Professor Nick Bishop
Clinical Medicine, School of Medicine and Population Health
Chair in Paediatric Bone Disease
Full contact details
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
91直播
S10 2RX
- Profile
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For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
The UK's only Professor of Paediatric Bone Disease.
Trained in Manchester (clinical), Cambridge (MRC and Wellcome Fellowships) and Montreal (visiting Professor at McGill). Appointed to Chair in 91直播 in 1998.
Clinical research group focuses on the treatment of childhood bone fragility and rare bone diseases; basic science group on early life events and skeletal development, as well as the pathophysiology of childhood bone diseases.
- Research interests
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Our research aims to improve outcomes for children with inherited and acquired bone diseases and understand better the factors contributing to fracture in apparently healthy children.
We are working with colleagues locally and nationally to determine the phenotype-genotype relationships in early onset bone fragility disorders, and to develop a pipeline to bring forward new therapies in these disorders.
Our previous clinical studies of the use of bisphosphonates in osteogenesis imperfecta (OI) showed that bone mass increases in a dose-responsive manner in moderate-severely affected children without a clear reduction in fracture risk; and that mildly affected children can reduce fracture risk by approximately 50% when taking the oral bisphosphonate risedronate. We recruited the first UK patient to the Amgen-funded study of Denosumab in OI. We participated in the global studies of asfotase alfa, a recombinant enzyme replacement therapy for hypophosphatasia (HPP), leading in Europe initially with children travelling from other EU countries to participate.
We have developed a new biomarker to assess the acute skeletal response to mechanical stimulation that is now being used in prospective studies of children with fracture and OI.
In collaboration with colleagues nationally, we are assessing the effects of antenatal vitamin D supplementation on skeletal development and health; we have developed a model system of antenatal vitamin D depletion in which we are assessing the postnatal response to mechanical loading.
Internationally, we are developing the European Reference Network for Rare Bone Diseases that will deliver improved health care outcomes for patients with skeletal disorders such as OI and HPP, translating our research into clinical practice.
Principal funding sources:
- MRC
- NIHR
- Arthritis Research Campaign
- Sir Halley Stewart Trust
- Amgen
- Alexion Pharma
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . The Lancet Child & Adolescent Health.
- Maternal pregnancy vitamin D supplementation increases offspring bone formation in response to mechanical loading : findings from a MAVIDOS trial sub-study. Journal of Musculoskeletal Neuronal Interactions, 20(1), 4-11.
- . EClinicalMedicine, 12, 79-87.
- . Lancet Diabetes and Endocrinology, 7(2), 93-105.
- . PLoS ONE, 13(1), ---.
- . Journal of Bone and Mineral Research, 32(1), 172-180.
- . The Lancet Diabetes & Endocrinology, 4(5), 393-402.
- Acute bone response to whole body vibration in healthy pre-pubertal boys. Journal of Musculoskeletal Neuronal Interactions, 15(2), 112-122.
- . Journal of Clinical Densitometry.
- . Lancet, 382(9902), 1424-1432.
- Enzyme-replacement therapy in life-threatening hypophosphatasia. New England Journal of Medicine, 366(10), 904-913.
- . J BONE MINER RES, 21(9), 1489-1495.
- . New England Journal of Medicine, 339(14), 947-952.
- . New England Journal of Medicine, 336(22), 1557-1562.
All publications
Journal articles
- . The American Journal of Clinical Nutrition, 120(5), 1134-1142.
- . Bone Reports, 22.
- . Archives of Disease in Childhood, 109(3), 256-257.
- A focus on fractures: Understanding and addressing fracture risk in rare bone disorders. JBMR PLUS, 7.
- . Child Abuse & Neglect, 131.
- . JBMR Plus.
- . Genes & Nutrition, 17(1).
- . Archives of Disease in Childhood.
- . Bone Reports, 15.
- . Archives of Disease in Childhood.
- . Proceedings of the Nutrition Society, 80(OCE5).
- . Bone.
- . Journal of Medical Genetics.
- . The Lancet Child & Adolescent Health.
- . WSEAS Transactions on Biology and Biomedicine, 17, 39-47.
- . Rheumatology, 59(Supplement_2).
- . Osteoporosis International, 31(8), 1445-1460.
- Maternal pregnancy vitamin D supplementation increases offspring bone formation in response to mechanical loading : findings from a MAVIDOS trial sub-study. Journal of Musculoskeletal Neuronal Interactions, 20(1), 4-11.
- . Journal of Bone and Mineral Research.
- . QJM: An International Journal of Medicine, 112(9), 724-729.
- . Journal of Pediatric Endocrinology and Metabolism, 32(8), 907-909.
- . EClinicalMedicine, 12, 79-87.
- . The Journal of Clinical Endocrinology & Metabolism, 104(7), 2735-2747.
- . Journal of the Endocrine Society, 3(Supplement_1).
- . Rheumatology, 58(Supplement_3).
- . Journal of Bone and Mineral Research, 34(2), 231-240.
- . Lancet Diabetes and Endocrinology, 7(2), 93-105.
- . Nutrients, 11(1).
- . JBMR Plus, 2(S2), S1-S14.
- . Pediatric Radiology.
- . Early Human Development, 126, 32-37.
- . Clinical Endocrinology.
- . American Journal of Medical Genetics Part A, 176(7), 1578-1586.
- . Bone Reports, 8, 156-162.
- . Rheumatology, 57(suppl_3).
- . Archives of Disease in Childhood, 103(8), 767-771.
- . Journal of Medical Genetics, 55(3), 158-165.
- . European Spine Journal, 27(9), 2079-2084.
- . PLoS ONE, 13(1), ---.
- . The Journal of Clinical Endocrinology & Metabolism, 102(11), 4262-4263.
- . J Clin Endocrinol Metab, 102(0), 2941-2949.
- . Molecular Genetics and Metabolism, 122(1-2), 4-17.
- . Nephrology Dialysis Transplantation, 32(7), 1098-1113.
- . The Journal of Clinical Endocrinology & Metabolism.
- . European Radiology, 27(5), 2188-2199.
- . Journal of Multidisciplinary Healthcare, 10, 145-155.
- . Rheumatology, 56(suppl_2).
- . Osteoporosis International, 28(1), 77-84.
- . BONE, 94, 65-74.
- . Journal of Bone and Mineral Research, 32(1), 172-180.
- . Journal of Clinical Endocrinology and Metabolism, 101(12), 5012-5020.
- . Orphanet Journal of Rare Diseases, 11(1).
- . Am J Med Genet A.
- . Am J Med Genet A.
- . Osteoporosis International, 27(7), 2367-2372.
- . Osteoporosis International, 27(9), 2889-2889.
- . Archives of Disease in Childhood, 101(6).
- . The Lancet Diabetes & Endocrinology, 4(5), 393-402.
- . Arch Dis Child Educ Pract Ed, 101, 268-270.
- . Journal of Bone and Mineral Research, 31(4), 699-708.
- . Journal of Bone and Mineral Research, 31(7), 1449-1454.
- . Ultrastructural Pathology, 40(2), 71-76.
- . The Journal of Clinical Endocrinology & Metabolism, 101(1), 334-342.
- . American Journal of Medical Genetics Part A, 170(2), 476-481.
- . Archives of disease in childhood - Education & practice edition, 101(1), 2-7.
- Acute bone response to whole body vibration in healthy pre-pubertal boys. Journal of Musculoskeletal Neuronal Interactions, 15(2), 112-122.
- . The Journal of Clinical Endocrinology & Metabolism, 100(2), 594-602.
- . American Journal of Medical Genetics Part A, 167(3), 587-591.
- . Clinical Dysmorphology, 24(2), 45-54.
- . Bone, 72, 53-64.
- . Health Technol Assess, 18(45), 1-190.
- . Annals of Medicine and Surgery, 3(2), 49-50.
- . Journal of Clinical Investigation, 124(2), 476-477.
- . Lancet, 383(9929), 1665-1676.
- . Journal of Clinical Densitometry.
- . Lancet, 382(9902), 1424-1432.
- . Clin Dysmorphol, 22(3), 93-101.
- . Annals of Paediatric Rheumatology, 2(1), 56-56.
- . BMJ, 346, f964.
- , 655-677.
- . Proceedings of the 2012 8th International Symposium on Communication Systems, Networks and Digital Signal Processing, CSNDSP 2012.
- . BMJ, 345, e8182.
- . British Journal of Neurosurgery, 26(4), 487-489.
- . Trials, 13.
- Enzyme-replacement therapy in life-threatening hypophosphatasia. New England Journal of Medicine, 366(10), 904-913.
- . Bone, 50(2), 457-466.
- . J Clin Densitom, 14(4), 440-446.
- . Am J Med Genet A, 155A(6), 1414-1418.
- TREATMENT OF HYPOPHOSPHATASIA (HPP) IN INFANTS AND YOUNG CHILDREN WITH SUBCUTANEOUS ENZYME REPLACEMENT THERAPY, ENB-0040: SKELETAL RADIOGRAPHIC OUTCOMES AT 6 AND 12 MONTHS. JOURNAL OF INHERITED METABOLIC DISEASE, 34, S222-S222.
- . Paediatrics and Child Health, 21(12), 569-570.
- . Bone, 48(2), 189-196.
- . J Bone Miner Res, 26(4), 894-898.
- . Early Hum Dev, 86(11), 743-746.
- . Bone, 47(5), 989-994.
- . Bone, 47, S222-S222.
- . Paediatrics and Child Health, 20(5), 225-231.
- . J Bone Miner Res, 25(1), 32-40.
- . J BONE MINER RES, 25(3), 527-536.
- . PEDIATR NEPHROL, 25(1), 37-47.
- , 151-158.
- , 264-267.
- . PEDIATRICS, 124(6), 1709-1709.
- . PEDIATRICS, 124(5), 1372-1379.
- . BONE, 45, S50-S51.
- . Arch Pediatr, 16(6), 596.
- . Endocr Dev, 16, 157-169.
- Adipokines may modify osteoblast Wnt signalling through Dickkopf-1, and promote osteoclastogenesis by altering RANK-ligand and osteoprotegerin signalling in obese children. HORM RES, 72, 220-221.
- . BONE, 43(6), 1115-1121.
- . Calcif Tissue Int, 83(4), 285-292.
- . OSTEOPOROSIS INT, 19(10), 1369-1378.
- Special report on the 2007 pediatric Position Development Conference of the International Society for Clinical Densitometry. SOUTH MED J, 101(7), 740-743.
- . Arch Dis Child, 93(5), 398-400.
- . Mol Genet Metab, 93(3), 347-349.
- . Biochem Biophys Res Commun, 365(4), 840-845.
- Intravenous zoledronic acid (ZOL) compared to IV pamidronate (PAM) in children with severe osteogenesis imperfecta (OI). CALCIFIED TISSUE INTERNATIONAL, 82, S85-S85.
- . American Journal of Medical Genetics, Part A, 146(2), 182-190.
- . J Clin Densitom, 11(1), 29-42.
- . NAT GENET, 39(8), 960-962.
- . J BONE MINER RES, 22(8), 1314-1314.
- . Paediatrics and Child Health, 17(7), 279-287.
- . Arch Dis Child, 92(3), 251-256.
- . Current Opinion in Orthopaedics, 18(5), 486-493.
- . Bone, 39(3), 652-657.
- . J BONE MINER RES, 21(9), 1489-1495.
- . Hum Mutat, 27(7), 716.
- . Arch Dis Child, 91(7), 549-550.
- . J MED GENET, 43(4), 315-325.
- , 459-467.
- Treatment modalities in paediatric bone disease. HORMONE RESEARCH, 65, 6-6.
- Osteogenesis imperfecta. BONE, 36, S14-S14.
- . ARCH DIS CHILD, 90(5), 494-499.
- . Dev Med Child Neurol, 47(4), 220.
- , 1, 803-810.
- . Medicine, 33(12), 67-69.
- . J BONE MINER RES, 19(12), 1976-1981.
- . Am J Clin Nutr, 80(6 Suppl), 1748S-1751S.
- . OSTEOPOROSIS INT, 15(10), 785-791.
- . Bone, 35(2), 471-478.
- . Bone, 34(3), 539-546.
- . Clinical Reviews in Bone and Mineral Metabolism, 2(1), 19-35.
- . Clinical Reviews in Bone and Mineral Metabolism, 2(1), 19-35.
- VITAMIN D DURING PREGNANCY AND GROWTH IN EARLY INFANCY. CALCIFIED TISSUE INT, 74, S111-S111.
- WHAT CAUSES RECURRENT FRACTURES IN CHILDHOOD?. CALCIFIED TISSUE INT, 74, S110-S111.
- Children and the risk of fractures caused by oral corticosteroids. J BONE MINER RES, 18(5), 913-918.
- . Lancet, 362(9393), 1389-1400.
- The burden of musculoskeletal conditions at the start of the new millennium. World Health Organization - Technical Report Series(919).
- . Current Paediatrics, 13(2), 151-157.
- Skeletal health during childhood and adolescence. Duodecim; l盲盲ketieteellinen aikakauskirja, 118(12).
- Clinical aspects of collagen disorders. J BONE MINER RES, 17(7), 1319-1319.
- . J Bone Miner Res, 17(6), 1073-1080.
- Clinical management of childhood osteoporosis.. Int J Clin Pract, 56(4), 280-286.
- Proliferative effects of growth factors on osteoprogenitor cells isolated from skeletal muscle. BONE, 30(3), 11S-11S.
- . Current Paediatrics, 12(2), 125-129.
- Mutation detection in Osteogenesis Imperfecta patients. JOURNAL OF MEDICAL GENETICS, 38, S67-S67.
- The use of inhaled corticosteroids is not associated with an increased risk of fracture in children.. J BONE MINER RES, 16, S174-S174.
- Neonatal factors predicting childhood height in preterm infants: Evidence for a persisting effect of early metabolic bone disease?. J PEDIATR, 137(5), 668-673.
- . Journal of Bone and Mineral Research, 15(9), 1650-1658.
- . European Journal of Gastroenterology & Hepatology, 12(8), 931-935.
- Peripheral blood as an alternative source of mesenchymal stem cells.. JOURNAL OF BONE AND MINERAL RESEARCH, 15(6), 1239-1239.
- Osteogenesis imperfecta in the differential diagnosis of child abuse. OSTEOPOROSIS INT, 11, S16-S17.
- . Journal of Clinical Endocrinology and Metabolism, 85(5), 1846-1850.
- . Clinical Science, 97(2), 157-157.
- . Nature Medicine, 5(5), 466-466.
- . Journal of Anatomy, 194(4), 519-524.
- Bone mineralization and turnover in preterm infants at 8-12 years of age: The effect of early diet. J BONE MINER RES, 14(5), 810-820.
- Osteogenesis imperfecta calls for caution. NAT MED, 5(5), 466-466.
- . New England Journal of Medicine, 341(8), 602-604.
- . Seminars in Neonatology, 3(2), 143-147.
- . New England Journal of Medicine, 339(14), 947-952.
- . Bone, 23(2), 95-102.
- . Inflammatory Bowel Diseases, 4(4), 261-267.
- . The Journal of Pediatrics, 131(4), 592-597.
- . New England Journal of Medicine, 337(15), 1090-1091.
- . Acta Paediatrica, 86(6), 564-569.
- . British Journal of Haematology, 97(4), 734-736.
- . New England Journal of Medicine, 336(22), 1557-1562.
- . Journal of Infection, 34(1), 75-78.
- . Archives of Disease in Childhood - Fetal and Neonatal Edition, 75(1), F46-F48.
- . The American Journal of Clinical Nutrition, 64(2), 142-151.
- . Acta Paediatrica, 85(2), 230-236.
- . European Journal of Pediatrics, 154(6), 483-487.
- . Acta Paediatrica, 84(4), 383-387.
- . Archives of Disease in Childhood, 72(2), 177-179.
- . The Analyst, 120(3), 705-705.
- Erratum: Osteoporosis in severe congenital neutropenia treated with granulocyte colony-stimulating factor (British Journal of Haematology, 89, (1995) 927-928). British Journal of Haematology, 90(2), 492.
- . Pediatric Nephrology, 8(4), 494-498.
- . Food and Chemical Toxicology, 32(8), 697-705.
- . Archives of Disease in Childhood, 68(5 Spec No), 573-578.
- . Acta Paediatrica, 81(6-7), 463-468.
- Reference values for radial bone width and mineral content using single photon absorptiometry in healthy children aged 4 to 10 years.. Acta paediatrica (Oslo, Norway : 1992), 81(6-7), 463-468.
- . Archives of Disease in Childhood, 67(3), 324-327.
- . Bone and Mineral, 12(1), 57-65.
- . Archives of Disease in Childhood, 65(7 Spec No), 707-708.
- . Archives of Disease in Childhood, 65(7 Spec No), 705-706.
- . The Lancet, 333(8637), 565-565.
- . The Lancet, 333(8636), 490-490.
- . Archives of Disease in Childhood, 64(7 Spec No), 902-909.
- . Archives of Disease in Childhood, 64(10 Spec No), 1384-1385.
- . Archives of Disease in Childhood, 64(9), 1316-1317.
- . International Journal of Cardiology, 19(3), 341-354.
- . The Lancet, 327(8473), 157-157.
- . Calcified Tissue International.
- . Endocrine Abstracts.
- . Journal of Public Health.
- . Bone Abstracts.
- . Bone Abstracts.
- . Bone Abstracts.
- . Bone Abstracts.
- . Bone Abstracts.
- . Rheumatology.
- . Bone Abstracts.
- . Bone Abstracts.
- . Bone Abstracts.
- . Bone Abstracts.
- . Bone Abstracts.
- . Bone Abstracts.
- . Clinical Cases in Mineral and Bone Metabolism.
- , 162-175.
- . Endocrine Abstracts.
- . Malaysian Journal of Fundamental and Applied Sciences, 9(3).
- . British Journal of Haematology, 89(4), 927-928.
- . Pediatric Radiology.
- . JBMR Plus.
Chapters
- , Encyclopedia of Endocrine Diseases (pp. 355-365). Elsevier
- , Diagnosis of Non-Accidental Injury: Illustrated Clinical Cases (pp. 255-256).
- , Diagnosis of Non-Accidental Injury: Illustrated Clinical Cases (pp. 259-260).
- , Diagnosis of Non-Accidental Injury: Illustrated Clinical Cases (pp. 159-160).
- , Diagnosis of Non-Accidental Injury: Illustrated Clinical Cases (pp. 19-22).
- , Osteogenesis Imperfecta (pp. 495-500). Elsevier
- , Osteogenesis Imperfecta: A Translational Approach to Brittle Bone Disease (pp. 495-500).
- , Rennie & Roberton's Textbook of Neonatology (pp. ix-xv). Elsevier
- , Pediatric Bone (pp. xi-xiii). Elsevier
- , Pediatric Bone: Biology and Diseases (pp. 655-677).
- , Bone and Development (pp. 215-231). Springer London
- , Vitamin D (pp. 803-810). Elsevier
- , Pediatric Bone: Biology & Diseases (pp. 567-581).
- CRC Press
- , Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism (pp. 249-263). John Wiley & Sons, Inc.
- , Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism (pp. 468-472). John Wiley & Sons, Inc.
- , Bone Densitometry in Growing Patients (pp. 173-178). Humana Press
Conference proceedings papers
- Orbit: A Randomized, Double-Blind, Placebo-controlled, Phase 2/3 Study to Assess the Efficacy and Safety of Setrusumab in Pediatric and Young Adult Participants with Osteogenesis Imperfecta. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 38 (pp 325-325)
- Orbit: A Randomized Phase 2/3 Study Consisting of a Phase 2 Single-Blind, Dose-Evaluation Phase and a Phase 3, Double-Blind, Placebo-controlled Phase to Assess the Efficacy and Safety of Setrusumab in Subjects with Osteogenesis Imperfecta. HORMONE RESEARCH IN PAEDIATRICS, Vol. 96(SUPPL 2) (pp 67-68)
- VITAMIN D SUPPLEMENTATION IN PREGNANCY RESULTS IN GREATER OFFSPRING BONE MASS AT 4 YEARS: FINDINGS FROM THE MAVIDOS TRIAL. OSTEOPOROSIS INTERNATIONAL, Vol. 31(SUPPL 1) (pp S50-S50)
- PREGNANCY VITAMIN D SUPPLEMENTATION LEADS TO GREATER OFFSPRING BONE MINERAL DENSITY AT 4 YEARS: THE MAVIDOS RANDOMISED PLACEBO CONTROLLED TRIAL. RHEUMATOLOGY, Vol. 59
- EFFECT OF HIGH DOSE VITAMIN D AND WHOLE BODY VIBRATION ON BONE DENSITY OF THE DISTAL TIBIA AS MEASURED BY HR-PQCT, SERUM 25(OH)D AND PTH. OSTEOPOROSIS INTERNATIONAL, Vol. 31(SUPPL 1) (pp S443-S444)
- . Bone Abstracts, Vol. 7. Salzburg, Austria, 22 June 2019 - 25 June 2019.
- BONE TURNOVER IN PREGNANCY, MEASURED BY URINARY C-TERMINAL TELOPEPTIDE OF TYPE I COLLAGEN (CTX), IS INFLUENCED BY VITAMIN D SUPPLEMENTATION AND IS ASSOCIATED WITH MATERNAL BONE HEALTH: FINDINGS FROM THE MAVIDOS TRIAL. RHEUMATOLOGY, Vol. 58
- Maternal pregnancy vitamin D supplementation is associated with greater offspring bone mineral density at 4 years: findings from the MAVIDOS trial. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 34 (pp 68-68)
- VITAMIN D SUPPLEMENTATION IN PREGNANCY LEADS TO ALTERED PERINATAL RXRA DNA METHYLATION: FINDINGS FROM THE MAVIDOS TRIAL. OSTEOPOROSIS INTERNATIONAL, Vol. 29 (pp 628-628)
- URINE C-TERMINAL TELOPEPTIDE OF TYPE I COLLAGEN (CTX) IN PREGNANCY IS INFLUENCED BY VITAMIN D SUPPLEMENTATION AND IS ASSOCIATED WITH MATERNAL BONE HEALTH: FINDINGS FROM THE MAVIDOS TRIAL. OSTEOPOROSIS INTERNATIONAL, Vol. 29 (pp 606-606)
- Natural history of maternal urinary beta-C-terminal telopeptide of type I collagen (CTX) in pregnancy, and response to cholecalciferol supplementation: findings from the MAVIDOS trial. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 33 (pp 109-109)
- Dynamics of Vitamin D Metabolism in the Maternal-Fetal Dyad in Response to Vitamin D Supplementation. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 33 (pp 356-356)
- PLASMA CTX IN PREGNANCY IS ALTERED BY CHOLECALCIFEROL SUPPLEMENTATION AND IS ASSOCIATED WITH MATERNAL BONE INDICES: THE MAVIDOS TRIAL. OSTEOPOROSIS INTERNATIONAL, Vol. 29 (pp S70-S71)
- OSTEOGENESIS IMPERFECTA: PATHOPHYSIOLOGY AND TREATMENT IN CHILDHOOD. RHEUMATOLOGY, Vol. 57
- Hypophosphatasia: Disease and Treatment. HORMONE RESEARCH IN PAEDIATRICS, Vol. 90 (pp 9-9)
- The response to antenatal cholecalciferol supplementation is associated with common vitamin D related genetic variants: findings from the MAVIDOS trial.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 32 (pp S208-S208)
- Maternal gestational vitamin D supplementation alters perinatal RXRA DNA methylation: findings from the MAVIDOS trial.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 32 (pp S61-S61)
- . Bone Abstracts, Vol. 6, 10 June 2017 - 13 June 2017.
- . Bone Abstracts, Vol. 6(2017). Bristol, UK, 10 June 2017 - 13 June 2017.
- DNA METHYLATION AT THE RXRA PROMOTER AT BIRTH IS ASSOCIATED WITH GESTATIONAL VITAMIN D SUPPLEMENTATION: RESULTS FROM THE MAVIDOS TRIAL. OSTEOPOROSIS INTERNATIONAL, Vol. 28 (pp S72-S73)
- 25-HYDROXYVITAMIN D RESPONSE TO GESTATIONAL CHOLECALCIFEROL SUPPLEMENTATION IS ASSOCIATED WITH COMMON VITAMIN D RELATED GENETIC VARIANTS: FINDINGS FROM THE MAVIDOS TRIAL. OSTEOPOROSIS INTERNATIONAL, Vol. 28 (pp S70-S71)
- . Archives of Disease in Childhood, Vol. 102(Suppl 1) (pp a29-a29), 24 May 2017 - 26 May 2017.
- 25-HYDROXYVITAMIN D RESPONSE TO GESTATIONAL CHOLECALCIFEROL SUPPLEMENTATION IS ASSOCIATED WITH COMMON VITAMIN D RELATED GENETIC VARIANTS: FINDINGS FROM THE MAVIDOS TRIAL. RHEUMATOLOGY, Vol. 56 (pp 153-153)
- PERINATAL DNA METHYLATION AT THE RXRA PROMOTER IS ASSOCIATED WITH GESTATIONAL VITAMIN D SUPPLEMENTATION: RESULTS FROM THE MAVIDOS TRIAL. RHEUMATOLOGY, Vol. 56 (pp 112-112)
- THE EFFECT OF WHOLE BODY VIBRATION TRAINING ON BONE AND MUSCLE FUNCTION IN CHILDREN WITH OSTEOGENESIS IMPERFECTA. HORMONE RESEARCH IN PAEDIATRICS, Vol. 88 (pp 444-444)
- PREDICTORS OF MATERNAL 25(OH)-VITAMIN D RESPONSE TO ANTENATAL VITAMIN D SUPPLEMENTATION: RESULTS FROM THE MAVIDOS TRIAL. OSTEOPOROSIS INTERNATIONAL, Vol. 27 (pp 628-629)
- DETERMINANTS OF THE MATERNAL RESPONSE TO VITAMIN D SUPPLEMENTATION DURING PREGNANCY: THE MAVIDOS TRIAL. OSTEOPOROSIS INTERNATIONAL, Vol. 27 (pp S49-S50)
- MATERNAL GESTATIONAL VITAMIN D SUPPLEMENTATION RESULTS IN GREATER BONE MASS FOR OFFSPRING BORN DURING WINTER MONTHS: THE MAVIDOS MULTICENTRE RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL. RHEUMATOLOGY, Vol. 55 (pp 41-41)
- EFFECTIVENESS OF MATERNAL VITAMIN D SUPPLEMENTATION: A MULTICENTRE RANDOMISED, DOUBLE-BLIND, PLACEBO CONTROLLED TRIAL (MAVIDOS). OSTEOPOROSIS INTERNATIONAL, Vol. 26 (pp S40-S40)
- . 2014 9th International Symposium on Communication Systems, Networks & Digital Sign (CSNDSP), 23 July 2014 - 25 July 2014.
- . Archives of Disease in Childhood, Vol. 99(Suppl 1) (pp A29-A29)
- Enzyme-Replacement Therapy in Life-Threatening Hypophosphatasia: The 3-Year Experience with Asfotase Alfa.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 29 (pp S120-S120)
- MATERNAL VITAMIN D STATUS IN PREGNANCY AND OFFSPRING BONE HEALTH: A SYSTEMATIC REVIEW AND META-ANALYSIS. OSTEOPOROSIS INTERNATIONAL, Vol. 24 (pp S33-S33)
- Maternal Pregnancy Vitamin D Status and Offspring Bone Health: A Systematic Review and Meta-analysis. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 28
- Assessing bone quality and fracture resistance in children using microindentation. Bone Abstracts, Vol. 2 (pp P86-P86)
- Prolidase deficient mice are osteoporotic in early life. Bone Abstracts, Vol. 2 (pp OC22-OC22)
- Reference point indentation testing detects age-related changes in tissue mechanical properties in mice. Bone Abstracts, Vol. 2 (pp P81-P81)
- . PROCEEDINGS OF THE NUTRITION SOCIETY, Vol. 70(3) (pp 299-304)
- . BONE, Vol. 48 (pp S58-S58)
- . BONE, Vol. 48 (pp S82-S82)
- . BONE, Vol. 48 (pp S270-S270)
- . BONE, Vol. 45 (pp S71-S71)
- . BONE, Vol. 45 (pp S97-S98)
- . BONE, Vol. 45 (pp S53-S53)
- OSTEOPOROSIS IN CHILDREN. OSTEOPOROSIS INTERNATIONAL, Vol. 20 (pp S257-S257)
- The Relationship of Urinary Excretion of C-Telopeptides to Growth in Children. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S110-S110)
- . BONE, Vol. 42 (pp S48-S49)
- . BONE, Vol. 42 (pp S68-S68)
- Cerebroretinal microangiopathy with calcification and cysts (CRMCC). JOURNAL OF MEDICAL GENETICS, Vol. 44 (pp S49-S49)
- RANKL mutations are responsible for the defective osteoclast formation seen in six patients with osteoclast-poor osteopetrosis. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 22(7) (pp 1111-1112)
- . BONE, Vol. 40(6) (pp S9-S9)
- . BONE, Vol. 40(6) (pp S39-S40)
- . BONE, Vol. 40(6) (pp S71-S72)
- . BONE, Vol. 40(6) (pp S28-S29)
- . BONE, Vol. 40(6) (pp S32-S33)
- Identification of novel mutations in rankl as a cause of osteoclast-poor osteopetrosis. CALCIFIED TISSUE INT, Vol. 80 (pp S35-S35)
- The peroxisome proliferator activator receptor Alpha/Delta (PPARa/d) agonists linoleic acid and bezafibrate upregulate osteoblast differentiation and induce periosteal bone formation in vivo.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 21 (pp S204-S204)
- The association between bone mass and fractures in childhood: A prospective cohort study.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 21 (pp S19-S19)
- Skeletal fragility is an important determinant of fracture risk in children, even in the presence of significant trauma.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 21 (pp S30-S30)
- Activation of peroxisome proliferator activated receptor delta (PPARdelta) increases periosteal bone formation. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 21(7) (pp 1152-1152)
- Mutation analysis of COL1A1 and COL1A2 in a cohort of patients with osteogenesis imperfecta type I-IV. JOURNAL OF MEDICAL GENETICS, Vol. 42 (pp S91-S91)
- Risedronate pharmacokinetics in children with osteogenesis imperfecta. BONE, Vol. 36 (pp S223-S224)
- Failure of a successful bone marrow transplant to rescue osteoclast deficient autosomal recessive osteopetrosis. BONE, Vol. 36 (pp S226-S226)
- Development of a specific assessment tool for children with osteogenesis imperfecta. BONE, Vol. 36 (pp S51-S51)
- Risedronate pharmacokinetics in children with osteogenesis imperfecta. BONE, Vol. 36 (pp S82-S82)
- Chimeraplasty for gene repair in carnitine palmitoyl transferase II deficiency. BONE, Vol. 36 (pp S28-S28)
- Phalangeal ultrasound and fracture risk in childhood. BONE, Vol. 36 (pp S100-S100)
- A paediatric lumbar spine phantom for inter-site and inter-machine cross-calibration. BONE, Vol. 36 (pp S44-S44)
- Pamidronate for infants with osteogenesis imperfecta; comparison of different doses. BONE, Vol. 36 (pp S82-S82)
- Observations on cell fusion in RAW264.7 cells stimulated with RANK ligand using time lapse videomicroscopy and expression microarrays. BONE, Vol. 36 (pp S25-S26)
- Pediatric spine phantom for use in DXA pediatric bone studies. OSTEOPOROSIS INTERNATIONAL, Vol. 15 (pp S21-S21)
- COL3A1: An unsuitable comparator for measuring collagen mRNA expression levels in bone of patients with osteogenesis imperfecta. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19(6) (pp 1039-1039)
- Further examples of Coats' plus; expanding the phenotype. JOURNAL OF MEDICAL GENETICS, Vol. 41 (pp S43-S43)
- Osteoporosis in children with rheumatic disease. ANNALS OF THE RHEUMATIC DISEASES, Vol. 62 (pp 14-14)
- Matrix metalloproteinase inhibition does not recapitulate the action of chemically modified tetracyclines on osteoclast lineage cells. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 18(7) (pp 1359-1359)
- Growing bones - A famework for the future. PEDIATRIC RESEARCH, Vol. 53(6) (pp 5A-5A)
- A diagnostic assay for COL1A1 expression levels in Osteogenesis Imperfecta patients.. JOURNAL OF MEDICAL GENETICS, Vol. 39 (pp S81-S81)
- Children and the risk of fractures due to oral corticosteroids.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 17 (pp S171-S171)
- Heterogeneity of RANK-L expression in bone marrow of patients with acute lymphoblastic leukaemia. BONE, Vol. 30(3) (pp 29S-29S)
- Failure of osteoclast induction from peripheral blood in a child with osteopetrosis. BONE, Vol. 30(3) (pp 16S-16S)
- Inhibition of osteoclast and CFU-f development in culture with chemically modified tetracyclines. BONE, Vol. 30(3) (pp 18S-18S)
- Perinatal metabolism of vitamin D. AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol. 71(5) (pp 1317S-1324S)
- Skeletal growth and development in infants born preterm: Effect of early diet. Monatsschrift fur Kinderheilkunde, Vol. 143(7 SUPPL. 2)
- Aluminium in infant feeding: Is it a problem?. European Journal of Clinical Nutrition, Vol. 46(SUPPL. 4)
- Bone growth and mineralisation in preterm infants. Pediatric Reviews and Communications, Vol. 6(3) (pp 181-183)
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