Turner, Nick, Professor

Professor Nick Turner

School of Mathematical and Physical Sciences

Professor in Bioanalytical Chemistry

n.w.turner@sheffield.ac.uk
+44 114 222 9371

Dainton Building

Full contact details

Professor Nick Turner
School of Mathematical and Physical Sciences
Dainton Building
13 Brook Hill
91ֱ��
S3 7HF

Profile

Nick obtained a BSc in Pharmacology (Southampton 1997) followed by an MRes in Biochemistry (Exeter 1999). His PhD was in the sensor development for detection of fungal toxins using molecularly imprinted polymers (MIPs) with Professor Sergey Piletsky (Cranfield 2004). Following his PhD he was awarded a fellowship from a collaboration of East of England Universities (i10), studying polymers for environmental controlled drug release. This was jointly based out of the Judge Institute of Management, University of Cambridge and Cranfield. He then spent a year at the University of Utah working with Professor Vladimir Hlady (Bioengineering), working on the development of novel imprinting methodologies, before returning to Cranfield to work on several different industrial sponsored commercially sensitive biosensor projects. After this he spent two and a half years at the University of Newcastle, Australia with Professor Adam McCluskey exploring gas phase detection of explosives.In 2009 Nick moved to the Open University, UK to take up a full academic appointment as a Lecturer on Analytical Science where he worked on the development of multiple new modules across the faculty, alongside projects such as the Open Science Laboratory and MOOC development. In August 2018 he moved to De Montfort University School of Pharmacy in the role of Senior Lecturer, then Reader in Bioanalytical Chemistry.

In 2022, Nick won a prestigious EPSRC Established Career Fellowship to explore the development of artificial chaperones. He was awarded his personal chair in mid-2022. Nick joined the Department of Chemistry at 91ֱ�� in March 2023.

Qualifications: BSc (Hons) - Pharmacology - University of Southampton – 1997
MRes - Biological Research Methods (Biochemistry) - University of Exeter - 1999
PhD - Bio-organic Chemistry - Cranfield University – 2004
Senior Fellowship of Higher Education Academy (SFHEA) - 2016

Research interests

My research interests lie in the field of molecular recognition, and in particular the development of artificial recognition elements. Molecularly Imprinted Polymers (MIP) are a simple elegant biomimetic technology where recognition sites, analogous to the binding sites of antibodies, enzymes and receptors are created in polymeric materials containing complementary functionality to a target molecule. After preparation cavities that are complementary to the shape and chemical profile of the target are formed allowing specific recognition and rebinding.
MIPs represent a generic, versatile, scalable and cost-effective approach to the creation of synthetic molecular receptors; and are rapidly becoming commercially relevant.

My work is focused on three key areas.

1: Use of MIPs for biosensing.
Through application of MIP recognition, we can create high affinity, highly selective, sensitive sensors able to detect a wide range of analytes in complex mixtures. Examples include pharmaceuticals in river water; performance-enhancing drugs in urine and protein biomarkers for cancers in serum/saliva. We work with SPR, QCM, optical and electrochemical detection methods. Here we consider different types of polymeric materials, (including nanoMIPs, thin films, membranes etc.) all with controllable functionality. As part of this polymer design and composition plays a significant part in these studies.

2: Nucleic-acid-polymer hybrids.
The development of imprinted nanoparticles that are hybrids between nucleic acids and MIPs. Here we have focused on stabilising aptamers towards improving their recognition capabilities. We are also exploring wider use of these materials for multiple applications.

3: Creation of artificial chaperones.
The molecular recognition provided by the MIPs can offer capabilities in modulating function of biological molecules (cell surface proteins, enzymes, receptors etc.). Here we are exploring how targeted selective recognition through nanaoscale imprinting can demonstrate inhibition or activation of protein function; or affect the structural properties of proteins.

I am willing to support PhD applications in the above areas. Please contact me via email.

Publications

Journal articles

Singla P, Broughton T, Sullivan MV, Garg S, Berlinguer‐Palmini R, Gupta P, Smith KJ, Gardner B, Canfarotta F, Turner NW , Velliou E et al (2024) . Advanced Science.
Wild MI, Sullivan MV, Blackburn C & Turner NW (2024) . RSC Applied Polymers.
Miller CL, Herrmann M, Carter DRF, Turner N, Samuel P & Patel BA (2024) . Biosensors and Bioelectronics, 254, 116224-116224.
Blackburn C, Sullivan MV, Wild MI, O’ Connor AJ & Turner NW (2024) . Analytica Chimica Acta, 1285, 342004-342004.
Sullivan MV, Nanalal S, Dean BE & Turner NW (2024) . Talanta, 266(Pt 2), 125083-125083.
Sullivan MV, Fletcher C, Armitage R, Blackburn C & Turner NW (2023) . NANOSCALE ADVANCES, 5(19), 5352-5360.
Sullivan MV, Dean B, Mates A, Farrow ME, Fletcher C, German M, Patel R & Turner NW (2023) . Nano Express, 4(2).
Sullivan MV, Allabush F, Flynn H, Balansethupathy B, Reed JA, Barnes ET, Robson C, O'Hara P, Milburn LJ, Bunka D , Tolley A et al (2023) . Global Challenges.
Henderson A, Sullivan MV, Hand RA & Turner NW (2022) . Journal of Materials Chemistry B, 10(35), 6792-6799.
Piletsky SA, Bedwell TS, Paoletti R, Karim K, Canfarotta F, Norman R, Jones DJL, Turner NW & Piletska EV (2022) . Journal of Materials Chemistry B, 10(35), 6732-6741.
Sullivan MV, Henderson A, Hand RA & Turner NW (2022) . Analytical and Bioanalytical Chemistry, 414(12), 3687-3696.
El-Sharif HF, Turner NW, Reddy SM & Sullivan MV (2022) . Talanta, 240.
Hand RA, Bassindale T, Turner N & Morgan G (2021) . Journal of Chromatography B, 1178, 122584-122584.
Wankar S, Turner NW & Krupadam RJ (2016) . Biosensors and Bioelectronics, 82, 20-25.
Turner NW, Bramhmbhatt H, Szabo-Vezse M, Poma A, Coker R & Piletsky SA (2015) . Analytica Chimica Acta, 901, 12-33.
Poma A, Brahmbhatt H, Pendergraff HM, Watts JK & Turner NW (2015) . Advanced Materials, 27(9), 1478-1478.
Nicoara SC, Turner NW, Minnikin DE, Lee OY-C, O'Sullivan DM, McNerney R, Mutetwa R, Corbett LE & Morgan GH (2015) . Journal of Chromatography B, 986-987, 135-142.
Poma A, Brahmbhatt H, Pendergraff HM, Watts JK & Turner NW (2015) . Advanced Materials, 27(4), 750-758.
Poma A, Brahmbhatt H, Watts JK & Turner NW (2014) . Macromolecules, 47(18), 6322-6330.
Peng Y, Turner NW & Britt DW (2014) . Colloids and Surfaces B: Biointerfaces, 119, 6-13.
Guerreiro A, Poma A, Karim K, Moczko E, Takarada J, de Vargas-Sansalvador IP, Turner N, Piletska E, de Magalhães CS, Glazova N , Serkova A et al (2014) . Advanced Healthcare Materials, 3(9), 1426-1429.
Pitman S, Xu Y-Z, Taylor P & Turner N (2014) . Future Medicinal Chemistry, 6(8), 865-869.
Turner NW, Holdsworth CI, McCluskey A & Bowyer MC (2012) . Australian Journal of Chemistry, 65(10), 1405-1405.
Turner NW, Holdsworth CI, Donne SW, McCluskey A & Bowyer MC (2010) . New Journal of Chemistry, 34(4), 686-686.
Turner NW, Holmes N, Brisbane C, McGeachie AB, Bowyer MC, McCluskey A & Holdsworth CI (2009) . Soft Matter, 5(19), 3663-3663.
Turner NW, Cauchi M, Piletska EV, Preston C & Piletsky SA (2009) . Biosensors and Bioelectronics, 24(11), 3322-3328.
Turner NW, Subrahmanyam S & Piletsky SA (2009) . Analytica Chimica Acta, 632(2), 168-180.
Chegel V, Whitcombe MJ, Turner NW & Piletsky SA (2009) . Biosensors and Bioelectronics, 24(5), 1270-1275.
Turner NW, Liu X, Piletsky SA, Hlady V & Britt DW (2007) . Biomacromolecules, 8(9), 2781-2787.
Turner NW, Wright BE, Hlady V & Britt DW (2007) . Journal of Colloid and Interface Science, 308(1), 71-80.
Turner NW, Jeans CW, Brain KR, Allender CJ, Hlady V & Britt DW (2006) . Biotechnology Progress, 22(6), 1474-1489.
Piletsky SA, Turner NW & Laitenberger P (2006) . Medical Engineering & Physics, 28(10), 971-977.
Piletska EV, Turner NW, Turner APF & Piletsky SA (2005) . Journal of Controlled Release, 108(1), 132-139.
Piletsky S, Piletska E, Bossi A, Turner N & Turner A (2003) . Biotechnology and Bioengineering, 82(1), 86-92.
Wood AC, Johnson EC, Prasad RRR, Sullivan MV, Turner NW, Armes SP, Staniland SS & Foster JA () . Small.
Winder CI, Blackburn C, Hutchinson CL, Shen AQ, Turner NW & Sullivan MV () . Biomacromolecules.
Kaur S, Singla P, Dann AJ, McClements J, Sullivan MV, Kim M, Stoufer S, Dawson JA, Crapnell RD, Banks CE , Turner NW et al () . ACS Applied Materials & Interfaces.
Hix-Janssens T, Davies JR, Turner NW, Sellergren B & Sullivan MV () . Analytical and Bioanalytical Chemistry.
Sullivan MV, Clay O, Moazami MP, Watts JK & Turner NW () . Macromolecular Bioscience, 2100002-2100002.
Sullivan MV, Allabush F, Bunka D, Tolley A, Mendes PM, Tucker JHR & Turner NW () . Polymer Chemistry, 12(30), 4394-4405.
Hand RA, Piletska E, Bassindale T, Morgan G & Turner N () . The Analyst, 145(14), 4716-4736.
Brahmbhatt HA, Surtees A, Tierney C, Ige OA, Piletska EV, Swift T & Turner NW () . Polymer Chemistry, 11(36), 5778-5789.
Turner NW, Bloxham M, Piletsky SA, Whitcombe MJ & Chianella I () . The Analyst, 142(1), 229-236.
Brahmbhatt H, Poma A, Pendergraff HM, Watts JK & Turner NW () . Biomaterials Science, 4(2), 281-287.
Zulfiqar A, Morgan G & Turner NW () . The Analyst, 139(19), 4955-4955.

Chapters

Sullivan M, Hand R & Turner N (2021) , Molecularly Imprinted Polymers (pp. 109-121). Springer US
Canfarotta F, Piletsky SA & Turner NW (2020) , Methods in Molecular Biology (pp. 183-194). Springer US

Conference proceedings papers

Turner NW, Piletska EV, Karim K, Whitcombe M, Malecha M, Magan N, Baggiani C & Piletsky SA (2004) . Biosensors and Bioelectronics, Vol. 20(6) (pp 1060-1067)

Preprints

Wood AC, Johnson EC, Prasad RRR, Sullivan MV, Turner NW, Armes SP, Staniland SS & Foster JA (2023) , American Chemical Society (ACS).
Singla P, Broughton T, Sullivan MV, Garg S, Berlinguer-Palmini R, Gupta P, Canfarotta F, Turner NW, Velliou E, Amarnath S & Peeters M (2023) , Cold Spring Harbor Laboratory.

Teaching interests

Analytical Chemistry:
Core to all the sciences, understanding of analytical methods and analysis is often forgotten, despite the vital importance it has to nearly all strands of experimental design. My interests lie in developing learning designed to bring analytical understanding and method development to the fore, though combined use of modern instrumentation and online simulations, alongside traditional taught materials.

Pharmacology/ Medicinal Chemistry:
As we move into the digital age, the use of technology to explore drug design and ligand-target interactions is rapidly becoming central to studies, both in the academic and industrial setting. Specifically, here, I am interested in the use of virtual teaching spaces (VR/AR) to support this.

I am willing to support PhD applications in the above areas. Please contact me via email.

Teaching activities: CHM1011 - Analytical Chemistry

Professional activities and memberships

Senior Fellowship of Higher Education Academy (SFHEA) - 2016
Member of the Royal Society of Chemistry
Secretary of Macro Group UK

The Pure and Applied Macromolecular Chemistry Group (Macro Group UK) is a joint interest group of the Royal Society of Chemistry and the Society of Chemical Industry. The Group aims to encourage and enhance polymer chemistry in the UK.