Professor Frederik Claeyssens
Licentiate, PhD
School of Chemical, Materials and Biological Engineering
School of Chemical, Materials and Biological Engineering
Professor of Biomaterials
+44 114 222 5513
Full contact details
School of Chemical, Materials and Biological Engineering
North Campus
Broad Lane
91直播
S3 7HQ
- Profile
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Frederik Claeyssens joined the department in 2008 from the University of Bristol, where he was a Research Fellow at the Life Sciences Interface of the Chemistry Department.
He obtained his first degree in Chemistry at Ghent University (Belgium) and his PhD in Chemistry at the University of Bristol, and he was a PDRA at the University of Birmingham and the University of Bristol.
- Research interests
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Frederik麓s research expertise focusses mainly on laser processing of biomaterials and its applications. This research portfolio can be divided into three projects:
Coatings for biology: Biocompatible coatings of semiconductors to be integrated into cell-silicon interfaces for biosensors. These coatings are currently investigated for in vivo/in vitro recording devices of electroactive cells (heart/brain cells).
Bioprinting: Laser-based techniques for printing biomolecules/cells for producing biomolecule arrays and biosensors. I have further developed this technique as a parallel direct-write technique, able to print 1000 pixels in one single laser shot. This technique is able to print viscous fluids containing DNA, proteins and even living cell.
Biomaterials manufacture via micro stereolithography: Using top-down approaches to controllable (via CAD/CAM) produce 3D biocompatible/degradable polymer structures with micrometre resolution. Combination of this technique with bottom-up approaches to achieve hybrid biomaterials as 3D scaffolds for implants, tissue engineering and pharmaceutical testing.
Additionally, Frederik has a keen research interest in computational solid-state and biological chemistry. His previous work in this area includes predicting the stabilisation mechanism for the growth of polar wurtzite surfaces, based on the existence of a low energy graphite-like structure (or h-BN) for ultra-thin wurtzite films. This model has recently been confirmed experimentally and forms the basis for understanding growth of polar surfaces in a large number of key technological materials (e.g. ZnO, GaN, CdSe and SiC).
Frederik has also studied enzyme reactions on an unprecedented high level of theory, providing powerful new tools for modelling enzyme reactions, and enabling for the first time the study of enzyme reactions computationally with chemical accuracy.
Key projects
- Laser based bioprinting (EPSRC funded)
- 3D microstructure fabrication of biomaterials for tissue engineering
- Publications
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Journal articles
- . Advances in Colloid and Interface Science, 336, 103375-103375.
- . J Mater Chem B.
- . Biofabrication, 16(3).
- . Materials & Design, 239, 112779-112779.
- . Materials Today Advances, 20, 100432-100432.
- . Colloids and Surfaces A: Physicochemical and Engineering Aspects, 132629-132629.
- . Frontiers in Chemistry, 11.
- . Materials Today Advances, 19, 100410-100410.
- . ACS Appl Mater Interfaces.
- . Materials Letters, 134566-134566.
- . ACS Biomaterials Science & Engineering, 9(3), 1472-1485.
- . 3D Printing and Additive Manufacturing.
- . Reactive and Functional Polymers, 180.
- . Journal of Materials Chemistry B.
- . Frontiers in Oral Health, 3.
- . Frontiers in Materials, 8.
- . Frontiers in Molecular Biosciences, 8(11).
- . Biomacromolecules.
- . Frontiers in Materials, 8.
- . ACS Biomater Sci Eng.
- . ACS biomaterials science & engineering.
- . Bioengineering (Basel), 8(5).
- . Molecules, 26(5).
- . IEEE Transactions on Magnetics.
- . Biomater Sci.
- . Polymer Chemistry.
- . Frontiers in Bioengineering and Biotechnology, 8.
- . Frontiers in Bioengineering and Biotechnology, 8.
- . Biotechnology and Bioengineering.
- . Microvascular Research, 131, 104035-104035.
- . International Journal of Bioprinting, 6(2), 99-113.
- . ACS Biomaterials Science & Engineering.
- . Polymers, 12(4).
- . ACS Applied Materials & Interfaces, 12(11), 12510-12524.
- . Macromolecular Rapid Communications, 41(3).
- . Bioengineering, 7(1).
- . Frontiers in Bioengineering and Biotechnology, 7.
- . Journal of Biomaterials Applications.
- . ACS Biomaterials Science & Engineering, 6(1), 705-714.
- . Tissue Engineering and Regenerative Medicine, 17(4), 445-458.
- . Journal of Tissue Engineering and Regenerative Medicine, 13(9), 1581-1594.
- . Materials, 12(16), 2643-2643.
- . PLoS ONE, 14(7).
- . Journal of Biomaterials Applications, 34(4), 546-559.
- . Polymer, 175, 243-254.
- . ACS Biomaterials Science & Engineering, 5(7), 3190-3200.
- . The FASEB Journal, 33(S1), 575.7-575.7.
- . Regenerative Medicine.
- . Journal of the Mechanical Behavior of Biomedical Materials, 90, 20-29.
- . Experimental Biology and Medicine.
- . Materials & Design, 156, 494-503.
- . Journal of Tissue Engineering, 9.
- . Acta Biomaterialia, 78, 48-63.
- . APL Bioengineering.
- . Frontiers in Physics, 6.
- . AIP Advances, 8(5), 056322-056322.
- . Advanced Materials, 29(47).
- . Tissue Engineering - Part A., 22(23 - 24), 1317-1326.
- . Materials Science and Engineering: C, 67, 51-58.
- . Ultramicroscopy, 171, 126-138.
- . Cells Tissues Organs, 202(5-6).
- . International Journal of Bioprinting, 2(2).
- . Metals, 6(5), 97-97.
- . Journal of the Mechanical Behavior of Biomedical Materials, 54, 159-172.
- . Materials Science and Engineering: C, 58, 1199-1206.
- . Data in Brief, 5, 616-620.
- . Tissue Engineering Part B: Reviews.
- . Biomaterials, 49, 77-89.
- . Biomedical Microdevices, 17(2).
- . Investigative Ophthalmology & Visual Science, 56(3), 1553-1561.
- . Biomaterials Science, 3(4), 592-596.
- . Engineering in Life Sciences, 15(6), 612-621.
- . JOVE-JOURNAL OF VISUALIZED EXPERIMENTS(91).
- . Biomed Mater, 9(4), 045009.
- Photochemical functionalisation of diamond-like-carbon for electronic neural interfaces. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 8, 401-401.
- Photo stereolithography of high internal phase emulsions for tissue engineering applications. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 8, 198-199.
- PolyHIPE-based porous microparticles for tissue engineering. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 8, 422-423.
- . Acta Biomater, 10(7), 3029-3037.
- . Biomaterials Science, 2(5), 723-734.
- . Applied Surface Science.
- . Middle East Conference on Biomedical Engineering, MECBME, 59-62.
- . Biomaterials, 34(21), 5088-5106.
- . Adv Mater, 25(23), 3177.
- . Biofabrication, 5(2), 025008.
- . Adv Mater, 25(23), 3178-3181.
- . Journal of Solid State Chemistry, 198, 466-474.
- . 2013 Conference on Lasers and Electro-Optics Europe and International Quantum Electronics Conference, CLEO/Europe-IQEC 2013.
- The effect of porosity on cell ingrowth in 3D laser-fabricated biodegradable scaffolds for bone regeneration. Optics InfoBase Conference Papers.
- . Advanced Functional Materials, 10(6).
- . Acta Biomater, 9(3), 5511-5520.
- Development of tissue engineered stem cell niches for corneal repair. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 137-137.
- Development of a 3D neuronal glial co-culture model for peripheral nerve studies and repair strategies. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 352-352.
- Amine functionalised nanodiamond for neuronal cell culture. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 76-77.
- RGD functionalised highly branched poly(N-isopropylacrylamide) (HB-p(NIPAM)) semi interpenetrating polymer networks (semi-IPNs) for peripheral nerve repair. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 78-79.
- Functionalised degrable photocurable polymers for peripheral nerve repair. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 78-78.
- . Biofabrication, 4(2), 025005.
- An aligned 3D neuronal-glial co-culture model for peripheral nerve studies. Biomaterials.
- . Biomaterials, 33(25), 5901-5913.
- . PHYSICAL REVIEW B, 84(24).
- . Biofabrication, 3(4), 045005.
- . Org Biomol Chem, 9(5), 1578-1590.
- Diamond and related materials for biological applications, 155-194.
- Direct laser writing of polylactide 3D scaffolds. Optics InfoBase Conference Papers.
- Development of a microfabricated outer ring for corneal repair. European Cells and Materials, 22(SUPPL.3), 14.
- Neuronal growth and patterning on diamond like carbon substrates. European Cells and Materials, 22(SUPPL.2), 40.
- Two photon polymerisation of photocurable biomaterials. European Cells and Materials, 22(SUPPL.2), 50.
- Microstructuring of photocurable biomaterials with applications in neuronal repair. European Cells and Materials, 22(SUPPL.3), 15.
- Morphological influence of functionalised nanodiamond surfaces on neuronal cells. European Cells and Materials, 22(SUPPL.3), 44.
- . Biofabrication, 3(4).
- . 2011 Conference on Lasers and Electro-Optics Europe and 12th European Quantum Electronics Conference, CLEO EUROPE/EQEC 2011.
- . Methods Mol Biol, 695, 309-321.
- . PHYS REV B, 82(9).
- . Phys Chem Chem Phys, 12(30), 8620-8631.
- . AIP Conference Proceedings, 1288, 154-161.
- . Biomaterials, 31(2), 207-215.
- . PHYS REV B, 80(17).
- . PHYS REV B, 79(13).
- . Langmuir.
- . SPIE Newsroom.
- Cell patterning on modified diamond-like carbon (DLC). European Cells and Materials, 18(SUPPL. 2), 89.
- . Biomaterials, 29(17), 2573-2580.
- . J Am Chem Soc, 130(4), 1367-1375.
- A theoretical study of ultra-thin films with the wurtzite and zinc blende structures. Materials Research Society Symposium Proceedings, 1035, 122-127.
- . APPL PHYS A-MATER, 87(1), 17-22.
- . Angewandte Chemie, 118(41), 7010-7013.
- . Angew Chem Int Ed Engl, 45(41), 6856-6859.
- . Phys Rev Lett, 96(6), 066102.
- . NANOTECHNOLOGY, 17(3), 805-807.
- . Chem Commun (Camb)(40), 5068-5070.
- . J MATER CHEM, 15(1), 139-148.
- . Dalton Trans(19), 3085-3092.
- . APPL PHYS A-MATER, 79(4-6), 1237-1241.
- . ChemInform, 35(16).
- . Chem Soc Rev, 33(1), 23-31.
- . ChemInform, 34(52).
- . Chem Commun (Camb)(19), 2440-2441.
- . J APPL PHYS, 94(4), 2203-2211.
- Erratum: Solid phosphorus carbide (Chemical Communications (2002) (2494)). Chemical Communications(16), 2086.
- Solid phosphorus carbide? (pg 2494, 2002). CHEM COMMUN(17), 2086-2086.
- . J APPL PHYS, 92(11), 6886-6894.
- . J APPL PHYS, 91(9), 6162-6172.
- . CHEM COMMUN(21), 2494-2495.
- Investigations of the plume accompanying pulsed ultraviolet laser ablation of graphite in vacuum. J APPL PHYS, 89(1), 697-709.
- . Biofabrication.
- . Frontiers in Bioengineering and Biotechnology, 11.
- . ACS Applied Materials & Interfaces.
- . International Journal of Molecular Sciences, 24(13), 10445-10445.
- . ACS Applied Materials & Interfaces.
- . Bioengineering, 10(5), 522-522.
- . Biomaterials Science.
- . Langmuir.
- . Polymer Chemistry, 13(23), 3513-3528.
- . International Journal of Bioprinting, 7(1).
- . ACS Biomaterials Science & Engineering.
- . Nanoscale Advances, 1(5), 1924-1935.
- . Faraday Discussions, 211, 613-642.
- . Faraday Discussions, 211, 569-591.
- . International Journal of Bioprinting, 4(1).
- . Metals, 5(4), 1902-1920.
- . Soft Matter, 11(38), 7567-7578.
- . Journal of Visualized Experiments(91).
- . Biomedical Materials.
- . Journal of Visualized Experiments(91), e51826-e51826.
- . Advanced Science, 2003762-2003762.
- . Bioengineering, 8(8), 105-105.
- . Bioengineering, 8(11), 148-148.
Chapters
- , Optical Techniques in Regenerative Medicine (pp. 110-131). CRC Press
- Two-Photon Polymerization for Tissue-Engineered Scaffold Fabrication, Optical Techniques in Regenerative Medicine (pp. 93-113).
- , Optical Techniques in Regenerative Medicine (pp. 93-114). Taylor & Francis
- Growth of ZnO Nanorods from the Gas Phase In Prescott WV & Schwartz AI (Ed.), Nanorods, nanotubes, and nanomaterials research progress (pp. 239-278). Nova Science Publishers
Conference proceedings papers
- . Tissue Engineering Part A, Vol. 29(13-14). Manchester, UK, 28 March 2023 - 28 March 2023.
- Production of porous polycaprolactone polyHIPEs as substrates for in vitro 3D breast cancer cell culture. TISSUE ENGINEERING PART A, Vol. 29(13-14)
- THE ROLE OF MULTIFUNCTIONAL NANOMATERIALS IN NEW TISSUE REGENERATION STRATEGIES. TISSUE ENGINEERING PART A, Vol. 29(11-12) (pp 828-828)
- THE BIOACTIVITY OF PLATELET-RICH FIBRIN CONDITIONED MEDIUM ON ZOLEDRONATE-INDUCED ORAL KERATINOCYTE TOXICITY IN VITRO. TISSUE ENGINEERING PART A, Vol. 29(11-12) (pp 1276-1277)
- Porous Poly(glycerol sebacate)-methacrylate Scaffolds For Adipose Tissue Engineering. TISSUE ENGINEERING PART A, Vol. 29(13-14)
- Porous poly(glycerol sebacate) methacrylate nerve guidance conduits for peripheral nerve regeneration. TISSUE ENGINEERING PART A, Vol. 29(13-14)
- Platelet-rich fibrin prevents the toxicity of Pamidronate on oral fibroblasts. TISSUE ENGINEERING PART A, Vol. 29(13-14)
- Development of an in vitro musculoskeletal model using poly (glycerol sebacate methacrylate) (PGSM) polyHIPE-based 3D microporous scaffold encompassing regionally controlled mechanical properties. TISSUE ENGINEERING PART A, Vol. 29(13-14)
- Development and characterisation of new bioelastomers based on poly(glycerol sebacate)-copolyethylene glycol for biomedical applications. TISSUE ENGINEERING PART A, Vol. 29(13-14)
- Bone Clip: Developing an angiogenic biomaterial to increase bone healing. TISSUE ENGINEERING PART A, Vol. 29(13-14)
- CRANIOFACIAL BONE DEFECT REPAIR USING POLYMER SCAFFOLDS AND CELL DERIVED MATRIX. TISSUE ENGINEERING PART A, Vol. 29(11-12) (pp 1118-1119)
- A digital reconstruction of the dermal-epidermal junction (DEJ) of the skin in three dimensions. TISSUE ENGINEERING PART A, Vol. 29(13-14)
- Developing Biodegradable Polymer Resins for Additive Manufacturing via a Novel Synthesis Method. TISSUE ENGINEERING PART A, Vol. 29(13-14)
- MCSS SUPPORT A LAMELLA-LIKE TWISTING ORIENTATION OF COLLAGEN WHEN CULTURED ON ALIGNED ELECTROSPUN POLYCAPROLACTONE FIBRES. TISSUE ENGINEERING PART A, Vol. 29(11-12) (pp 1586-1587)
- Porous Poly(glycerol sebacate)-methacrylate Scaffolds For Adipose Tissue Engineering. TISSUE ENGINEERING PART A, Vol. 29(13-14)
- TOPOGRAPHICALLY CONTROLLED NANOFIBROUS MEMBRANES TO MIMIC THE EPIDERMAL STEM CELL MICROENVIROMENT OF THE RETE RIDGES. TISSUE ENGINEERING PART A, Vol. 28 (pp S51-S51)
- THE INCORPORATION OF A NATIVE-LIKE EXTRACELLULAR MATRIX IN NERVE GUIDE CONDUITS FOR PERIPHERAL NERVE REPAIR. TISSUE ENGINEERING PART A, Vol. 28 (pp S376-S376)
- CRANIOFACIAL BONE DEFECT REPAIR USING POLYMER SCAFFOLDS AND CELL DERIVED MATRIX. TISSUE ENGINEERING PART A, Vol. 28 (pp S551-S552)
- BIOMATERIAL SURFACE FUNCTIONALIZATION FOR SUSTAINED DELIVERY OF NGF AND BDNF TO STIMULATE NEURITE GROWTH. TISSUE ENGINEERING PART A, Vol. 28 (pp S51-S51)
- BIOACTIVE 3D SCAFFOLDS FOR THE DELIVERY OF NEUROTROPHINS TO IMPROVE NEURITE OUTGROWTH AND INDUCE SCHWANN CELL MIGRATION. TISSUE ENGINEERING PART A, Vol. 28 (pp S602-S602)
- . 2018 11th Biomedical Engineering International Conference (BMEiCON), 21 November 2018 - 24 November 2018.
- Assessment of the osteogenic and angiogenetic potential of in vitro generated extracellular matrix decorated multiscale porous polyHIPE scaffolds. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 256
- Investigating the barrier membrane properties of biphasic PCL scaffolds for guided tissue regeneration. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 256
- Hierarchically structured biocompatible materials for tissue engineering. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 256
- Tissue-Engineered Blood Vessels with User-Defined Geometries. TISSUE ENGINEERING PART A, Vol. 23 (pp S140-S140)
- Measuring continuous concentration of mass pollutants in the aquatic environment. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 251
- . Journal of Physics: Conference Series, Vol. 644 (pp 012022-012022)
- Patterning of Neurons on Diamond-like Carbon by Pulsed Laser Ablation. TISSUE ENGINEERING PART A, Vol. 21 (pp S259-S260)
- Light-based Bioprinting of Native Silk. TISSUE ENGINEERING PART A, Vol. 21 (pp S339-S339)
- Highly Porous Particles for Cell Recruitment and Delivery in Bone Tissue Engineering. TISSUE ENGINEERING PART A, Vol. 21 (pp S287-S288)
- Nerve Tissue Engineering using Blends of Polyhydroxyalkanoates for Peripheral Nerve Regeneration. TISSUE ENGINEERING PART A, Vol. 21 (pp S325-S325)
- Developing a Degradable Polymer Scaffold for Vascular Graft Tissue Engineering using a Novel Photocurable Poly(glycerol Sebacate). TISSUE ENGINEERING PART A, Vol. 21 (pp S182-S182)
- 3D Printing and Plasma Coating of Nerve Guide Conduits (NGC). TISSUE ENGINEERING PART A, Vol. 21 (pp S359-S360)
- Development of a Three-Dimensional In Vitro Model to Study Neovascularization. TISSUE ENGINEERING PART A, Vol. 21 (pp S325-S326)
- PERIPHERAL NERVE REGENERATION USING BLENDS OF POLYHYDROXYALKANOATES. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, Vol. 20(2) (pp 185-185)
- . Journal of Physics: Conference Series, Vol. 644 (pp 012018-012018)
- Microfabrication of artificial stem cell microenvironments for tissue regeneration. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 8 (pp 175-176)
- Nerve guides from photocurable polymers for peripheral nerve repair. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 8 (pp 172-172)
- In vitro biocompatibility of a poly(high internal phase emulsion) biomaterial. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 8 (pp 452-453)
- Microfabricated niches for the culture of limbal epithelial cells. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol. 55(13)
- . Journal of Tissue Engineering and Regenerative Medicine, Vol. 6 (pp 1-429)
- Feasibility of 3D printing and stereolithography for fabrication of custom-shaped poly (lactic acid): hydroxyapatite composite biomaterial scaffolds. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 6 (pp 367-367)
- Direct Laser Writing of Neural Tissue Engineering Scaffolds for Biohybrid Devices.. Living Machines, Vol. 7375 (pp 392-393)
- . 2011 Conference on Lasers and Electro-Optics Europe and 12th European Quantum Electronics Conference (CLEO EUROPE/EQEC), 22 May 2011 - 26 May 2011.
- . THIN SOLID FILMS, Vol. 515(24) (pp 8529-8533)
- . INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, Vol. 107(12) (pp 2274-2285)
- . Materials Research Society Symposium Proceedings, Vol. 1035-L09-08(1035E)
- . JOURNAL OF CRYSTAL GROWTH, Vol. 294(1) (pp 111-117)
- . DIAMOND AND RELATED MATERIALS, Vol. 13(4-8) (pp 661-665)
- . INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, Vol. 95(4-5) (pp 546-553)
- 193-nm laser ablation of CVD diamond and graphite in vacuum: plume analysis and film properties. APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, Vol. 69 (pp S935-S939)
- . USES Conference Proceedings
- Differences in VEGFA isoform expression regulate modes of migration and their sensitivity to anti-VEGFA therapy. International Journal of Experimental Pathology, Vol. 100(4)
Datasets
Preprints
- Research group
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Postdoctoral researchers
Dr Adam Glen (Neurimp-FP7)
Dr Jim Dugan (EPSRC)
Dr Richard Plenderleith (TSB)Former group members
Dr Ilida Ortega (Lecturer in School of Clinical Dentistry, 91直播)
Dr Ivana Barbaric (Lecturer in Biomedical Sciences, 91直播)
Dr Andrew Gill (KTP Associate, 91直播)
- Professional activities and memberships
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I鈥檝e had a few opportunities to highlight my work to a broader audience, and my work has been publicised on various different media websites, amongst them:
I have also been interviewed on live radio by BBC 91直播 during the evening drive-time program, and I have been interviewed together with my colleague Prof. J.W. Haycock by the BBC World News for their 'Horizon' programme.
- Member of the Materials Research Society
- Member of the Royal Society of Chemistry
- Member of the scientific editorial board for 鈥楾he Open Materials Science Journal鈥 (Bentham Science)