Elder, Charlotte, Dr

Dr Charlotte Elder

BSc, MBBS, PhD, DRCOG, MRCPCH

Clinical Medicine, School of Medicine and Population Health

Senior Clinical Lecturer in Paediatric Endocrinology and UKRI Biomedical Sciences Innovation Scholar

c.j.elder@sheffield.ac.uk
+44 114 305 3282

+44 114 271 7149 (NHS Secretary)

Room 10, The Damer Street Building, 91ֱ�� Children's Hospital

Full contact details

Dr Charlotte Elder
Clinical Medicine, School of Medicine and Population Health
Room 10, The Damer Street Building
91ֱ�� Children's Hospital
Western Bank
91ֱ��
S10 2TH

Profile

For enquiries, please contact – ClinMed-Operational@sheffield.ac.uk

Charlotte Elder received her undergraduate medical degree from Imperial College, (University of London) UK in 1999 and, after initially training as a general practitioner, retrained in paediatrics and further specialised in paediatric endocrinology and diabetes. She moved from London to 91ֱ�� in 2005 in pursuit of excellent paediatric endocrinology training combined with affordable housing and fabulous local countryside.

Dr Elder started working for the University of 91ֱ�� in 2009 when she undertook a clinical research fellowship to study for her PhD. After two years she moved to a clinical lectureship, combining her PhD work with running the Child Health undergraduate course for The Medical School. Her PhD was awarded in 2015 and she returned to clinical medicine to train in tertiary level paediatric endocrinology and diabetes but missed academia, so 8 months later returned to 91ֱ�� as an NIHR Academic Clinical Lecturer. In May 2018 Dr Elder took up the post of Consultant in Paediatric Endocrinology and Diabetes at 91ֱ�� Children’s Hospital and three months later was appointed as Senior Clinical Lecturer at the University. In June 2021 Dr Elder started a three year secondment as a UKRI Biomedical Science Innovation Scholar. Clinically her specialist interests are adrenal insufficiency, adrenal function testing and paediatric and adolescent gynaecology.

Dr Elder is passionate about fostering research interests in junior colleagues and making research accessible for all health care professionals. She has supervised over 75 medical students and junior doctors, helping them present, publish and win prizes. Her enthusiasm extends to teaching and she was awarded a Clinical Teaching Award by the University in 2015 and appointed Director of Undergraduate Medical Education at 91ֱ�� Children’s NHS Foundation Trust in 2021.

Research interests

Charlotte Elder's main research area is adrenal insufficiency, with the development of a non-invasive Short Synacthen Test (diagnostic test), using a novel formulation of Synacthen (Nasacthin) for nasal administration and the measurement of the glucocorticoid response in saliva samples. She has led a team over five pharmacokinetic studies in adults and children and is currently working up the next phase of clinical trials. There is a patent application filed for the novel formulation and both commercial and research arms to the current workstream. She is the lead for a clinical trial looking to determine whether awakening salivary cortisone is an effective screening test for adrenal insufficiency in children (SCAIT-junior study) and is working on novel approaches to salivary collection in very young children and babies (NITS study). She is involved with other related projects, particularly involving iatrogenic adrenal insufficiency caused by prescription corticosteroids.

Charlotte's other research interests include a cross-discipline bioengineering project developing pubertal simulation tools for training purposes.

Current projects:

Nasal Tetracosactide and Chitosan for Adrenal Stimulation - Chief Investigator
- Randomised, double-blinded, placebo-controlled cross-over trial in healthy women, men and children
- Randomised cross-over trial in a patient population with adrenal insufficiency
- Normative data study in healthy children to derive reference centiles for The Nasacthin Test
SCAIT-junior (Salivary Cortisone Adrenal Insufficiency Test) assessing awakening salivary cortisone for AI screening - Chief investigator
NITS (Neonatal, Infant and Toddler salivary collection study) - Chief investigator
ACTH and cortisol modelling to improve AI screening - Co-lead
Tertiary Adrenal Insufficiency programme of work - Co-lead

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Low A, Parry-Okeden S, Ferguson EC, Wright N & Elder CJ (2021) . Archives of Disease in Childhood: Education & Practice.
Craig JN, Sharman MR, Fitzgerald CG, Wigg D, Williams BS, Wilkinson EE, Wright NP, Langley J & Elder CJ (2021) . Journal of Pediatric Endocrinology and Metabolism, 34(1), 65-70.
Elder C, Vilela R, Johnson T, Taylor R, Kemp E, Keevil B, Cross A, Ross R & Wright N (2020) . Journal of Clinical Endocrinology and Metabolism, 105(8), 2692-2703.
Elder CJ, Langley J, Stanton A, De Silva S, Akbarian-Tefaghi L, Wales JKH & Wright NP (2018) . Clinical Endocrinology.
Elder CJ, Harrison RF, Cross AS, Vilela R, Keevil BG, Wright NP & Ross RJ (2018) . Clinical Endocrinology, 88(6), 772-778.
Cross AS, Helen Kemp E, White A, Walker L, Meredith S, Sachdev P, Krone NP, Ross RJ, Wright NP & Elder CJ (2018) . Clinical Endocrinology, 88(5), 744-751.
King D, West N & Elder CJ (2017) . Archives of Disease in Childhood Education and Practice Edition, 102(2), 94-99.
Elder CJ & Dimitri P (2015) . Archives of Disease in Childhood.education and Practice Edition, 100(5), 272-276.
Elder CJ & Bishop NJ (2014) . Lancet, 383(9929), 1665-1676.
Elder CJ, Somerset LM, Ram V, Wright NP, Wales JK & Dimitri PJ (2014) . Clin Endocrinol (Oxf), 80(6), 925.
Elder CJ, Sachdev P & Wright NP (2012) . Arch Dis Child, 97(10), 870-873.

All publications

Journal articles

Debono M, Caunt S, Elder C, Fearnside J, Lewis J, Keevil B, Dixon S & Ross R (2023) . Clinical Endocrinology.
Lawrence NR, Keevil BG, Elder C, Fearnside J, Caunt S, Dixon S, Newell-Price JDC, Ross RJM & Debono M (2023) . Journal of the Endocrine Society, 7(Supplement_1), bvad114.351.
Cross AS, Moustafa M & Elder CJ (2023) . Archives of disease in childhood - Education & practice edition.
Tonge JJ, Keevil BG, Craig JN, Whitaker MJ, Ross RJ & Elder CJ (2022) . Journal of Clinical Endocrinology and Metabolism.
Low A, Parry-Okeden S, Ferguson EC, Wright N & Elder CJ (2021) . Archives of Disease in Childhood: Education & Practice.
Craig JN, Sharman MR, Fitzgerald CG, Wigg D, Williams BS, Wilkinson EE, Wright NP, Langley J & Elder CJ (2021) . Journal of Pediatric Endocrinology and Metabolism, 34(1), 65-70.
Elder C, Vilela R, Johnson T, Taylor R, Kemp E, Keevil B, Cross A, Ross R & Wright N (2020) . Journal of Clinical Endocrinology and Metabolism, 105(8), 2692-2703.
Devaraja J, Elder C & Scott A (2020) . Endocrinology, Diabetes & Metabolism Case Reports, 2020(1).
Ferguson EC, Stewart EK, Hannah C & Elder CJ (2019) . Archives of Disease in Childhood.
Lawrence N, Cheetham T & Elder C (2019) . Clinical Endocrinology.
Bacila I-A, Elder C & Krone N (2019) . Archives of Disease in Childhood.
Elder CJ, Langley J, Stanton A, De Silva S, Akbarian-Tefaghi L, Wales JKH & Wright NP (2018) . Clinical Endocrinology.
Elder CJ, Harrison RF, Cross AS, Vilela R, Keevil BG, Wright NP & Ross RJ (2018) . Clinical Endocrinology, 88(6), 772-778.
Cross AS, Helen Kemp E, White A, Walker L, Meredith S, Sachdev P, Krone NP, Ross RJ, Wright NP & Elder CJ (2018) . Clinical Endocrinology, 88(5), 744-751.
Cockill TG, Hewitt A, Heafey C, Wright NP & Elder CJ (2017) . Journal of Pediatric Endocrinology and Metabolism, 30(12).
King D, West N & Elder CJ (2017) . Archives of Disease in Childhood Education and Practice Edition, 102(2), 94-99.
Elder CJ & Dimitri PJ (2017) . ADC Education & Practice.
Calvert A, West N & Elder C (2016) . Archives of Disease in Childhood, 101(Suppl 1).
Elder CJ & Dimitri P (2015) . Archives of Disease in Childhood.education and Practice Edition, 100(5), 272-276.
Elder CJ & Wright NP (2014) . Developmental Medicine & Child Neurology, 56(10), 921-922.
Elder CJ & Bishop NJ (2014) . Lancet, 383(9929), 1665-1676.
Elder CJ, Somerset LM, Ram V, Wright NP, Wales JK & Dimitri PJ (2014) . Clin Endocrinol (Oxf), 80(6), 925.
Jackson C, Wernham EM, Elder CJ & Wright NP (2013) . Practical Diabetes, 30(1), 16-18.
(2012) . Archives of Disease in Childhood, 97(11), 1008-1008.
Elder C, Hinchliffe C & Wright N (2012) . Diabetic Medicine, 29(9), 1213-1214.
Elder CJ, Sachdev P & Wright NP (2012) . Arch Dis Child, 97(10), 870-873.
Elder CJ, Sachdev P & Wright NP (2012) . Archives of Disease in Childhood, 97(10), 870-873.
Elder C, Hinchliffe C & Wright N (2010) . Journal of Clinical Pathology, 63(7), 660-660.
Elder CJ & Natarajan A (2010) Mauriac Syndrome - A Modern Reality. J PEDIATR ENDOCR MET, 23(3), 311-313.
Elder CJ, Wright VJ & Wright NP (2009) . ARCH DIS CHILD, 94(12), 1000-1001.
Elder CJ, Ackerman B & Kingdon C (2008) Audit cycle of newborn observations on the postnatal wards.. Archives of Disease in Childhood - Fetal and Neonatal Edition, 93(6), f475.
Elder CJ, Ackerman B & Kingdon C (2008) Audit cycle of newborn observations on the postnatal wards. ARCH DIS CHILD-FETAL, 93(6), 1475-1475.
Elder CJ, Barton JS, Brook CGD, Preece MA, Dattani MT & Hindmarsh PC (2008) . Hormone Research, 70(2), 89-92.
Pilling EL, Elder CJ & Gibson AT (2008) . Best Pract Res Clin Endocrinol Metab, 22(3), 447-462.
Elder CJ, Sprigg A & Coombs RC (2008) . Arch Dis Child Fetal Neonatal Ed, 93(1), F23.
Elder CJ & Urquhart DS (2006) Limitations of empirical therapy for bacterial meningitis in a healthy child with Listeria monocytogenes meningitis. Journal of Pediatric Neurology, 4(1), 65-67.
Arshad MF, Elder C, Newell-Price J, Ross R & Debono M () . The Journal of Clinical Endocrinology & Metabolism.
Tavernier M, Ross C, Jessica C, Balagamage C, Keevil B, Ross R, Debono M & Elder C () . Endocrine Abstracts.
Fahad AM, Lawrence N, Elder C, Newell-Price J, Ross R & Debono M () . Endocrine Abstracts.
Lawrence NR, Arshad MF, Pofi R, Ashby S, Dawson J, Tomlinson JW, Newell-Price J, Ross RJ, Elder CJ & Debono M () . Journal of the Endocrine Society.
Fahad AM, Elder C, Newell-Price J, Ross R & Debono M () . Endocrine Abstracts.
Mushtaq T, Ali SR, Boulos N, Boyle R, Cheetham T, Davies JH, Elder CJ, Gan H-W, Hindmarsh PC, Katugampola H , Krone N et al () . Archives of Disease in Childhood.
Debono M, Elder CJ, Lewis J, Fearnside J, Caunt S, Dixon S, Jacques RM, Newell-Price J, Whitaker MJ, Keevil B & Ross RJ () . NEJM Evidence.
Mushtaq T, Ali S, Boulos N, Boyle R, Cheetham T, Davies J, Elder C, Gan H-W, Hindmarsh P, Katugampola H , Kerr S et al () . Endocrine Abstracts.

Conference proceedings papers

Burn S, Colyer S, Dimitri P, Wright N, Krone N & Elder C (2018) . Endocrine Abstracts, Vol. 90(S1) (pp 146-146), 27 September 2018 - 29 September 2018.
Aji A, Colyer S, Burn S, Dimitri P, Wright N, Krone N & Elder C (2018) . Hormone Research in Paediatrics, Vol. 90(Suppl 1) (pp 128-129), 27 September 2018 - 29 September 2018.
Cross AS, Sachdev P, Wright NP, Jabbar I & Elder CJ (2017) . British Society for Paediatric Endocrinology and Diabetes and British Society of Paediatric Gastroenterology, Hepatology and Nutrition
Aji A, Colyer S, Burn S, Dimitri P, Wright N, Krone N & Elder C () . Endocrine Abstracts