Professor Richard Clayton

PhD

School of Computer Science

Professor of Computational Physiology

Director of Research and Innovation

Member of the Complex Systems Modelling research group

Richard Clayton profile photo
Profile picture of Richard Clayton profile photo
r.h.clayton@sheffield.ac.uk
+44 114 222 1845

Full contact details

Professor Richard Clayton
School of Computer Science
Regent Court (DCS)
211 Portobello
91Ö±²¥
S1 4DP
Profile

Richard Clayton has a first degree in Applied Physics and Electronics from the University of Durham, and a PhD in Medical Physics from the University in Newcastle upon Tyne. After completing his PhD, Richard continued research at the Freeman Hospital in Newcastle upon Tyne, funded by British Heart Foundation junior and intermediate fellowships.

The main focus of these projects was on understanding the electrical mechanisms that underlie life-threatening disorders of heart rhythm, based on the analysis of data recorded from patients. A move to the University of Leeds, funded by a British Heart Foundation Lectureship enabled Richard to work on developing mechanistic models of cardiac electrophysiology in the human heart.

Richard Clayton was appointed Senior Lecturer in the School of Computer Science in 91Ö±²¥ in 2003, promoted to Reader in Computer Science in 2008, and Professor of Computational Physiology in 2014. He is a core member of the , and serves on the INSIGNEO board.

Research interests

Richard Clayton’s research interests are focussed on developing physics-based and mechanistic computational models and simulations as tools to examine the structure and function of human tissues and organs. This theme aligns with the recently established INSIGNEO institute for in-silico medicine in 91Ö±²¥.

Richard Clayton has had a long running interest in developing computational models to investigate the mechanisms that initiate and sustain dangerous disorders of heart rhythm in the human heart, and this has been funded through grants and fellowships from the British Heart Foundation.

Recent funding from EPSRC will develop techniques to handle the quantification and propagation of uncertainty within multiscale models of physiology.

Publications

Journal articles

  • Weiner OJF, Das M, Clayton RH, McComb JM, Murray A, Parry G & Lord SW (2024) . The Journal of Heart and Lung Transplantation. RIS download Bibtex download
  • Sridhar S & Clayton RH (2024) . Scientific Reports, 14(1). RIS download Bibtex download
  • Dharmaprani D, Jenkins E, Tiver K, Quah J, Mitchell L, Tung M, Ahmad W, Stoyanov N, Aguilar M, Nash M , Clayton R et al (2023) . Heart, Lung and Circulation, 32, S196-S196. RIS download Bibtex download
  • Jenkins EV, Dharmaprani D, Schopp M, Quah JX, Tiver K, Mitchell L, Nash MP, Clayton RH, Pope K & Ganesan AN (2023) . Chaos: An Interdisciplinary Journal of Nonlinear Science, 33(6). RIS download Bibtex download
  • Mamalakis M, Garg P, Nelson T, Lee J, Swift AJ, Wild JM & Clayton RH (2023) . Artificial Intelligence in Medicine, 102610-102610. RIS download Bibtex download
  • Corrado C, Roney CH, Razeghi O, Lemus JAS, Coveney S, Sim I, Williams SE, O’Neill MD, Wilkinson RD, Clayton RH & Niederer SA (2023) . Computers in Biology and Medicine, 106528-106528. RIS download Bibtex download
  • Mamalakis M, Garg P, Nelson T, Lee J, Swift AJ, Wild JM & Clayton RH (2023) . Computerized Medical Imaging and Graphics, 103, 102152-102152. RIS download Bibtex download
  • Jenkins EV, Dharmaprani D, Schopp M, Quah JX, Tiver K, Mitchell L, Xiong F, Aguilar M, Pope K, Akar FG , Roney CH et al (2022) . Frontiers in Physiology. RIS download Bibtex download
  • Jenkins E, Dharmaprani D, Schopp M, Xian Quah J, Tiver K, Mitchell L, Nash M, Clayton R & Ganesan A (2022) . Heart, Lung and Circulation, 31, S116-S116. RIS download Bibtex download
  • Lee JMS, Nelson TA, Clayton RH & Kelland NF (2021) . Journal of Arrhythmia. RIS download Bibtex download
  • Dharmaprani D, Jenkins EV, Quah JX, Lahiri A, Tiver K, Mitchell L, Bradley CP, Hayward M, Paterson DJ, Taggart P , Clayton RH et al (2021) . Heart Rhythm. RIS download Bibtex download
  • Coveney S, Corrado C, Oakley JE, Wilkinson RD, Niederer SA & Clayton RH (2021) . Frontiers in Physiology, 12, 765622. RIS download Bibtex download
  • Mamalakis M, Garg P, Nelson T, Lee J, Wild JM & Clayton RH (2021) . Computerized Medical Imaging and Graphics, 93. RIS download Bibtex download
  • Roney CH, Child N, Porter B, Sim I, Whitaker J, Clayton RH, Laughner JI, Shuros A, Neuzil P, Williams SE , Razavi RS et al (2021) . Frontiers in Physiology, 12. RIS download Bibtex download
  • Dharmaprani D, Jenkins E, Aguilar M, Quah JX, Lahiri A, Tiver K, Mitchell L, Kuklik P, Meyer C, Willems S , Clayton R et al (2021) . Frontiers in Physiology, 11(1). RIS download Bibtex download
  • Mamalakis M, Swift AJ, Vorselaars B, Ray S, Weeks S, Ding W, Clayton RH, Mackenzie LS & Banerjee A (2021) DenResCov-19: A deep transfer learning network for robust automatic classification of COVID-19, pneumonia, and tuberculosis from X-rays.. CoRR, abs/2104.04006. RIS download Bibtex download
  • Dharmaprani D, Jenkins E, Quah J, Lahiri A, Tiver K, Mitchell L, Bradley C, Hayward M, Paterson D, Taggart P , Clayton R et al (2021) . Heart, Lung and Circulation, 30, S144-S145. RIS download Bibtex download
  • Coveney S, Corrado C, Roney CH, O’Hare D, Williams SE, O’Neill MD, Niederer SA, Clayton RH, Oakley JE & Wilkinson RD (2020) . Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 378(2173). RIS download Bibtex download
  • Mirams GR, Niederer SA & Clayton RH (2020) . Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 378(2173), 20200119-20200119. RIS download Bibtex download
  • Clayton RH, Aboelkassem Y, Cantwell CD, Corrado C, Delhaas T, Huberts W, Lei CL, Ni H, Panfilov AV, Roney C & dos Santos RW (2020) . Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 378(2173). RIS download Bibtex download
  • Coveney S & Clayton RH (2020) . Frontiers in Physiology, 11. RIS download Bibtex download
  • Corrado C, Razeghi O, Roney C, Coveney S, Williams S, Sim I, O'Neill M, Wilkinson R, Oakley J, Clayton R & Niederer S (2020) . Medical Image Analysis, 61. RIS download Bibtex download
  • Nelson T, Garg P, Clayton RH & Lee J (2019) . Arrhythmia & Electrophysiology Review, 8(3), 191-201. RIS download Bibtex download
  • Melis A, Moura F, Larrabide I, Janot K, Clayton RH, Narata AP & Marzo A (2019) . Journal of Biomechanics, 90, 24-32. RIS download Bibtex download
  • Holland BL, Monk NAM, Clayton RH & Osborne CP (2019) . in silico Plants (isP), 1(1). RIS download Bibtex download
  • Coveney S, Corrado C, Roney C, Wilkinson R, Oakley J, Lindgren F, Williams S, O'Neill M, Niederer S & Clayton R (2019) . IEEE Transactions on Biomedical Engineering. RIS download Bibtex download
  • Coveney S & Clayton RH (2018) . Progress in Biophysics & Molecular Biology. RIS download Bibtex download
  • Child N, Clayton RH, Roney CR, Laughner JI, Shuros A, Neuzil P, Petru J, Jackson T, Porter B, Bostock J , Niederer SA et al (2018) . Circulation: Arrhythmia and Electrophysiology, 11(6). RIS download Bibtex download
  • Robson J, Aram P, Nash MP, Bradley CP, Hayward M, Paterson DJ, Taggart P, Clayton RH & Kadirkamanathan V (2018) . Annals of Biomedical Engineering, 46(6), 864-876. RIS download Bibtex download
  • Melis A, Clayton RH & Marzo A (2017) . International Journal for Numerical Methods in Biomedical Engineering, 33(12). RIS download Bibtex download
  • Chang ETY, Bernjak A, Nelson T, Smith G, Lee J & Clayton RH (2017) . EP Europace, 19(suppl_1), i13-i13. RIS download Bibtex download
  • Johnston BM, Coveney S, Chang ETY, Johnston PR & Clayton RH (2017) . Medical & Biological Engineering & Computing. RIS download Bibtex download
  • Lin YT, Chang ETY, Eatock J, Galla T & Clayton RH (2017) . Journal of the Royal Society Interface, 14(128). RIS download Bibtex download
  • Mirams GR, Pathmanathan P, Gray RA, Challenor P & Clayton RH (2016) . Journal of Physiology, 594(23), 6833-6847. RIS download Bibtex download
  • Johnstone RH, Chang ETY, Bardenet R, De Boer T, Gavaghan DJ, Pathmanathan P, Clayton RH & Mirams GR (2016) . Journal of Molecular and Cellular Cardiology, 96, 49-62. RIS download Bibtex download
  • Chang ETY, Lin YT, Galla T, Clayton RH & Eatock J (2016) . PLOS ONE, 11(4), e0152349-e0152349. RIS download Bibtex download
  • Chang ETY, Strong M & Clayton RH (2015) . PLoS ONE, 10(6). RIS download Bibtex download
  • Clayton RH & Nash MP (2015) . Cardiac Electrophysiology Clinics, 7(1), 49-58. RIS download Bibtex download
  • Clayton RH & Bishop MJ (2014) . Drug Discovery Today: Disease Models, 14, 17-22. RIS download Bibtex download
  • Taggart P, Orini M, Hanson B, Hayward M, Clayton R, Dobrzynski H, Yanni J, Boyett M & Lambiase PD (2014) . Prog Biophys Mol Biol, 115(2-3), 252-260. RIS download Bibtex download
  • Clayton RH (2013) . Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 1526-1529. RIS download Bibtex download
  • Steinacher A, Leyser O & Clayton RR (2012) . Journal of Theoretical Biology, 296, 84-94. RIS download Bibtex download
  • Niederer SA, Kerfoot E, Benson AP, Bernabeu MO, Bernus O, Bradley C, Cherry EM, Clayton R, Fenton FH, Garny A , Heidenreich E et al (2011) . PHILOS T R SOC A, 369(1954), 4331-4351. RIS download Bibtex download
  • Bradley CP, Clayton RH, Nash MP, Mourad A, Hayward M, Paterson DJ & Taggart P (2011) . Circ Arrhythm Electrophysiol, 4(5), 684-691. RIS download Bibtex download
  • Clayton RH, Nash MP, Bradley CP, Panfilov AV, Paterson DJ & Taggart P (2011) . Prog Biophys Mol Biol, 107(1), 101-111. RIS download Bibtex download
  • Smith N, Waters S, Hunter P & Clayton R (2011) . Progress in Biophysics and Molecular Biology, 104(1-3), 1-1. RIS download Bibtex download
  • Clayton RH, Nash MP, Bradley CP, Panfilov AV, Paterson DJ & Taggart P (2011) . Progress in Biophysics and Molecular Biology, 107(1), 101-111. RIS download Bibtex download
  • Fry CH, Sadananda P, Wood DN, Thiruchelvam N, Jabr RI & Clayton R (2011) . NEUROUROL URODYNAM, 30(5), 692-699. RIS download Bibtex download
  • Clayton RH, Bernus O, Cherry EM, Dierckx H, Fenton FH, Mirabella L, Panfilov AV, Sachse FB, Seemann G & Zhang H (2011) . Prog Biophys Mol Biol, 104(1-3), 22-48. RIS download Bibtex download
  • Garnett P, Steinacher A, Stepney S, Clayton R & Leyser O (2010) . BIOESSAYS, 32(9), 828-835. RIS download Bibtex download
  • Sheridan PJ, Marques JLB, Newman CMH, Heller SR & Clayton RH (2010) . Europace, 12(4), 553-560. RIS download Bibtex download
  • Clayton RH (2010) Re-entry in a model of ischaemic ventricular tissue. Computing in Cardiology, 37, 181-184. RIS download Bibtex download
  • Clayton RH, Abdalhamid S, Bloor R, Kyprianou G, Kotagiri K, Lee J, Mane A & White R (2010) Transmural changes in fibre helix angle in normal and failing canine ventricles. Computing in Cardiology, 37, 915-918. RIS download Bibtex download
  • Clayton RH (2009) . PHYSICA D, 238(11-12), 951-961. RIS download Bibtex download
  • ten Tusscher KHWJ, Mourad A, Nash MP, Clayton RH, Bradley CP, Paterson DJ, Hren R, Hayward M, Panfilov AV & Taggart P (2009) . EXP PHYSIOL, 94(5), 553-562. RIS download Bibtex download
  • Scarle S & Clayton RH (2009) . Med Biol Eng Comput, 47(3), 291-300. RIS download Bibtex download
  • Clayton RH (2008) . Chaos, 18(4), 043127. RIS download Bibtex download
  • Clayton R & Nash M (2008) , 175-193. RIS download Bibtex download
  • Clayton RH & Panfilov AV (2008) . Prog Biophys Mol Biol, 96(1-3), 19-43. RIS download Bibtex download
  • Nash MP, Mourad A, Bradley CP, Paterson DJ, Clayton RH, Sutton PM, Hayward M & Taggart P (2007) . Circulation, 116(suppl_16). RIS download Bibtex download
  • Holden AV, Aslanidi OV, Benson AP, Clayton RH, Halley G, Li P & Tong WC (2006) . J BIOL PHYS, 32(3-4), 355-368. RIS download Bibtex download
  • Scarle S & Clayton RH (2006) . Chaos, 16(3), 033115. RIS download Bibtex download
  • Nash MP, Mourad A, Clayton RH, Sutton PM, Bradley CP, Hayward M, Paterson DJ & Taggart P (2006) . CIRCULATION, 114(6), 536-542. RIS download Bibtex download
  • Benson AP, Clayton RH, Holden AV, Kharche S & Tong WC (2006) . PHILOS T R SOC A, 364(1842), 1313-1327. RIS download Bibtex download
  • Crampin EJ, Smith NP, Langham AE, Clayton RH & Orchard CH (2006) . PHILOS T R SOC A, 364(1842), 1171-1186. RIS download Bibtex download
  • Clayton RH & Taggart P (2006) . Heart Rhythm, 3(5), S309-S310. RIS download Bibtex download
  • Mourad A, Nash MP, Clayton RH, Sutton PM, Bradley CP, Hayward M, Paterson DJ & Taggart P (2006) . Heart Rhythm, 3(5), S264-S264. RIS download Bibtex download
  • Nash MP, Bradley CP, Sutton PM, Clayton RH, Kallis P, Hayward MP, Paterson DJ & Taggart P (2006) . EXP PHYSIOL, 91(2), 339-354. RIS download Bibtex download
  • Clayton RH & Scarle S (2006) Re-entry by early afterdepolarisations in a computational model. Computers in Cardiology, 33, 221-224. RIS download Bibtex download
  • Mourad A, Nash MP, Clayton RH, Bradley CP, Sutton PM, Hayward M, Paterson DJ & Taggart P (2006) . IET Conference Publications(520), 47. RIS download Bibtex download
  • Clayton RH, Zhuchkova EA & Panfilov AV (2006) . Prog Biophys Mol Biol, 90(1-3), 378-398. RIS download Bibtex download
  • Aslanidi OV, Clayton RH, Lambert JL & Holden AV (2005) . J THEOR BIOL, 237(4), 369-381. RIS download Bibtex download
  • Clayton RH & Taggart P (2005) . Biomed Eng Online, 4, 54. RIS download Bibtex download
  • Clayton RH & Holden AV (2005) . Biomed Eng Online, 4, 11. RIS download Bibtex download
  • Aslanidi OV, Biktashev VN, Biktasheva IV, Clayton RH & Holden AV (2005) . Studies in Multidisciplinarity, 3(C), 389-410. RIS download Bibtex download
  • Clayton RH & Holden AV (2004) . Prog Biophys Mol Biol, 85(2-3), 473-499. RIS download Bibtex download
  • Clayton RH & Holden AV (2004) . IEEE Trans Biomed Eng, 51(1), 28-34. RIS download Bibtex download
  • Clayton RH & Holden AV (2003) Virtual tissue engineering of the heart. INT J BIFURCAT CHAOS, 13(12), 3531-3534. RIS download Bibtex download
  • Clayton RH & Holden AV (2003) . Phys Med Biol, 48(1), 95-111. RIS download Bibtex download
  • Smye SW & Clayton RH (2002) . Med Eng Phys, 24(9), 565-574. RIS download Bibtex download
  • Clayton RH & Holden AV (2002) . Physiol Meas, 23(4), 707-726. RIS download Bibtex download
  • Aslanidi OV, Bailey A, Biktashev VN, Clayton RH & Holden AV (2002) . Chaos, 12(3), 843-851. RIS download Bibtex download
  • Clayton RH & Holden AV (2002) From excitable media to virtual cardiac tissue. CHAOS SOLITON FRACT, 13(8), 1579-1580. RIS download Bibtex download
  • Clayton RH & Holden AV (2002) . Phys Med Biol, 47(10), 1777-1792. RIS download Bibtex download
  • Clayton RH & Holden AV (2002) . Phys Med Biol, 47(2), 225-238. RIS download Bibtex download
  • Clayton RH (2001) . Physiol Meas, 22(3), R15-R34. RIS download Bibtex download
  • Clayton RH, Bailey A, Biktashev VN & Holden AV (2001) . J Theor Biol, 208(2), 215-225. RIS download Bibtex download
  • Whittam AM, Clayton RH, Lord SW, McComb JM & Murray A (2000) Heart rate and blood pressure variability in normal subjects compared with data from beat-to-beat models developed from de Boer's model of the cardiovascular system. PHYSIOL MEAS, 21(2), 305-318. RIS download Bibtex download
  • Clayton RH & Murray A (1999) . Physiol Meas, 20(2), 159-166. RIS download Bibtex download
  • Clayton RH & Murray A (1999) . Med Biol Eng Comput, 37(3), 354-358. RIS download Bibtex download
  • Murray A, Whittam AM, Clayton RH, Lord SW & McComb JM (1998) Computer simulation of heart rate and blood pressure changes, and comparison with clinical data. IEE Colloquium (Digest)(526). RIS download Bibtex download
  • (1998) . Clinical Science, 95(5), 575-575. RIS download Bibtex download
  • Clayton RH & Murray A (1998) Comparison of techniques for time-frequency analysis of the ECG during human ventricular fibrillation. IEE P-SCI MEAS TECH, 145(6), 301-306. RIS download Bibtex download
  • Lord SW, Clayton RH, Hall MC, Gray JC, Murray A, McComb JM & Kenny RA (1998) . Clin Sci (Lond), 95(5), 575-581. RIS download Bibtex download
  • Clayton RH, Campbell RW & Murray A (1998) . IEEE Eng Med Biol Mag, 17(1), 39-55. RIS download Bibtex download
  • Clayton RH, Campbell RWF & Murray A (1997) Time-frequency analysis of ventricular arrhythmias. IEE Colloquium (Digest)(6). RIS download Bibtex download
  • Bowman AJ, Clayton RH, Murray A, Reed JW, Subhan MF & Ford GA (1997) . Age Ageing, 26(4), 289-294. RIS download Bibtex download
  • Lord SW, Clayton RH, Mitchell L, Dark JH, Murray A & McComb JM (1997) . Heart, 77(6), 532-538. RIS download Bibtex download
  • Lord SW, Clayton RH, Hall MCS, Bishop J, Murray A, McComb JM & Kenny RA (1997) Baroreflex sensitivity may be estimated using spectral analysis. Heart, 77(SUPPL. 1). RIS download Bibtex download
  • Bowman AJ, Clayton RH, Murray A, Reed JW, Subhan MM & Ford GA (1997) . Eur J Clin Invest, 27(5), 443-449. RIS download Bibtex download
  • Clayton RH, Murray A & Campbell RW (1995) . Pacing Clin Electrophysiol, 18(10), 1876-1881. RIS download Bibtex download
  • BOWMAN AJ, CLAYTON RH, MURRAY A & FORD GA (1995) EFFECTS OF AEROBIC ON BAROREFLEX SENSITIVITY IN HEALTHY SEDENTARY ELDERLY SUBJECTS. J AM GERIATR SOC, 43(9), SA77-SA77. RIS download Bibtex download
  • Clayton RH, Murray A & Campbell RW (1995) . Eur Heart J, 16(8), 1115-1119. RIS download Bibtex download
  • Clayton RH, Murray A & Campbell RW (1995) . J Cardiovasc Electrophysiol, 6(8), 616-624. RIS download Bibtex download
  • Clayton RH, Bowman AJ, Ford GA & Murray A (1995) . Physiol Meas, 16(2), 131-139. RIS download Bibtex download
  • Murray A, Clayton RH & Campbell RW (1995) . Resuscitation, 29(2), 113-117. RIS download Bibtex download
  • Bowman AJ, Clayton RH, Murray A & Ford GA (1995) . Age and Ageing, 24(suppl 2), P3-P3. RIS download Bibtex download
  • Murray A, Allen J, Allen V, Clayton RH, McLaughlin NB & Relf GT (1994) . Physiol Meas, 15(3), 235-242. RIS download Bibtex download
  • Clayton RH, Murray A & Pearson DT (1994) . Perfusion, 9(3), 163-171. RIS download Bibtex download
  • Clayton RH, Murray A & Campbell RW (1994) . Med Biol Eng Comput, 32(2), 217-220. RIS download Bibtex download
  • Clayton RH, Murray A & Campbell RW (1994) . Eur Heart J, 15(2), 184-188. RIS download Bibtex download
  • Murray A, Clayton RH & Campbell RW (1993) . Resuscitation, 26(2), 163-172. RIS download Bibtex download
  • Clayton RH, Murray A & Campbell RW (1993) . Med Biol Eng Comput, 31(2), 111-117. RIS download Bibtex download
  • Clayton RH, Murray A, Higham PD & Campbell RW (1993) . Lancet, 341(8837), 93-95. RIS download Bibtex download
  • Clayton RH, Pearson DT & Murray A (1992) . Clin Phys Physiol Meas, 13(2), 167-177. RIS download Bibtex download
  • Murray A, Lawrence GP & Clayton RH (1991) Repeatability of dynamic eye pupil response measurement using the Pupilscan instrument.. Clin Phys Physiol Meas, 12(4), 377-385. RIS download Bibtex download
  • Clayton RH, Pearson DT & Murray A (1990) . Clin Phys Physiol Meas, 11(4), 327-332. RIS download Bibtex download
  • Pfeifer PM, Pearson DT & Clayton RH (1988) . Anaesthesia, 43(8), 677-682. RIS download Bibtex download
  • Pearson DT, Clayton R, Murray A & McArdle B (1988) . Perfusion, 3(1), 55-63. RIS download Bibtex download
  • PEARSON DT, POSLAD SJ, MURRAY A & CLAYTON R (1987) EXTRACORPOREAL-CIRCULATION MATERIAL EVALUATION - MICROEMBOLI. LIFE SUPPORT SYST, 5(1), 53-67. RIS download Bibtex download
  • Mamalakis M, Banerjee A, Ray S, Wilkie C, Clayton RH, Swift AJ, Panoutsos G & Vorselaars B () . Neural Computing and Applications. RIS download Bibtex download
  • Saxton H, Xu X, Schenkel T, Clayton RH & Halliday I () Convergence, sampling and total order estimator effects on parameter orthogonality in global sensitivity analysis. PLoS Computational Biology. RIS download Bibtex download
  • Dharmaprani D, Tiver K, Salari Shahrbabaki S, Jenkins EV, Chapman D, Strong C, Quah JX, Tonchev I, O’Loughlin L, Mitchell L , Tung M et al () . Circulation: Arrhythmia and Electrophysiology. RIS download Bibtex download
  • Clayton RH & Sridhar S () . Frontiers in Physiology, 15. RIS download Bibtex download
  • Coveny S, Roney C, Corrado C, Wilkinson R, Oakley J, Niederer S & Clayton R () Calibrating cardiac electrophysiology models using latent Gaussian processes on atrial manifolds. Scientific Reports. RIS download Bibtex download
  • Clayton RH () . Frontiers in Physiology, 9. RIS download Bibtex download
  • Chang ETY, Strong M & Clayton RH () . PLOS ONE, 10(8), e0137004-e0137004. RIS download Bibtex download
  • Kazbanov IV, Clayton RH, Nash MP, Bradley CP, Paterson DJ, Hayward MP, Taggart P & Panfilov AV () . PLoS Computational Biology, 10(11). RIS download Bibtex download
  • Coveny S, Corrado C, Oakley J, Wilkinson R, Niederer S & Clayton R () Bayesian Calibration of Electrophysiology Models using Restitution Curve Emulators. Frontiers in Physiology. RIS download Bibtex download
  • Bernjak A, Iqbal A, Heller S & Clayton R () Hypoglycaemia combined with mild hypokalaemia reduces the heart rate and causes abnormal pacemaker activity in a computational model of a human sinoatrial cell.. Journal of the Royal Society Interface. RIS download Bibtex download

Chapters

  • Clayton RH & Hose DR (2017) , Cardiovascular Biomechanics (pp. 107-126). Springer International Publishing RIS download Bibtex download
  • Clayton RH (2013) , Encyclopedia of Systems Biology (pp. 1638-1640). Springer New York RIS download Bibtex download
  • Clayton R & Nash M (2008) Modelling the mammalian heart. In Grierson C & Hetherington A (Ed.), Practical systems biology (pp. 175-193). Taylor and Francis Group RIS download Bibtex download
  • Clayton RH & Nash MP (2008) Modelling the mammalian heart In Grierson C & Hetherington AM (Ed.), Practical systems biology Taylor & Francis Group RIS download Bibtex download
  • Aslanidi OV, Biktashev VN, Biktasheva IV, Clayton RH & Holden AV (2006) Towards understanding the physical basis of re-entrant cardiac arrhythmias, MULTIDISCIPLINARY APPROACHES TO THEORY IN MEDICINE (pp. 389-410). RIS download Bibtex download

Conference proceedings papers

  • Bernjak A, Heller SR & Clayton RH (2019) Can computational modelling explain the dead in bed syndrome?. DIABETOLOGIA, Vol. 62 (pp S46-S46) RIS download Bibtex download
  • Bernjak A, Chow E, Lee J, Iqbal A, Lubina-Solomon A, Walkinshaw E, Macdonald IA, Heller SR, Clayton RH & Sheridan PJ (2017) Pharmacological autonomic blockade during experimental hypoglycaemia exacerbates cardiac repolarisation abnormalities. DIABETOLOGIA, Vol. 60 (pp S74-S74) RIS download Bibtex download
  • Bernjak A, Chow E, Lee J, Iqbal A, Lubina-Solomon A, Walkinshaw E, Heller SR, Clayton RH & Sheridan PJ (2017) Pharmacological Autonomic Blockade Exacerbates Cardiac Repolarization Abnormalities during Experimental Hypoglycemia. DIABETES, Vol. 66 (pp A95-A95) RIS download Bibtex download
  • Chang ETY, Coveney S & Clayton RH (2017) . Functional Imaging and Modelling of the Heart 2017, Proceedings, Vol. 10263 LNCS (pp 249-259) RIS download Bibtex download
  • Chang ETY & Clayton RH (2015) . 2015 Computing in Cardiology Conference (CinC), 6 September 2015 - 9 September 2015. RIS download Bibtex download
  • Eatock J, Lin YT, Chang ETY, Galla T & Clayton RH (2015) . 2015 Computing in Cardiology Conference (CinC), 6 September 2015 - 9 September 2015. RIS download Bibtex download
  • Chang ETY & Clayton RH (2015) . 2015 Computing in Cardiology Conference (CinC), 6 September 2015 - 9 September 2015. RIS download Bibtex download
  • Chang ETY & Clayton RH (2014) Parameter sensitivity analysis of a human atrial cell model using multivariate regression. Computing in Cardiology, Vol. 41(January) (pp 521-524) RIS download Bibtex download
  • Malyala S & Clayton RH (2014) The effect of scar tissue on complexity of activation patterns in simulated human ventricular fibrillation. Computing in Cardiology, Vol. 41(January) (pp 1133-1136) RIS download Bibtex download
  • Abbasi M & Clayton R (2014) Formulation of ATP sensitive K+ current and action potential shape in models of human ventricular myocytes. Computing in Cardiology, Vol. 41(January) (pp 201-204) RIS download Bibtex download
  • Clayton RH & Malyala S (2013) Clustering of Re-entry Close to Scar Boundaries in Ventricular Tissue during Simulated Ventricular Fibrillation. Computing in Cardiology, Vol. 40 (pp 1131-1134). Barcelona RIS download Bibtex download
  • Clayton RH & Abbasi M (2013) A Comparison of Two Models of Human Ventricular Tissue: Simulated Ischaemia and Re-entry. Computing in Cardiology, Vol. 40 (pp 385-388). Barcelona RIS download Bibtex download
  • Clayton RH, Bradley CP, Nash MP, Mourad A, Hayward M, David P & Peter T (2009) Transient Type II Ventricular Fibrillation During Global Ischemia in the in-situ Human Heart. CIRCULATION, Vol. 120(18) (pp S630-S630) RIS download Bibtex download
  • Skolidis G, Clayton RH & Sanguinetti G (2008) Automatic Classification of Arrhythmic Beats Using Gaussian Processes. COMPUTERS IN CARDIOLOGY 2008, VOLS 1 AND 2 (pp 921-924) RIS download Bibtex download
  • Clayton RH, Bradley CP, Nash MP, Varma S, Mourad A, Paterson DJ, Hayward M & Taggart P (2008) Epicardial Mapping of Ventricular Fibrillation in the Human Heart during Ischaemia and Reperfusion. COMPUTERS IN CARDIOLOGY 2008, VOLS 1 AND 2 (pp 1029-1032) RIS download Bibtex download
  • Nash MP, Mourad A, Bradley CP, Paterson DJ, Clayton RH, Sutton PM, Hayward M & Taggart P (2007) Is human ventricular fibrillation different from experimental models?. CIRCULATION, Vol. 116(16) (pp 278-278) RIS download Bibtex download
  • Nash MP, Mourad A, Bradley CP, Paterson DJ, Clayton RH, Sutton PM, Hayward M & Taggart P (2007) Mobility of epicardial rotors during human ventricular fibrillation. CIRCULATION, Vol. 116(16) (pp 278-278) RIS download Bibtex download
  • Handley JW, Brodfie KW & Clayton RH (2006) Model based visualization of cardiac virtual tissue. Proceedings of the UK e-Science All Hands Meeting 2006 (pp 233-240) RIS download Bibtex download
  • Handley JW, Brodlie KW & Clayton RH (2006) Multi-variate visualization of cardiac virtual tissue. 19TH IEEE INTERNATIONAL SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS, PROCEEDINGS (pp 665-670) RIS download Bibtex download
  • Mourad A, Nash MP, Clayton RH, Bradley CP, Paterson DJ, Sutton PM, Hayward M & Taggart P (2005) Early ventricular fibrillation in the human heart is sustained by a small number of re-entrant sources. CIRCULATION, Vol. 112(17) (pp U131-U131) RIS download Bibtex download
  • Zhuchkova E & Clayton R (2005) Methods for identifying and tracking phase singularities in computational models of re-entrant fibrillation. FUNCTIONAL IMAGING AND MODELING OF HEART, PROCEEDINGS, Vol. 3504 (pp 246-255) RIS download Bibtex download
  • Kharche S, Zhang H, Clayton RC & Holden AV (2005) . Lecture Notes in Computer Science, Vol. 3504 (pp 153-161) RIS download Bibtex download
  • Kharche S, Zhang H, Clayton R & Holden AV (2004) Simulation of hypertrophy in rat left ventricular cells. Computers in Cardiology 2004, Vol 31, Vol. 31 (pp 513-516) RIS download Bibtex download
  • Clayton RH, Holden AV & Tong WC (2003) Can endogenous, noise-triggered early after-depolarizations initiate reentry in a modified Luo-Rudy ventricular virtual tissue?. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, Vol. 13(12) (pp 3835-3843) RIS download Bibtex download
  • Aslanidi OV, Clayton RH, Holden AV, Phillips HK & Ward RJ (2003) Vulnerability to reentry, and drift, stability and breakdown of spiral waves in a linear gradient of G(K) in a Luo-Rudy 1 virtual ventricular tissue. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, Vol. 13(12) (pp 3865-3871) RIS download Bibtex download
  • Chen M, Tucker JV, Clayton RH & Holden AV (2003) Constructive volume geometry applied to visualization of cardiac anatomy and electrophysiology. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, Vol. 13(12) (pp 3591-3604) RIS download Bibtex download
  • Clayton RH & Holden AV (2003) Dynamics and interaction of filaments during reentry and fibrillation in mammalian virtual ventricular tissue. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, Vol. 13(12) (pp 3733-3745) RIS download Bibtex download
  • Chen M, Clayton RH, Holden AV & Tucker JV (2003) Visualising cardiac anatomy using constructive volume geometry. FUNCTIONAL IMAGING AND MODELING OF THE HEART, PROCEEDINGS, Vol. 2674 (pp 30-38) RIS download Bibtex download
  • Clayton RH & Holden AV (2002) Regional differences in action potential duration and stability of re-entry: insights from computational models. JOURNAL OF PHYSIOLOGY-LONDON, Vol. 544 (pp 3P-3P) RIS download Bibtex download
  • Clayton RH, Parkinson K & Holden AV (2002) Re-entry in computational models of ischaemic myocardium. CHAOS SOLITONS & FRACTALS, Vol. 13(8) (pp 1671-1683) RIS download Bibtex download
  • Clayton RH & Holden AV (2002) Simulating the ECG of ventricular tachyarrhythmias. COMPUTERS IN CARDIOLOGY 2002, VOL 29, Vol. 29 (pp 321-324) RIS download Bibtex download
  • Clayton RH & Holden AV (2002) Filament dynamics in a computational model of re-entrant fibrillation in anatomically detailed canine ventricular anatomy. SECOND JOINT EMBS-BMES CONFERENCE 2002, VOLS 1-3, CONFERENCE PROCEEDINGS (pp 1417-1418) RIS download Bibtex download
  • Aslanidi OV, Biktashev VN, Clayton RH & Holden AV (2001) Differential meander of re-entrant spiral waves in mammalian virtual ventricular tissue. JOURNAL OF PHYSIOLOGY-LONDON, Vol. 536 (pp 71P-71P) RIS download Bibtex download
  • Small M, Yu DJ, Harrison RG, Clayton R, Eftestol T, Sunde K & Steen PA (2001) Temporal evolution of nonlinear dynamics in ventricular arrhythmia. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, Vol. 11(10) (pp 2531-2548) RIS download Bibtex download
  • Aslanidi OV, Clayton RH & Holden AV (2001) Re-entry in the Luo-Rudy ventricular tissue model with different models of Ca2+ dynamics. COMPUTERS IN CARDIOLOGY 2001, VOL 28, Vol. 28 (pp 233-236) RIS download Bibtex download
  • Clayton RH & Holden AV (2000) Computational simulation of multiple wavelet re-entry and fibrillatory conduction shows differences in the ECG characteristics of each mechanism. COMPUTERS IN CARDIOLOGY 2000, VOL 27, Vol. 27 (pp 343-346) RIS download Bibtex download
  • Clayton RH, Bailey A, Biktashev VN & Holden AV (1999) Re-entrant arrhythmias in simulations of the Long-QT syndrome. COMPUTERS IN CARDIOLOGY 1999, VOL 26 (pp 121-124) RIS download Bibtex download
  • Clayton RH, Yu DJ, Small M, Biktashev VN, Harrison RG & Holden AV (1999) Linear and nonlinear characteristics of ECG signals produced by simulations of ventricular tachyarrhythmias. COMPUTERS IN CARDIOLOGY 1999, VOL 26 (pp 479-482) RIS download Bibtex download
  • Whittam AM, Clayton RH, Lord SW, McComb JM & Murray A (1998) Computer modelling of heart rate and blood pressure. COMPUTERS IN CARDIOLOGY 1998, VOL 25, Vol. 25 (pp 149-152) RIS download Bibtex download
  • Clayton RH & Murray A (1997) Model based investigation of cardiovascular variability. IEE Colloquium (Digest)(9) RIS download Bibtex download
  • Clayton RH, Lord SW, McComb JM & Murray A (1997) Comparison of autoregressive and Fourier transform based techniques for estimating RR interval spectra. COMPUTERS IN CARDIOLOGY 1997, VOL 24, Vol. 24 (pp 379-382) RIS download Bibtex download
  • Clayton RH, Campbell RWF & Murray A (1997) Time-frequency analysis of human polymorphic ventricular tachycardia. COMPUTERS IN CARDIOLOGY 1997, VOL 24, Vol. 24 (pp 97-100) RIS download Bibtex download
  • Clayton RH, Campbell RWF & Murray A (1996) Relation between intracardiac and surface ECG signals during the onset of human ventricular fibrillation. COMPUTERS IN CARDIOLOGY 1996 (pp 341-344) RIS download Bibtex download
  • Clayton RH, Murray A & Campbell RWF (1995) Frequency analysis of ventricular fibrillation. IEE Colloquium (Digest)(43) RIS download Bibtex download
  • Clayton RH, Bowman AJ, Ford GA & Murray A (1995) Comparison of techniques for estimating baroreflex gain from heart rate and blood pressure spectra. COMPUTERS IN CARDIOLOGY 1995 (pp 301-304) RIS download Bibtex download
  • CLAYTON RH & MURRAY A (1993) ESTIMATION OF THE ECG SIGNAL SPECTRUM DURING VENTRICULAR-FIBRILLATION USING THE FAST FOURIER-TRANSFORM AND MAXIMUM-ENTROPY METHODS. COMPUTERS IN CARDIOLOGY 1993, PROCEEDINGS (pp 867-870) RIS download Bibtex download
  • Clayton RH, Murray A, Whittam AM & Campbell RWF (1992) Automatic recording of ventricular fibrillation. Computers in Cardiology (pp 685-688) RIS download Bibtex download
  • Clayton RH, Murray A & Campbell RWF (1991) Changes in the surface ECG frequency spectrum during the onset of ventricular fibrillation. Computers in Cardiology (pp 515-518) RIS download Bibtex download
  • Coveney S, Corrado C, Roney C, D. Wilkinson R, Oakley J, niederer S & H. Clayton" R () . Computing in Cardiology Conference (CinC) RIS download Bibtex download
  • Abbasi M & Clayton RH () Formulation of ATP sensitive K+ current and action potential shape in models of human ventricular myocytes. Computing in Cardiology, Vol. 41 (pp 201-201). Cambridge, 7 September 2014 - 10 September 2014. RIS download Bibtex download
  • Small M, Yu DJ, Clayton RH, Simonotto J & Harrison RG () . Computers in Cardiology 2000. Vol.27 (Cat. 00CH37163) RIS download Bibtex download
  • Clayton RH, Murray A & Campbell RWF () . Proceedings Computers in Cardiology RIS download Bibtex download
  • Corrado C, Williams S, Sim I, Coveney S, O'Neill M, Wilkinson R, Oakley J, Clayton R & Niederer S () . 2018 Computing in Cardiology Conference (CinC), Vol. 45. Maastricht, The Netherlands, 23 September 2018 - 26 September 2018. RIS download Bibtex download

Reports

  • Carusi A (2015) In silico Clinical Trials: How Computer Simulations Will Transform the Biomedical Industry. An International Roadmap for an Industry-Driven Initiative. RIS download Bibtex download

Working papers

  • Argungu M, Bayram S, Brook B, Chakrabarti B, Clayton RH, Daly DM, Dyson RJ, Holloway C, Manhas V, Naire S , Shearer T et al () Modelling afferent nerve responses to bladder filling. RIS download Bibtex download

Datasets

  • Clayton R & Coveney S . RIS download Bibtex download

Preprints

  • Saxton H, Taylor DJ, Faulkner G, Halliday I, Newman T, Schenkel T, Morris PD, Clayton RH & Xu X (2024) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Saxton H, Xu X, Schenkel T, Clayton RH & Halliday I (2024) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Holland BL, Monk NAM, Clayton RH & Osborne CP (2023) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Dharmaprani D, Jenkins EV, Quah JX, Tiver K, Mitchell L, Tung M, Ahmad W, Stoyanov N, Aguilar M, Nash MP , Clayton RH et al (2023) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Coveney S, Roney CH, Corrado C, Wilkinson RD, Oakley JE, Niederer SA & Clayton RH (2022) Calibrating cardiac electrophysiology models using latent Gaussian processes on atrial manifolds. RIS download Bibtex download
  • Mamalakis M, Swift AJ, Vorselaars B, Ray S, Weeks S, Ding W, Clayton RH, Mackenzie LS & Banerjee A (2021) DenResCov-19: A deep transfer learning network for robust automatic classification of COVID-19, pneumonia, and tuberculosis from X-rays, arXiv. RIS download Bibtex download
  • Coveney S, Corrado C, Roney CH, O'Hare D, Williams SE, O'Neill MD, Niederer SA, Clayton RH, Oakley JE & Wilkinson RD (2020) Gaussian Process Manifold Interpolation for Probabilistic Atrial Activation Maps and Uncertain Conduction Velocity. RIS download Bibtex download
  • Coveney S & Clayton RH () . RIS download Bibtex download
Grants

Current grants

  • , EPSRC, 04/2022 - 03/2026, £314,026, as PI
  • The SofTMech Statistical Emulation and Translation Hub, EPSRC, 03/2021 - 02/2025, £207,617, as PI
  • SANO: Centre for New Methods in Computational Diagnostics and Personalised Therapy, EC H2020, 08/2019 - 07/2026, £2,497,386, as Co-PI
  • PRIMAGE: , Empowered by imaging biomarkers, EC H2020, 12/2018 to 05/2023, £549,018, as Co-PI

Previous grants

  • Neurocardiac Interaction In Malignant Ventricular Arrhythmias And Sudden Cardiac Death, British Heart Foundation, 7/2017 to 03/2023, £128,604, as PI
  • , EPSRC, 05/17 to 04/22, £460,590, as PI
  • , EC H2020, 02/2016 to 01/2019, £401,801, as Co-PI
  • , EPSRC, 04/2013 to 09/2017, £665,262, as PI
  • , EPSRC, 04/2013 to 03/2017, £218,232, as PI
  • Development of a novel diagnostic model of urinary dysfunction, 91Ö±²¥ Hospitals Charitable Trust, 03/2014 to 08/2014, £15,715, as Co-PI
  • Determination of thresholds for the development of ventricular arrhythmias using computer modelling, 91Ö±²¥ Hospitals Charitable Trust, 03/2010 to 12/2014, £48,370, as Co-PI
  • , EPSRC, 03/2008 to 03/2010, £85,491, as Co-PI
  • Initiation of re-entry and fibrillation in the ventricle: A mechanistic investigation using computational models, British Heart Foundation, 07/2004 to 06/2007, £97,443, as PI
Professional activities and memberships
  • Member of the  research group
  • Member of INSIGNEO board
  • Member of EPSRC review college