Jackson, Richard F.W. , Emeritus Professor

Emeritus Professor Richard F.W. Jackson

School of Mathematical and Physical Sciences

Emeritus Professor of Synthetic Organic Chemistry

r.f.w.jackson@sheffield.ac.uk
+44 114 222 9464

Dainton Building

Full contact details

Emeritus Professor Richard F.W. Jackson
School of Mathematical and Physical Sciences
Dainton Building
13 Brook Hill
91ֱ��
S3 7HF

Profile

Prof. Jackson obtained his BA in Chemistry from the University of Cambridge in 1981. After his PhD (Cambridge 1984) he became a Postdoctoral Research Fellow at the ETH in Zürich, Switzerland. In 1985 he was appointed to a lectureship at the University of Newcastle, where he was promoted to Reader in 1994 and to Professor in Synthetic Organic Chemistry in 1996.

In 2001 he was appointed to a Chair in Synthesis at the University of 91ֱ��. He served as Head of the Department of Chemistry from 2003-2007, returning to this role for a further term between 2011-2014.

Research interests

I carried out research for my PhD under the supervision of the late Professor Ralph Raphael. I developed a new route to dihydrofuranones, and completed a synthetic approach to the Pseudomonic acids. With this training in target synthesis, I spent one year at the ETH, Zürich, working with Professor Dieter Seebach on the synthesis of a derivative of the macrodiolide Elaiophylin.

I returned to the UK in 1985 to take up a lectureship in Newcastle. Our initial work was in nucleophilic epoxidation, and epoxide anion chemistry, but we also initiated a programme in the area of unnatural amino acid synthesis.

We found that organozinc derivatives of amino acids could be prepared, were surprisingly stable, and provided an easy route to a large variety of useful compounds. This latter area blossomed, and resulted in various awards, from Pfizer, Zeneca and the Hickinbottom Fellowship of the Royal Society of Chemistry.

More recently, we have extended our research to the area of asymmetric catalysis, and discovered a simple method for the asymmetric epoxidation of enones, and a highly efficient method for the asymmetric oxidation of alkyl aryl sulfides to the corresponding sulfoxides. We are also interested in solid phase chemistry, and the application of combinatorial techniques to the discovery of new catalysts.

Publications

Journal articles

Zreigh MM, Adams H, Jackson RFW & Robertson CC (2019) . Acta Crystallographica Section E: Crystallographic Communications, 75(9), 1336-1338.
Reeve PAP, Grabowska U, Oden LS, Wiktelius D, Wångsell F & Jackson RFW (2019) . ACS Omega, 4(6), 10854-10865.
Makwana MV, Muimo R & Jackson RFW (2019) . Laboratory Investigation, 99(3), 438-438.
Makwana MV, Muimo R & Jackson RFW (2018) . Laboratory Investigation, 98(3), 291-303.
Salih N, Adams H & Jackson RF (2016) . Journal of Organic Chemistry, 81(18), 8386-8393.
Lilley M, Mambwe B, Thompson MJ, Jackson RFW & Muimo R (2015) . Chem. Commun., 51(34), 7305-7308.
Lilley M, Mambwe B, Jackson RFW & Muimo R (2014) . Chem Commun (Camb), 50(66), 9343-9345.
Wuttke C, Ford R, Lilley M, Grabowska U, Wiktelius D & Jackson RFW (2012) . Synlett(2), 243-246.
Massah AR, Dreiocker F, Jackson RFW, Pickup BT, Oomens J, Meijer AJHM & Schäfer M (2011) . Phys Chem Chem Phys, 13(29), 13255-13267.
Ross AJ, Dreiocker F, Schaefer M, Oomens J, Meijer AJHM, Pickup BT & Jackson RFW (2011) . ChemInform, 42(25), no-no.
Goddard CML, Massah AR & Jackson RFW (2011) . ChemInform, 42(12), no-no.
Massah AR, Ross AJ & Jackson RFW (2011) . ChemInform, 42(12), no-no.
Ross AJ, Dreiocker F, Schäfer M, Oomens J, Meijer AJHM, Pickup BT & Jackson RFW (2011) . J Org Chem, 76(6), 1727-1734.
Wuttke C, Ford R, Lilley M, Grabowska U, Wiktelius D & Jackson RF (2011) New Routes to Lipophilic Amino Acids: Synthesis of Alkynyl and Fluoro-Containing Alanine Derivatives. Synlett.
Massah AR, Ross AJ & Jackson RFW (2010) . J Org Chem, 75(23), 8275-8278.
Ross AJ, Lang HL & Jackson RFW (2010) . ChemInform, 41(18).
Nolasco L, Gonzalez MP, Caggiano L & Jackson RFW (2010) . ChemInform, 41(12).
Dreiocker F, Oomens J, Meijer AJHM, Pickup BT, Jackson RFW & Schäfer M (2010) . J Org Chem, 75(4), 1203-1213.
Bartrum HE & Jackson RFW (2010) . ChemInform, 41(3).
Goddard CML, Massah AR & Jackson RFW (2010) Improved synthesis of phenylethylamine derivatives by Negishi cross-coupling reactions. Tetrahedron.
Ross AJ, Lang HL & Jackson RFW (2010) . J Org Chem, 75(1), 245-248.
Jackson RFW (2009) . ChemInform, 40(52).
Nolasco L, Perez Gonzalez M, Caggiano L & Jackson RFW (2009) . J Org Chem, 74(21), 8280-8289.
Drago C, Walker EJ, Caggiano L, Jackson RFW, Rawls K & Ellman JA (2009) . Organic Syntheses, 86, 121-129.
Heravi MRP, Loghmani-Khouzani H, Sadeghi MMM, Zendehdel M, Jackson RFW & Adams H (2009) . X-ray Structure Analysis Online, 25(4), 43-44.
Bartrum HE & Jackson RFW (2009) . Synlett(14), 2257-2260.
Rilatt I & Jackson RFW (2008) . J Org Chem, 73(22), 8694-8704.
Bartrum HE, Adams H, Caggiano L & Jackson RFW (2008) . ChemInform, 39(38).
Loghmani-Khouzani H, Poorheravi MR, Sadeghi MMM, Caggiano L & Jackson RFW (2008) . Tetrahedron, 64(30-31), 7419-7425.
Oswald CL, Carrillo-Marquez T, Caggiano L & Jackson RFW (2008) . ChemInform, 39(24).
Jamookeeah CE, Beadle CD, Jackson RFW & Harrity JPA (2008) . ChemInform, 39(22).
Jamookeeah CE, Beadle CD, Jackson RFW & Harrity JPA (2008) . J Org Chem, 73(3), 1128-1130.
Poorheravi MR, Loghmani-Khouzani H, Sadeghi MMM, Zendehdel M, Jackson RFW & Adams H (2008) . Analytical Sciences: X-ray Structure Analysis Online, 24(3).
Oswald CL, Carrillo-Márquez T, Caggiano L & Jackson RFW (2008) . Tetrahedron, 64(4), 681-687.
Bartrum HE, Adams H, Caggiano L & Jackson RFW (2008) . Tetrahedron, 64(17), 3701-3712.
Caggiano L, Jackson RFW, Meijer AJHM, Pickup BT & Wilkinson KA (2008) . Chemistry, 14(29), 8798-8802.
Evans LA, Adams H, Barber CG, Caggiano L & Jackson RFW (2007) . Org Biomol Chem, 5(19), 3156-3163.
Mohammadpoor-Baltork I, Hill M, Caggiano L & Jackson RFW (2007) . ChemInform, 38(16).
Jackson RFW (2007) Recent developments in the application of organometallic chemistry to amino acid synthesis. ABSTR PAP AM CHEM S, 233.
Poorheravi MR, Loghmani-Khouzani H, Sadeghi MMM, Zendehdel M, Jackson RFW & Adams H (2007) . Analytical Sciences: X-ray Structure Analysis Online, 23(11).
Mohammadpoor-Baltork I, Hill M, Caggiano L & Jackson RFW (2006) . Synlett(20), 3540-3544.
Moreno E, Nolasco LA, Caggiano L & Jackson RFW (2006) . Org Biomol Chem, 4(19), 3639-3647.
Carrillo-Marquez T, Caggiano L, Jackson RFW, Grabowska U, Rae A & Tozer MJ (2006) . ChemInform, 37(13).
Drago C, Caggiano L & Jackson RFW (2006) . ChemInform, 37(9).
Rilatt I, Caggiano L & Jackson RFW (2006) . ChemInform, 37(8).
Hinch M, Jacques O, Drago C, Caggiano L, Jackson RFW, Dexter C, Anson MS & Macdonald SJF (2006) . Journal of Molecular Catalysis A: Chemical, 251(1-2), 123-128.
Carrillo-Marquez T, Caggiano L, Jackson RFW, Grabowska U, Rae A & Tozer MJ (2005) . Org Biomol Chem, 3(22), 4117-4123.
Drago C, Caggiano L & Jackson RFW (2005) . Angewandte Chemie, 117(44), 7387-7389.
Drago C, Caggiano L & Jackson RFW (2005) . Angew Chem Int Ed Engl, 44(44), 7221-7223.
(2005) . Organic Syntheses, 81, 77-77.
Jackson RFW & Perez-Gonzalez M (2005) Synthesis of N-(tert-Butoxycarbonyl)-β-iodoalanine methyl ester: A useful building block in the synthesis of nonnatural α-amino acids via palladium catalyzed cross coupling reactions. Organic Syntheses, 81.
Rilatt I, Caggiano L & Jackson RFW (2005) . Synlett(18), 2701-2719.
Jackson RFW, Rilatt I & Murray PJ (2004) . ChemInform, 35(22).
Tabanella S, Valancogne I & Jackson RFW (2004) . ChemInform, 35(15).
Jackson RFW, Rilatt I & Murray PJ (2004) . Org Biomol Chem, 2(1), 110-113.
Tabanella S, Valancogne I & Jackson RFW (2003) . Org Biomol Chem, 1(23), 4254-4261.
Jackson RFW, Rilatt I & Murray PJ (2003) . ChemInform, 34(37).
Jackson RF, Dunn SF, McCamley A & Clegg W (2003) . Org Biomol Chem, 1(14), 2527-2530.
Rodriguez A, Miller DD & Jackson RFW (2003) . ChemInform, 34(26).
Jackson RFW, Rilatt I & Murray PJ (2003) . Chem Commun (Camb)(11), 1242-1243.
Rodríguez A, Miller DD & Jackson RF (2003) . Org Biomol Chem, 1(6), 973-977.
Oates LJ, Jackson RFW & Block MH (2003) Cross coupling reactions of organozinc iodides with solid-supported electrophiles: synthesis of 4-substituted benzoic and 3-substituted (E)- and (Z)-propenoic acids and amides. ORG BIOMOL CHEM, 1(1), 140-144.
Clegg W, Heath SL, Jackson RFW & Palmer NJ (2003) . Acta Crystallographica Section E: Structure Reports Online, 59(7).
Ambroise L, Dumez E, Szeki A & Jackson RFW (2002) Stereocontrolled synthesis of anti-alpha-hydroxy-beta-amino and anti-alpha,beta-diamino acid derivatives by epoxidation of 1-arylthio-l-nitroalkenes. SYNTHESIS-STUTTGART(15), 2296-2308.
MacCulloch AC, Yolka S & Jackson RFW (2002) Asymmetric Michael reactions using tartrate-based magnesium catalysts. SYNLETT(10), 1700-1702.
Pelotier B, Anson MS, Campbell IB, Macdonald SJF, Priem G & Jackson RFW (2002) Enantioselective sulfide oxidation with H2O2: A solid phase and array approach for the optimisation of chiral Schiff base-vanadium catalysts. SYNLETT(7), 1055-1060.
Dumez E, Snaith JS, Jackson RFW, McElroy AB, Overington J, Wythes MJ, Withka JM & McLellan TJ (2002) . Journal of Organic Chemistry, 67(14), 4882-4892.
Wilson I & Jackson RFW (2002) . Journal of the Chemical Society. Perkin Transactions 1, 2(24), 2845-2850.
Deboves HJC, Hunter C & Jackson RFW (2002) . Journal of the Chemical Society. Perkin Transactions 1, 2(6), 733-736.
Green SD, Monti C, Jackson RFW, Anson MS & Macdonald SJF (2001) Discovery of new solid phase sulfur oxidation catalysts using library screening. CHEM COMMUN(24), 2594-2595.
Jackson RFW (2001) . Angewandte Chemie International Edition, 40(19), 3700-3700.
Jackson RFW (2001) . Angewandte Chemie, 113(19), 3814-3814.
Dumez E, Szeki A & Jackson RFW (2001) Stereoselective synthesis of differentially protected anti-alpha,beta-diamino acid derivatives using arylthionitrooxiranes. SYNLETT(8), 1214-1216.
Hunter C, Jackson RFW & Rami HK (2001) . Journal of the Chemical Society. Perkin Transactions 1(12), 1349-1352.
Jacques O, Richards SJ & Jackson RFW (2001) . Chemical Communications, 1(24), 2712-2713.
Deboves HJC, Montalbetti CAGN & Jackson RFW (2001) . Journal of the Chemical Society. Perkin Transactions 1(16), 1876-1884.
Deboves HJC, Hunter C & Jackson RFW () . ChemInform, 33(33), no-no.
Jacques O, Richards SJ & Jackson RFW () . ChemInform, 33(13), no-no.
Deboves HJC, Montalbetti CAGN & Jackson RFW () . ChemInform, 32(51), no-no.
Hunter C, Jackson RFW & Rami HK () . ChemInform, 32(45), no-no.

Chapters

Jackson RFW () John Wiley & Sons, Ltd

Teaching interests: Organic Chemistry

Teaching activities

Undergraduate and postgraduate taught modules

Metals in Organic Synthesis (Level 4)
This course describes the use of organometallic reagents in synthesis. In particular, the use of both stoichiometric organometallics and transition metal catalysts is illustrated.