & Gowen M (1995) , Mechanisms and Models in Rheumatoid Arthritis (pp. 205-220). Elsevier
Skerry TM & Fermor BF (1994) , Biomechanics and Cells (pp. 164-177).
Skerry TM (1989) , Proceedings of the First International Conference on Interfaces in Medicine and Mechanics (pp. 167-172). Springer Netherlands
Skerry TM () , Methods in Bone Biology (pp. 149-176). Springer US

Conference proceedings papers

Avgoustou P, Lilley E, Skerry T & Richards G (2023) GPRC6A; a Novel Cell Surface Testosterone & Osteocalcin Receptor. BRITISH JOURNAL OF PHARMACOLOGY, Vol. 180 (pp 692-692)
Jailani A, Bigos K, Dascombe L, Richards G & Skerry T (2023) Effect of adrenomedullin and its receptors in pancreatic cancer progression and chemoresistance. BRITISH JOURNAL OF PHARMACOLOGY, Vol. 180 (pp 653-656)
Balasubramanian M, Hurst J, DeVile C, Bishop N, Arundel P, Offiah A, Pollitt R, Hughes D, Longman D, Caceres J & Skerry T (2017) . Bone Abstracts, Vol. 6(2017). Bristol, UK, 10 June 2017 - 13 June 2017.
Skerry TM, Samvelyan H & Mathers J (2017) TIMING OF EATING POTENTIATES THE EFFECT OF MECHANICAL LOADING ON BONE. OSTEOPOROSIS INTERNATIONAL, Vol. 28 (pp S466-S467)
Samvelyan H, Mathers J & Skerry T (2017) . Journal of Bone and Mineral Research, Vol. 31(S1) (pp S403-S403). USA, 16 September 2016 - 19 September 2016.
Notomi T, Kuno N, Amano H & Skerry TM (2008) The Pacemaker Channel, HCN, Controls Functions of Osteoclasts.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S267-S267)
Martinez-Bautista S, Wang N, Richards Q & Skerry TM (2008) Mice Lacking NMDA Receptor Expression in Osteoblasts Have Pronounced Vertebral Bone Abnormalities. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S87-S87)
Roberts DJ & Skerry T (2007) The cognition enhancer aniracetam increases the number of osteoblastic colonies in MSC cultures when combined with fluid shear stress. CALCIFIED TISSUE INT, Vol. 80 (pp S85-S85)
Skerry TM & Dastjerdi AM (2006) Microarray analysis of bones from Myod Myf5 null mice to identify genes regulated in bone by disuse.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 21 (pp S373-S373)
Lanham SA, Roberts C, Burford J, Skerry TM, Taylor P, Green LR, Hanson MA, Cooper C & Oreffo ROC (2005) Intrauterine programming of skeletal development. PEDIATRIC RESEARCH, Vol. 58(5) (pp 1045-1045)
Notomi T, Ludwig A, Reilly G, Hofmann FB & Skerry TM (2005) HCN2 ion channels regulate bone development, mass and strength.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20(9) (pp S62-S62)
Bowe EA & Skerry TM (2005) Repetitions of mechanical loading potentiate bone cellular responses by a mechanism involving NMDA type glutamate receptors. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20(9) (pp S25-S25)
MOLLOY T, WANG Y, HORNER A, SKERRY T & MURRELL G (2005) . Journal of Orthopaedic Research
Lanham SA, Roberts C, Burford J, Skerry TM, Taylor P, Green LR, Hanson MA, Cooper C & Oreffo ROC (2005) Intrauterine programming of skeletal development. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20(7) (pp 1299-1299)
Burford JH, Perrien DS, Horner A, Bowe EA, Notomi T, Suva LJ & Skerry TM (2004) Glutamate signalling regulates skeletogenesis and bone growth.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19 (pp S212-S213)
Chenu CC, De Souza RL, Pitsillides AA, Lanyon LE & Skerry TM (2004) Sciatic denervation increases load-induced cortical new bone formation independently of the sympathetic nervous system.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19 (pp S38-S38)
Odoi S, Burford JH, Souza RL, Parry LK & Skerry TM (2004) Increased osteoblastic differentiation in cultured marrow cells after blood loss or surgery. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19(6) (pp 1048-1048)
Skerry TM (2004) Neurotransmitters in bone: New players in bone physiology. OSTEOPOROSIS INTERNATIONAL, Vol. 15 (pp S2-S2)
Horner A, Bowe E, Burford J, Bailey R & Skerry T (2004) Glutamate signalling via AMPA receptors regulates cell survival during embryonic mesenchymal cell differentiation. Bone, Vol. 34 (pp S5-S6)
Bowe EA, Notomi T, Horner A & Skerry T (2004) Glutamate signalling and LTP-like mechanisms account for loading memory in osteoblasts.. Journal of Bone and Mineral Research, Vol. 19 (pp S10-S10)
Parry LK, Burton VJ, Perry MJ & Skerry TM (2004) Anaesthetics Effect the Osteogenic Response to Mechanical Loading. Calcified tissue international, Vol. 74 (pp S54-S55)
Whitehouse C, Horner A, Stewart A, Cobourne M, McGowan N, Burford J, Grigoriadis A, Sharpe P, Skerry T & Solomon E (2004) Nbr1 mutant mice exhibit age dependent increases in bone volume and mass. Bone, Vol. 34 (pp S15-S16)
Parry LK, Burton VJ, Gheduzzi S, Beresford J, Perry MJ, Skerry TM & Humphrey VF (2003) Ultrasound mimics the effect of mechanical loading in vivo on rat ulnae and bone marrow cells.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 18 (pp S217-S217)
Dallas-Skerry DJ, Murphy G & Skerry TM (2003) Regulation of bone resorption and formation through the cell-surface processing of RANKL and Jagged-1. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 18(7) (pp 1361-1361)
Skerry TM & Peet NM (2002) MyoD/Myf5 null mice cannot move actively in utero and have thin weak long bones and no rib development.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 17 (pp S170-S170)
Taylor AF, Odoi SO, Nokes CJ & Skerry TM (2002) AMPA type glutamate receptors regulate osteoblast/adipocyte plasticity and bone formation. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 17(7) (pp 1327-1327)
Odoi SO, Taylor AF, Lee K, Lanyon LE & Skerry TM (2002) Interactions between estrogen and glutamate signalling pathways. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 17(7) (pp 1331-1331)
Skerry TM & Peet NM (2002) Mechanical influences on skeletal development in utero. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 17(7) (pp 1324-1324)
Lacey JE, Skerry TM & Grabowski PS (1997) Differences in nitric oxide modulated matrix metalloproteinase activity in chondrocytes and synoviocytes. J BONE MINER RES, Vol. 12(9) (pp P18-P18)
Peet N, Grabowski P, Birch M, Patton A, Haman G & Skerry T (1997) Inhibition of bone resorption by the glutamate receptor antagonist MK-801 through suppression of osteoclast differentiation.. J BONE MINER RES, Vol. 12 (pp T379-T379)
Skerry TM, Genever PG, Patton AJ, Grabowski PS, Stueckle S & Suva LJ (1996) Glutamate receptors in bone cells suggest a paracrine role for excitatory amino acids in regulation of the skeleton?. J BONE MINER RES, Vol. 11 (pp P202-P202)

Patents

Richards G, Skerry T, Harrity J, Zirimwabagabo J-O, Tozer M, Porter R, Gibson K, Glossop P & Blaney P (2018) Compounds. WO2018/211275Al Appl. 16 May 2018.

Preprints

Avgoustou P, Jailani ABA, Desai AJ, Roberts DJ, Lilley E, Stothard G, Richards GO & Skerry TM (2024) , Cold Spring Harbor Laboratory.
Ascolani G, Skerry TM, Lacroix D, Dall'Ara E & Shuaib A (2019) ABM of osteoblast's mechanotransduction pathway: time patterns of critical events, arXiv.
Samvelyan HJ, Mathers JC & Skerry TM () .

Research group

Members of research group

Dr Gareth Richards (Joint Group Leader)
Dr Paris Avgoustou
Dr Ameera Jailani

PhD students

Jo Holmes
Kamilla Bigos
Ewan Lilley
Robbie Hathaway (jointly with Prof Joe Harrity)

Grants

Principal funding sources

Professional activities and memberships

CSO Modulus Oncology.