Professor David James
School of Chemical, Materials and Biological Engineering
Professor of Bioprocess Engineering
Research Centre Director Advanced Biomanufacturing Centre
+44 114 222 7505
Full contact details
School of Chemical, Materials and Biological Engineering
Room D62
Sir Robert Hadfield Building
Mappin Street
91直播
S1 3JD
- Profile
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I graduated in 1989 from King麓s College London with a Ph.D. in Biochemistry, followed by postdoctoral research in Wye College (University of London), then the University of Kent; the latter a joint project with the Advanced Centre for Biochemical Engineering at University College London.
Following appointment to Lecturer, then Senior Lecturer at Kent, I moved to the University of Queensland in 2001 as an Associate Professor of Bioengineering, then Professorial Research Fellow in the Australian Institute of Bioengineering and Nanotechnology.
I was appointed to a Chair in Bioprocess Engineering at 91直播 in 2006 with a Royal Society Wolfson Research Merit Award, Research and Training in Biopharmaceutical Bioprocessing for UK Bioindustry.
- Research interests
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- Production of high-value therapeutic recombinant protein biopharmaceuticals
- Systems Biotechnology for Rational Bioprocess Engineering
- Cell Factory and Gene Vector Engineering
- Process Analytical Technology
- Publications
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Books
Journal articles
- . Biotechnology Journal, 19(6), e2300685.
- . Metabolic Engineering, 81, 53-69.
- . ACS Synthetic Biology, 12(8), 2339-2352.
- . Biotechnology Progress.
- . Journal of Chromatography A, 1691, 463809-463809.
- . Biotechnology Journal.
- . Wellcome Open Research, 6, 220.
- . Biotechnology Journal.
- . ACS Synthetic Biology, 11(4), 1613-1626.
- . Journal of Chromatography A, 462944-462944.
- . Wellcome Open Research, 6.
- . ACS Synth Biol.
- . Biotechnology and Bioengineering.
- . Biotechnology and Bioengineering, 117(7), 2295-2299.
- . Journal of Biotechnology, 312, 11-22.
- . Biotechnology Progress.
- . Antioxidants, 8(6).
- . Rapid Communications in Mass Spectrometry, 33(10), 897-906.
- . Journal of Biotechnology.
- . Biotechnology and Bioengineering, 116(2), 375-387.
- . Biotechnology and Bioengineering, 115(12), 2908-2929.
- . Biotechnology and Bioengineering, 115(6), 1485-1498.
- . Biotechnol Bioeng, 115(3), 645-660.
- . Nucleic Acids Research, 45(18), 10906-10919.
- . Analytical Biochemistry, 534, 49-55.
- . Biotechnology Journal.
- , 131-145.
- . Biotechnology Advances, 34(5), 492-503.
- . Applied Biochemistry and Biotechnology, 178(7), 1286-1302.
- . Biotechnology and Bioengineering, 112(12), 2527-2542.
- . Biotechnology Journal, 10(7), 1019-1028.
- . Biotechnol Bioeng, 111(8), 1638-1647.
- . Biotechnol Prog, 30(5), 1161-1170.
- . Biotechnol Prog, 30(1), 188-197.
- . Biotechnol Bioeng, 111(2), 372-385.
- . Anal Biochem, 443(2), 205-210.
- . Biotechnol Bioeng, 110(11), 2970-2983.
- . Biotechnol Bioeng, 110(1), 260-274.
- . Biosci Rep, 32(6), 653-660.
- . Biotechnol Prog, 28(1), 179-187.
- . Biotechnol Prog, 27(6), 1689-1699.
- . Biotechnol Bioeng, 108(10), 2434-2446.
- . Biotechnol Bioeng, 108(9), 2193-2204.
- . Biotechnol Bioeng, 106(6), 938-951.
- . Brief Funct Genomic Proteomic, 7(2), 95-110.
- Dynamic analysis of GS-NS0 cells producing a recombinant monoclonal antibody during fed-batch culture. BIOTECHNOL BIOENG, 97(2), 410-424.
- . Biotechnology Progress, 23(2), 435-443.
- . Biotechnology and Bioengineering, 94(5), 830-841.
- . Journal of Microbiological Methods, 66(1), 43-55.
- . Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1764(7), 1179-1187.
- . Biotechnology Progress, 22(3), 753-762.
- . PROTEOMICS, 5(18), 4689-4704.
- . Journal of Chromatography B, 826(1-2), 177-187.
- . Biotechnology Progress, 21(6), 1644-1652.
- . Biotechnology and Bioengineering, 91(2), 180-189.
- . Biotechnology and Bioengineering, 88(6), 707-721.
- . Biotechnology and Bioengineering, 88(4), 474-488.
- . PROTEOMICS, 4(1), 123-135.
- . Molecular Immunology, 40(6), 381-389.
- . Biochemical and Biophysical Research Communications, 306(4), 1050-1055.
- . Biotechnology Progress, 19(1), 121-129.
- . Trends in Biotechnology, 20(4), 149-156.
- . Biotechnology and Bioengineering, 77(1), 37-48.
- . Biotechnology and Bioengineering, 75(2), 239-251.
- . Biotechnology Progress, 17(5), 974-978.
- . Biotechnology and Bioengineering, 73(3), 188-202.
- . Rapid Communications in Mass Spectrometry, 15(5), 351-356.
- . Biotechnology and Applied Biochemistry, 32(2), 109-109.
- Metabolic control of recombinant monoclonal antibody N-glycosylation in GS-NS0 cells. GLYCOBIOLOGY, 10(10), 1108-1108.
- . Biotechnology and Bioengineering, 67(2), 177-188.
- . Biochemical Society Transactions, 28(5), A259-A259.
- . Biotechnology and Bioengineering, 63(5), 559-572.
- Characterisation of glycated albumin using electrospray ionisation mass spectrometry. Clinical Chemistry and Laboratory Medicine, 37(SPEC. SUPPL.), S520-S520.
- . Journal of Interferon & Cytokine Research, 19(2), 137-144.
- . Biotechnology and Bioengineering, 60(5), 596-607.
- . Journal of Interferon & Cytokine Research, 18(5), 287-295.
- Real-time monitoring of recombinant protein concentration in animal cell cultures using an optical biosensor. Genetic Engineer and Biotechnologist, 17(2-3), 69-74.
- . Cytotechnology, 23(1/3), 103-111.
- . Nature Biotechnology, 14(8), 975-981.
- . Protein Science, 5(2), 331-340.
- . Cytotechnology, 22(1-3), 17-24.
- . Biotechnology and Bioengineering, 48(6), 639-648.
- . Nature Biotechnology, 13(6), 592-596.
- . Analytical Biochemistry, 222(2), 315-322.
- PURIFICATION AND CHARACTERIZATION OF A NITRILASE FROM BRASSICA-NAPUS. PHYSIOLOGIA PLANTARUM, 89(4), 811-816.
- DEVELOPMENT AND CHARACTERISTICS OF MYROSINASE IN BRASSICA-NAPUS DURING EARLY SEEDLING GROWTH. PHYSIOLOGIA PLANTARUM, 82(2), 163-170.
- . Journal of the Chemical Society, Perkin Transactions 1(7), 1909-1909.
- BIOSYNTHESIS OF R-2 HYDROXYBUT-3-ENYLGLUCOSINOLATE PROGOITRIN FROM 3 4 TRITIATED BUT-3-ENYLGLUCOSINOLATE IN BRASSICA-NAPUS. Journal of the Chemical Society Perkin Transactions I(7), 1909-1914.
- . Phytochemistry, 29(8), 2509-2512.
- . Molecular Biotechnology.
- . Wellcome Open Research, 6, 220-220.
- . Cells, 10(6), 1419-1419.
- . Biotechnology and Bioengineering.
- . Biotechnology Progress.
- . Molecular Biotechnology, 34(2), 141-150.
- . Biotechnology Progress, 21(1), 122-133.
- . Molecular Biotechnology, 14(3), 241-249.
- , 277-288.
Chapters
- , Comprehensive Biotechnology (pp. 405-412).
- Wiley-VCH Verlag GmbH & Co. KGaA
- , Comprehensive Biotechnology (pp. 419-426). Elsevier
- , Comprehensive Biotechnology (pp. 405-412).
- , Springer Protocols Handbooks (pp. 1335-1346). Humana Press
- , Encyclopedia of Bioprocess Technology
- , Animal Cell Technology: Basic & Applied Aspects (pp. 315-321). Springer Netherlands
- , Methods and Principles in Medicinal Chemistry (pp. 423-467). Wiley-VCH Verlag GmbH & Co. KGaA
- , Therapeutic Proteins (pp. 375-380). Humana Press
- , Therapeutic Proteins (pp. 461-470). Humana Press
- , Food Allergy and Intolerance (pp. 150-161). Royal Society of Chemistry
Conference proceedings papers
- Small molecule chemical additives for enhanced recombinant AAV production in HEK293 cells. HUMAN GENE THERAPY, Vol. 33(23-24) (pp A105-A105)
- . AIP Conference Proceedings
- . Allergy, Vol. 56(s67) (pp 56-60)
- Control of therapeutic monoclonal antibody glycosylation. ANIMAL CELL TECHNOLOGY: PRODUCTS FROM CELLS, CELLS AS PRODUCTS (pp 255-257)
- Resolution glycoform analysis of recombinant human interferon-gamma during batch cultures of Chinese hamster ovary cells. ANIMAL CELL TECHNOLOGY: BASIC & APPLIED ASPECTS, VOL 8 (pp 315-321)
- (pp 339-345)
- (pp 277-282)
- A COMPARISON OF 2 ELECTROPHORETIC METHODS FOR ANALYSING RECOMBINANT PROTEIN GLYCOFORMS. 1995 ICHEME RESEARCH EVENT - FIRST EUROPEAN CONFERENCE FOR YOUNG RESEARCHERS IN CHEMICAL ENGINEERING, VOLS 1 AND 2 (pp 896-898)
- (pp 71-74)
- (pp 655-657)
- (pp 263-265)
Patents
- In silico design of mammalian promoters with user-defined functionality. WO 2018/193072 A1 Appl. 25 Oct 2018.
- Synthetic promoters for CHO cells, methods of producing synthetic promoters using transcription factor binding site modules. WO2015079053-A2; WO2015079053-A3 Appl. 08 Oct 2015.
- Regulating recombinant gene expression in vitro comprises providing a host cell encoding recombinant genes for expression, and contacting the cell with an exonuclease resistant block decoy. WO2014202640-A1 Appl. 24 Dec 2014.
- Predicting relative production titer of a panel of clonal producer cells in fed batch culture by simultaneously incubating each producer cell with a chemical cell stressor and determining the production titer response of each cell. EP2902493-A1; WO2015113704-A1 Appl. 01 Jan 1970.
- Method for determining e.g. cell identity of mammalian producer of user, involves comparing query cell-specific growth response fingerprint with reference cell-specific growth response fingerprints corresponding to cells. WO2014207166-A1 Appl. 01 Jan 1970.
Theses / Dissertations
- Screening and development of natural compounds as tools to improve IgG production and quality in recombinant CHO cell culture.
Preprints
- Teaching activities
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CPE412 鈥 Molecular Biotechnology