Serbanovic-Canic, Jovana , Dr

Dr Jovana Serbanovic-Canic

Clinical Medicine, School of Medicine and Population Health

BHF Intermediate Basic Science Research Fellow

j.serbanovic-canic@sheffield.ac.uk
+44 114 215 9502

The Medical School

Full contact details

Dr Jovana Serbanovic-Canic
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
91ֱ��
S10 2RX

Profile

For enquiries please contact - ClinMed-Operational@sheffield.ac.uk

In 2013 I received my PhD from the University of Cambridge where, as a Marie Curie Fellow in the lab of Professor Willem Ouwehand, I used the zebrafish model for studying regulators of haematopoiesis.

Following my PhD, I took up the position of John Stokes Postdoctoral Fellow in the lab of Professor Paul Evans at the University of 91ֱ��. Here I developed a platform for functional screening of flow-responsive apoptotic regulators in zebrafish.

I subsequently used this model to identify mechanoreceptors regulating endothelial apoptosis in response to flow, which was the basis for my British Heart Foundation Intermediate Basic Science Research Fellowship, awarded in February 2018.

Research interests

I am interested in mechanoreceptors on endothelial cells which convert mechanical signals associated with blood flow into physiological changes. Disturbed blood flow conditions lead to endothelial cell injury which contributes to the development of cardiovascular disease, one of the leading causes of death globally.

My work is aimed at identifying mechanoreceptors which regulate endothelial cell death in response to mechanical forces and to study this I use a range of different models and approaches, including zebrafish, murine models and human cells.

Understanding the function and downstream pathways of these mechanoreceptors may provide useful targets for the prevention and treatment of cardiovascular disease.

Current projects

Role of the mechanoreceptor Pkd1 in endothelial dysfunction and atherosclerosis (British Heart Foundation funding, 2018-2023).

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Souilhol C, Gauci I, Feng S, Tardajos Ayllon B, Mahmoud M, Canham L, Fragiadaki M, Serbanovic-Canic J, Ridger V & Evans PC (2019) . Cardiovascular Research.
Mahmoud M, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis S , Van der Heiden K et al (2017) . Scientific Reports, 7.
Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C , Bowden N et al (2016) . Arteriosclerosis, Thrombosis, and Vascular Biology, 37(1), 130-143.
Bryan MT, Duckles H, Feng S, Hsiao ST, Kim HR, Serbanovic-Canic J & Evans PC (2014) . Arterioscler Thromb Vasc Biol, 34(10), 2199-2205.
Serbanovic-Canic J, Cvejic A, Soranzo N, Stemple DL, Ouwehand WH & Freson K (2011) . Blood, 118(18), 4967-4976.
Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U, Goodall AH, Labrune Y , Lopez LM et al (2011) New gene functions in megakaryopoiesis and platelet formation. Nature.

All publications

Journal articles

Bowley G, Irving S, Hoefer I, Wilkinson R, Pasterkamp G, Darwish HMS, White S, Francis SE, Chico T, Noel E , Serbanovic-Canic J et al (2024) . Scientific Reports, 14(1).
Pirri D, Tian S, Tardajos-Ayllon B, Irving S, Donati F, Allen SP, Mammoto T, Vilahur G, Kabir L, Bennett J , Rasool Y et al (2024) . Circ Res.
Li X, Souilhol C, Canham L, Jia X, Diagbouga M, Ayllon BT, Serbanovic-Canic J & Evans PC (2023) . Vascular Pharmacology, 150, 107178-107178.
Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ , Ariaans M et al (2022) . Sci Adv, 8(35), eabo7958.
Kugler E, Snodgrass R, Bowley G, Plant K, Serbanovic-Canic J, Hamilton N, Evans PC, Chico T & Armitage P (2021) . Vascular Biology, 3(1), 1-16.
Evans PC, Fragiadaki M, Morris PD & Serbanovic-Canic J (2020) . Cardiovascular Research.
Mahmoud MM, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis SE , Van der Heiden K et al (2020) . Scientific Reports, 10(1).
Souilhol C, Serbanovic-Canic J, Fragiadaki M, Chico TJ, Ridger V, Roddie H & Evans PC (2020) . Nature Reviews Cardiology, 17(1), 52-63.
Souilhol C, Gauci I, Feng S, Tardajos Ayllon B, Mahmoud M, Canham L, Fragiadaki M, Serbanovic-Canic J, Ridger V & Evans PC (2019) . Cardiovascular Research.
Xanthis I, Souilhol C, Serbanovic-Canic J, Roddie H, Kalli AC, Fragiadaki M, Wong R, Shah DR, Askari JA, Canham L , Akhtar N et al (2019) . Journal of Cell Science.
Serbanovic-Canic J, Souilhol C & Evans PC (2019) . Cardiovascular Research.
Mahmoud M, Souilhol C, Serbanovic-Canic J & Evans P (2019) . Cardiovascular Drugs and Therapy.
Mahmoud M, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis S , Van der Heiden K et al (2017) . Scientific Reports, 7.
Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C , Bowden N et al (2016) . Arteriosclerosis, Thrombosis, and Vascular Biology, 37(1), 130-143.
Bowden N, Bryan MT, Duckles H, Feng S, Hsiao S, Kim HR, Mahmoud M, Moers B, Serbanovic-Canic J, Xanthis I , Ridger VC et al (2016) . Antioxidants & Redox Signaling, 25(7), 389-400.
Mahmoud M, Kim HR, Xing R, Hsiao S, Mammmoto A, Chen J, Serbanovic-Canic J, Feng S, Bowden NP, Maguire R , Ariaans M et al (2016) . Circulation Research, 119, 450-462.
Bryan MT, Duckles H, Feng S, Hsiao ST, Kim HR, Serbanovic-Canic J & Evans PC (2014) . Arterioscler Thromb Vasc Biol, 34(10), 2199-2205.
Bielczyk-Maczyńska E, Serbanovic-Canic J, Ferreira L, Soranzo N, Stemple DL, Ouwehand WH & Cvejic A (2014) . PLoS Genet, 10(7), e1004450.
Gray C, Bratt D, Lees J, daCosta M, Plant K, Watson OJ, Solaymani-Kohal S, Tazzyman S, Serbanovic-Canic J, Crossman DC , Keavney BD et al (2013) . Arterioscler Thromb Vasc Biol, 33(6), 1257-1263.
Brieu N, Navab N, Serbanovic-Canic J, Ouwehand WH, Stemple DL, Cvejic A & Groher M (2012) . Med Image Anal, 16(4), 915-931.
Serbanovic-Canic J, Cvejic A, Soranzo N, Stemple DL, Ouwehand WH & Freson K (2011) . Blood, 118(18), 4967-4976.
Cvejic A, Serbanovic-Canic J, Stemple DL & Ouwehand WH (2011) . Haematologica, 96(2), 190-198.
Brieu N, Groher M, Serbanovic-Canic J, Cvejic A, Ouwehand W & Navab N (2011) . Med Image Comput Comput Assist Interv, 14(Pt 3), 579-586.
Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U, Goodall AH, Labrune Y , Lopez LM et al (2011) New gene functions in megakaryopoiesis and platelet formation. Nature.
Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U, Goodall AH, Labrune Y , Lopez LM et al (2011) . Nature, 480(7376), 201-208.
Soranzo N, Spector TD, Mangino M, Kühnel B, Rendon A, Teumer A, Willenborg C, Wright B, Chen L, Li M , Salo P et al (2009) . Nat Genet, 41(11), 1182-1190.
X S, Aitken C, Mehta V, Tardajos-Ayllon B, Serbanovic-Canic J, Zhu J, Miao B, Tzima E, Evans P, Fang Y & Schwartz MA () . Journal of Cell Science.
Canham L, Sendac S, Diagbouga MR, Wolodimeroff E, Pirri D, Tardajos Ayllon B, Feng S, Souilhol C, Chico TJA, Evans PC & Serbanovic-Canic J () . Arteriosclerosis, Thrombosis, and Vascular Biology.
Bowley G, Chico TJA, Serbanovic-Canic J & Evans PC () . F1000Research, 10, 1032-1032.
Bowley G, Kugler E, Wilkinson R, Lawrie A, Eeden F, Chico TJA, Evans PC, Noël ES & Serbanovic‐Canic J () . British Journal of Pharmacology.

Conference proceedings papers

Serbanovic-Canic J, Evans PC & Chico T (2023) . Basic Science
Bowley G, Evans P, Serbanovic-Canic J & Chico T (2021) . Basic science
Souilhol C, Feng S, Gauci I, Serbanovic-Canic J, Canham L & Evans PC (2019) Mechanosensitive Hox Genes Control Vascular Dysfunction in Adult Arteries. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 272-272)
Serbanovic-Canic J, Feng S, Souilhol C & Evans PC (2019) The Role of FAM176A in Endothelial Cell Responses to Flow. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 273-273)
Serbanovic-Canic J, de Luca A, Warboys C, Chico T & Evans P (2013) . Heart, Vol. 99(suppl 2) (pp A6.1-A6)
Freson K, Serbanovic-Canic J, Cvejic A, Soranzo N, Stemple D & Ouwehand W (2011) Silencing of RhoA nucleotide exchange factor, ARHGEF3, reveals its role in thrombopoiesis and iron uptake. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol. 9 (pp 33-33)
Cvejic A, Serbanovic-Canic J, Stemple D & Ouwehand W (2010) THE ROLE OF MEIS1 IN PRIMITIVE AND DEFINITIVE HAEMATOPOIESIS AND VASCULAR PATTERNING DURING ZEBRAFISH DEVELOPMENT. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, Vol. 95 (pp 247-247)
Brieu N, Serbanovic-Canic J, Cvejic A, Stemple D, Ouwehand W, Navab N & Groher M (2010) . Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol. 7623(PART 1)

Preprints

Pirri D, Tian S, Tardajos-Ayllon B, Irving S, Donati F, Allen SP, Mammoto T, Vilahur G, Miller C, Schenkel T , Chambers EV et al (2023) , Cold Spring Harbor Laboratory.
Kugler E, Snodgrass R, Bowley G, Plant K, Serbanovic-Canic J, Evans PC, Chico T & Armitage P () , Cold Spring Harbor Laboratory.
Souilhol C, Li X, Canham L, Roddie H, Pirri D, Ayllon BT, Chambers EV, Dunning MJ, Ariaans M, Li J , Fang Y et al () , Cold Spring Harbor Laboratory.

Research group

Mr George Bowley (NC3R PhD Studentship)
Mr Samuel Sendac (Research Technician)

Professional activities and memberships

Member of British Atherosclerosis Society (since 2013)
Committee member of the British Society for Cardiovascular Research (since January 2021)