Le Maitre, Christine, Professor

Professor Christine Le Maitre

BSc (Hons). PGCert, FHEA, PhD

Clinical Medicine, School of Medicine and Population Health

Professor of Musculoskeletal Cell Biology and Tissue Regeneration

c.lemaitre@sheffield.ac.uk
+44 114 215 9010

Room GU22, The Medical School

Full contact details

Professor Christine Le Maitre
Clinical Medicine, School of Medicine and Population Health
Room GU22
The Medical School
Beech Hill Road
91ֱ��
S10 2RX

Profile

For enquiries please contact - ClinMed-Operational@sheffield.ac.uk

I joined 91ֱ�� in 2022 as a Professor in the Department of Oncology and Metabolism, in the Medical School where I co-lead the Osteoarthritis and Disc Research Group in the Bone and Joint theme. I graduated with a 1^st class honours degree in Pharmacology from The University of Manchester in 2000, and went on to undertake a Wellcome funded PhD at The University of Manchester investigating the role of IL-1 in intervertebral disc degeneration. Following completion, I remained in Manchester for several postdoctoral positions investigating the cellular pathogenesis of intervertebral disc degeneration. I moved to 91ֱ�� Hallam University in 2008 as a Senior Lecturer to establish my own research group, I was promoted to Reader in 2014 and Professor in 2017. I recently moved to the Medical School at 91ֱ�� as Professor of Musculoskeletal Cell Biology and Tissue Regeneration in November 2022.

My research focuses on investigating the pathogenesis of musculoskeletal disorders and novel therapies targeting pathogenesis and regenerative approaches. Working collaboratively nationally and internationally with clinicians, scientists, engineers, industrial partners and patients to pursue an improved understanding of musculoskeletal conditions and utilise this knowledge to develop the next generation of therapies. My research to date has led to 2 patents, >100 publications with >8,600 citations a current H index of 43 and i10 index 78, with over £22 million in research grant income and £10 million in doctoral training grant income to date. I have been invited to present my research at several national and international meetings and am an elected committee member of Society of Back Pain Research, ORS Spine section, Musculoskeletal research advisory group for Versus Arthritis and DISCs Chairlady.

I am passionate to support the next generation of scientists and previously led postgraduate research student provision in my previous roles, I have supervised 16 PhD students to completion and currently supervise 16 further doctoral students, I have also received several accolades for my doctoral supervision and mentoring roles.

Qualifications: 2000 BSc (1st Class) Pharmacology, University of Manchester.
2003 PhD, University of Manchester.
2009 PGCert (Higher education teaching), 91ֱ�� Hallam University.

Research interests: My research investigates the cellular pathogenesis of musculoskeletal conditions. Including intervertebral disc degeneration and its links to low back pain; osteoarthritis; and bone physiology; working in close collaboration with relevant clinical partners and collaborators nationally and internationally. With a particular interest in the interaction of cells, biomechanics and matrix biology. My research has provided key insights to the normal physiology of musculoskeletal conditions and identified dysregulated cellular mechanisms during pathogenesis of intervertebral disc degeneration and osteoarthritis. Including the roles of inflammatory cytokines, cellular senescence and altered mechanotransduction pathways. I have a passion for developing alternative disease models, which utilise human 3D cell and tissue cultures within physiologically relevant environments. These systems are utilised to understand normal physiology, pathogenesis, and test new therapeutic strategies. I have developed 3D culture systems to maintain the phenotype of isolated chondrocytes, nucleus pulposus cells, annulus fibrosus cells, osteoblasts and osteocytes, or drive stem cell differentiation enabling cell and mechanobiology to be investigated using primary human cell sources. I have also developed several complex tissue culture systems enabling maintenance of cell/matrix interactions from osteochondral and IVD tissue explants to whole organ culture systems. Current PhD students under my supervision are also developing 3D printed models of cortical and trabecular bone and bone infection models. The improved understanding in pathogenesis of musculoskeletal conditions have led to strategies for next generation therapies involving stem cells, biomaterials and gene therapy approaches to inhibit disease processes and support regeneration. Investigating a range of potential cell sources to promote regeneration including bone marrow and adipose stromal cells; and induced pluripotent stem cells. My work has investigated these cell strategies either alone or in combination with smart biomaterials which can restore the biomechanical environment, whilst inhibiting catabolic signalling processes and supporting stem cell differentiation. I have also investigated the potential of gene therapy approaches to modulate abnormal cytokine signalling to inhibit cellular pathogenesis, providing the correct tissue niche to support repair and regeneration. My work on next generation therapies has led to patent generation, industry collaborations and potential commercialisation opportunities.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Basatvat S, Bach FC, Barcellona MN, Binch AL, Buckley CT, Bueno B, Chahine NO, Chee A, Creemers LB, Dudli S , Fearing B et al (2023) . JOR SPINE.
Paskins Z, Farmer CE, Manning F, Andersson DA, Barlow T, Bishop FL, Brown CA, Clark A, Clark EM, Dulake D , Gulati M et al (2022) . The Lancet Rheumatology, 4(9), e635-e645.
Le Maitre CL, Dahia CL, Giers M, Illien‐Junger S, Cicione C, Samartzis D, Vadala G, Fields A & Lotz J (2021) . JOR SPINE, 4(2).
Thorpe AA, Freeman C, Farthing P, Callaghan J, Hatton PV, Brook IM, Sammon C & Le Maitre CL (2018) . Oncotarget, 9(26), 18277-18295.
Thorpe AA, Dougill G, Vickers L, Reeves ND, Sammon C, Cooper G & Le Maitre CL (2017) . Acta Biomaterialia, 54, 212-226.
Phillips KLE, Cullen K, Chiverton N, Michael ALR, Cole AA, Breakwell LM, Haddock G, Bunning RAD, Cross AK & Le Maitre CL (2015) . Osteoarthritis and Cartilage, 23(7), 1165-1177.
Phillips KLE, Jordan-Mahy N, Nicklin MJH & Le Maitre CL (2013) . Annals of the Rheumatic Diseases, 72(11), 1860-1867.
Le Maitre CL, Frain J, Millward-Sadler J, Fotheringham AP, Freemont AJ & Hoyland JA (2009) . Arthritis & Rheumatism, 60(2), 460-469.
Le Maitre C, Freemont A & Hoyland J (2007) . Arthritis Research & Therapy, 9(3), R45-R45.
Le Maitre CL, Freemont AJ & Hoyland JA (2005) The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration.. Arthritis research & therapy, 7(4).
Snuggs JW, Bunning RAD & Le Maitre CL () . European Cells and Materials, 41, 121-141.
Rustenburg CME, Snuggs JW, Emanuel KS, Thorpe A, Sammon C, Le Maitre CL & Smit TH () . European Cells and Materials, 40, 21-37.

All publications

Journal articles

Williamson A, Bateman L, LeMaitre C, Jones TH, Aberdein N & Kelly DM (2024) . Journal of the Endocrine Society, 8(Supplement_1).
Mengis T, Bernhard L, Nüesch A, Heggli I, Herger N, Devan J, Marcus R, Laux CJ, Brunner F, Farshad M , Distler O et al (2024) . Cells, 13(17).
Compte R, Freidin MB, Granville Smith I, Le Maitre CL, Vaitkute D, Nessa A, Lachance G & Williams FMK (2024) . JOR SPINE, 7(1).
Bermudez-Lekerika P, Tseranidou S, Kanelis E, Crump KB, Le Maitre C, Wuertz-Kozak K, Alexopoulos LG, Noailly J & Gantenbein B (2024) . Orthopaedic Proceedings, 106-B(SUPP_2), 93-93.
Cherif H, Li L, Snuggs J, Li X, Sammon C, Li J, Beckman L, Haglund L & Maitre CLL (2023) . Acta Biomaterialia.
Williamson A, da Silva A, do Carmo JM, Le Maitre CL, Hall JE & Aberdein N (2023) . Physiological Reports, 11(19).
Lama P, Tiwari J, Mutreja P, Chauhan S, Harding IJ, Dolan T, Adams MA & Maitre CL (2023) . Anatomy & Cell Biology.
Snuggs J, Senter R, Whitt J & Le Maitre C (2023) . Orthopaedic Proceedings, 105-B(SUPP_9), 91-91.
Bermudez-Lekerika P, Croft A, Crump K, Wuertz-Kozak K, Le Maitre C & Gantenbein B (2023) . Orthopaedic Proceedings, 105-B(SUPP_9), 64-64.
Williams R, Snuggs J, Schmitz TC, Janani R, Basatvat S, Sammon C, Benz K, Ito K, Tryfonidou M & Le Maitre C (2023) . Orthopaedic Proceedings, 105-B(SUPP_8), 90-90.
Dascombe L, Le Maitre C & Aberdein N (2023) . Orthopaedic Proceedings, 105-B(SUPP_8), 89-89.
Williamson A, Bateman L, Kelly D, Le Maitre C & Aberdein N (2023) . Orthopaedic Proceedings, 105-B(SUPP_8), 85-85.
Nüesch A, Kanelis E, Alexopoulos L, Williams F, Geris L, Gantenbein B, Lacey M & Le Maitre C (2023) . Orthopaedic Proceedings, 105-B(SUPP_8), 73-73.
Basatvat S, Braun T, Snuggs J, Williams R, Templin M, Tryfonidou M & Le Maitre C (2023) . Orthopaedic Proceedings, 105-B(SUPP_8), 52-52.
Boyce S, Le Maitre C, Smith T & Nichol T (2023) . Orthopaedic Proceedings, 105-B(SUPP_8), 36-36.
Salzer E, Schmitz TC, Mouser VHM, Vernengo A, Gantenbein B, Jansen JU, Neidlinger-Wilke C, Wilke H-J, Grad S, Le Maitre CL , Tryfonidou MA et al (2023) . European Cells & Materials, 45, 88-112.
Faber BG, Frysz M, Hartley AE, Ebsim R, Boer CG, Saunders FR, Gregory JS, Aspden RM, Harvey NC, Southam L , Giles W et al (2023) . Arthritis & Rheumatology.
Basatvat S, Bach FC, Barcellona MN, Binch AL, Buckley CT, Bueno B, Chahine NO, Chee A, Creemers LB, Dudli S , Fearing B et al (2023) . JOR SPINE.
Jansen JU, Teixeira GQ, Williams R, Janani R, Sammon C, Maitre CL, Benz K, Vernengo A, Grad S, Neidlinger-Wilke C & Wilke HJ (2023) . Brain and Spine, 3, 102376-102376.
Tang SN, Bonilla AF, Chahine NO, Colbath AC, Easley JT, Grad S, Haglund L, Le Maitre CL, Leung V, McCoy AM , Purmessur D et al (2022) . JOR SPINE, 5(4).
Laagland LT, Bach FC, Creemers LB, Le Maitre CL, Poramba‐Liyanage DW & Tryfonidou MA (2022) . JOR SPINE, 5(3).
Paskins Z, Farmer CE, Manning F, Andersson DA, Barlow T, Bishop FL, Brown CA, Clark A, Clark EM, Dulake D , Gulati M et al (2022) . The Lancet Rheumatology, 4(9), e635-e645.
Bermudez-Lekerika P, Crump KB, Tseranidou S, Nüesch A, Kanelis E, Alminnawi A, Baumgartner L, Muñoz-Moya E, Compte R, Gualdi F , Alexopoulos LG et al (2022) . Frontiers in Cell and Developmental Biology, 10.
Poillot P, Snuggs JW, Le Maitre CL & Huyghe JM (2022) . JOR SPINE, 5(4).
Mahbub AA, Le Maitre CL, Cross NA & Jordan-Mahy N (2022) . Scientific Reports, 12(1).
Paskins Z, Farmer CE, Jones RK, Clark A, Troeberg L, Pandit H, Richardson SM, Loughlin J, Brown CA, Taylor EJ , Le Maitre CL et al (2022) . Rheumatology, 61(Supplement_1).
Bach FC, Poramba-Liyanage DW, Riemers FM, Guicheux J, Camus A, Iatridis JC, Chan D, Ito K, Le Maitre CL & Tryfonidou MA (2022) . Frontiers in Cell and Developmental Biology, 9.
Lama P, Tewari J, Adams MA & Maitre CL (2022) . Histology and Histopathology, 37(1), 11-20.
Williams RJ, Tryfonidou MA, Snuggs JW & Le Maitre CL (2021) . JOR SPINE, 4(4).
Boyes VL, Janani R, Partridge S, Fielding LA, Breen C, Foulkes J, Le Maitre CL & Sammon C (2021) . Polymer, 233, 124201-124201.
Dahia CL, Engiles JB, Gullbrand SE, Iatridis JC, Lai A, Le Maitre CL, Lotz JC, Masuda K, Séguin CA & Tryfonidou MA (2021) . JOR SPINE, 4(2).
Le Maitre CL, Dahia CL, Giers M, Illien‐Junger S, Cicione C, Samartzis D, Vadala G, Fields A & Lotz J (2021) . JOR SPINE, 4(2).
Nichol T, Callaghan J, Townsend R, Stockley I, Hatton PV, Le Maitre C, Smith TJ & Akid R (2021) . The Bone & Joint Journal, 103-B(3), 522-529.
Poillot P, Le Maitre CL & Huyghe JM (2021) . Biophysical Reviews, 13(1), 91-100.
Baumgartner L, Wuertz-Kozak K, Le Maitre CL, Wignall F, Richardson SM, Hoyland J, Wills CR, González Ballester MA, Neidlin M, Alexopoulos LG & Noailly J (2021) . International Journal of Molecular Sciences, 22(2), 1-42.
Dahia CL & Le Maitre CL (2020) . JOR SPINE, 3(3).
Schmitz TC, Salzer E, Crispim JF, Fabra GT, LeVisage C, Pandit A, Tryfonidou M, Maitre CL & Ito K (2020) . Acta Biomaterialia, 114, 1-15.
Binch A, Snuggs J & Le Maitre CL (2020) . JOR SPINE, 3(3).
Bateman L, Dalton C, Maitre CL, Jones TH & Kelly DM (2020) . Journal of the Endocrine Society, 4(Supplement_1).
Mardling P, Alderson A, Jordan-Mahy N & Le Maitre CL (2020) . Biomaterials Science, 8(8), 2074-2083.
Silagi ES, Novais EJ, Bisetto S, Telonis AG, Snuggs J, Le Maitre CL, Qiu Y, Kurland IJ, Shapiro IM, Philp NJ & Risbud MV (2020) . Journal of Bone and Mineral Research, 35(3), 550-570.
Palubeckaitė I, Crooks L, Smith DP, Cole LM, Bram H, Le Maitre C, Clench MR & Cross NA (2020) . Journal of Mass Spectrometry, 55(4), e4461-e4461.
Bach FC, Rooij KM, Riemers FM, Snuggs JW, Jong WAM, Zhang Y, Creemers LB, Chan D, Le Maitre C & Tryfonidou MA (2019) . JOR SPINE, 2(4).
Mahbub AA, Maitre CLL, Haywood-Small S, Cross NA & Jordan-Mahy N (2019) . Oncotarget, 10(44), 4570-4586.
Vickers L, Thorpe AA, Snuggs J, Sammon C & Le Maitre CL (2019) . JOR SPINE, 2(2).
Dosh RH, Jordan-Mahy N, Sammon C & Le Maitre C (2019) . Oncotarget, 10(37), 3559-3575.
Snuggs JW, Day RE, Bach FC, Conner MT, Bunning RAD, Tryfonidou MA & Le Maitre CL (2019) . JOR SPINE, 2(1).
Dosh RH, Jordan-Mahy N, Sammon C & Le Maitre CL (2019) . Scientific Reports, 9(1).
Taylor-Whiteley TR, Le Maitre CL, Duce JA, Dalton CF & Smith DP (2019) . DMM Disease Models and Mechanisms, 12(4).
Dosh RH, Jordan-Mahy N, Sammon C & Le Maitre CL (2019) . Biomaterials Science, 7(10), 4310-4324.
Smith LJ, Silverman L, Sakai D, Le Maitre CL, Mauck RL, Malhotra NR, Lotz JC & Buckley CT (2018) . JOR Spine, 1(4), e1036-e1036.
Thorpe AA, Bach FC, Tryfonidou MA, Le Maitre CL, Mwale F, Diwan AD & Ito K (2018) . JOR Spine, 1(3), e1027-e1027.
Lama P, Le Maitre CL, Harding IJ, Dolan P & Adams MA (2018) . Journal of Anatomy, 233(1), 86-97.
Thorpe AA, Freeman C, Farthing P, Callaghan J, Hatton PV, Brook IM, Sammon C & Le Maitre CL (2018) . Oncotarget, 9(26), 18277-18295.
Dosh RH, Jordan-Mahy N, Sammon C & Le Maitre CL (2018) . Tissue Engineering Part B: Reviews, 24(2), 98-111.
Steinberg J, Ritchie GRS, Roumeliotis TI, Jayasuriya RL, Clark MJ, Brooks RA, Binch ALA, Shah KM, Coyle R, Pardo M , Le Maitre CL et al (2017) . Scientific Reports, 7(1).
Dosh RH, Essa A, Jordan-Mahy N, Sammon C & Le Maitre CL (2017) . Acta Biomaterialia, 62, 128-143.
Johnson ZI, Doolittle AC, Snuggs JW, Shapiro IM, Le Maitre CL & Risbud MV (2017) . Journal of Biological Chemistry, 292(42), 17561-17575.
Mahbub A, Le Maitre C, Haywood-Small S, Cross N & Jordan-Mahy N (2017) . Oncotarget, 8(62), 104877-104893.
Thorpe AA, Dougill G, Vickers L, Reeves ND, Sammon C, Cooper G & Le Maitre CL (2017) . Acta Biomaterialia, 54, 212-226.
Daniels J, Binch AAL & Le Maitre CL (2017) . Journal of Orthopaedic Research, 35(1), 74-85.
Vo NV, Hartman RA, Patil PR, Risbud MV, Kletsas D, Iatridis JC, Hoyland JA, Le Maitre CL, Sowa GA & Kang JD (2016) . Journal of Orthopaedic Research, 34(8), 1289-1306.
Thorpe AA, Boyes VL, Sammon C & Le Maitre CL (2016) . Acta Biomaterialia, 36, 99-111.
Dunn SL, Wilkinson JM, Crawford A, Bunning RAD & Le Maitre CL (2016) . Cannabis and Cannabinoid Research, 1(1), 3-15.
Mader KT, Peeters M, Detiger SEL, Helder MN, Smit TH, Le Maitre CL & Sammon C (2016) . Faraday Discussions, 187, 393-414.
Thorpe AA, Binch ALA, Creemers LB, Sammon C & Le Maitre CL (2016) . Oncotarget, 7(3), 2189-2200.
Mahbub AA, Le Maitre CL, Haywood-Small SL, Cross NA & Jordan-Mahy N (2015) . Cell Death & Disease, 6(12), e2028-e2028.
Binch ALA, Cole AA, Breakwell LM, Michael ALR, Chiverton N, Creemers LB, Cross AK & Le Maitre CL (2015) . Arthritis Research & Therapy, 17(1).
Mahbub A, Le Maitre C, Haywood-Small S, Cross N & Jordan-Mahy N (2015) . Cell Death Discovery, 1(1).
Binch ALA, Cole AA, Breakwell LM, Michael ALR, Chiverton N, Creemers LB, Cross AK & Le Maitre CL (2015) . Oncotarget, 6(21), 18338-18354.
Johnson ZI, Gogate SS, Day R, Binch A, Markova DZ, Chiverton N, Cole A, Conner M, Shapiro IM, Le Maitre CL & Risbud MV (2015) . Oncotarget, 6(14), 11945-11958.
Phillips KLE, Cullen K, Chiverton N, Michael ALR, Cole AA, Breakwell LM, Haddock G, Bunning RAD, Cross AK & Le Maitre CL (2015) . Osteoarthritis and Cartilage, 23(7), 1165-1177.
Le Maitre CL, Binch ALA, Thorpe AA & Hughes SPF (2015) Degeneration of the intervertebral disc with new approaches for treating low back pain. Journal of Neurosurgical Sciences, 59(1), 47-61.
Daniels J, Binch AL, Dunn S, Phillips KL, Chiverton N, Cole A, Michael AR, Breakwell L & Le Maitre CL (2014) . Global Spine Journal, 4(1_suppl).
Binch AL, Phillips KL, Chiverton N, Cole A, Michael AR, Breakwell L, Cross AK & Le Maitre CL (2014) . Global Spine Journal, 4(1_suppl).
Boyes V, Barthrop B, Chiverton N, Cole A, Michael AR, Breakwell L, Sammon C & Le Maitre CL (2014) . Global Spine Journal, 4(1_suppl).
Gogate S, Johnson Z, Day R, Binch A, Markova D, Chiverton N, Cole A, Conner M, Shapiro I, Le Maitre CL & Risbud M (2014) . Global Spine Journal, 4(1_suppl).
Le Maitre CL (2014) . Global Spine Journal, 4(1_suppl).
Mader KT, Le Maitre CL & Sammon C (2014) . Global Spine Journal, 4(1_suppl).
Daniels J, Binch AL, Chiverton N, Cole A, Michael AR, Breakwell L & Le Maitre CL (2014) . Global Spine Journal, 4(1_suppl).
LA Binch A, Cole AA, Breakwell LM, Michael ALR, Chiverton N, Cross AK & Le Maitre CL (2014) . Arthritis Research & Therapy, 16(4).
Dunn SL, Wilkinson JM, Crawford A, Le Maitre CL & Bunning RAD (2014) . Osteoarthritis and Cartilage, 22(1), 133-144.
Phillips KLE, Chiverton N, Michael ALR, Cole AA, Breakwell LM, Haddock G, Bunning RAD, Cross AK & Le Maitre CL (2013) . Arthritis Research & Therapy, 15(6), R213-R213.
Mahbub A, Maitre C, Haywood-Small S, McDougall G, Cross N & Jordan-Mahy N (2013) . Anti-Cancer Agents in Medicinal Chemistry, 13(10), 1601-1613.
Wang H, Tian Y, Wang J, Phillips KLE, Binch ALA, Dunn S, Cross A, Chiverton N, Zheng Z, Shapiro IM , Le Maitre CL et al (2013) . Journal of Biological Chemistry, 288(23), 16761-16774.
Kasaragod D, Lu Z, Le Maitre C, Wilkinson JM & Matcher S (2013) . Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII.
Wang J, Tian Y, Phillips KLE, Chiverton N, Haddock G, Bunning RA, Cross AK, Shapiro IM, Le Maitre CL & Risbud MV (2013) . Arthritis & Rheumatism, 65(3), 832-842.
Dahlawi H, Jordan‐Mahy N, Clench M, McDougall GJ & Maitre CL (2013) . Food Science & Nutrition, 1(2), 196-208.
Phillips KLE, Jordan-Mahy N, Nicklin MJH & Le Maitre CL (2013) . Annals of the Rheumatic Diseases, 72(11), 1860-1867.
Lama P, Le Maitre CL, Dolan P, Tarlton JF, Harding IJ & Adams MA (2013) . The Bone & Joint Journal, 95-B(8), 1127-1133.
Phillips KLE, Chiverton N, Haddock G, Bunning R, Cross A & Le Maitre C (2012) . Global Spine Journal, 2(1_suppl).
Phillips KLE, Chiverton N, Haddock G, Bunning R, Cross A & Le Maitre C (2012) . Global Spine Journal, 2(1_suppl).
Daniels J, Phillips KL, Chiverton N & Le Maitre CL (2012) . Global Spine Journal, 2(1_suppl).
Barthrop B, Boyes V, Sabnis S, Chiverton N, Breen C, Foulkes J, Sammon C & Le Maitre CL (2012) . Global Spine Journal, 2(1_suppl).
Thomas S, Colletta R, Phillips KL, Chiverton N, Cross A & Le Maitre CL (2012) . Global Spine Journal, 2(1_suppl).
G. Zaini R, Brandt K, R. Clench M & L. Le Maitre C (2012) . Anti-Cancer Agents in Medicinal Chemistry, 12(6), 640-652.
Dunn SL, Wilkinson JM, Crawford A, Le Maitre CL & Bunning RAD (2012) . Future Medicinal Chemistry, 4(6), 713-725.
Dahlawi H, Jordan-Mahy N, Clench MR & Le Maitre CL (2012) . Nutrition and Cancer, 64(1), 100-110.
Zaini R, Clench MR & Le Maitre CL (2011) . Journal of Medicinal Food, 14(11), 1303-1312.
Le Maitre CL, Freemont AJ & Hoyland JA (2009) . Arthritis Research & Therapy, 11(5), R137-R137.
Le Maitre CL, Fotheringham AP, Freemont AJ & Hoyland JA (2009) . Journal of Tissue Engineering and Regenerative Medicine, 3(6), 461-469.
Le Maitre CL, Baird P, Freemont AJ & Hoyland JA (2009) . Arthritis Research & Therapy, 11(1), R20-R20.
Pockert AJ, Richardson SM, Le Maitre CL, Lyon M, Deakin JA, Buttle DJ, Freemont AJ & Hoyland JA (2009) . Arthritis & Rheumatism, 60(2), 482-491.
Le Maitre CL, Frain J, Millward-Sadler J, Fotheringham AP, Freemont AJ & Hoyland JA (2009) . Arthritis & Rheumatism, 60(2), 460-469.
Ali R, Le Maitre C, Richardson S, Hoyland J & Freemont A (2008) . Biotechnic & Histochemistry, 83(5), 239-245.
Le Maitre CL, Frain J, Fotheringham AP, Freemont AJ & Hoyland JA (2008) . Biorheology, 45(5), 563-575.
Heathfield S, Le Maitre C & Hoyland J (2008) . Arthritis Research & Therapy, 10(4), R87-R87.
Le Maitre CL, Hoyland JA & Freemont AJ (2007) . Arthritis Research & Therapy, 9(4), R83-R83.
Lally S, Mackenzie P, LeMaitre CL, Freemont TJ & Saunders BR (2007) . Journal of Colloid and Interface Science, 316(2), 367-375.
Le Maitre C, Hoyland J & Freemont AJ (2007) . Arthritis Research & Therapy, 9(4), R77-R77.
Le Maitre CL, Pockert A, Buttle DJ, Freemont AJ & Hoyland JA (2007) . Biochemical Society Transactions, 35(4), 652-655.
Le Maitre C, Freemont A & Hoyland J (2007) . Arthritis Research & Therapy, 9(3), R45-R45.
Saunders JM, Tong T, Le Maitre CL, Freemont TJ & Saunders BR (2007) . Soft Matter, 3(4), 486-486.
Le Maitre C, Freemont A & Hoyland J (2006) . Biotechnic & Histochemistry, 81(4-6), 125-131.
Le Maitre CL, Richardson SMA, Baird P, Freemont AJ & Hoyland JA (2005) . The Journal of Pathology, 207(4), 445-452.
Le Maitre CL, Freemont AJ & Hoyland JA (2005) The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration.. Arthritis research & therapy, 7(4).
Le Maitre CL, Freemont AJ & Hoyland JA (2004) . The Journal of Pathology, 204(1), 47-54.
Le Maitre CL, Hoyland JA & Freemont AJ (2004) . Spine, 29(11), 1187-1195.
Freemont AJ, Watkins A, Le Maitre C, Baird P, Jeziorska M, Knight MTN, Ross ERS, O'Brien JP & Hoyland JA (2002) . The Journal of Pathology, 197(3), 286-292.
Freemont AJ, Watkins A, Le Maitre C, Jeziorska M & Hoyland JA (2002) . The Journal of Pathology, 196(4), 374-379.
Freemont TJ, LeMaitre C, Watkins A & Hoyland JA (2001) . Expert Reviews in Molecular Medicine, 3(11), 1-10.
Le Maitre CL, Byers RJ, Liu Yin JA, Hoyland JA & Freemont AJ (2001) . Journal of Clinical Pathology, 54(9), 730-733.
Bermudez-Lekerika P, Crump KB, Wuertz-Kozak K, Le Maitre CL & Gantenbein B () . Gels, 10(10), 612-612.
Bermudez-Lekerika P, Crump KB, Wuertz-Kozak K, Le Maitre CL & Gantenbein B () . Gels, 10(5), 330-330.
Chakraborty LS, Le Maitre CL, Chahine NO, Fields AJ, Gawri R, Giers MB, Smith LJ, Tang SY, Zehra U, Haglund L , Samartzis D et al () . Journal of Orthopaedic Research.
Williams RJ, Basatvat S, Schmitz TC, Janani R, Sammon C, Benz K, Ito K, Tryfonidou MA, Snuggs JW & Le Maitre CL () . European Cells and Materials, 47, 30-50.
Guarnerio S, Tempest R, Maani R, Hunt S, Cole LM, Le Maitre CL, Chapple K & Peake N () . International Journal of Molecular Sciences, 24(23), 16755-16755.
Laagland LT, Bach FC, Riemers FM, Erdmann G, Braun TS, van den Akker GGH, Schmitz TC, Creemers LB, Sachse C, Le Maitre CL , Welting TJM et al () . European Cells and Materials, 46, 57-90.
Crump KB, Alminnawi A, Bermudez‐Lekerika P, Compte R, Gualdi F, McSweeney T, Muñoz‐Moya E, Nüesch A, Geris L, Dudli S , Karppinen J et al () . JOR SPINE.
Williams RJ, Laagland LT, Bach FC, Ward L, Chan W, Tam V, Medzikovic A, Basatvat S, Paillat L, Vedrenne N , Snuggs JW et al () . JOR SPINE.
Martin JT, Asimakopoulos D, Hornung AL, Toro SJ, Le Maitre CL, Chahine NO, Fields AJ, Gawri R, Giers MB, Smith LJ , Tang SY et al () . European Spine Journal.
Snuggs JW, Emanuel KS, Rustenburg C, Janani R, Partridge S, Sammon C, Smit TH & Le Maitre CL () . Biomaterials Science.
Alaswad HA, Mahbub AA, Le Maitre CL & Jordan-Mahy N () . International Journal of Molecular Sciences, 22(6), 3085-3085.
Snuggs JW, Tessier S, Bunning RAB, Shapiro IM, Risbud MV & Le Maitre CL () . Scientific Reports, 11(1).
Snuggs JW, Bunning RAD & Le Maitre CL () . European Cells and Materials, 41, 121-141.
Rustenburg CME, Snuggs JW, Emanuel KS, Thorpe A, Sammon C, Le Maitre CL & Smit TH () . European Cells and Materials, 40, 21-37.
Lama P, Claireaux H, Flower L, Harding IJ, Dolan T, Le Maitre CL & Adams MA () . Cell Death Discovery, 5(1).
Thorpe AA, Creasey S, Sammon C & Le Maitre CL () . European Cells and Materials, 32, 1-23.
Hoyland JA, Le Maitre C & Freemont AJ () . Rheumatology, 47(6), 809-814.
Le Maitre CL, Freemont AJ & Hoyland JA () . International Journal of Experimental Pathology, 87(1), 17-28.

Conference proceedings papers

Le Maitre C (2023) DEVELOPMENT OF ADVANCED REGENERATIVE APPROACHES FOR DISC DEGENERATION CONSIDERATION OF THE DEGENERATE NICHE. TISSUE ENGINEERING PART A, Vol. 29(11-12) (pp 913-913)
Smith CL, Kelly DM, Le Maitre CL & Stafford P (2023) Developing a microfluidic model to investigate the crosstalk between Porphyromonas gingivalis and vascular endothelial cells. TISSUE ENGINEERING PART A, Vol. 29(13-14)
Lekerika PB, Kanelis E, Croft AS, Crump KB, Kozak KW, Le Maitre C, Alexopoulos L, Rutsche D & Gantenbein B (2023) Sulfated hydrogels as primary intervertebral disc cell culture systems. TISSUE ENGINEERING PART A, Vol. 29(13-14)
Basatvat S, Kanelis E, Braun T, Snuggs J, Williams R, Tryfonidou M, Templin M, Alexopoulos L & Le Maitre C (2023) Understanding the behaviour of Notochordal cells in healthy and degenerated disc environment and their anti-catabolic properties on degenerated Nucleus pulposus cells. TISSUE ENGINEERING PART A, Vol. 29(13-14)
Alminnawi A, Crump KB, Lekerika PB, Croft AS, Geeroms C, Le Maitre C, Gantenbein B & Geris L (2023) Direction Dependent Mass Transport Through the Cartilage Endplate. TISSUE ENGINEERING PART A, Vol. 29(13-14)
Hanson F, Chapple K, Lambert D, Le Maitre C & Peake N (2023) Friend or foe? Transglutaminase-2 and a complex role in the tumour microenvironment. TISSUE ENGINEERING PART A, Vol. 29(13-14)
Dascombe L, Nichol T, Le Maitre C & Aberdein N (2023) Translating resolution: Altering micro-computed tomography outputs for 3D bio-printing. TISSUE ENGINEERING PART A, Vol. 29(13-14)
Laagland L, Poramba-Liyanage D, Bach F, Creemers L, Le Maitre C & Tryfonidou M (2023) HYPEROSMOLAR EXPANSION MEDIUM IMPROVES CANINE NUCLEUS PULPOSUS CELL PHENOTYPE. TISSUE ENGINEERING PART A, Vol. 29(11-12) (pp 1641-1641)
Basatvat S, Kanelis E, Braun T, Snuggs J, Williams R, Tryfonidou M, Templin M, Alexopoulos L & Le Maitre C (2023) Understanding the behaviour of Notochordal cells in healthy and degenerated disc environment and their anti-catabolic properties on degenerated Nucleus pulposus cells. TISSUE ENGINEERING PART A, Vol. 29(13-14)
Hanson F, Chapple K, Lambert D, Le Maitre C & Peake N (2023) Friend or foe? Transglutaminase-2 and a complex role in the tumour microenvironment. TISSUE ENGINEERING PART A, Vol. 29(13-14)
Williams R, Basatvat S, Binch A, Tryfonidou M, Sammon C, Snuggs J & Le Maitre C (2022) THERMORESPONSIVE INJECTABLE HYDROGEL FOR DELIVERY OF NOTOCHORDAL CELLS FOR INTERVERTEBRAL DISC REGENERATION. TISSUE ENGINEERING PART A, Vol. 28 (pp S277-S278)
Le Maitre C (2022) REGENERATIVE MEDICINE APPROACHES TO INTERVERTEBRAL DISC, IMPORTANCE OF PATHOLOGY. TISSUE ENGINEERING PART A, Vol. 28 (pp S14-S14)
Laagland L, Poramba-Lyanage D, Bach F, Creemers L, Le Maitre C & Tryfonidou M (2022) INVESTIGATING THE EFFECT OF CULTURE MEDIUM OSMOLARITY ON THE PHENOTYPE AND REGENERATIVE CAPACITY OF CANINE NUCLEUS PULPOSUS CELLS. TISSUE ENGINEERING PART A, Vol. 28 (pp S483-S483)
Le Maitre C, Snuggs J, Beckman L, Cherif H, Partridge S, Breakwell L, Cole A, Chiverton N, Sammon C & Haglund L (2022) INJECTABLE HYDROGEL FOR DISC REGENERATION STUDY OF INJECTABLITIY AND MECHANICAL PROPERTIES IN WHOLE HUMAN INTERVERTEBRAL DISCS. TISSUE ENGINEERING PART A, Vol. 28 (pp S14-S14)
Janani R, Le Maitre CC & Sammon C (2022) INCORPORATION OF LAPONITE (R)-PNIPAM HYDROGEL INTO BIOACTIVE GLASS SCAFFOLDS FOR BONE REGENERATION. TISSUE ENGINEERING PART A, Vol. 28 (pp S348-S349)
Owen D, Partridge S, Snuggs J, Michael A, Cole A, Chiverton N, Wilkinson M, Sammon C & Le Maitre C (2022) IMPROVING SPINAL FUSION WITH INJECTABLE HYDROGELS. TISSUE ENGINEERING PART A, Vol. 28 (pp S34-S34)
Basatvat S, Williams R, Binch A, Laagland L, Medzikovic A, Batch FC, Liyanage DP, Ito K, Tryfonidou MA & Le Maitre C (2022) COMPARISON OF NOTOCHORDAL CELL MARKERS EXPRESSION BETWEEN 2D AND 3D IN VITRO CULTURE SYSTEMS. TISSUE ENGINEERING PART A, Vol. 28 (pp S27-S27)
Snuggs J, Rustenburg C, Emanuel K, Partridge S, Mader K, Sammon C, Smit T & Le Maitre C (2022) A CAPRINE MODEL OF INTERVERTEBRAL DISC DEGENERATION: A TESTING PLATFORM FOR AN INJECTABLE HYDROGEL. TISSUE ENGINEERING PART A, Vol. 28 (pp S118-S118)
Paskins Z, Farmer CE, Jones RK, Clark A, Troeberg L, Pandit H, Richardson SM, Loughlin J, Brown CA, Taylor EJ , Le Maitre CL et al (2022) RESEARCH PRIORITIES TO REDUCE THE IMPACT OF MUSCULOSKELETAL DISORDERS. RHEUMATOLOGY, Vol. 61 (pp I69-I70)
Steinberg J, Ritchie G, Roumeliotis T, Jayasuriya R, Brooks R, Binch A, Shah K, Coyle R, Pardo M, Le Maitre C , Ramos Y et al (2017) . Osteoarthritis and Cartilage, Vol. 25 (pp S209-S210)
Dahlawi H, Jordan-Mahy N & Le Maitre C (2015) Antiproliferative and induction of apoptosis by pomegranate's anthocyanidins (delphinidin, cyanidin and pelargonidin) on lymphoid and myelopid leukaemia cell lines. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 169 (pp 72-73)
Zaini R, Small SH, Cross N & Le Maitre C (2015) Combination therapy with Falcarinol on human lymphoid leukaemia cell lines and increase the expression of cytochrome C, Bax and SMAC/Diablo. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 169 (pp 72-72)
Sammon CS, Le Maitre C & Mader KM (2014) Novel pNIPAM/clay based hydrogels to tackle degenerative disc disease. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 8 (pp 151-152)
Mader K, Sammon C & Le Maitre C (2014) Characterisation of intervertebral discs using MID-IR spectroscopic imaging. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 8 (pp 112-112)
Smallwood T, Le Maitre C & Sammon C (2014) Characterisation of sterilised and aged IVD replacement candidate materials. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 8 (pp 472-473)
Daniels J, Phillips KLE, Chiverton N & Le Maitre CL (2012) INTRACELLULAR SIGNALLING MECHANISMS INDUCED BY IL-1 IN HUMAN NUCLEUS PULPOSUS CELLS. RHEUMATOLOGY, Vol. 51 (pp 145-145)
Thomas S, Colletta R, Phillips K, Chiverton N, Cole A, Michael AR, Breakwell L, Cross A & Le Maitre C (2012) Regulation of Neurotrophic Factor Expression in Nerve Cells and Intervertebral Disc Cells by Inflammatory Cytokines, Implications for Pain Pathways.. JOURNAL OF PATHOLOGY, Vol. 228 (pp S18-S18)
Dunn S, Crawford A, Wilkinson M, Le Maitre C & Bunning RAD (2012) The effects of cannabinoids on IL-1 induced matrix metalloproteinase expression. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 93(4) (pp A15-A16)
Dunn S, Crawford A, Wilkinson M, Le Maitre C & Bunning R (2012) THE EFFECTS OF CANNABINOIDS ON IL-1 INDUCED MATRIX METALLOPROTEINASE EXPRESSION. RHEUMATOLOGY, Vol. 51 (pp 145-145)
Phillips KLE, Cross A, Chiverton N, Haddock G, Bunning RAD & Le Maitre CL (2012) ROLE OF CYTOKINES AND CHEMOKINES IN HUMAN INTERVERTEBRAL DISC DEGENERATION. RHEUMATOLOGY, Vol. 51 (pp 147-147)
Zaini R, Haywood S, Brandt K, Clench MR, Cross N & Le Maitre C (2012) Synergistic Action of Falcarinol on Induction of Apoptosis on Human Lymphoid Leukaemia Cell Lines. JOURNAL OF PATHOLOGY, Vol. 228 (pp S38-S38)
Mahbub A, Le Maitre C, Haywood-Small SL, McDougall G, Cross NA & Jordan-Mahy N (2012) The Anti-cancerous Potential of Polyphenols in the Treatment of Human Myeloid and Lymphoid Leukaemia. JOURNAL OF PATHOLOGY, Vol. 228 (pp S34-S34)
Phillips KLE, Chiverton N, Cole A, Michael A, Breakwell L, Haddock G, Bunning RAD, Cross AK & Le Maitre CL (2012) Interleukin-1 Regulates Chemokine Expression in the Human Intervertebral Disc. JOURNAL OF PATHOLOGY, Vol. 228 (pp S30-S30)
Estevao ACB, Phillips KLE, Chiverton N, Cole A, Michael A, Breakwell L, Cross AK & Le Maitre CL (2012) CXCL1, CXCL2 and CXCL3 in the Pathogenesis of Intervertebral Disc Degeneration. JOURNAL OF PATHOLOGY, Vol. 228 (pp S30-S30)
Phillips KLE, Chiverton N, Cole A, Michael A, Breakwell L, Haddock G, Bunning RAD, Cross AK & Le Maitre CL (2012) Chemokines and their Receptors in the Human Intervertebral Disc. JOURNAL OF PATHOLOGY, Vol. 228 (pp S30-S30)
Barthrop B, Boyes VL, Sabnis S, Chiverton N, Cole A, Michael AR, Breakwell L, Foulkes J, Sammon C & Le Maitre CL (2012) Injectable Hydrogel Delivery System for Mesenchymal Stem Cell Delivery to the Degenerate Intervertebral Disc. JOURNAL OF PATHOLOGY, Vol. 228 (pp S17-S17)
Daniels J, Phillips KL, Cole A, Michael A, Breakwell L, Chiverton N & Le Maitre CL (2012) Differential Intracellular Signalling Pathways Induced by IL-1 and CDMP-1 in Human Nucleus Pulposus Cells, and their Potential as Therapeutic Targets.. JOURNAL OF PATHOLOGY, Vol. 228 (pp S17-S17)
Wilson A, Jordan-Mahy N, Haywood-Small S, Cross NA & Le Maitre C (2012) Extracts From Red and White Cabbage Contains Bio-Active Compounds Which Induce Apoptosis in Myeloid and Lymphoid Leukaemia Cell Lines. JOURNAL OF PATHOLOGY, Vol. 228 (pp S37-S37)
Phillips KLE, Chiverton N, Bunning RD, Haddock G, Cross AK & Le Maitre CL (2012) CYTOKINE AND CHEMOKINE EXPRESSION PROFILE IN HUMAN INTERVERTEBRAL DISC DEGENERATION. RHEUMATOLOGY, Vol. 51 (pp 147-147)
Dahlawi H, Jordan-Mahy N, Clench MR, McDougall GJ & Le Maitre C (2012) Impact of Anthocyanin Chemical Structure Found in Pomegranate Juice on Leukaemia Treatment. JOURNAL OF PATHOLOGY, Vol. 228 (pp S37-S37)
Dunn SL, Crawford A, Wilkinson M, Le Maitre C & Bunning RAD (2012) Cannabinoids Inhibit IL-1 Signalling Pathways in Human Chondrocytes. JOURNAL OF PATHOLOGY, Vol. 228 (pp S18-S18)
Le Maitre C, Covington J, Dove A, Bon S & Hoyland J (2008) Tailored lithographic fabrication of a cell-seeded polymeric intervertebral disc: A novel therapy for intervertebral disc degeneration. 8th World Biomaterials Congress 2008, Vol. 4 (pp 2284)
Pockert AJ, Le Maitre CL, Buttle DJ, Freemont AJ & Hoyland JA (2006) The expression of the aggrecanolytic ADAMTSs and their endogenous inhibitor TIMP-3 in human intervertebral discs. JOURNAL OF PATHOLOGY, Vol. 210 (pp 24-24)
Pockert AJ, Le Maitre CL, Buttle DJ, Freemont AJ & Hoyland JA (2006) Gene expression of aggrecanolytic ADAMTS and TIMP-3 in the human intervertebral disc. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 87(1) (pp A19-A19)
Richardson S, Le Maitre CL, Russell A, Rice J, Hunt J, Freemont AJ & Hoyland JA (2004) Human bone marrow mesenchymal stromal cells as a source of chondrocytes for tissue engineering of the human intervertebral disc. Transactions - 7th World Biomaterials Congress (pp 147)
Sharma P, El Haj A, Maffulli N, Hoyland J & le Maitre C (2003) Ion channel expresion in intervertebral disc cells. European Cells and Materials, Vol. 6(SUPPL. 2) (pp 50)
Richardson S, le Maitre CL, Russell A, Greenway E, Li Y, Freemont AJ & Hoyland JA (2003) Human bone marrow mesenchymal stromal cells as a source of chondrocytes for treatment of intervertebral disc degeneration. European Cells and Materials, Vol. 6(SUPPL. 2) (pp 20)

Preprints

Tseranidou S, Segarra-Queralt M, Chemorion FK, Le Maitre C, Piñero J & Noailly J (2024) , Cold Spring Harbor Laboratory.
Faber BG, Frysz M, Hartley AE, Ebsim R, Boer CG, Saunders FR, Gregory JS, Aspden RM, Harvey NC, Southam L , Giles W et al (2022) , Cold Spring Harbor Laboratory.
Mahbub AA, Maitre CLL, Cross NA & Jordan-Mahy N (2021) , Research Square Platform LLC.
Paskins Z, Manning F, Farmer C, Le Maitre C, Clark E, Mason D, Wilkinson C, Andersson D, Barlow T, Bishop F , Brown C et al (2021) , Cold Spring Harbor Laboratory.
Steinberg J, Ritchie GRS, Roumeliotis TI, Jayasuriya RL, Brooks RA, Binch ALA, Shah KM, Coyle R, Pardo M, Le Maitre CL , Ramos YFM et al (2016) , Cold Spring Harbor Laboratory.

Research group

Dr Joseph Snuggs
Dr Shaghayegh Basatvat
Miss Rebecca Williams
Miss Andrea Nueesch

Grants

Total Research Funding 2006-to date: £22,208,092.07. Plus £2,788,999 as a collaborator.

2023-2023: MRC-Arthritis Research UK Centre For Integrated Research Into Musculoskeletal Ageing / CIMA OMICS Award: Spatial Transcriptomics of human intervertebral disc tissue to understand the pathophysiological role of cellular senescence during ageing and degeneration. Le Maitre CL, Wilkinson M. £18,080
2023-2023: MRC-Arthritis Research UK Centre For Integrated Research Into Musculoskeletal Ageing / CIMA OMICS Award: Effect of RANK ligand inhibition on human osteoclasts in a randomised clinical trial: A bone tissue level spatial transcriptomics analysis. Wilkinson M, Le Maitre CL. £25,049.16
2022-2023: 2022 ISSLS Research Grant Award, sponsored by Taisho Pharmaceutical. The effect of notochordal extracellular vesicles on human and bovine nucleus pulposus explants. Bach F, van Maanen J, Tryfonidou M, Le Maitre CL, Ito K. £20,000
2022-2023: MRC Confidence in Concept. Breaking down barriers: repurposing anti-fibrosis agents to improve cancer drug delivery. Peake N, Le Maitre CL, Lambert D. £35,000
2022-2026: 91ֱ�� Hallam University, BMRC Graduate Teaching Assistant. Matrix cross-linking – linking diabetes to increased bowel cancer risk. Peake N, Kelly D, Samrein A, Le Maitre CL. £92,000
2021-2025: 91ֱ�� Hallam University, BMRC Graduate Teaching Assistant. Optimisation and development of 3D bone models using high resolution Micro-Computed Tomography. Aberdein N, Le Maitre CL. £92,000
2021-2025: 91ֱ�� Hallam University, BMRC Graduate Teaching Assistant. Antimicrobial sol-gel coating: validation in a laboratory tissue model of orthopaedic implantation. Nichol T, Smith T, Le Maitre CL. £92,000
2021-2024: 91ֱ�� Hallam University, BMRC Graduate Teaching Assistant. Role of periodontitis related platelet activation in vascular disease models. Stafford P, Kelly D, Le Maitre CL. £92,000
2020-2024: H2020 Marie Currie ITN: Disc4All. Consortia lead Noailly J, UoS PI: Le Maitre CL. €3,996,776 (£ 3,575,796)
2019-2022: Bowel and Cancer Research: Extracellular Vesicles: small packages with a big role in bowel cancer metastasis. Peake N, Cole L, Le Maitre CL. £74,659
2019-2025: H2020, iPSpine, Consortia lead Tryfonidou M. UoS PI Le Maitre CL. €15,396,030 (£13,600,000)
2019-2023: 91ֱ�� Hallam University, BMRC PhD Studentship. Role of Hormones and Load on Trabecular and Cortical Bone Remodelling. Aberdein N, Le Maitre CL.&�Բ��;£80,000
2019-2024: MRC: A mechanistic understanding of corneal pathobiology and the development of novel therapeutic strategies for the treatment of connective tissue disorders. Meek K et al., Collaborator: Le Maitre CL. £2,400,000

Teaching interests: My teaching interests include fundamental cell and molecular biology and the cellular and molecular pathogenesis of disease. Together with research design, execution, data presentation and statistical analysis. I am passionate about developing the next generation and have delivered teaching to UG, PGT and PGR students. I have supervised numerous PhD students to completion and won a number of accolades for my contributions to Mentorship and supervision.

Professional activities and memberships: My professional activities include serving on numerous society and journal boards and advisory committees. I have led the organisation of symposia and conferences including acting as the local host for the Society of Back Pain Research Conference which I hosted in 91ֱ�� in 2019. I regularly review for journals and granting bodies nationally and internationally. I am passionate to communicate science to all levels and backgrounds and have been a STEM ambassador for ~15 years delivering public and school presentations, exhibitions and co-creation workshops.

Current projects

iPSPINE:
Disc4All: