Professor Damien Lacroix
School of Mechanical, Aerospace and Civil Engineering
Professor of Mechanobiology
Insigneo Institute Co-Director
Full contact details
School of Mechanical, Aerospace and Civil Engineering
F21
Pam Liversidge Building
Mappin Street
91直播
S1 3JD
- Profile
-
I am a Professor of Mechanobiology in Mechanical Engineering. I hold a first degree in Mechanical Engineering from the National Institute of Applied Science (INSA Lyon, France) and a PhD in Biomechanics from Trinity College Dublin.
After a post-doc in 2001 in Toulouse (France) for Smith and Nephew at the Purpan Hospital, I was awarded a Marie-Curie TMR EU fellowship in 2002 and a Ramon y Cajal senior fellowship in 2004 at the Technical University of Catalonia (Spain).
In 2008 I was appointed Group Leader of Biomechanics and Mechanobiology at the Institute of Bioengineering of Catalonia (Spain) and I joined Mechanical Engineering in 2012 when I took a Chair in Biomedical Engineering within the INSIGNEO research institute.
- Research interests
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My research covers bone mechanobiology (osteoarthritis, bone tissue engineering, fracture healing) and spine biomechanics (mechanobiology of disc degeneration, disc angiogenesis, disc implant analysis).
The focus of my research group is the study of the effect of mechanical stimuli on biological response. The group's objective is to make scientific advancements in simulations of in vitro and in vivo biomechanics and mechanobiology and in experimental in vitro mechanobiology.
The current focus of the group is mainly on the development of simulations in spine biomechanics and modelling of inflammation in osteoarthritic joints. These numerical simulations based on the finite element method are complemented with in vitro tests using bioreactors and microfluid chambers.
Projects
- Multiscale modelling of the musculoskeletal system
- Development of a predictive computational platform for disc degeneration and bone fracture
- Simulation of a biological / biomaterials interactions in tissue engineering
- Simulation of inflammation in osteoarthritic joints
- Publications
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Books
Journal articles
- . Frontiers in Bioengineering and Biotechnology, 11.
- . Frontiers in Surgery, 8(1).
- . PLoS ONE, 16(5).
- . Interface Focus, 11(1).
- . Frontiers in Surgery, 7.
- . Journal of Materials Research.
- . Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine.
- . Bone Reports, 12.
- . BMC Bioinformatics, 21(1).
- . Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine.
- . Biomechanics and Modeling in Mechanobiology.
- . Scientific Reports, 9(1).
- . PLoS ONE, 14(6).
- . Journal of the Mechanical Behavior of Biomedical Materials, 94, 259-266.
- . Biomechanics and Modeling in Mechanobiology, 17(6), 1715-1730.
- . PLoS ONE, 13(10).
- . Frontiers in Bioengineering and Biotechnology, 6.
- . PLoS ONE, 13(1).
- . Biomechanics and Modeling in Mechanobiology, 17(3), 675-687.
- . Biomechanics and Modeling in Mechanobiology, 17(2), 531-541.
- . Journal of the Mechanical Behavior of Biomedical Materials, 75, 463-469.
- . Journal of the Mechanical Behavior of Biomedical Materials, 71, 165-174.
- . Journal of Biomechanics, 58, 27-36.
- . Annals of Biomedical Engineering, 45(5), 1341-1351.
- . Journal of the Mechanical Behavior of Biomedical Materials, 65, 478-489.
- . Biomechanics and Modeling in Mechanobiology, 15(6), 1495-1508.
- . Frontiers in Bioengineering and Biotechnology, 4.
- . Wiley Interdiscip Rev Syst Biol Med.
- . Journal of the Mechanics and Physics of Solids, 90, 108-123.
- . Journal of Materials Science: Materials in Medicine, 27(4).
- . Biophysical Journal, 109(8), 1533-1536.
- . Journal of Theoretical Biology, 379, 38-46.
- . Interface Focus, 5(2), 20140097-20140097.
- . The Proceedings of the Asian Pacific Conference on Biomechanics : emerging science and technology in biomechanics, 2015.8(0), 219-219.
- The effect of mechanical stimuli on cell adhesion. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 8, 33-34.
- Effect of mechanical stimulation on osteogenesis of self-assembled collagen-heMSC/MG63 microspheres. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 8, 258-258.
- Microfluidic bioreactor for high-throughput and prolonged perfusion of bone scaffolds. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 8, 480-480.
- . Injury, 45 Suppl 2, S23-S31.
- . Osteoarthritis Cartilage, 22(7), 1053-1060.
- . Journal of Biomechanics.
- . Clinical Biomechanics.
- . J Mech Behav Biomed Mater, 38, 219-231.
- . J Mech Behav Biomed Mater, 26, 1-10.
- . Biomaterials, 34(26), 6119-6126.
- . Comput Methods Biomech Biomed Engin, 16(9), 923-928.
- . Journal of Biomechanics, 45, S414-S414.
- . Journal of Biomechanics, 45, S646-S646.
- . Journal of Biomechanics, 45, S418-S418.
- . Tissue Eng Part C Methods, 18(8), 624-631.
- , 144-232.
- . Materials Letters, 78, 154-158.
- . Eur Spine J, 21 Suppl 5, S675-S687.
- . Revista Iberoamericana de Cirug铆a de la Mano, 39(01), 022-031.
- . JOURNAL OF ORTHOPAEDIC RESEARCH, 29(10), 1496-1503.
- . JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 4(7), 1234-1241.
- . PLoS Computational Biology, 7(8).
- . Biomech Model Mechanobiol, 10(4), 565-576.
- . Biomech Model Mechanobiol, 10(2), 203-219.
- . ACTA BIOMATERIALIA, 7(2), 478-484.
- . Biomaterials, 32(11), 2878-2884.
- . Annals of Biomedical Engineering, 39(12), 2972-2983.
- . Biomaterials, 31(34), 8946-8952.
- . Bone, 47, S127-S128.
- . Biomaterials, 31(8), 2446-2452.
- , 353-372.
- . Journal of Biomedical Materials Research - Part A, 95(4), 1011-1018.
- . Biomechanics and Modeling in Mechanobiology, 9(5), 583-596.
- . J Biomech, 42(16), 2780-2788.
- . Biomaterials, 30(25), 4219-4226.
- . Bone Repair Biomaterials, 1-477.
- . Philos Trans A Math Phys Eng Sci, 367(1895), 1993-2009.
- Mode of failure of a biomaterial composite scaffold for bone tissue engineering using synchrotron micro-tomography and finite element analysis. 12th International Conference on Fracture 2009, ICF-12, 8, 6179-6186.
- , 123-154.
- . Biomaterials, 30(30), 6142-6149.
- Material characterization and dynamic cell seeding on PLA/glass composite scaffolds for bone tissue engineering. 8th World Biomaterials Congress 2008, 3, 1248.
- . Journal of Materials Science: Materials in Medicine, 19(4), 1503-1513.
- . Trends in Biotechnology, 26(1), 39-47.
- . Journal of Biomechanics, 41(5), 1005-1014.
- . BIOMATERIALS, 28(36), 5544-5554.
- . Biomaterials, 28(30), 4429-4438.
- . Revista Espa帽ola de Cirug铆a Ortop茅dica y Traumatolog铆a (English Edition), 51(5), 284-295.
- . Revista Espa帽ola de Cirug铆a Ortop茅dica y Traumatolog铆a (English Edition), 51(2), 88-93.
- . Revista de Ortopedia y Traumatologia, 51(2), 88-93.
- . Revista de Ortopedia y Traumatologia, 51(5), 284-295.
- . J Biomech, 40(11), 2414-2425.
- . Biomaterials, 27(30), 5326-5334.
- The effect of bone graft geometry on spinal fusion vertebral stresses.. J Appl Biomater Biomech, 4(3), 135-142.
- . Spine (Phila Pa 1976), 30(20), 2257-2264.
- Intramedullary nails vs osteosynthesis plates for femoral fracture stabilization: A finite element analysis.. J Appl Biomater Biomech, 3(3), 157-167.
- . J Mater Sci Mater Med, 15(4), 541-546.
- . Comput Methods Biomech Biomed Engin, 5(5), 369-376.
- . J Biomech, 35(9), 1163-1171.
- . Med Biol Eng Comput, 40(1), 14-21.
- . J Biomech Eng, 122(4), 430-436.
- . Irish Journal of Medical Science, 168(3), 208-220.
- . Proc Inst Mech Eng H, 211(6), 467-474.
- . Connective Tissue Research, 1-17.
- . PLOS ONE, 13(8), e0200899-e0200899.
- . Universitas Scientiarum, 24(1), 49-72.
Chapters
- , Biomedical Materials (pp. 303-336). Springer International Publishing
- , Frontiers of Biomechanics (pp. 195-199). Springer Singapore
- , Frontiers of Biomechanics (pp. 181-193). Springer Singapore
- , Frontiers of Biomechanics (pp. 1-22). Springer Singapore
- , Frontiers of Biomechanics (pp. 37-57). Springer Singapore
- , Frontiers of Biomechanics (pp. 23-36). Springer Singapore
- , Frontiers of Biomechanics (pp. 105-125). Springer Singapore
- , Frontiers of Biomechanics (pp. 81-104). Springer Singapore
- , Frontiers of Biomechanics (pp. 59-80). Springer Singapore
- , Frontiers of Biomechanics (pp. 143-158). Springer Singapore
- , Frontiers of Biomechanics (pp. 127-142). Springer Singapore
- , Bone Repair Biomaterials (pp. xi-xiv). Elsevier
- , Bone Repair Biomaterials (pp. 53-64). Elsevier
- , Frontiers of Biomechanics (pp. 159-179). Springer Singapore
- Multiscale Mechanobiology in Tissue Engineering Preface, MULTISCALE MECHANOBIOLOGY IN TISSUE ENGINEERING (pp. V-VIII).
- , Biomedical Composites (pp. 479-500). Elsevier
- , Biomaterials for Spinal Surgery (pp. xiii-xvii). Elsevier
- , Computational Modeling in Tissue Engineering (pp. 107-126). Springer Berlin Heidelberg
- , Biomaterials for Spinal Surgery (pp. 144-234e). Elsevier
- , Bone Repair Biomaterials (pp. 106-118).
Conference proceedings papers
- MultiSim: Report of Stakeholder Workshop Outcomes. MultiSim: Report of Stakeholder Workshop Outcomes, Vol. 1(1) (pp 1-7). Insigneo Institute for in silico medicine, 7 September 2014 - 7 September 2014.
- Effect of Mechanical Stimulation on Osteogenic Differentiation of Self-Assembled Collagen-Cell Seeded Hydrogels. TISSUE ENGINEERING PART A, Vol. 21 (pp S271-S271)
- mu-Particle Image Velocimetry and Computational Fluid Dynamics Study of Perfusion Cell Seeding Within a 3d Porous Scaffold. TISSUE ENGINEERING PART A, Vol. 21 (pp S117-S118)
- . Poromechanics V
- (pp 55-69)
- . ADVANCES IN REGENERATIVE MEDICINE: ROLE OF NANOTECHNOLOGY AND ENGINEERING PRINCIPLES (pp 233-+)
Datasets
Presentations
Preprints
- Grants
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- European Commission, Horizon Europe Programme 'Computer-aided effective fracture risk stratification of patients with vertebral metastases for personalised treatment through robust computational models validated in clinical settings (METASTRA)' 07/2023-06/2028. 鈧0.98m. Co-Investigator
- European Research Council Starting Grant, MECHANOBIO - 'Finite element simulations of mechanobiology in tissue engineering', 10/2011-09/2016. 鈧1.49m
- European Commission, FP7 ICT 269909, MySpine - 'Functional prognosis simulation of patient-specific spinal treatment for clinical use', 03/2011-02/2014. 鈧0.68m.
- ESPRC Frontier Engineering Award (EP/K03877X/1), M J Hounslow, D Lacroix, M Viceconti, S A Billings, V Kadirkamanathan, A pavic, E McCloskey, T Skerry, 'Modelling Complex and Partially Identified Engineering Problems - Application to the Individualised Multi-scale Simulation of the Musculoskeletal System', 01.09.2013 to 31.08.2018 拢4.86m
- Teaching interests
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Professor Lacroix supervises final year undergraduate and MSc projects.
- Professional activities and memberships
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- Past-President of the European Society of Biomechanics
- Council Member of the European Alliance for Medical and Biological Engineering and Science (EAMBES)
- Editorial Board member of Biomaterials, Journal of Biomechanics and Clinical Biomechanics
- 2010 Jean Leray Award from the European Society of Biomaterials
- 2006 City Award of Barcelona in Technology Research for the development of a new injectable porous material based on calcium phosphate
- Recipient of European Research Council Starting Grant in 2011
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Member of the Board of Directors, Virtual Physiological Human Institute