Francis, Sheila, Professor

Professor Sheila Francis

BSc PhD SFHEA FRSB

Clinical Medicine, School of Medicine and Population Health

Faculty Director of One University Strategy Delivery (FDOU)

Professor of Cardiovascular Biology

s.francis@sheffield.ac.uk
+44 114 215 9501

The Medical School

Full contact details

Professor Sheila Francis
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
91ֱ��
S10 2RX

Profile

For enquiries, please contact – ClinMed-Operational@sheffield.ac.uk

For One University Strategy enquiries in the Faculty of Health, please contact Isabel Andrews.

I joined the University of 91ֱ�� in 1990 after a BBSRC CASE PhD studentship at the University of Manchester. After four years as a Postdoctoral Research Associate in Cardiac Surgery (with Angelini) and Molecular Medicine (with Duff), I held an Independent Open Competition Fellowship from the Lloyd´s Tercentenary Foundation on the molecular and inflammatory basis of coronary artery disease.

After being appointed Lecturer in 1994, I spent a sabbatical period in the at MIT as a Fulbright Scholar. I am currently a Professor of Cardiovascular Biology at the University of 91ֱ��.

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Research interests

I have a long-standing interest in the role of interleukin-1 (IL-1) and its naturally occurring antagonist, IL-1ra in modulating vascular cell function in experimental models and in human disease. Over the past 10-15 years, I have shown that IL-1 and IL-1ra are increased in diseased human arteries and in other experimental cardiovascular systems. I described the association of a genetic variant of IL-1ra with coronary artery disease and showed that this variant alters protein levels and the biology of endothelial cells.

Programme funding from the British Heart Foundation (with Professor David Crossman) allowed the use of strategies to inhibit IL-1 in several experimental models including atherosclerosis in mice. The impact of this early work alongside that of others has now been translated to man through the ILA-HEART and .

My current research areas of interest relate to the mechanisms by which IL-1 is released from vascular cells especially endothelial cells, IL-1 related molecules and their antagonists, and the role of IL-1 in complex vascular phenotypes such as inflammatory vascular plaques in the brain and the mixed models of atherosclerosis after chronic infection and also episodes of hypoglycaemia. More recently, I have become interested in the control of endothelial senescence and impacts upon age-related diseases working with colleague in HELSI.

I collaborate with colleagues in Infection, Immunity and Cardiovascular Disease, Metabolism, Psychology and Neuroscience at the University of 91ֱ�� and with colleagues at the Universities of Manchester (Pinteaux, Allan), the University of Virginia (Owens, Abbate) and others.

Current projects

Release of IL-1 from vascular cells especially endothelial cells.
S.pneumoniae infection and atherosclerosis (with Bazaz and Dockrell (Edinburgh)).
Hypoglycaemia and risk of atherosclerosis (with Iqbal and Heller).
Interleukin-1 alpha versus interleukin-1 beta in atherosclerosis, hypertension and stroke (with Pinteaux and Allan, Manchester)).
Macrophage phenotypes in human carotid atherosclerosis (with Kiss-Toth and Redgrave).
Neurovascular function in atherosclerosis (with Wharton, Berwick and Howarth).
Approaches to alter endothelial senescence and ageing (with Bellantuono).
PKC alpha/TGF beta axis in atherosclerosis and medical calcification (with Brennan, Canfield and Borland, Manchester)
Vascular Brain pathology (with Simpson and Wharton)
Inflammation, atherosclerosis and molecular manipulation of the microbiome (with Jon Shaw)

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Kidder E, Gangopadhyay S, Francis S & Alfaidi M (2024) . Journal of the American Heart Association, e032987.
Prince LR & Francis SE (2023) . Disease Models & Mechanisms, 16(7).
Bazaz R, Marriott HM, Wright C, Chamberlain J, West LE, Gelsthorpe C, Heath PR, Maleki-Dizaji A, Francis SE & Dockrell DH (2023) . Frontiers in Cellular and Infection Microbiology, 13.
Eyre B, Shabir O, Lee L, Francis S, Howarth C & Berwick J (2022) . Alzheimer's & Dementia, 18(S6).
Al Mansouri M, Patel PA, Chamberlain J & Francis S (2022) . Vascular Biology, 4(1), 11-18.
Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ , Ariaans M et al (2022) . Science Advances, 8(35).
Martinez-Campesino L, Kocsy K, Cañedo J, Johnston JM, Moss CE, Johnston SA, Hamby S, Goodall AH, Redgrave J, Francis SE , Kiss-Toth E et al (2022) . Frontiers in Cardiovascular Medicine, 9.
Shabir O, Pendry B, Lee L, Eyre B, Sharp P, Rebollar M, Drew D, Howarth C, Heath P, Wharton S , Francis S et al (2022) . eLife, 2022(11).
Shabir O, Moll TA, Matuszyk MM, Eyre B, Dake MD, Berwick J & Francis SE (2020) . Mechanisms of Ageing and Development, 192, 111361-111361.
Pinteaux E, Abdulaal WH, Mufazalov IA, Humphreys NE, Simonsen-Jackson M, Francis S, Müller W & Waisman A (2020) . Journal of Molecular Medicine, 98(7), 923-930.
Johnston JM, Angyal A, Bauer RC, Hamby S, Suvarna SK, Baidžajevas K, Hegedus Z, Dear TN, Turner M, Wilson HL , Goodall AH et al (2019) . Science Advances, 5(10).
Bageghni SA, Hemmings KE, Yuldasheva NY, Maqbool A, Gamboa-Esteves FO, Humphreys NE, Jackson MS, Denton CP, Francis S, Porter KE , Ainscough JFX et al (2019) . JCI Insight, 4(17).
Helyes Z, Tékus V, Szentes N, Pohóczky K, Botz B, Kiss T, Kemény Á, Környei Z, Tóth K, Lénárt N , Ábrahám H et al (2019) . Proceedings of the National Academy of Sciences, 116(26), 13067-13076.
Wong R, Lénárt N, Hill L, Toms L, Coutts G, Martinecz B, Császár E, Nyiri G, Papaemmanouil A, Waisman A , Müller W et al (2019) . Brain Behavior and Immunity, 76, 126-138.
Gomez D, Baylis RA, Durgin BG, Newman AAC, Alencar GF, Mahan S, St. Hilaire C, Müller W, Waisman A, Francis SE , Pinteaux E et al (2018) . Nature Medicine, 24(9), 1418-1429.
Alfaidi MA, Chamberlain J, Rothman A, Crossman D, Villa‐Uriol MC, Hadoke P, Wu J, Schenkel T, Evans PC & Francis SE (2018) . Journal of the American Heart Association, 7(13).
Pickworth JA, Rothman A, Iremonger J, Casbolt H, Hopkinson K, Hickey P, Gladson S, Shay S, Morrell N, Francis S , West JD et al (2017) . Pulmonary Circulation.
Smith SA, Samokhin AO, Alfadi M, Murphy EC, Rhodes D, Kiss-Toth E, Storey RF, Yee S-P, Francis SE & Qwarnstrom EE (2017) . JACC - Journal of the American College of Cardiology bts, 2(4), 398-414.
Holen I, Lefley DV, Francis SE, Rennicks S, Bradbury S, Coleman RE & Ottewell P (2016) . Oncotarget, 7, 75571-75584.
Mahmoud M, Kim HR, Xing R, Hsiao S, Mammmoto A, Chen J, Serbanovic-Canic J, Feng S, Bowden NP, Maguire R , Ariaans M et al (2016) . Circulation Research, 119, 450-462.
Rothman AM, Arnold N, Pickworth J, Iremonger J, Ciuclan L, Allan R, Guth-Gundel S, Southwood M, Morrell N, Thomas M , Francis S et al (2016) . Journal of Clinical Investigation, 126(7), 2495-2508.
Alfaidi M, Wilson H, Daigneault M, Burnett A, Ridger V, Chamberlain J & Francis SE (2015) . Journal of Biological Chemistry, 290, 24067-24078.
Dénes Á, Pradillo JM, Drake C, Sharp A, Warn P, Murray KN, Rohit B, Dockrell DH, Chamberlain J, Casbolt H , Francis S et al (2014) . Annals of Neurology, 75(5), 670-683.

All publications

Journal articles

Kidder E, Gangopadhyay S, Francis S & Alfaidi M (2024) . Journal of the American Heart Association, e032987.
Prince LR & Francis SE (2023) . Disease Models & Mechanisms, 16(7).
Bazaz R, Marriott HM, Wright C, Chamberlain J, West LE, Gelsthorpe C, Heath PR, Maleki-Dizaji A, Francis SE & Dockrell DH (2023) . Frontiers in Cellular and Infection Microbiology, 13.
Eyre B, Shabir O, Lee L, Francis S, Howarth C & Berwick J (2022) . Alzheimer's & Dementia, 18(S6).
Al Mansouri M, Patel PA, Chamberlain J & Francis S (2022) . Vascular Biology, 4(1), 11-18.
Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ , Ariaans M et al (2022) . Science Advances, 8(35).
Martinez-Campesino L, Kocsy K, Cañedo J, Johnston JM, Moss CE, Johnston SA, Hamby S, Goodall AH, Redgrave J, Francis SE , Kiss-Toth E et al (2022) . Frontiers in Cardiovascular Medicine, 9.
Shabir O, Pendry B, Lee L, Eyre B, Sharp P, Rebollar M, Drew D, Howarth C, Heath P, Wharton S , Francis S et al (2022) . eLife, 2022(11).
Gustschin A, Riedel M, Taphorn K, Petrich C, Gottwald W, Noichl W, Busse M, Francis SE, Beckmann F, Hammel JU , Moosmann J et al (2021) . Optica, 8(12), 1588-1595.
Tulotta C, Lefley DV, Moore CK, Amariutei AE, Spicer-Hadlington AR, Quayle LA, Hughes RO, Ahmed K, Cookson V, Evans CA , Vadakekolathu J et al (2021) . npj Breast Cancer, 7(1).
Lawrie A & Francis SE (2021) . Journal of Clinical Investigation, 131(11).
Iqbal J, Chamberlain J, Alfaidi M, Hughes M, Alizadeh T, Casbolt H, Evans P, Mann B, Motterlini R, Francis S & Gunn J (2021) . Journal of Cardiovascular Pharmacology, Publish Ahead of Print.
Shabir O, Moll TA, Matuszyk MM, Eyre B, Dake MD, Berwick J & Francis SE (2020) . Mechanisms of Ageing and Development, 192, 111361-111361.
Pinteaux E, Abdulaal WH, Mufazalov IA, Humphreys NE, Simonsen-Jackson M, Francis S, Müller W & Waisman A (2020) . Journal of Molecular Medicine, 98(7), 923-930.
Shabir O, Sharp P, Rebollar MA, Boorman L, Howarth C, Wharton SB, Francis SE & Berwick J (2020) . Scientific Reports, 10(1).
Mahmoud MM, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis SE , Van der Heiden K et al (2020) . Scientific Reports, 10(1).
Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M, Luong LA, West L , Long M et al (2020) . Nature Communications, 11(1).
Arnold ND, Pickworth JA, West LE, Dawson S, Carvalho JA, Casbolt H, Braithwaite AT, Iremonger J, Renshall L, Germaschewski V , McCourt M et al (2019) . Nature Communications, 10(1).
Johnston JM, Angyal A, Bauer RC, Hamby S, Suvarna SK, Baidžajevas K, Hegedus Z, Dear TN, Turner M, Wilson HL , Goodall AH et al (2019) . Science Advances, 5(10).
Bazaz R, Francis S & Dockrell D (2019) . Open Forum Infectious Diseases, 6(Supplement_2), S207-S207.
Bageghni SA, Hemmings KE, Yuldasheva NY, Maqbool A, Gamboa-Esteves FO, Humphreys NE, Jackson MS, Denton CP, Francis S, Porter KE , Ainscough JFX et al (2019) . JCI Insight, 4(17).
(2019) . Proceedings of the National Academy of Sciences, 116(29), 14782-14782.
Helyes Z, Tékus V, Szentes N, Pohóczky K, Botz B, Kiss T, Kemény Á, Környei Z, Tóth K, Lénárt N , Ábrahám H et al (2019) . Proceedings of the National Academy of Sciences, 116(26), 13067-13076.
Borland S, Behnsen J, Akerele A, Sherratt MJ, Brennan K, Holt C, Francis S & Canfield A (2019) . Basic Science.
Borland S, Facchi C, Behnsen J, Adamson A, Humphrey N, Sherratt MJ, Brennan K, Francis S, Ashton N & Canfield A (2019) . Basic Science.
Kocsy K, Francis S, Kiss-Toth E, Lonsdale R, Majid A & Redgrave J (2019) . Basic Science.
Iqbal A, Prince LR, Novodvorsky P, Bernjak A, Thomas MR, Birch L, Lambert D, Kay LJ, Wright FJ, Macdonald IA , Jacques RM et al (2019) . Journal of Clinical Endocrinology and Metabolism, 104(4), 1187-1199.
Wong R, Lénárt N, Hill L, Toms L, Coutts G, Martinecz B, Császár E, Nyiri G, Papaemmanouil A, Waisman A , Müller W et al (2019) . Brain Behavior and Immunity, 76, 126-138.
Shabir O, Berwick J & Francis S (2018) . BMC Neuroscience, 19.
Johnston JM, Francis SE & Kiss-Toth E (2018) . Cardiovascular Research, 114(14), 1845-1847.
Martinez Campesino L, Johnston JM, Francis SE, Kiss-Toth E & Wilson HL (2018) . Cardiovascular Research, 114(suppl_2), S2-S2.
Gomez D, Baylis RA, Durgin BG, Newman AAC, Alencar GF, Mahan S, St. Hilaire C, Müller W, Waisman A, Francis SE , Pinteaux E et al (2018) . Nature Medicine, 24(9), 1418-1429.
Alfaidi MA, Chamberlain J, Rothman A, Crossman D, Villa‐Uriol MC, Hadoke P, Wu J, Schenkel T, Evans PC & Francis SE (2018) . Journal of the American Heart Association, 7(13).
Tuñón J, Bäck M, Badimón L, Bochaton-Piallat M-L, Cariou B, Daemen MJ, Egido J, Evans PC, Francis SE, Ketelhuth DFJ , Lutgens E et al (2018) . European Journal of Preventive Cardiology, 25(9), 948-955.
Renshall L, Arnold N, West L, Braithwaite A, Pickworth J, Walker R, Alfaidi M, Chamberlain J, Casbolt H, Thompson AAR , Holt C et al (2018) . Pulmonary Circulation, 8(1), 1-11.
Borland SJ, Morris TG, Borland SC, Morgan MR, Francis SE, Merry CLR & Canfield AE (2017) . Cardiovascular Research, 113(13), 1639-1652.
Pickworth JA, Rothman A, Iremonger J, Casbolt H, Hopkinson K, Hickey P, Gladson S, Shay S, Morrell N, Francis S , West JD et al (2017) . Pulmonary Circulation.
Smith SA, Samokhin AO, Alfadi M, Murphy EC, Rhodes D, Kiss-Toth E, Storey RF, Yee S-P, Francis SE & Qwarnstrom EE (2017) . JACC - Journal of the American College of Cardiology bts, 2(4), 398-414.
Mahmoud M, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis S , Van der Heiden K et al (2017) . Scientific Reports, 7.
Holen I, Lefley DV, Francis SE, Rennicks S, Bradbury S, Coleman RE & Ottewell P (2016) . Oncotarget, 7, 75571-75584.
Mahmoud M, Kim HR, Xing R, Hsiao S, Mammmoto A, Chen J, Serbanovic-Canic J, Feng S, Bowden NP, Maguire R , Ariaans M et al (2016) . Circulation Research, 119, 450-462.
Rothman AM, Arnold N, Pickworth J, Iremonger J, Ciuclan L, Allan R, Guth-Gundel S, Southwood M, Morrell N, Thomas M , Francis S et al (2016) . Journal of Clinical Investigation, 126(7), 2495-2508.
Iqbal J, Chamberlain J, Francis SE & Gunn J (2016) . Annals of Biomedical Engineering, 44(2), 453-465.
Rothman AM, Arnold ND, Pickworth JA, Iremonger J, Ciuclan L, Allen R, Guth-Gundel S, Southwood M, Morrell NW, Francis SE , Rowlands D et al (2015) . Circulation, 132(suppl_3).
Pickworth JA, Shay S, Gladson S, Iremonger J, Rothman AM, Francis S, West J & Lawrie A (2015) . Circulation, 132(suppl_3).
Alfaidi M, Wilson H, Daigneault M, Burnett A, Ridger V, Chamberlain J & Francis SE (2015) . Journal of Biological Chemistry, 290, 24067-24078.
Johnston J, Basatvat S, Ilyas Z, Francis S & Kiss-Toth E (2015) . Biochemical Society Transactions, 43(5), 1069-1074.
Salazar M, Lorente M, García-Taboada E, Gómez EP, Dávila D, Zúñiga-García P, Flores JM, Rodríguez A, Hegedus Z, Mosén-Ansorena D , Aransay AM et al (2015) . Molecular & Cellular Oncology, 2(3).
Salazar M, Lorente M, García-Taboada E, Pérez Gómez E, Dávila D, Zúñiga-García P, María Flores J, Rodríguez A, Hegedus Z, Mosén-Ansorena D , Aransay AM et al (2015) . Cell Death & Differentiation, 22(1), 131-144.
Raina T, Iqbal J, Arnold N, Moore H, Aflatoonian B, Walsh J, Whitehouse S, Al-Lamee K, Francis S & Gunn J (2014) . EuroIntervention, 10(6), 709-716.
Alfaidi M, Wilson H, Ridger V, Chamberlain J & Francis S (2014) Neutrophil elastase enhances IL-1 beta secretion from coronary endothelium via an endolysosomal mediated mechanism, without caspase-1 activation. ANGIOGENESIS, 17(4), 941-941.
Amini N, Boyle JJ, Moers B, Warboys CM, Malik TH, Zakkar M, Francis SE, Mason JC, Haskard DO & Evans PC (2014) . Atherosclerosis, 235(2), 613-618.
Raina T, Arnold N, Moore H, Aflatoonian B, Walsh J, Whitehouse S, Al-Lamee K, Francis S, Gunn J & Iqbal J (2014) . Heart, 100(Suppl 3), A88.2-A89.
Alfaidi M, Chamberlain J & Francis S (2014) . Heart, 100 Suppl 3, A116-A117.
Samokhin AO, Francis SE & Qwarnstrom EE (2014) . Heart, 100.
Dénes Á, Pradillo JM, Drake C, Sharp A, Warn P, Murray KN, Rohit B, Dockrell DH, Chamberlain J, Casbolt H , Francis S et al (2014) . Annals of Neurology, 75(5), 670-683.
Steiner T, Francescut L, Byrne S, Hughes T, Jayanthi A, Guschina I, Harwood J, Cianflone K, Stover C & Francis S (2014) . PLoS ONE, 9(3).
Ellam T, Hameed A, ul Haque R, Muthana M, Wilkie M, Francis SE & Chico TJA (2014) . PLoS One, 9(2), e88767.
West LE, Steiner T, Judge HM, Francis SE & Storey RF (2014) . Cardiovasc Res, 102(3), 429-435.
Ellam T, Fotheringham J, Wilkie ME, Francis SE & Chico TJA (2014) . PLoS One, 9(2), e88388.
Francis SE (2014) . Prog Mol Biol Transl Sci, 124, 1-18.
Alfaidi M, Wilson HL, Burnett A, Abdul-Aema BH, Ridger V, Chamberlain J & Francis SE (2014) . Heart, 100 Suppl 1, A2.
West LE, Steiner T, Francis SE & Storey RF (2013) The role of vessel wall P2Y12 in early atherogenesis is not blocked by ticagrelor or clopidogrel. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 11, 156-156.
McDonald RA, White KM, Wu J, Cooley BC, Robertson KE, Halliday CA, McClure JD, Francis S, Lu R, Kennedy S , George SJ et al (2013) . European Heart Journal, 34(22), 1636-1643.
Salazar M, Lorente M, García-Taboada E, Hernández-Tiedra S, Davila D, Francis SE, Guzmán M, Kiss-Toth E & Velasco G (2013) . Biochim Biophys Acta, 1831(10), 1573-1578.
Hameed A, Bennett E, Ciani B, Hoebers LPC, Milner R, Lawrie A, Francis SE & Grierson AJ (2013) . PLoS One, 8(1), e54636.
Bazaz R, Marriott HM, Francis SE & Dockrell DH (2013) . J Infect, 66(1), 1-17.
Sung HY, Francis SE, Arnold ND, Holland K, Ernst V, Angyal A & Kiss-Toth E (2012) . Biology (Basel), 1(1), 43-57.
Hameed AG, Arnold ND, Chamberlain J, Pickworth JA, Paiva C, Dawson S, Cross S, Long L, Zhao L, Morrell NW , Crossman DC et al (2012) . J Exp Med, 209(11), 1919-1935.
Denes A, Drake C, Stordy J, Chamberlain J, McColl BW, Gram H, Crossman D, Francis S, Allan SM & Rothwell NJ (2012) . Journal of the American Heart Association, 1(3).
Neilan M, Zhang X, Steiner T, Boyle J, Francis S, Haskard D & Qwarnstrom E (2012) . Heart, 98(Suppl 3), A6.1-A6.
Francescut L, Steiner T, Byrne S, Cianflone K, Francis S & Stover C (2012) . Journal of Innate Immunity, 4(3), 260-272.
Condliffe R, Pickworth JA, Hopkinson K, Walker SJ, Hameed AG, Suntharaligam J, Soon E, Treacy C, Pepke-Zaba J, Francis SE , Crossman DC et al (2012) . Pulm Circ, 2(1), 21-27.
Steiner T, Francescut L, Stover C & Francis S (2011) . Heart, 97(20), e7-e7.
Francescut L, Byrne S, Steiner T, Francis S & Stover C (2011) . Heart, 97(20), e7-e7.
Ellam T, Wilkie M, Chamberlain J, Crossman D, Eastell R, Francis S & Chico TJ (2011) . Arteriosclerosis Thrombosis and Vascular Biology, 31, 1988-1990.
McGrath EE, Marriott HM, Lawrie A, Francis SE, Sabroe I, Renshaw SA, Dockrell DH & Whyte MKB (2011) . J Leukoc Biol, 90(5), 855-865.
Watt V, Chamberlain J, Steiner T, Francis S & Crossman D (2011) TRAIL attenuates the development of atherosclerosis in apolipoprotein E deficient mice. Atherosclerosis.
Lawrie A, Hameed AG, Chamberlain J, Arnold N, Kennerley A, Hopkinson K, Pickworth J, Kiely DG, Crossman DC & Francis SE (2011) . Am J Pathol, 179(4), 1693-1705.
Drake C, Boutin H, Jones MS, Denes A, McColl BW, Selvarajah JR, Hulme S, Georgiou RF, Hinz R, Gerhard A , Vail A et al (2011) . Brain, Behavior, and Immunity, 25(6), 1113-1122.
Watt V, Chamberlain J, Steiner T, Francis S & Crossman D (2011) . Atherosclerosis, 215(2), 348-354.
Drake C, Boutin H, Jones MS, Denes A, McColl BW, Selvarajah JR, Hulme S, Georgiou RF, Hinz R, Gerhard A , Vail A et al (2011) Brain inflammation is induced by co-morbidities and risk factors for stroke. Brain, Behavior, and Immunity.
Bewley MA, Marriott HM, Tulone C, Francis SE, Mitchell TJ, Read RC, Chain B, Kroemer G, Whyte MKB & Dockrell DH (2011) . PLoS Pathog, 7(1), e1001262.
Patil SB, Jackman LE, Francis SE, Judge HM, Nylander S & Storey RF (2010) Sustained P2Y12 Receptor Inhibition is Required to Effectively Inhibit Neointima Formation in a Murine Vascular Injury Model. CIRCULATION, 122(21).
Patil SB, Jackman LE, Francis SE, Judge HM, Nylander S & Storey RF (2010) . Arterioscler Thromb Vasc Biol, 30(12), 2385-2391.
Neilan M, Zhang X, Francis S & Qwarnstrom EE (2010) . Heart, 96(17), e27-e27.
Docherty LM, Angyal A, Francis S & Kiss-Toth E (2010) . Heart, 96(17), e18-e18.
Ward JR, West PW, Ariaans MP, Parker LC, Francis SE, Crossman DC, Sabroe I & Wilson HL (2010) . J Biol Chem, 285(30), 23147-23158.
Al-Malki A, Newton S, Francis SE & El-Ghariani K (2010) . TRANSFUS APHER SCI, 42(1), 97-99.
Ward JR, Francis SE, Marsden L, Suddason T, Lord GM, Dower SK, Crossman DC & Sabroe I (2009) . Immunology, 128(1), 58-68.
Chamberlain J, Wheatcroft M, Arnold N, Lupton H, Crossman DC, Gunn J & Francis S (2009) . Cardiovasc Res, 85, 38-44.
Francis S, Chamberlain J, Brookes Z, Shaw G, Alp N, Rogus J, Kornman K & Crossman D (2009) . Atherosclerosis Supplements, 10(2), e463-e463.
Ward JR, Wilson HL, Francis SE, Crossman DC & Sabroe I (2009) . Clin Exp Immunol, 156(3), 386-394.
Evans DJW, Jackman LE, Chamberlain J, Crosdale DJ, Judge HM, Jetha K, Norman KE, Francis SE & Storey RF (2009) . Circulation, 119(1), 116-122.
Eder K, Guan H, Sung HY, Ward J, Angyal A, Janas M, Sarmay G, Duda E, Turner M, Dower SK , Francis SE et al (2008) . Int Immunol, 20(12), 1543-1550.
Dewberry RM, King AR, Crossman DC & Francis SE (2008) . FEBS Lett, 582(6), 886-890.
Eder K, Guan H, Sung HY, Francis SE, Crossman DC & Kiss-Toth E (2008) . Immunol Lett, 116(2), 178-183.
Lawrie A, Waterman E, Southwood M, Evans D, Suntharalingam J, Francis S, Crossman D, Croucher P, Morrell N & Newman C (2008) . The American Journal of Pathology, 172(1), 256-264.
Lawrie A, Southwood M, Suntharalingam J, Francis SE, Crossman DC, Morrell NW & Newman CM (2007) . Circulation, 116(suppl_16).
Watt V, Francis S & Crossman D (2007) Deletion of tumour necrosis factor-related apoptosis-inducing ligand attenuates development of atherosclerosis in ApoE null mice. EUROPEAN HEART JOURNAL, 28, 110-110.
Patil SBG, Norman KE, Robins SJ, Crosdale DJ, Nylander S, Francis SE & Storey RF (2007) . Journal of Thrombosis and Haemostasis, 5.
Sung HY, Guan H, Czibula A, King AR, Eder K, Heath E, Suvarna SK, Dower SK, Wilson AG, Francis SE , Crossman DC et al (2007) . J Biol Chem, 282(25), 18379-18387.
Wilson HL, Varcoe RW, Stokes L, Holland KL, Francis SE, Dower SK, Surprenant A & Crossman DC (2007) . Br J Pharmacol, 151(1), 115-127.
Dewberry R, Jetha K, Shaw G, Crossman D & Francis S (2006) . Vascular Pharmacology, 45(3), e28-e28.
Sung HY, Francis SE, Crossman DC & Kiss-Toth E (2006) . Immunol Lett, 104(1-2), 171-177.
Chamberlain J, Evans D, King A, Dewberry R, Dower S, Crossman D & Francis S (2006) . The American Journal of Pathology, 168(4), 1396-1403.
Evans I, Dower SK, Francis SE, Crossman DC & Wilson HL (2006) . Cytokine, 33(5), 274-280.
Morton AC, Arnold ND, Gunn J, Varcoe R, Francis SE, Dower SK & Crossman DC (2005) . Cardiovasc Res, 68(3), 493-501.
Satterthwaite G, Francis SE, Suvarna K, Blakemore S, Ward C, Wallace D, Braddock M & Crossman D (2005) . Am Heart J, 150(3), 488-499.
Akowuah EF, Gray C, Lawrie A, Sheridan PJ, Su C-H, Bettinger T, Brisken AF, Gunn J, Crossman DC, Francis SE , Baker AH et al (2005) . Gene Ther, 12(14), 1154-1157.
RAY KK, FRANCIS S & CROSSMAN DC (2005) . Journal of Thrombosis and Haemostasis, 3(2), 287-291.
Ray KK, Francis S & Crossman DC (2004) . Journal of Thrombosis and Haemostasis, 2(11), 2053-2054.
Hauser ER, Crossman DC, Granger CB, Haines JL, Jones CJH, Mooser V, McAdam B, Winkelmann BR, Wiseman AH, Muhlestein JB , Bartel AG et al (2004) . The American Journal of Human Genetics, 75(3), 436-447.
Wilson HL, Francis SE, Dower SK & Crossman DC (2004) . J Immunol, 173(2), 1202-1208.
Francis S (2004) . Heart, 90(6), 591-592.
Morton AC, Varcoe R, Francis S, Dower S, Arnold N, Gunn J & Crossman D (2004) . Cardiovascular Pathology, 13(3), 93-93.
Evans D, Crossman D, Francis S & Chamberlain J (2004) . Cardiovascular Pathology, 13(3), 117-117.
Dewberry R, Crossman D & Francis S (2004) . Cardiovascular Pathology, 13(3), 95-95.
Chamberlain J, Dower S, Crossman D & Francis S (2004) . Cardiovascular Pathology, 13(3), 116-117.
King AR, Rowe SJ, Francis SE, Whyte MKB & Crossman DC (2004) . Cardiovascular Pathology, 13(3), 127-127.
Morton AC, Francis SE, Dower S, Arnold ND, Gunn J & Grossman DC (2004) . Clinical Science, 106(s50), 2P-2P.
Lawrie A, Brisken AF, Francis SE, Wyllie D, Kiss-Toth E, Qwarnstrom EE, Dower SK, Crossman DC & Newman CM (2003) . Ultrasound Med Biol, 29(10), 1453-1461.
King AR, Francis SE, Bridgeman CJ, Bird H, Whyte MKB & Crossman DC (2003) . Lab Invest, 83(10), 1497-1508.
Dewberry RM, Crossman DC & Francis SE (2003) . Circ Res, 92(12), 1285-1287.
Satterthwaite G, Francis SE, Blakemore SJ, Ward CL, Wallace DM, Braddock M & Crossman DC (2002) . Biochemical Society Transactions, 30(5), A130-A130.
Ray KK, Camp NJ, Bennett CE, Francis SE & Crossman DC (2002) . Clin Sci (Lond), 103(3), 303-310.
Francis SE, Goh KL, Hodivala-Dilke K, Bader BL, Stark M, Davidson D & Hynes RO (2002) . Arterioscler Thromb Vasc Biol, 22(6), 927-933.
Hynes RO, Lively JC, McCarty JH, Taverna D, Francis SE, Hodivala-Dilke K & Xiao Q (2002) . Cold Spring Harbor Symposia on Quantitative Biology, 67, 143-153.
Lambert DL, Malik N, Shepherd L, Gunn J, Francis SE, King A, Crossman DC, Cumberland DC & Holt CM (2001) . Arterioscler Thromb Vasc Biol, 21(11), 1727-1732.
Ray KK, Camp NJ, Bennett CE, Francis SE & Crossman DC (2001) Differential regulation of endothelial function and systemic inflammation by gene variation at the IL-1 locus during acute coronary syndromes. CIRCULATION, 104(17), 390-391.
Ray KK, Bennett CE, Francis SE, Crossman DC & Camp NJ (2001) Polymorphism at the IL-1 locus determines the endothelial but not the systemic response in acute coronary syndromes. EUR HEART J, 22, 373-373.
Francis SE, Camp NJ, Burton AJ, Dewberry RM, Gunn J, Stephens-Lloyd A, Cumberland DC, Gershlick A & Crossman DC (2001) . Heart, 86(3), 336-340.
Chamberlain J, Gunn J, Francis SE, Holt CM, Arnold ND, Cumberland DC, Ferguson MW & Crossman DC (2001) . Cardiovasc Res, 50(1), 125-136.
Chico TJ, Chamberlain J, Gunn J, Arnold N, Bullens SL, Gadek TR, Francis SE, Bunting S, Horton M, Shepherd L , Lipari MT et al (2001) . Circulation, 103(8), 1135-1141.
Kalashnik L, Bridgeman CJ, King AR, Francis SE, Mikhalovsky S, Wallis C, Denyer SP, Crossman D & Faragher RGA (2000) A cell kinetic analysis of human umbilical vein endothelial cells. MECH AGEING DEV, 120(1-3), 23-32.
Lawrie A, Brisken AF, Francis SE, Cumberland DC, Crossman DC & Newman CM (2000) . Gene Ther, 7(23), 2023-2027.
Dewberry R, Holden H, Crossman D & Francis S (2000) . Arteriosclerosis, Thrombosis, and Vascular Biology, 20(11), 2394-2400.
Crossman DC, Francis SE, Camp NJ, Dewberry RM, Gunn J, Cumberland DC, Duff GW, Syrris P, Carter ND, Jeffery S & Kaski JC (2000) Possible different involvement of interleukin-1 receptor antagonist gene polymorphism in coronary single vessel disease and myocardial infarction - Response. CIRCULATION, 101(18), E193-E193.
Townsend CF, Francis SE & Newman CM (2000) Mammalian suppressor of sgv-1 (MSS1), a putative transcription factor and differentiation related gene, is upregulated in explant derived compared with enzyme dispersed human aortic vascular smooth muscle cells in vitro. J AM COLL CARDIOL, 35(2), 49A-49A.
Owens PE, Watson CJ, Canfield AE, Francis SE, Crossman DC & Brenchley PE (2000) VEGF promoter polymorphisms and the risk of ischaemic heart disease. J AM COLL CARDIOL, 35(2), 306A-306A.
Lambert DL, Gunn J, Francis SE, Malik N, King A, Cumberland DC, Crossman DC & Holt CM (2000) Antisense oligonucleotide to c-myb induces apoptosis in vascular smooth muscle cells in vitro and in vivo. Heart, 83(SUPPL. 1).
Galea J, Armstrong J, Francis SE, Cooper G, Crossman DC & Holt CM (1999) . Cardiovasc Res, 44(2), 436-448.
Chamberlain J (1999) . Cardiovascular Research, 44(1), 156-165.
Lawrie A, Brisken AF, Francis SE, Tayler DI, Chamberlain J, Crossman DC, Cumberland DC & Newman CM (1999) . Circulation, 99(20), 2617-2620.
Francis SE, Camp NJ, Dewberry RM, Gunn J, Syrris P, Carter ND, Jeffery S, Kaski JC, Cumberland DC, Duff GW & Crossman DC (1999) . Circulation, 99(7), 861-866.
Townsend CF, Newman CM & Francis SE (1999) . Methods Mol Med, 30, 39-46.
Dewberry RM, Holden H, Crossman DC & Francis SE (1999) Interleukin-1 receptor antagonist (IL-1RA) in human diseased arteries: Association of allele 2 of IL-1RN (+2016) human gene polymorphism with reduced expression in endothelial cells. Heart, 81(SUPPL. 1).
(1998) . Clinical Science, 95(6), 659-659.
Syrris P, Carter ND, Metcalfe JC, Kemp PR, Grainger DJ, Kaski JC, Crossman DC, Francis SE, Gunn J, Jeffrey S & Heathcote K (1998) Transforming growth factor-beta gene polymorphisms and coronary artery disease. CLIN SCI, 95(6), 659-667.
Malik N, Gunn J, Holt CM, Shepherd L, Francis SE, Newman CM, Crossman DC & Cumberland DC (1998) . Heart, 80(5), 509-516.
John AE, Galea J, Francis SE, Holt CM & Finn A (1998) . Perfusion, 13(6), 409-417.
Malik N, Francis SE, Holt CM, Gunn J, Thomas GL, Shepherd L, Chamberlain J, Newman CM, Cumberland DC & Crossman DC (1998) . Circulation, 98(16), 1657-1665.
Lawrie A, Brisken AF, Chamberlain JC, Francis SE, Tayler DI, Crossman DC, Cumberland DC & Newman CM (1998) 1MHz ultrasound enhances transfection of porcine aortic endothelial cells in vitro and oligonucleotide uptake in an organ culture model.. AM J CARDIOL, 82(7A), 29S-29S.
Malik N, Gunn J, Holt CM, Francis SE, Arnold N, Newman CMH, Crossman DC & Cumberland DC (1998) Aorto-ostial stent: Procedural, angiographic and histological evaluation in porcine coronary arteries.. AM J CARDIOL, 82(7A), 68S-68S.
MALIK NM, SYRRIS P, SCHWARTZMAN R, KASKI JC, CROSSMAN DC, FRANCIS SE, CARTER ND & JEFFERY S (1998) . Clinical Science, 95(3), 311-315.
Malik NM, Syrris P, Schwartzman R, Kaski JC, Crossman DC, Francis SE, Carter ND & Jeffery S (1998) Methylenetetrahydrofolate reductase polymorphism (C-677T) and coronary artery disease. CLIN SCI, 95(3), 311-315.
Malik N, Francis SE, Holt CM, Gunn J, Shepherd L, Newman CMH, Cumberland DC & Crossman DC (1998) Apoptosis and cell proliferation following porcine angioplasty. J AM COLL CARDIOL, 31(2), 22A-22A.
Lawrie A, Brisken AF, Francis SE, Tayler DI, Crossman DC, Cumberland DC & Newman CM (1998) Nigh frequency ultrasound enhances transfection of porcine vascular smooth muscle cells in vitro. J AM COLL CARDIOL, 31(2), 25A-25A.
Francis SE, Holden H, Holt CM & Duff GW (1998) . J Mol Cell Cardiol, 30(2), 215-223.
Dewberry RM, Camp NJ, Gunn J, Burton AJ, Carter ND, Jeffery S, Syrris P, Schwartzmann RA, Kaski JC, Cumberland DC , Duff GW et al (1998) Interleukin-1 (IL-1) gene polymorphisms: Risk of coronary arterial disease. Heart, 79(SUPPL. 1).
Gunn J, Malik N, Holt C, Francis S, Shepherd L, Newman C, Crossman D & Cumberland D (1997) The BioDivYsio(R) stent: Morphometric superiority to the Palmaz-Schatz stent in the porcine coronary model. AMERICAN JOURNAL OF CARDIOLOGY, 80, TCT95-TCT95.
Gunn J, Holt CM, Francis SE, Shepherd L, Grohmann M, Newman CM, Crossman DC & Cumberland DC (1997) . Circ Res, 80(4), 520-531.
Bridgeman CJ, King A, Francis SE & Crossman D (1997) Modulation of Bcl-2 and the related proteins Bak and Bax during in vitro ageing of HUVEC. Heart, 77(SUPPL. 1).
Gunn J, Malik N, Shepherd L, Holt CM, Francis SE, Newman CMH, Crossman DC & Cumberland DC (1997) In-stent restenosis: More metal and more symmetry required?. Heart, 77(SUPPL. 1).
Bridgeman CJ, Francis SE & Crossman D (1997) Z-VAD but not Z-DEVD inhibits serum withdrawal induced apoptosis of HUVEC in vitro. Heart, 77(SUPPL. 1).
Galea J, Armstrong J, Gadsdon P, Holden H, Francis SE & Holt CM (1996) . Arterioscler Thromb Vasc Biol, 16(8), 1000-1006.
John AE, Galea J, Francis SE, Holt CM, Crossman DC & Finn A (1996) Neutrophils are a source of interleukin-6 in human cardiopulmonary bypass surgery. HEART, 75(5), 100-100.
Francis SE, Duff GW & Crossman DC (1996) c-fms proto-oncogene expression is increased in endothelial and smooth muscle cells following vascular grafting. HEART, 75(5), 161-161.
Galea J, Armstrong J, Francis SE, Crossman DC & Holt CM (1996) Early response gene expression and vascular cell proliferation in human saphenous vein prepared for coronary bypass grafting. HEART, 75(5), 279-279.
Bridgeman CJ, King AR, Francis SE & Crossman DC (1996) Apoptosis of human umbilical vein endothelial cells (HUVEC) - Role of interleukin-1 beta converting enzyme (ICE) and associated proteases. HEART, 75(5), 11-11.
Gunn J, Holt GM, Francis SE, Shepherd L, Malik N, Grohmann M, Crossman DC & Cumberland DC (1996) Restenosis after balloon angioplasty: Intimal hyperplasia or vessel remodelling?. HEART, 75(5), 88-88.
GALEA J, FRANCIS SE, CROSSMAN DC & HOLT CM (1995) UP-REGULATION OF THE EARLY RESPONSE GENES C-FOS, C-JUN AND C-MYC IN SURGICALLY PREPARED HUMAN SAPHENOUS-VEIN. CIRCULATION, 92(8), 3080-3080.
GUNN J, HOLT CM, SHEPHERD L, GROHMANN M, FRANCIS SE, CROSSMAN DC & CUMBERLAND DC (1995) INTRA-CORONARY DRUG-DELIVERY VIA POROUS BALLOON - LOCAL OR REGIONAL. CIRCULATION, 92(8), 3220-3220.
Gunn J, Holt CM, Shepherd L, Francis SE, Smith GH & Cumberland DC (1995) . Journal of the American College of Cardiology, 25(2), 376A-377A.
Cooper GJ, Gillot T, Francis SE & Angelini GD (1995) . Cardiovasc Surg, 3(2), 171-174.
Francis SE, Hunter S, Holt CM, Gadsdon PA, Rogers S, Duff GW, Newby AC & Angelini GD (1994) Release of platelet-derived growth factor activity from pig venous arterial grafts.. J Thorac Cardiovasc Surg, 108(3), 540-548.
Holt CM, Francis SE, Gadsdon PA, Violaris A, Izzat MB & Angelini GD (1994) . Cardiovasc Res, 28(8), 1170-1175.
HOLT CM, ARMSTRONG J, GADSDON P, FRANCIS SE & SMITH GH (1994) DETECTION OF IL-1 IN HUMAN ATHEROSCLEROSIS. J CELL BIOCHEM, 285-285.
FRANCIS SE, HOLDEN H, HOLT CM, SMITH GH & DUFF GW (1994) INTERLEUKIN-10 IN HUMAN ARTERIES AND VEINS. J CELL BIOCHEM, 284-284.
Francis SE & Duff GW (1993) . Nucleic Acids Res, 21(12), 2944.
Holt CM, Francis SE, Newby AC, Rogers S, Gadsdon PA, Taylor T & Angelini GD (1993) . Ann Thorac Surg, 55(6), 1522-1528.
Jones MN, Francis SE, Hutchinson FJ, Handley PS & Lyle IG (1993) . Biochimica et Biophysica Acta (BBA) - Biomembranes, 1147(2), 251-261.
Violaris A, Francis S, Holt C, Clelland C, Gadsdon P & Angelini G (1993) . International Journal of Angiology, 2(03), 105-111.
Holt CM, Francis SE, Rogers S, Gadsdon PA, Taylor T, Clelland C, Soyombo A, Newby AC & Angelini GD (1992) . Cardiovasc Res, 26(12), 1189-1194.
FRANCIS SE, HOLT CM, GADSDON PA, TAYLOR T & ANGELINI GD (1992) SERUM-FREE ORGAN-CULTURE OF VASCULAR TISSUES. IN VITRO CELL DEV-AN, 28A(11-12), 693-694.
FRANCIS SE, HOLT CM, GADSDON PA, TAYLOR T & ANGELINI GD (1992) ANOTHER CAUTIONARY NOTE ON THE USE OF PCNA. J PATHOL, 166(4), 418-418.
FRANCIS SE, HOLT CM, TAYLOR T, GADSDON P & ANGELINI GD (1992) HEPARIN AND NEOINTIMAL THICKENING IN AN ORGAN-CULTURE OF HUMAN SAPHENOUS-VEIN. ATHEROSCLEROSIS, 93(1-2), 155-156.
Francis SE, Hutchinson FJ, Lyle IG & Jones MN (1992) . Colloids and Surfaces, 62(1-2), 177-184.
Imrie F, Karim SN, Goudie RB, Francis SE, Holt CM, Gadsdon PA, Taylor T, Angelini GD, Friedmann I, Laing RW & Carter N (1992) . The Journal of Pathology, 166(4), 417-420.
Francis SE, Lyle IG & Jones MN (1991) . Biochimica et Biophysica Acta (BBA) - Biomembranes, 1062(2), 117-122.
Hutchinson FJ, Francis SE, Lyle IG & Jones MN (1989) . Biochimica et Biophysica Acta (BBA) - Biomembranes, 987(2), 212-216.
HUTCHINSON FJ, FRANCIS SE & JONES MN (1989) . Biochemical Society Transactions, 17(3), 558-559.
Hutchinson FJ, Francis SE, Lyle IG & Jones MN (1989) . Biochimica et Biophysica Acta (BBA) - Biomembranes, 978(1), 17-24.
Borland SJ, Behnsen J, Ashton N, Francis SE, Brennan K, Sherratt MJ, Withers PJ & Canfield AE () . International Journal of Molecular Sciences, 21(12), 4538-4538.
Shabir O, Pendry B, Heath PR, Rebollar MA, Howarth C, Wharton SB, Berwick J & Francis SE () .
() . PLoS ONE, 9(5), e97392-e97392.
Chamberlain J, Francis S, Brookes Z, Shaw G, Graham D, Alp NJ, Dower S & Crossman DC () . PLoS ONE, 4(4), e5073-e5073.
Violaris A, Francis S, Holt C, Clelland C, Gadsdon P & Angelini G () . International Journal of Angiology, 2(03), 105-111.
Borland SJ, Facchi C, Behnsen J, Adamson A, Humphreys NE, Withers PJ, Sherratt MJ, Francis SE, Brennan K, Ashton N & Canfield AE () .
Gomez D, Baylis R, Durgin B, Newman A, Alencar G, Mahan S, St Hilaire C, Mueller W, Waisman A, Pinteaux E , Randolph G et al () Interleukin-1β promotes an atheroprotective distribution of smooth muscle cells and macrophages in late stage murine atherosclerotic lesions. Nature Medicine.
Shabir O, Pendry B, Lee L, Eyre B, Sharp P, Rebollar MA, Howarth C, Heath PR, Wharton SB, Francis SE & Berwick J () .

Chapters

Francis SE (2006) (pp. 331-340).

Conference proceedings papers

Turton H, West L, Arnold N, Wright C, Francis S, Marriott H, Lawrie A & Thompson R (2023) . 13.01 - Pulmonary hypertension
Lawrie A, Zawia A, West L, Arnold N, Pickworth J, Turton H, Thompson AAR & Francis SE (2023) . A14. THIS IS GETTING COMPLICATED: EPIGENETICS, -OMICS, AND CELL SIGNALING IN PULMONARY HYPERTENSION
Zhou Z, Van-Hateren N, Francis S, Fragiadaki M & Evans P (2021) . Heart, Vol. 107(Suppl 1) (pp a172-a173)
Kocsy K, Kiss-Toth E, Redgrave J, Majid A & Francis S (2021) . Heart, Vol. 107(Suppl 1) (pp a156-a156)
Guagnelli MAR, Wharton S, Francis S & Simpson J (2021) The effect of systemic atherosclerosis on the neurovascular unit. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 21-21)
Lawrie A, Arnold ND, Pickworth JA, West LE, Papworth J, Germaschewski V, Thompson AAR & Francis SE (2020) . A107. BYSTANDERS NO MORE: INFLAMMATION, IMMUNITY AND THROMBOSIS IN PULMONARY VASCULAR AND LUNG DISEASE
Johnston JM, Martinez-Campesino L, Angyal A, Hadadi E, Kraus R, Wilson HL, Bauer R, Rader D, Hamby SE, Goodall AH , Francis SE et al (2019) Myeloid TRIB1 Controls Metabolic Tissue Resident Macrophage Phenotype Associated with Immuno-Metabolic Diseases. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 271-271)
Rebollar MA, Wharton S, Francis S & Simpson J (2019) The effect of systemic atherosclerosis in the neurovascular unit. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 45 (pp 31-31)
Iqbal A, Prince L, Novodvorsky P, Bernjak A, Thomas M, Birch L, Lambert D, Kay L, Wright F, Jacques R , Storey R et al (2018) Acute hypoglycaemia results in increased activation of responses to an inflammatory challenge induced 48 hours later in human subjects. DIABETOLOGIA, Vol. 61 (pp S446-S446)
Kocsy K, Alqurashi R, Johnston JM, Baidzajevas K, Majid A, Wilson HL, Kiss-Toth E, Redgrave J & Francis SE (2018) . Cardiovascular Research, Vol. 114(suppl_2) (pp S5-S6)
Johnston JM, Angyal A, Bauer R, Hamby SE, Suvarna SK, Baidžajevas K, Hegedus Z, Dear NT, Turner M, Wilson HL , Goodall AH et al (2018) . Cardiovascular Research, Vol. 114(suppl_2) (pp S4-S4)
Campesino LM, Johnston JM, Francis SE, Kiss-Toth E & Wilson HL (2018) CONSEQUENCES OF TRIB3 DEFICIENCY ON EXPERIMENTAL ATHEROSCLEROSIS AND MACROPHAGE PHENOTYPE. CARDIOVASCULAR RESEARCH, Vol. 114 (pp S2-S2)
Almansouri M, Francis S & Chamberlain J (2018) . Heart, Vol. 104(Suppl 6) (pp A102-A103), 4 June 2018 - 6 June 2018.
Wright K, Haycock J & Francis S (2018) . Basic Science
Johnston J, Angyal A, Bauer R, Rader D, Shoulders C, Francis S & Kiss-Toth E (2018) . Basic Science
Kocsy K, Wadanamby S, Tang K, Majid A, Redgrave J, Johnston J, Francis S & Kiss-Toth E (2018) . Basic Science
Johnston J, Angyal A, Bauer R, Rader D, Shoulders C, Francis S & Kiss-Toth E (2018) . Atherosclerosis Supplements, Vol. 32 (pp 11-11)
Rothman AM, West L, Srivastava S, Quigley C, Southwood M, Lawrie A, Francis S, Morrell N & Rowlands D (2018) Expression of SMURF1 is Increased in Patients With Pulmonary Arterial Hypertension and SiRNA Inhibition of SMURF1 Reduces Pulmonary Artery Smooth Muscle Cell Proliferation. CIRCULATION, Vol. 138
Arnold ND, Pickworth JA, Carvalho JA, Braithwaite AT, Iremonger J, West L, Casbolt HL, Renshall LJ, Germaschewski V, McCourt M , Evans HR et al (2017) Development of a Novel Human Anti-OPG Antibody That Attenuates Experimental Pulmonary Arterial Hypertension. CIRCULATION, Vol. 136
Iqbal A, Thomas M, Novodvorsky P, Bernjak A, Birch L, Lambert D, Kay L, Wright F, Prince L, Francis S , Storey R et al (2017) Hypoglycaemia increases platelet reactivity and promotes formation of proatherogenic platelet-leucocyte aggregates. DIABETOLOGIA, Vol. 60 (pp S532-S532)
Johnston JM, Angyal A, Hadadi E, Hamby SE, Bauer R, Ilyas Z, Szili D, Ariaans M, Wilson HL, Krauss RM , Rader DJ et al (2017) . Heart, Vol. 103(Suppl 5) (pp A113.2-A113)
Borland S, Borland S, Morgan M, Francis S, Merry C & Canfield A (2017) . Heart, Vol. 103(Suppl 5) (pp A139.2-A140)
Wong L, Sharp P, Howarth C, Hoggard N, Berwick J & Francis S (2016) . Heart, Vol. 102(Suppl 6) (pp A123.2-A124), 6 June 2016 - 8 June 2016.
Bowden N, Feng S, Francis S & Evans P (2016) . Heart, Vol. 102(Suppl 6) (pp A140.1-A140), 6 June 2016 - 8 June 2016.
Johnston J, Kiss-Toth E & Francis SE (2016) . Heart, Vol. 102(Suppl 6) (pp A116.2-A117)
Rothman AMK, Arnold ND, Pickworth JA, Iremonger J, Ciuclan L, Allen R, Guth-Gundel S, Southwood M, Morrell NW, Thomas M , Francis SE et al (2016) . Heart, Vol. 102(Suppl 6) (pp A147-A147)
Alfaidi M, Hughes M, Alizadeh T, Casbolt H, Chamberlain J, Mann BE, Francis SE, Iqbal J & Gunn J (2016) . Heart, Vol. 102(Suppl 6) (pp A114.2-A114), 6 June 2016 - 8 August 2016.
Pickworth J, Shay S, Gladson S, Iremonger J, Rothman AMK, Francis S, West J & Lawrie A (2015) . Thorax, Vol. 70(Suppl 3) (pp A5.3-A6)
Rothman AMK, Arnold ND, Pickworth JA, Iremonger J, Ciuclan L, Allen R, Guth-Gundel S, Southwood M, Morrell NW, Francis SE , Rowlands DJ et al (2015) . Thorax, Vol. 70(Suppl 3) (pp A3.1-A3)
Angyal A, Ilyas Z, Hadadi E, Johnston J, Ariaans M, Kraus R, Wilson H, Bauer R, Rader D, Francis S & Kiss-Toth E (2015) . Atherosclerosis, Vol. 241(1) (pp e34-e34)
Alfaidi M, Schenkel T, Evans P, Chamberlain J & Francis S (2015) . Heart, Vol. 101(Suppl 4) (pp A107.2-A107)
Smith S, Samokhin A, Murphy E, Francis S & Qwarnstrom E (2015) . Heart, Vol. 101(Suppl 4) (pp A118.2-A119)
Johnston J, Angyal A, Alfaidi M, Francis S & Kiss-Toth E (2015) . Heart, Vol. 101(Suppl 4) (pp A104.2-A105)
Bazaz R, Francis S & Dockrell D (2015) . Heart, Vol. 101(Suppl 4) (pp A117.2-A118)
Dawson S, Pickworth J, Rothman A, Iremonger J, Arnold N, Francis S & Lawrie A (2014) . Thorax, Vol. 69(Suppl 2) (pp A2-A3)
Bowden N, Duckles H, Mahmoud M, Hsiao S, Francis SE & Evans PC (2014) . Atherosclerosis, Vol. 237(2) (pp e2-e2)
Murphy E, Samokhin A, Francis S, Bowskill S & Qwarnstrom E (2014) . Heart, Vol. 100(Suppl 3) (pp A104.2-A105)
Arnold N, Dawson S, Pickworth J, Rothman AMK, Iremonger J, Francis S & Lawrie A (2014) Bone Marrow Derived Osteoprotegerin Drives Experimental Pulmonary Arterial Hypertension In The Murine Sugen/hypoxia Model. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
West L, Francis S & Storey R (2013) . Heart, Vol. 99(suppl 2) (pp A7-A7)
Alfaidi M, Wilson H, Burnett A, Chamberlain J & Francis S (2013) . Heart, Vol. 99(suppl 2) (pp A99.2-A99)
Hameed AG, Arnold ND, Chamberlain J, Pickworth JA, Paiva C, Dawson S, Cross S, Long L, Zhao L, Morrell NW , Crossman DC et al (2013) . The Lancet, Vol. 381, Supplement 1 (pp S47 --S47 -)
Hameed AG, Arnold ND, Chamberlain J, Pickworth J, Newman CMH, Crossman DC, Francis SE & Lawrie A (2012) . HEART, Vol. 98 (pp A1-A1)
Pickworth J, Hopkinson K, Francis SE, Kiss-Toth E & Lawrie A (2012) . B26. PULMONARY VASCULAR SIGNALING IN PULMONARY HYPERTENSION
Lawrie A, Hameed AG, Arnold N, Chamberlain J, Pickworth J, Dawson S, Newman CMH & Francis SE (2012) . D97. PULMONARY HYPERTENSION: NEW INSIGHTS INTO CAUSES AND TREATMENTS?
Hameed AG, Arnold ND, Pickworth J, Chamberlain JC, Newman CMH, Crossman DC, Francis SE & Lawrie A (2011) . THORAX, Vol. 66 (pp A3-A3)
Condliffe R, Pickworth J, Hopkinson K, Hameed A, Walker S, Elliot C, Francis S, Newman C, Crossman D, Morton A , Kiely D et al (2011) . Thorax, Vol. 66(Suppl 4) (pp A34-A34)
Ellam T, Wilkie M, Crossman D, Francis S & Chico T (2011) . Heart, Vol. 97(20) (pp e7-e7)
Lawrie A, Hameed AG, Chamberlain J, Arnold N, Crossman DC & Francis SE (2011) . HEART, Vol. 97(20) (pp 10-10)
Hameed AG, Chamberlain J, Arnold N, Newman C, Francis S, Crossman D & Lawrie A (2011) . B61. PULMONARY HYPERTENSION: EXPERIMENTAL MODELS I
Hameed AG, Chamberlain J, Arnold ND, Francis SE, Newman CMH, Crossman DC & Lawrie A (2010) . THORAX, Vol. 65 (pp A68-A68)
Hameed AG, Francis SE, Crossman DC & Lawrie A (2010) . A96. INFLAMMATION AND BONE MARROW DERIVED CELLS IN PULMONARY ARTERIAL HYPERTENSION
Hameed AG, Francis SE, Neilan M, Parmar S, Crossman DC & Lawrie A (2009) . THORAX, Vol. 64 (pp A9-A10)
Condliffe R, Hameed AG, Paiva C, Suntharalingam J, Francis SE, Newman CMH, Crossman DC, Morrell NW & Lawrie A (2009) . THORAX, Vol. 64 (pp A58-A59)
Hameed AG, Vinogradova T, Francis SE, Newman CMH, Crossman DC & Lawrie A (2009) . THORAX, Vol. 64 (pp A8-A8)
Vinogradova T, Hameed AG, Francis SE, Newman CMH, Crossman DC & Lawrie A (2009) . THORAX, Vol. 64 (pp A9-A9)
Paiva C, Francis SE, Newman CMH, Crossman DC & Lawrie A (2009) . THORAX, Vol. 64 (pp A9-A9)
Docherty LM, Angyal A, Francis S & Kiss-Toth E (2009) . HEART, Vol. 95(22)
Hameed AG, Francis SE, Neilan M, Parmar S, Crossman DC & Lawrie A (2009) Fat Fed ApoE/IL-1R1 Double Deficient Mice Are Protected From Atherosclerosis but Develop Severe Pulmonary Hypertension. CIRCULATION, Vol. 120(18) (pp S751-S751)
Watt V, Soon E, Suntharalingam J, Paiva C, Hameed AG, Francis SE, Newman CM, Crossman DC, Morrell NW & Lawrie A (2009) OPG:TRAIL Ratio as a Potential Biomarker for Pulmonary Arterial Hypertension. CIRCULATION, Vol. 120(18) (pp S806-S806)
Francis S, Chamberlain J, Brookes Z, Shaw G, Alp N, Rogus J, Kornman K & Crossman D (2009) IL-1 MODULATES BLOOD PRESSURE IN MICE AND MAN. ATHEROSCLEROSIS SUPPLEMENTS, Vol. 10(2)
Francis S, Chamberlain J, Brookes Z, Shaw G, Alp N, Rogus J, Kornman K & Crossman D (2009) IL-1 MODULATES BLOOD PRESSURE IN MICE AND MAN. ATHEROSCLEROSIS SUPPLEMENTS, Vol. 10(2). Boston, MA, 14 June 2009 - 18 June 2009.
Chamberlain J, Wheatcroft M, Arnold N, Francis S, Lupton H & Gunn J (2009) A NOVEL MURINE MODEL OF STENTING. HEART, Vol. 95 (pp A37-A38)
Lawrie A, Paiva C, Southwood M, Suntharalingam J, Francis SE, Crossman DC, Morrell NW & Newman CMH (2008) THE OSTEOPROTEGERIN-TNF-RELATED APOPTOSIS-INDUCING LIGAND AXIS IN PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 63 (pp A28-A28)
Guan H, Eder K, Sung HY, Sheridan PJ, Ward J, Morton A, Angyal A, Sarmay G, Duda E, Turner M , Dower SK et al (2008) Low-density lipoprotein controls IL-8 production in monocytes via tribbles-2. HEART, Vol. 94 (pp A44-A44)
Al-Malki A, Francis S & El-Ghariani K (2008) Leucodepletion filters do not eliminate circulating endothelial cells (CECs) in human whole blood donations. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 141 (pp 113-113)
Evans DJW, Crosdale DJ, Judge HM, Chamberlain J, Jetha K, Norman KE, Francis SE & Storey RF (2008) The platelet P2Y12 receptor influences the vessel wall response to arterial injury and thrombosis. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 51(10) (pp A291-A291)
Lawrie A, Southwood M, Suntharalingam J, Francis SE, Crossman DC, Morrell NW, Morrell NW & Newman CM (2007) A potential role for TRAIL in the pathogenesis of pulmonary arterial hypertension. CIRCULATION, Vol. 116(16) (pp 59-59)
Watt V, Francis S & Crossman DC (2007) . Atherosclerosis, Vol. 193(2) (pp S5-S5)
Lawrie A, Suntharalingham J, Southwood M, Francis S, Crossman D, Morrell N & Newman C (2007) A potential role for osteoprotegerin in idiopathic pulmonary arterial hypertension. HEART, Vol. 93 (pp A23-A24)
Ward JR, Francis SE, Marsden LL, Dower SK, Crossman DC & Sabroe I (2007) Bidirectional signalling between monocytes and endothelial cells regulate responses to TLR4 agonists in coculture models of vascular inflammation. JOURNAL OF LEUKOCYTE BIOLOGY (pp 51-51)
Lawrie A, Evans DJW, Waterman EA, Francis SE, Crossman DC & Newman CMH (2006) . Vascular Pharmacology, Vol. 45(3) (pp e106-e106)
Watt V, Ray KK, Francis SE & Crossman DC (2006) Interaction between tumour necrosis factor-related apoptosis inducing ligand & osteoprotegerin in acute coronary syndromes. EUROPEAN HEART JOURNAL, Vol. 27 (pp 229-229)
Morton AC, Francis SE, Arnold ND, Gunn J, Dower S & Crossman D (2006) The effect of Interleukin-1 receptor antagonist on restenosis - continued suppression of neointima at 90 days. EUROPEAN HEART JOURNAL, Vol. 27 (pp 230-231)
Evans D, Crosdale DJ, Norman KE, Francis SE & Storey RF (2006) The P2Y12 receptor regulates the vessel wall response to arterial injury and thrombosis. EUROPEAN HEART JOURNAL, Vol. 27 (pp 753-753)
Evans D, Crosdale D, Norman K, Francis S & Storey R (2006) The P2Y12 receptor regulates the vessel wall response to arterial injury and thrombosis. HEART, Vol. 92 (pp A111-A111)
Watt V, Ray KK, Francis SE, Whyte MK & Crossman DC (2006) Soluble tumour necrosis factor-related apoptosis inducing ligand is low early in the presentation of acute coronary syndromes and is inversely correlated with C-reactive protein and troponin T. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 47(4) (pp 194A-194A)
Wheatcroft M, Lupton H, Arnold N, Francis S & Gunn J (2005) A new murine model of arterial stenting. HEART, Vol. 91 (pp A51-A51)
Sung HY, Francis S, Crossman DC & Kiss-Toth E (2005) Tribbles-1, a mitogen activated protein kinase (MAPK) scaffold regulates inflammation in vascular smooth muscle cells (VSMC) and atherosclerosis. HEART, Vol. 91 (pp A15-A15)
Varcoe RW, Stokes L, Francis SE, Dower S, Surprenant A & Crossman DC (2005) Investigation of P2X7 dependent mechanisms of interleukin-1 beta (IL-1 beta) release from human endothelial cells. HEART, Vol. 91 (pp A13-A13)
Akowuah E, Gray C, Sheridon P, Bettinger T, Res B, Brisken A, Gunn J, Crossman D, Francis S, Baker A & Newman C (2004) Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model. CIRCULATION, Vol. 110(17) (pp 161-161)
Morton AC, Varcoe R, Francis SE, Dower S, Arnold ND, Gunn J & Crossman DC (2004) Interleukin-1 receptor antagonist (IL-1ra) modulates the porcine coronary arterial response to stenting. ATHEROSCLEROSIS, Vol. 174(1) (pp S4-S4)
Morton AC, Varcoe R, Francis SE, Dower S, Arnold ND, Gunn J & Crossman DC (2004) Interleukin 1 receptor antagonist (IL 1ra) modulates the response to oversized balloon angioplasty and stenting in a porcine coronary artery model. HEART, Vol. 90 (pp A1-A2)
Morton AC, Francis SE, Dower S, Arnold ND, Gunn J & Crossman DC (2003) Interleukin-1 receptor antagonist (IL-1ra) modulates the porcine coronary arterial response to oversized balloon angioplasty and stenting. CIRCULATION, Vol. 108(17) (pp 195-195)
Akowuah E, Gray C, Francis S, Gunn J, Bettinger T, Brisken A, Crossman D & Newman C (2003) Adjunctive ultrasound exposure enhances gene delivery to vascular smooth muscle cells in vitro and to ex vivo and in vivo porcine saphenous vein grafts. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 92(6A) (pp 100L-100L)
Ray KK, Francis SE & Crossman DC (2003) IL-1 RN (VNTR) gene polymorphism predicts clinical events up to 1 year after a non-ST-elevation acute coronary syndrome: An association independent of troponin T and C-reactive protein. EUROPEAN HEART JOURNAL, Vol. 24 (pp 70-70)
Ray KK, Francis SE & Crossman DC (2002) IL-1RN (VNTR) gene polymorphism predicts a proinflammatory endothelial cell phenotype in HUVEC-Implications for atherogenesis and plaque rupture. EUROPEAN HEART JOURNAL, Vol. 23 (pp 594-594)
Townsend CF, Francis SE, Chamberlain J, Gunn J, Crossman DC & Newman CMH (2001) Modulation of MSS1, a component of the 26S proteasome, in vascular smooth muscle cells in vitro and following experimental PTCA. EUR HEART J, Vol. 22 (pp 3-3)
Lawrie A, Brisken AF, Francis SE, Crossman DC, Cumberland D & Newman CM (1999) Ultrasound-enhanced reporter gene expression following naked DNA transfection is markedly enhanced by the presence of microbubble contrast agents.. AM J CARDIOL, Vol. 84(6A) (pp 64P-65P)
Chamberlain J, Gunn J, Francis SE, Holt CM, Cumberland DC & Crossman DC (1998) IL-1 beta synthesis and neovascularisation following porcine coronary arterial injury. J VASC RES, Vol. 35(5) (pp 389-389)
Lawrie A, Brisken AF, Francis SE, Tayler DI, Crossman DC, Cumberland DC & Newman CM (1998) . Journal of the American College of Cardiology, Vol. 31 (pp 25-25)
Gunn J, Francis S, Holt C, Chamberlain J, Lambert D, Newman C, Crossman D & Cumberland D (1997) Is local drug delivery truly a low efficiency procedure?. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 80 (pp TC240-TC240)
FRANCIS SE & JONES MN (1990) . Biochemical Society Transactions, Vol. 18(5) (pp 876-877)
Dawson S, Arnold N, Pickworth J, Francis S & Lawrie A () . Diseases, Vol. 2(3) (pp 260-273)
Alfaidi MAA, Wilson H, Ridger, V, Chamberlain J & Francis S () Neutrophil elastase enhances IL-1 beta secretion from coronary endothelium via an endolysosomal mediated mechanism, without caspase-1 activation. ANGIOGENESIS, Vol. 17(4) (pp 941-941). California, USA, 18 October 2014 - 23 October 2014.

Preprints

Kocsy K, Deshmukh S, Nawaz S, Ali AN, Baig S, Balami JS, Majid A, Kiss-Toth E, Francis S & Redgrave J (2024) , Cold Spring Harbor Laboratory.
Gustschin A, Riedel M, Taphorn K, Petrich C, Gottwald W, Noichl W, Busse M, Francis SE, Beckmann F, Hammel JU , Moosmann J et al (2021) High resolution and sensitivity bi-directional x-ray phase contrast imaging using 2D Talbot array illuminators, arXiv.
Bazaz R, Marriott H, Wright C, Chamberlain J, West L, Gelsthorpe C, Heath P, Maleki-Dizaji A, Francis S & Dockrell D () , Research Square Platform LLC.
Souilhol C, Li X, Canham L, Roddie H, Pirri D, Ayllon BT, Chambers EV, Dunning MJ, Ariaans M, Li J , Fang Y et al () , Cold Spring Harbor Laboratory.
Low EL, Schwartze JT, Kurkiewicz A, Pek M, Kelly DJ, Shaw AS, Thorikay M, McClure J, McBride M, Arias-Rivas S , Francis SE et al () , Cold Spring Harbor Laboratory.
Shabir O, Sharp P, Rebollar MA, Boorman L, Howarth C, Wharton SB, Francis SE & Berwick J () .
Johnston JM, Angyal A, Bauer RC, Hamby S, Suvarna SK, Baidžajevas K, Hegedus Z, Dear TN, Turner M, Wilson HL , Goodall AH et al () , Cold Spring Harbor Laboratory.
Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M, Luong LA, West L , Long M et al () .

Research group

Dr Osman Shabir
Dr Aya Elwazir
Mr Kieran Bowden
Miss Pooja Atul Patel
Dr Janet Chamberlain
Mr David Reid (with the Paul Evans group)
Ms Priscila Hirschfield (with the Paul Evans group)
Mr Oliver Heaney ( with the Shaw group)
Mr Rahul Sidhu ( with the Howarth/Berwick group)

Teaching interests

I am a Senior Fellow of the Higher Education Academy. I teach the MSc in Molecular Medicine, where I lead Molecular Genetics of Human Diseases (MED6003). I also teach phase 2a (Cardiology) MBChB.

I co-founded an undergraduate BMS 3rd year module ‘Cardiovascular Pharmacology – personalising medicine’ now led by Dr Janet Chamberlain and Dr Nigel Wheeldon.

Professional activities and memberships

Secretary of the (September 2018 - September 2023)
European Atherosclerosis Society Distinguished Awards and Prizes Committee (2022 - present)
Fellowships Committee, British Heart Foundation (July 2020 - present)
Academy of Medical Sciences, Springboard Awards Committee (November 2022 - present)