Dr Callum Jones

MChem, PhD, AFHEA

Clinical Medicine, School of Medicine and Population Health

Postdoctoral Research Associate

Callum G Jones
Callum G Jones
Profile picture of Callum G Jones
c.g.jones@sheffield.ac.uk
+44 114 215 9210
Room GU02, G Floor, The Medical School

Full contact details

Dr Callum Jones
Clinical Medicine, School of Medicine and Population Health
Room GU02, G Floor
The Medical School
Beech Hill Road
91Ö±²¥
S10 2RX
Profile

For enquiries, please contact – SMPH-West-Operational@sheffield.ac.uk

I completed my master’s degree in chemistry at the University of 91Ö±²¥ between 2013-2017 with my dissertation based in organic and medicinal chemistry.

I completed my PhD at the University of 91Ö±²¥ between the Department of Chemistry and the Department of Oncology and Metabolism. My thesis was centred on the development of transition metal complexes for their use in photodynamic therapy.

After this I joined the lab of Dr. Spencer Collis whereby my current research lies in using intermediate frequency, alternating electric fields (termed tumour treating fields) to disrupt and sensitise 3D-cultured, patient-derived glioblastoma cells towards chemoradiotherapy. This is in collaboration with Novocure.

Qualifications
  • 2013-2017, Master of Chemistry (MChem), the University of 91Ö±²¥
  • 2017-2021, Doctor of Philosophy (PhD), The Development of Photodynamic Therapy using Transition Metal Complexes, the University of 91Ö±²¥
Research interests

My research aims to develop and test new and innovative combination therapies to treat cancer which offers both higher potency and lower side effects than those currently available.

Currently, my work aims to enhance the treatment for glioblastoma multiforme (GBM) using alternating electric fields of intermediate frequency, termed tumour treating fields (TTF). Currently, GBM treatments still possess high relapse rates which are caused by repopulation from tumour edge cells which are often enriched with treatment resistant stem cell like subpopulations that possess a heightened DDR.

Primarily, TTF impose an anti-mitotic effect by disrupting microtubule alignment and their subsequent polymerisation which stalls mitotic progression and disrupts cytokinesis. Secondary lesser known TTF effects also cause DDR downregulation which permitting for potential sensitisation towards chemoradiotherapy and/or DDR inhibitors.

Additionally, I collaborate with the neurology team at the Royal Hallamshire Hospital to acquire, process and collect 3D grown, patient-derived glioma cells for testing and storage in the newly established GBM repository, the 91Ö±²¥ BioBank. This bank aims to build and store glioma cell lines which model spatial locations, biomarker expression and stem-cell like phenotypes which are all explicit difficulties in globally treating GBM.

Publications

Journal articles

  • Crowston B, Shipp J, Chekulaev DM, McKenzie L, Jones C, Weinstein J, Meijer AJHM, Bryant HE, Natrajan L, Woodward AW & Ward MD (2019) . Dalton Transactions, 48(18), 6132-6152. RIS download Bibtex download
  • Omar SAE, Scattergood PA, McKenzie LK, Jones C, Patmore NJ, Meijer AJHM, Weinstein JA, Rice CR, Bryant HE & Elliott PIP (2018) . Inorganic Chemistry. RIS download Bibtex download
  • Aeyad T, Jones C & Coldham I (2018) . European Journal of Organic Chemistry. RIS download Bibtex download
  • Jones C, Martinez-Alonso M, Gagg H, Kirby L, Weinstein JA & Bryant HE () . Journal of Medicinal Chemistry. RIS download Bibtex download
  • Gagg H, Williams ST, Conroy S, Myers KN, McGarrity-Cottrell C, Jones C, Helleday T, Rantala J, Rominiyi O, Danson SJ , Collis SJ et al () . F1000Research, 12, 954-954. RIS download Bibtex download
  • Jones CG, Vanderlinden A, Rominiyi O & Collis SJ () . Cancers, 16(5), 863-863. RIS download Bibtex download
  • Martínez-Alonso M, Jones CG, Shipp JD, Chekulaev D, Bryant HE & Weinstein JA () . JBIC Journal of Biological Inorganic Chemistry. RIS download Bibtex download
  • Vanderlinden A, Jones CG, Myers KN, Rominiyi O & Collis SJ () . British Journal of Cancer. RIS download Bibtex download
  • Gagg H, Williams ST, Conroy S, Myers KN, McGarrity-Cottrell C, Jones C, Helleday T, Rantala J, Rominiyi O, Danson SJ , Collis SJ et al () . F1000Research, 12, 954-954. RIS download Bibtex download
Grants
  • RoseTree Foundation PhD funding (2017-2020)
  • Doctoral Academic Scholarship from the University of 91Ö±²¥ (2017-2020)
  • Recipient of The Ray Charles Undergraduate Scholarship (2013-2017)
Teaching activities
  • Lecturer (Cancer Biology and Therapeutics, MSc)
  • Participates in teaching in lab-based projects both at pre and post graduate levels
  • Mentor in the Thesis Mentoring Programme
  • Associate Fellow of the Higher Education Academy