Dr Jovana Serbanovic-Canic

Clinical Medicine, School of Medicine and Population Health

BHF Intermediate Basic Science Research Fellow

Dr Jovana Serbanovic-Canic
Dr Jovana Serbanovic-Canic
Profile picture of Dr Jovana Serbanovic-Canic
j.serbanovic-canic@sheffield.ac.uk
+44 114 215 9502

Full contact details

Dr Jovana Serbanovic-Canic
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
91直播
S10 2RX
Profile

For enquiries please contact - ClinMed-Operational@sheffield.ac.uk

In 2013 I received my PhD from the University of Cambridge where, as a Marie Curie Fellow in the lab of Professor Willem Ouwehand, I used the zebrafish model for studying regulators of haematopoiesis.

Following my PhD, I took up the position of John Stokes Postdoctoral Fellow in the lab of Professor Paul Evans at the University of 91直播. Here I developed a platform for functional screening of flow-responsive apoptotic regulators in zebrafish.

I subsequently used this model to identify mechanoreceptors regulating endothelial apoptosis in response to flow, which was the basis for my British Heart Foundation Intermediate Basic Science Research Fellowship, awarded in February 2018.

Research interests

I am interested in mechanoreceptors on endothelial cells which convert mechanical signals associated with blood flow into physiological changes. Disturbed blood flow conditions lead to endothelial cell injury which contributes to the development of cardiovascular disease, one of the leading causes of death globally.

My work is aimed at identifying mechanoreceptors which regulate endothelial cell death in response to mechanical forces and to study this I use a range of different models and approaches, including zebrafish, murine models and human cells.

Understanding the function and downstream pathways of these mechanoreceptors may provide useful targets for the prevention and treatment of cardiovascular disease.

Current projects

Role of the mechanoreceptor Pkd1 in endothelial dysfunction and atherosclerosis (British Heart Foundation funding, 2018-2023).

Publications

Show: Featured publications All publications

Journal articles

  • Souilhol C, Gauci I, Feng S, Tardajos Ayllon B, Mahmoud M, Canham L, Fragiadaki M, Serbanovic-Canic J, Ridger V & Evans PC (2019) . Cardiovascular Research. RIS download Bibtex download
  • Mahmoud M, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis S , Van der Heiden K et al (2017) . Scientific Reports, 7. RIS download Bibtex download
  • Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C , Bowden N et al (2016) . Arteriosclerosis, Thrombosis, and Vascular Biology, 37(1), 130-143. RIS download Bibtex download
  • Bryan MT, Duckles H, Feng S, Hsiao ST, Kim HR, Serbanovic-Canic J & Evans PC (2014) . Arterioscler Thromb Vasc Biol, 34(10), 2199-2205. RIS download Bibtex download
  • Serbanovic-Canic J, Cvejic A, Soranzo N, Stemple DL, Ouwehand WH & Freson K (2011) . Blood, 118(18), 4967-4976. RIS download Bibtex download
  • Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U, Goodall AH, Labrune Y , Lopez LM et al (2011) New gene functions in megakaryopoiesis and platelet formation. Nature. RIS download Bibtex download

All publications

Journal articles

  • Pirri D, Tian S, Tardajos-Ayllon B, Irving S, Donati F, Allen SP, Mammoto T, Vilahur G, Kabir L, Bennett J , Rasool Y et al (2024) . Circ Res. RIS download Bibtex download
  • Li X, Souilhol C, Canham L, Jia X, Diagbouga M, Ayllon BT, Serbanovic-Canic J & Evans PC (2023) . Vascular Pharmacology, 150, 107178-107178. RIS download Bibtex download
  • Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ , Ariaans M et al (2022) . Sci Adv, 8(35), eabo7958. RIS download Bibtex download
  • Kugler E, Snodgrass R, Bowley G, Plant K, Serbanovic-Canic J, Hamilton N, Evans PC, Chico T & Armitage P (2021) . Vascular Biology, 3(1), 1-16. RIS download Bibtex download
  • Evans PC, Fragiadaki M, Morris PD & Serbanovic-Canic J (2020) . Cardiovascular Research. RIS download Bibtex download
  • Mahmoud MM, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis SE , Van der Heiden K et al (2020) . Scientific Reports, 10(1). RIS download Bibtex download
  • Souilhol C, Serbanovic-Canic J, Fragiadaki M, Chico TJ, Ridger V, Roddie H & Evans PC (2020) . Nature Reviews Cardiology, 17(1), 52-63. RIS download Bibtex download
  • Souilhol C, Gauci I, Feng S, Tardajos Ayllon B, Mahmoud M, Canham L, Fragiadaki M, Serbanovic-Canic J, Ridger V & Evans PC (2019) . Cardiovascular Research. RIS download Bibtex download
  • Xanthis I, Souilhol C, Serbanovic-Canic J, Roddie H, Kalli AC, Fragiadaki M, Wong R, Shah DR, Askari JA, Canham L , Akhtar N et al (2019) . Journal of Cell Science. RIS download Bibtex download
  • Serbanovic-Canic J, Souilhol C & Evans PC (2019) . Cardiovascular Research. RIS download Bibtex download
  • Mahmoud M, Souilhol C, Serbanovic-Canic J & Evans P (2019) . Cardiovascular Drugs and Therapy. RIS download Bibtex download
  • Mahmoud M, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis S , Van der Heiden K et al (2017) . Scientific Reports, 7. RIS download Bibtex download
  • Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C , Bowden N et al (2016) . Arteriosclerosis, Thrombosis, and Vascular Biology, 37(1), 130-143. RIS download Bibtex download
  • Bowden N, Bryan MT, Duckles H, Feng S, Hsiao S, Kim HR, Mahmoud M, Moers B, Serbanovic-Canic J, Xanthis I , Ridger VC et al (2016) . Antioxidants & Redox Signaling, 25(7), 389-400. RIS download Bibtex download
  • Mahmoud M, Kim HR, Xing R, Hsiao S, Mammmoto A, Chen J, Serbanovic-Canic J, Feng S, Bowden NP, Maguire R , Ariaans M et al (2016) . Circulation Research, 119, 450-462. RIS download Bibtex download
  • Bryan MT, Duckles H, Feng S, Hsiao ST, Kim HR, Serbanovic-Canic J & Evans PC (2014) . Arterioscler Thromb Vasc Biol, 34(10), 2199-2205. RIS download Bibtex download
  • Bielczyk-Maczy艅ska E, Serbanovic-Canic J, Ferreira L, Soranzo N, Stemple DL, Ouwehand WH & Cvejic A (2014) . PLoS Genet, 10(7), e1004450. RIS download Bibtex download
  • Gray C, Bratt D, Lees J, daCosta M, Plant K, Watson OJ, Solaymani-Kohal S, Tazzyman S, Serbanovic-Canic J, Crossman DC , Keavney BD et al (2013) . Arterioscler Thromb Vasc Biol, 33(6), 1257-1263. RIS download Bibtex download
  • Brieu N, Navab N, Serbanovic-Canic J, Ouwehand WH, Stemple DL, Cvejic A & Groher M (2012) . Med Image Anal, 16(4), 915-931. RIS download Bibtex download
  • Serbanovic-Canic J, Cvejic A, Soranzo N, Stemple DL, Ouwehand WH & Freson K (2011) . Blood, 118(18), 4967-4976. RIS download Bibtex download
  • Cvejic A, Serbanovic-Canic J, Stemple DL & Ouwehand WH (2011) . Haematologica, 96(2), 190-198. RIS download Bibtex download
  • Brieu N, Groher M, Serbanovic-Canic J, Cvejic A, Ouwehand W & Navab N (2011) . Med Image Comput Comput Assist Interv, 14(Pt 3), 579-586. RIS download Bibtex download
  • Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U, Goodall AH, Labrune Y , Lopez LM et al (2011) New gene functions in megakaryopoiesis and platelet formation. Nature. RIS download Bibtex download
  • Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U, Goodall AH, Labrune Y , Lopez LM et al (2011) . Nature, 480(7376), 201-208. RIS download Bibtex download
  • Soranzo N, Spector TD, Mangino M, K眉hnel B, Rendon A, Teumer A, Willenborg C, Wright B, Chen L, Li M , Salo P et al (2009) . Nat Genet, 41(11), 1182-1190. RIS download Bibtex download
  • X S, Aitken C, Mehta V, Tardajos-Ayllon B, Serbanovic-Canic J, Zhu J, Miao B, Tzima E, Evans P, Fang Y & Schwartz MA () . Journal of Cell Science. RIS download Bibtex download
  • Canham L, Sendac S, Diagbouga MR, Wolodimeroff E, Pirri D, Tardajos Ayllon B, Feng S, Souilhol C, Chico TJA, Evans PC & Serbanovic-Canic J () . Arteriosclerosis, Thrombosis, and Vascular Biology. RIS download Bibtex download
  • Bowley G, Chico TJA, Serbanovic-Canic J & Evans PC () . F1000Research, 10, 1032-1032. RIS download Bibtex download
  • Bowley G, Kugler E, Wilkinson R, Lawrie A, Eeden F, Chico TJA, Evans PC, No毛l ES & Serbanovic鈥怌anic J () . British Journal of Pharmacology. RIS download Bibtex download

Conference proceedings papers

  • Serbanovic-Canic J, Evans PC & Chico T (2023) . Basic Science RIS download Bibtex download
  • Bowley G, Evans P, Serbanovic-Canic J & Chico T (2021) . Basic science RIS download Bibtex download
  • Souilhol C, Feng S, Gauci I, Serbanovic-Canic J, Canham L & Evans PC (2019) Mechanosensitive Hox Genes Control Vascular Dysfunction in Adult Arteries. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 272-272) RIS download Bibtex download
  • Serbanovic-Canic J, Feng S, Souilhol C & Evans PC (2019) The Role of FAM176A in Endothelial Cell Responses to Flow. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 273-273) RIS download Bibtex download
  • Serbanovic-Canic J, de Luca A, Warboys C, Chico T & Evans P (2013) . Heart, Vol. 99(suppl 2) (pp A6.1-A6) RIS download Bibtex download
  • Freson K, Serbanovic-Canic J, Cvejic A, Soranzo N, Stemple D & Ouwehand W (2011) Silencing of RhoA nucleotide exchange factor, ARHGEF3, reveals its role in thrombopoiesis and iron uptake. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol. 9 (pp 33-33) RIS download Bibtex download
  • Cvejic A, Serbanovic-Canic J, Stemple D & Ouwehand W (2010) THE ROLE OF MEIS1 IN PRIMITIVE AND DEFINITIVE HAEMATOPOIESIS AND VASCULAR PATTERNING DURING ZEBRAFISH DEVELOPMENT. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, Vol. 95 (pp 247-247) RIS download Bibtex download
  • Brieu N, Serbanovic-Canic J, Cvejic A, Stemple D, Ouwehand W, Navab N & Groher M (2010) . Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol. 7623(PART 1) RIS download Bibtex download

Preprints

  • Pirri D, Tian S, Tardajos-Ayllon B, Irving S, Donati F, Allen SP, Mammoto T, Vilahur G, Miller C, Schenkel T , Chambers EV et al (2023) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Kugler E, Snodgrass R, Bowley G, Plant K, Serbanovic-Canic J, Evans PC, Chico T & Armitage P () , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Souilhol C, Li X, Canham L, Roddie H, Pirri D, Ayllon BT, Chambers EV, Dunning MJ, Ariaans M, Li J , Fang Y et al () , Cold Spring Harbor Laboratory. RIS download Bibtex download
Research group
  • Mr George Bowley (NC3R PhD Studentship)
  • Mr Samuel Sendac (Research Technician)
Professional activities and memberships
  • Member of British Atherosclerosis Society (since 2013)
  • Committee member of the British Society for Cardiovascular Research (since January 2021)