Professor Richard Clayton
PhD
School of Computer Science
Professor of Computational Physiology
Director of Research and Innovation
Member of the Complex Systems Modelling research group
+44 114 222 1845
Full contact details
School of Computer Science
Regent Court (DCS)
211 Portobello
91Ö±²¥
S1 4DP
- Profile
-
Richard Clayton has a first degree in Applied Physics and Electronics from the University of Durham, and a PhD in Medical Physics from the University in Newcastle upon Tyne. After completing his PhD, Richard continued research at the Freeman Hospital in Newcastle upon Tyne, funded by British Heart Foundation junior and intermediate fellowships.
The main focus of these projects was on understanding the electrical mechanisms that underlie life-threatening disorders of heart rhythm, based on the analysis of data recorded from patients. A move to the University of Leeds, funded by a British Heart Foundation Lectureship enabled Richard to work on developing mechanistic models of cardiac electrophysiology in the human heart.
Richard Clayton was appointed Senior Lecturer in the School of Computer Science in 91Ö±²¥ in 2003, promoted to Reader in Computer Science in 2008, and Professor of Computational Physiology in 2014. He is a core member of the , and serves on the INSIGNEO board.
- Research interests
-
Richard Clayton’s research interests are focussed on developing physics-based and mechanistic computational models and simulations as tools to examine the structure and function of human tissues and organs. This theme aligns with the recently established INSIGNEO institute for in-silico medicine in 91Ö±²¥.
Richard Clayton has had a long running interest in developing computational models to investigate the mechanisms that initiate and sustain dangerous disorders of heart rhythm in the human heart, and this has been funded through grants and fellowships from the British Heart Foundation.
Recent funding from EPSRC will develop techniques to handle the quantification and propagation of uncertainty within multiscale models of physiology.
- Publications
-
Journal articles
- . The Journal of Heart and Lung Transplantation.
- . Scientific Reports, 14(1).
- . Heart, Lung and Circulation, 32, S196-S196.
- . Chaos: An Interdisciplinary Journal of Nonlinear Science, 33(6).
- . Artificial Intelligence in Medicine, 102610-102610.
- . Computers in Biology and Medicine, 106528-106528.
- . Computerized Medical Imaging and Graphics, 103, 102152-102152.
- . Frontiers in Physiology.
- . Heart, Lung and Circulation, 31, S116-S116.
- . Journal of Arrhythmia.
- . Heart Rhythm.
- . Frontiers in Physiology, 12, 765622.
- . Computerized Medical Imaging and Graphics, 93.
- . Frontiers in Physiology, 12.
- . Frontiers in Physiology, 11(1).
- DenResCov-19: A deep transfer learning network for robust automatic classification of COVID-19, pneumonia, and tuberculosis from X-rays.. CoRR, abs/2104.04006.
- . Heart, Lung and Circulation, 30, S144-S145.
- . Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 378(2173).
- . Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 378(2173), 20200119-20200119.
- . Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 378(2173).
- . Frontiers in Physiology, 11.
- . Medical Image Analysis, 61.
- . Arrhythmia & Electrophysiology Review, 8(3), 191-201.
- . Journal of Biomechanics, 90, 24-32.
- . in silico Plants (isP), 1(1).
- . IEEE Transactions on Biomedical Engineering.
- . Progress in Biophysics & Molecular Biology.
- . Circulation: Arrhythmia and Electrophysiology, 11(6).
- . Annals of Biomedical Engineering, 46(6), 864-876.
- . International Journal for Numerical Methods in Biomedical Engineering, 33(12).
- . EP Europace, 19(suppl_1), i13-i13.
- . Medical & Biological Engineering & Computing.
- . Journal of the Royal Society Interface, 14(128).
- . Journal of Physiology, 594(23), 6833-6847.
- . Journal of Molecular and Cellular Cardiology, 96, 49-62.
- . PLOS ONE, 11(4), e0152349-e0152349.
- . PLoS ONE, 10(6).
- . Cardiac Electrophysiology Clinics, 7(1), 49-58.
- . Drug Discovery Today: Disease Models, 14, 17-22.
- . Prog Biophys Mol Biol, 115(2-3), 252-260.
- . Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 1526-1529.
- . Journal of Theoretical Biology, 296, 84-94.
- . PHILOS T R SOC A, 369(1954), 4331-4351.
- . Circ Arrhythm Electrophysiol, 4(5), 684-691.
- . Prog Biophys Mol Biol, 107(1), 101-111.
- . Progress in Biophysics and Molecular Biology, 104(1-3), 1-1.
- . Progress in Biophysics and Molecular Biology, 107(1), 101-111.
- . NEUROUROL URODYNAM, 30(5), 692-699.
- . Prog Biophys Mol Biol, 104(1-3), 22-48.
- . BIOESSAYS, 32(9), 828-835.
- . Europace, 12(4), 553-560.
- Re-entry in a model of ischaemic ventricular tissue. Computing in Cardiology, 37, 181-184.
- Transmural changes in fibre helix angle in normal and failing canine ventricles. Computing in Cardiology, 37, 915-918.
- . PHYSICA D, 238(11-12), 951-961.
- . EXP PHYSIOL, 94(5), 553-562.
- . Med Biol Eng Comput, 47(3), 291-300.
- . Chaos, 18(4), 043127.
- , 175-193.
- . Prog Biophys Mol Biol, 96(1-3), 19-43.
- . Circulation, 116(suppl_16).
- . J BIOL PHYS, 32(3-4), 355-368.
- . Chaos, 16(3), 033115.
- . CIRCULATION, 114(6), 536-542.
- . PHILOS T R SOC A, 364(1842), 1313-1327.
- . PHILOS T R SOC A, 364(1842), 1171-1186.
- . Heart Rhythm, 3(5), S309-S310.
- . Heart Rhythm, 3(5), S264-S264.
- . EXP PHYSIOL, 91(2), 339-354.
- Re-entry by early afterdepolarisations in a computational model. Computers in Cardiology, 33, 221-224.
- . IET Conference Publications(520), 47.
- . Prog Biophys Mol Biol, 90(1-3), 378-398.
- . J THEOR BIOL, 237(4), 369-381.
- . Biomed Eng Online, 4, 54.
- . Biomed Eng Online, 4, 11.
- . Studies in Multidisciplinarity, 3(C), 389-410.
- . Prog Biophys Mol Biol, 85(2-3), 473-499.
- . IEEE Trans Biomed Eng, 51(1), 28-34.
- Virtual tissue engineering of the heart. INT J BIFURCAT CHAOS, 13(12), 3531-3534.
- . Phys Med Biol, 48(1), 95-111.
- . Med Eng Phys, 24(9), 565-574.
- . Physiol Meas, 23(4), 707-726.
- . Chaos, 12(3), 843-851.
- From excitable media to virtual cardiac tissue. CHAOS SOLITON FRACT, 13(8), 1579-1580.
- . Phys Med Biol, 47(10), 1777-1792.
- . Phys Med Biol, 47(2), 225-238.
- . Physiol Meas, 22(3), R15-R34.
- . J Theor Biol, 208(2), 215-225.
- Heart rate and blood pressure variability in normal subjects compared with data from beat-to-beat models developed from de Boer's model of the cardiovascular system. PHYSIOL MEAS, 21(2), 305-318.
- . Physiol Meas, 20(2), 159-166.
- . Med Biol Eng Comput, 37(3), 354-358.
- Computer simulation of heart rate and blood pressure changes, and comparison with clinical data. IEE Colloquium (Digest)(526).
- . Clinical Science, 95(5), 575-575.
- Comparison of techniques for time-frequency analysis of the ECG during human ventricular fibrillation. IEE P-SCI MEAS TECH, 145(6), 301-306.
- . Clin Sci (Lond), 95(5), 575-581.
- . IEEE Eng Med Biol Mag, 17(1), 39-55.
- Time-frequency analysis of ventricular arrhythmias. IEE Colloquium (Digest)(6).
- . Age Ageing, 26(4), 289-294.
- . Heart, 77(6), 532-538.
- Baroreflex sensitivity may be estimated using spectral analysis. Heart, 77(SUPPL. 1).
- . Eur J Clin Invest, 27(5), 443-449.
- . Pacing Clin Electrophysiol, 18(10), 1876-1881.
- EFFECTS OF AEROBIC ON BAROREFLEX SENSITIVITY IN HEALTHY SEDENTARY ELDERLY SUBJECTS. J AM GERIATR SOC, 43(9), SA77-SA77.
- . Eur Heart J, 16(8), 1115-1119.
- . J Cardiovasc Electrophysiol, 6(8), 616-624.
- . Physiol Meas, 16(2), 131-139.
- . Resuscitation, 29(2), 113-117.
- . Age and Ageing, 24(suppl 2), P3-P3.
- . Physiol Meas, 15(3), 235-242.
- . Perfusion, 9(3), 163-171.
- . Med Biol Eng Comput, 32(2), 217-220.
- . Eur Heart J, 15(2), 184-188.
- . Resuscitation, 26(2), 163-172.
- . Med Biol Eng Comput, 31(2), 111-117.
- . Lancet, 341(8837), 93-95.
- . Clin Phys Physiol Meas, 13(2), 167-177.
- Repeatability of dynamic eye pupil response measurement using the Pupilscan instrument.. Clin Phys Physiol Meas, 12(4), 377-385.
- . Clin Phys Physiol Meas, 11(4), 327-332.
- . Anaesthesia, 43(8), 677-682.
- . Perfusion, 3(1), 55-63.
- EXTRACORPOREAL-CIRCULATION MATERIAL EVALUATION - MICROEMBOLI. LIFE SUPPORT SYST, 5(1), 53-67.
- . Neural Computing and Applications.
- Convergence, sampling and total order estimator effects on parameter orthogonality in global sensitivity analysis. PLoS Computational Biology.
- . Circulation: Arrhythmia and Electrophysiology.
- . Frontiers in Physiology, 15.
- Calibrating cardiac electrophysiology models using latent Gaussian processes on atrial manifolds. Scientific Reports.
- . Frontiers in Physiology, 9.
- . PLOS ONE, 10(8), e0137004-e0137004.
- . PLoS Computational Biology, 10(11).
- Bayesian Calibration of Electrophysiology Models using Restitution Curve Emulators. Frontiers in Physiology.
- Hypoglycaemia combined with mild hypokalaemia reduces the heart rate and causes abnormal pacemaker activity in a computational model of a human sinoatrial cell.. Journal of the Royal Society Interface.
Chapters
- , Cardiovascular Biomechanics (pp. 107-126). Springer International Publishing
- , Encyclopedia of Systems Biology (pp. 1638-1640). Springer New York
- Modelling the mammalian heart. In Grierson C & Hetherington A (Ed.), Practical systems biology (pp. 175-193). Taylor and Francis Group
- Modelling the mammalian heart In Grierson C & Hetherington AM (Ed.), Practical systems biology Taylor & Francis Group
- Towards understanding the physical basis of re-entrant cardiac arrhythmias, MULTIDISCIPLINARY APPROACHES TO THEORY IN MEDICINE (pp. 389-410).
Conference proceedings papers
- Can computational modelling explain the dead in bed syndrome?. DIABETOLOGIA, Vol. 62 (pp S46-S46)
- Pharmacological autonomic blockade during experimental hypoglycaemia exacerbates cardiac repolarisation abnormalities. DIABETOLOGIA, Vol. 60 (pp S74-S74)
- Pharmacological Autonomic Blockade Exacerbates Cardiac Repolarization Abnormalities during Experimental Hypoglycemia. DIABETES, Vol. 66 (pp A95-A95)
- . Functional Imaging and Modelling of the Heart 2017, Proceedings, Vol. 10263 LNCS (pp 249-259)
- . 2015 Computing in Cardiology Conference (CinC), 6 September 2015 - 9 September 2015.
- . 2015 Computing in Cardiology Conference (CinC), 6 September 2015 - 9 September 2015.
- . 2015 Computing in Cardiology Conference (CinC), 6 September 2015 - 9 September 2015.
- Parameter sensitivity analysis of a human atrial cell model using multivariate regression. Computing in Cardiology, Vol. 41(January) (pp 521-524)
- The effect of scar tissue on complexity of activation patterns in simulated human ventricular fibrillation. Computing in Cardiology, Vol. 41(January) (pp 1133-1136)
- Formulation of ATP sensitive K+ current and action potential shape in models of human ventricular myocytes. Computing in Cardiology, Vol. 41(January) (pp 201-204)
- Clustering of Re-entry Close to Scar Boundaries in Ventricular Tissue during Simulated Ventricular Fibrillation. Computing in Cardiology, Vol. 40 (pp 1131-1134). Barcelona
- A Comparison of Two Models of Human Ventricular Tissue: Simulated Ischaemia and Re-entry. Computing in Cardiology, Vol. 40 (pp 385-388). Barcelona
- Transient Type II Ventricular Fibrillation During Global Ischemia in the in-situ Human Heart. CIRCULATION, Vol. 120(18) (pp S630-S630)
- Automatic Classification of Arrhythmic Beats Using Gaussian Processes. COMPUTERS IN CARDIOLOGY 2008, VOLS 1 AND 2 (pp 921-924)
- Epicardial Mapping of Ventricular Fibrillation in the Human Heart during Ischaemia and Reperfusion. COMPUTERS IN CARDIOLOGY 2008, VOLS 1 AND 2 (pp 1029-1032)
- Is human ventricular fibrillation different from experimental models?. CIRCULATION, Vol. 116(16) (pp 278-278)
- Mobility of epicardial rotors during human ventricular fibrillation. CIRCULATION, Vol. 116(16) (pp 278-278)
- Model based visualization of cardiac virtual tissue. Proceedings of the UK e-Science All Hands Meeting 2006 (pp 233-240)
- Multi-variate visualization of cardiac virtual tissue. 19TH IEEE INTERNATIONAL SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS, PROCEEDINGS (pp 665-670)
- Early ventricular fibrillation in the human heart is sustained by a small number of re-entrant sources. CIRCULATION, Vol. 112(17) (pp U131-U131)
- Methods for identifying and tracking phase singularities in computational models of re-entrant fibrillation. FUNCTIONAL IMAGING AND MODELING OF HEART, PROCEEDINGS, Vol. 3504 (pp 246-255)
- . Lecture Notes in Computer Science, Vol. 3504 (pp 153-161)
- Simulation of hypertrophy in rat left ventricular cells. Computers in Cardiology 2004, Vol 31, Vol. 31 (pp 513-516)
- Can endogenous, noise-triggered early after-depolarizations initiate reentry in a modified Luo-Rudy ventricular virtual tissue?. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, Vol. 13(12) (pp 3835-3843)
- Vulnerability to reentry, and drift, stability and breakdown of spiral waves in a linear gradient of G(K) in a Luo-Rudy 1 virtual ventricular tissue. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, Vol. 13(12) (pp 3865-3871)
- Constructive volume geometry applied to visualization of cardiac anatomy and electrophysiology. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, Vol. 13(12) (pp 3591-3604)
- Dynamics and interaction of filaments during reentry and fibrillation in mammalian virtual ventricular tissue. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, Vol. 13(12) (pp 3733-3745)
- Visualising cardiac anatomy using constructive volume geometry. FUNCTIONAL IMAGING AND MODELING OF THE HEART, PROCEEDINGS, Vol. 2674 (pp 30-38)
- Regional differences in action potential duration and stability of re-entry: insights from computational models. JOURNAL OF PHYSIOLOGY-LONDON, Vol. 544 (pp 3P-3P)
- Re-entry in computational models of ischaemic myocardium. CHAOS SOLITONS & FRACTALS, Vol. 13(8) (pp 1671-1683)
- Simulating the ECG of ventricular tachyarrhythmias. COMPUTERS IN CARDIOLOGY 2002, VOL 29, Vol. 29 (pp 321-324)
- Filament dynamics in a computational model of re-entrant fibrillation in anatomically detailed canine ventricular anatomy. SECOND JOINT EMBS-BMES CONFERENCE 2002, VOLS 1-3, CONFERENCE PROCEEDINGS (pp 1417-1418)
- Differential meander of re-entrant spiral waves in mammalian virtual ventricular tissue. JOURNAL OF PHYSIOLOGY-LONDON, Vol. 536 (pp 71P-71P)
- Temporal evolution of nonlinear dynamics in ventricular arrhythmia. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, Vol. 11(10) (pp 2531-2548)
- Re-entry in the Luo-Rudy ventricular tissue model with different models of Ca2+ dynamics. COMPUTERS IN CARDIOLOGY 2001, VOL 28, Vol. 28 (pp 233-236)
- Computational simulation of multiple wavelet re-entry and fibrillatory conduction shows differences in the ECG characteristics of each mechanism. COMPUTERS IN CARDIOLOGY 2000, VOL 27, Vol. 27 (pp 343-346)
- Re-entrant arrhythmias in simulations of the Long-QT syndrome. COMPUTERS IN CARDIOLOGY 1999, VOL 26 (pp 121-124)
- Linear and nonlinear characteristics of ECG signals produced by simulations of ventricular tachyarrhythmias. COMPUTERS IN CARDIOLOGY 1999, VOL 26 (pp 479-482)
- Computer modelling of heart rate and blood pressure. COMPUTERS IN CARDIOLOGY 1998, VOL 25, Vol. 25 (pp 149-152)
- Model based investigation of cardiovascular variability. IEE Colloquium (Digest)(9)
- Comparison of autoregressive and Fourier transform based techniques for estimating RR interval spectra. COMPUTERS IN CARDIOLOGY 1997, VOL 24, Vol. 24 (pp 379-382)
- Time-frequency analysis of human polymorphic ventricular tachycardia. COMPUTERS IN CARDIOLOGY 1997, VOL 24, Vol. 24 (pp 97-100)
- Relation between intracardiac and surface ECG signals during the onset of human ventricular fibrillation. COMPUTERS IN CARDIOLOGY 1996 (pp 341-344)
- Frequency analysis of ventricular fibrillation. IEE Colloquium (Digest)(43)
- Comparison of techniques for estimating baroreflex gain from heart rate and blood pressure spectra. COMPUTERS IN CARDIOLOGY 1995 (pp 301-304)
- ESTIMATION OF THE ECG SIGNAL SPECTRUM DURING VENTRICULAR-FIBRILLATION USING THE FAST FOURIER-TRANSFORM AND MAXIMUM-ENTROPY METHODS. COMPUTERS IN CARDIOLOGY 1993, PROCEEDINGS (pp 867-870)
- Automatic recording of ventricular fibrillation. Computers in Cardiology (pp 685-688)
- Changes in the surface ECG frequency spectrum during the onset of ventricular fibrillation. Computers in Cardiology (pp 515-518)
- . Computing in Cardiology Conference (CinC)
- Formulation of ATP sensitive K+ current and action potential shape in models of human ventricular myocytes. Computing in Cardiology, Vol. 41 (pp 201-201). Cambridge, 7 September 2014 - 10 September 2014.
- . Computers in Cardiology 2000. Vol.27 (Cat. 00CH37163)
- . Proceedings Computers in Cardiology
- . 2018 Computing in Cardiology Conference (CinC), Vol. 45. Maastricht, The Netherlands, 23 September 2018 - 26 September 2018.
Reports
- In silico Clinical Trials: How Computer Simulations Will Transform the Biomedical Industry. An International Roadmap for an Industry-Driven Initiative.
Working papers
Datasets
Preprints
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- Calibrating cardiac electrophysiology models using latent Gaussian processes on atrial manifolds.
- DenResCov-19: A deep transfer learning network for robust automatic classification of COVID-19, pneumonia, and tuberculosis from X-rays, arXiv.
- Gaussian Process Manifold Interpolation for Probabilistic Atrial Activation Maps and Uncertain Conduction Velocity.
- .
- Grants
-
Current grants
- , EPSRC, 04/2022 - 03/2026, £314,026, as PI
- The SofTMech Statistical Emulation and Translation Hub, EPSRC, 03/2021 - 02/2025, £207,617, as PI
- SANO: Centre for New Methods in Computational Diagnostics and Personalised Therapy, EC H2020, 08/2019 - 07/2026, £2,497,386, as Co-PI
- PRIMAGE: , Empowered by imaging biomarkers, EC H2020, 12/2018 to 05/2023, £549,018, as Co-PI
Previous grants
- Neurocardiac Interaction In Malignant Ventricular Arrhythmias And Sudden Cardiac Death, British Heart Foundation, 7/2017 to 03/2023, £128,604, as PI
- , EPSRC, 05/17 to 04/22, £460,590, as PI
- , EC H2020, 02/2016 to 01/2019, £401,801, as Co-PI
- , EPSRC, 04/2013 to 09/2017, £665,262, as PI
- , EPSRC, 04/2013 to 03/2017, £218,232, as PI
- Development of a novel diagnostic model of urinary dysfunction, 91Ö±²¥ Hospitals Charitable Trust, 03/2014 to 08/2014, £15,715, as Co-PI
- Determination of thresholds for the development of ventricular arrhythmias using computer modelling, 91Ö±²¥ Hospitals Charitable Trust, 03/2010 to 12/2014, £48,370, as Co-PI
- , EPSRC, 03/2008 to 03/2010, £85,491, as Co-PI
- Initiation of re-entry and fibrillation in the ventricle: A mechanistic investigation using computational models, British Heart Foundation, 07/2004 to 06/2007, £97,443, as PI
- Professional activities and memberships
-
- Member of the research group
- Member of INSIGNEO board
- Member of EPSRC review college