Professor Stuart Wilson

School of Biosciences

Roper Chair in Genetics

Stuart Wilson
Profile picture of Stuart Wilson
Profile
  • 2019- present: Roper Chair in Genetics
  • 2008 - 2019: Professor, School of Biosciences, University of 91直播
  • 2008: Reader, Dept of Molecular Biology and Biotechnology, University of 91直播
  • 2003 - 2007: Senior Lecturer, Dept of Molecular Biology and Biotechnology, University of 91直播
  • 1999 - 2003: Lecturer Dept. of Biomolecular Sciences, UMIST
  • 1996 - 1999: Weir Junior Research Fellow, University College Oxford
  • 1995 - 1999: Wellcome Trust Career Development Fellow, Biochemistry Dept, Oxford University
  • 1991 - 1995: Post-doctoral fellow, Biochemistry Department, University College London
  • 1987 - 1991: PhD student, Biochemistry Department, University College London
  • 1984 - 1987: Degree in Cell and Molecular Biology, Biophysics Department, King's College London
Research interests

My laboratory studies human gene expression and how defects in this process lead to various diseases including motor neuron disease and neurodevelopmental disorders. The group have a long-standing interest in how RNA binding proteins regulate gene expression with a particular interest in how mRNA is processed in the nucleus and subsequently transported to the cytoplasm. We use a wide range of technologies to study these processes including CRISPR engineering of human cells including stem cells, proteomics and next generation DNA sequencing methods to globally analyse gene expression at multiple levels including chromatin organisation, transcription and RNA processing. We also work closely with industrial partners to develop improved expression systems for biopharmaceuticals and most recently we have been developing strategies for improved therapeutic mRNAs. We are also working on a project to develop gene therapy approaches for the treatment of neurodevelopmental disorders such as hnRNPU syndrome. I am also the Director and Founder of the 91直播 Institute for Nucleic Acids (SInFoNiA) () which is the home for nucleic acids focussed research at the University of 91直播.

Publications

Show: Featured publications All publications

Journal articles

  • Viphakone N, Sudbery I, Griffith L, Heath CG, Sims D & Wilson SA (2019) . Molecular Cell. RIS download Bibtex download
  • Viphakone N, Hautbergue GM, Walsh M, Chang C-T, Holland A, Folco EG, Reed R & Wilson SA (2012) . Nat Commun, 3, 1006. RIS download Bibtex download
  • Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang C-T, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM , Marshall LE et al (2011) . Science, 334(6057), 821-824. RIS download Bibtex download
  • Hung M-L, Hautbergue GM, Snijders APL, Dickman MJ & Wilson SA (2010) . Nucleic Acids Res, 38(10), 3351-3361. RIS download Bibtex download
  • Dufu K, Livingstone MJ, Seebacher J, Gygi SP, Wilson SA & Reed R (2010) . Genes and Development, 24(18), 2043-2053. RIS download Bibtex download
  • Hautbergue GM, Hung M-L, Walsh MJ, Snijders APL, Chang C-T, Jones R, Ponting CP, Dickman MJ & Wilson SA (2009) . Curr Biol, 19(22), 1918-1924. RIS download Bibtex download
  • Hautbergue GM, Hung M-L, Golovanov AP, Lian L-Y & Wilson SA (2008) . Proc Natl Acad Sci U S A, 105(13), 5154-5159. RIS download Bibtex download

All publications

Journal articles

  • Koffa MD, Clements JB, Izaurralde E, Wadd S, Wilson SA, Mattaj IW & Kuersten S (2023) . The EMBO Journal, 42(14). RIS download Bibtex download
  • Baquero-Perez B, Antanaviciute A, Yonchev ID, Carr IM, Wilson SA & Whitehouse A (2019) . eLife, 8. RIS download Bibtex download
  • Viphakone N, Sudbery I, Griffith L, Heath CG, Sims D & Wilson SA (2019) . Molecular Cell. RIS download Bibtex download
  • Lesbirel S & Wilson SA (2018) . Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. RIS download Bibtex download
  • Lesbirel S, Viphakone N, Parker M, Parker J, Heath C, Sudbery I & Wilson SA (2018) . Scientific Reports, 8(1). RIS download Bibtex download
  • Heath CG, Viphakone N & Wilson SA (2016) . The Biochemical journal, 473(19), 2911-2935. RIS download Bibtex download
  • Cumberbatch MGK, Viphakone N, Livingstone M, Heath PR, Dickman M, Catto JWF & Wilson SA (2015) . European Urology Supplements, 14(2), e227-e227b. RIS download Bibtex download
  • Pang KH, Cumberbatch MG, Wilson SA & Catto JWF (2015) . European Urology Supplements, 14(2), e527-e527a. RIS download Bibtex download
  • Snijders AP, Hautbergue GM, Bloom A, Williamson JC, Minshull TC, Phillips HL, Mihaylov SR, Gjerde DT, Hornby DP, Wilson SA , Hurd PJ et al (2015) . RNA, 21(3), 347-359. RIS download Bibtex download
  • Viphakone N, Cumberbatch MG, Livingstone MJ, Heath PR, Dickman MJ, Catto JW & Wilson SA (2015) . Nucleic Acids Research, 43(4), 2353-2366. RIS download Bibtex download
  • Caballero-Lima D, Hautbergue GM, Wilson SA & Sudbery PE (2014) . Molecular Microbiology, 94(4), 828-842. RIS download Bibtex download
  • Cooper-Knock J, Walsh MJ, Higginbottom A, Robin Highley J, Dickman MJ, Edbauer D, Ince PG, Wharton SB, Wilson SA, Kirby J , Hautbergue GM et al (2014) . Brain, 137(Pt 7), 2040-2051. RIS download Bibtex download
  • Cooper-Knock J, Walsh M, Higginbottom A, Highley JR, Bury J, Dickman M, Rattray M, Heath P, Wyles M, Ince P , Wharton S et al (2014) . Neurology, 82(10_supplement). RIS download Bibtex download
  • Cooper-Knock J, Walsh M, Higginbottom A, Highley JR, Bury J, Dickman M, Rattray M, Heath P, Wyles M, Ince P , Wharton S et al (2014) . Neurology, 82(10_supplement). RIS download Bibtex download
  • Tunnicliffe RB, Hautbergue GM, Wilson SA, Kalra P & Golovanov AP (2014) . PLoS Pathog, 10(2), e1003907. RIS download Bibtex download
  • Chang C-T, Hautbergue GM, Walsh MJ, Viphakone N, van Dijk TB, Philipsen S & Wilson SA (2013) . EMBO J, 32(3), 473-486. RIS download Bibtex download
  • Teng I-F & Wilson SA (2013) . PLoS One, 8(6), e67676. RIS download Bibtex download
  • Viphakone N, Hautbergue GM, Walsh M, Chang C-T, Holland A, Folco EG, Reed R & Wilson SA (2013) . Nature Communications, 4(1). RIS download Bibtex download
  • Viphakone N, Hautbergue GM, Walsh M, Chang C-T, Holland A, Folco EG, Reed R & Wilson SA (2012) . Nat Commun, 3, 1006. RIS download Bibtex download
  • Hautbergue GM & Wilson SA (2012) . Biochem Soc Trans, 40(4), 842-845. RIS download Bibtex download
  • Knuckles P, Vogt MA, Lugert S, Milo M, Chong MMW, Hautbergue GM, Wilson SA, Littman DR & Taylor V (2012) . Nat Neurosci, 15(7), 962-969. RIS download Bibtex download
  • Phelan MM, Goult BT, Clayton JC, Hautbergue GM, Wilson SA & Lian L-Y (2012) . Nucleic Acids Res, 40(7), 3232-3244. RIS download Bibtex download
  • Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang C-T, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM , Marshall LE et al (2011) . Science, 334(6057), 821-824. RIS download Bibtex download
  • Jackson BR, Boyne JR, Noerenberg M, Taylor A, Hautbergue GM, Walsh MJ, Wheat R, Blackbourn DJ, Wilson SA & Whitehouse A (2011) . PLoS Pathog, 7(7), e1002138. RIS download Bibtex download
  • Van Hateren NJ, Das RM, Hautbergue GM, Borycki A-G, Placzek M & Wilson SA (2011) . Development, 138(10), 1893-1902. RIS download Bibtex download
  • Tunnicliffe RB, Hautbergue GM, Kalra P, Jackson BR, Whitehouse A, Wilson SA & Golovanov AP (2011) . PLoS Pathog, 7(1), e1001244. RIS download Bibtex download
  • Clayton JC, Phelan M, Goult BT, Hautbergue GM, Wilson SA & Lian L-Y (2011) . Biomol NMR Assign, 5(1), 7-10. RIS download Bibtex download
  • Hung M-L, Hautbergue GM, Snijders APL, Dickman MJ & Wilson SA (2010) . Nucleic Acids Res, 38(10), 3351-3361. RIS download Bibtex download
  • Walsh MJ, Hautbergue GM & Wilson SA (2010) . Biochem Soc Trans, 38(Pt 1), 232-236. RIS download Bibtex download
  • Clayton JC, Phelan M, Goult BT, Hautbergue GM, Wilson SA & Lian L-Y (2010) The 1H, 13C and 15N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing. Biomolecular NMR Assignments, 1-4. RIS download Bibtex download
  • Dufu K, Livingstone MJ, Seebacher J, Gygi SP, Wilson SA & Reed R (2010) . Genes and Development, 24(18), 2043-2053. RIS download Bibtex download
  • Lambeth LS, Van Hateren NJ, Wilson SA & Nair V (2010) . BMC MOL BIOL, 11. RIS download Bibtex download
  • Snijders APL, Hung M-L, Wilson SA & Dickman MJ (2010) . J Am Soc Mass Spectrom, 21(1), 88-96. RIS download Bibtex download
  • Wright D, Ferjentsik Z, Chong SW, Qiu XH, Jiang YJ, Malapert P, Pourquie O, Van Hateren N, Wilson SA, Franco C , Gerhardt H et al (2009) . DEV DYNAM, 238(12), 3043-3055. RIS download Bibtex download
  • Hautbergue GM, Hung M-L, Walsh MJ, Snijders APL, Chang C-T, Jones R, Ponting CP, Dickman MJ & Wilson SA (2009) . Curr Biol, 19(22), 1918-1924. RIS download Bibtex download
  • Tang CW, Maya-Mendoza A, Martin C, Zeng K, Chen SB, Feret D, Wilson SA & Jackson DA (2008) . J CELL SCI, 121(7), 1014-1024. RIS download Bibtex download
  • Hautbergue GM, Hung M-L, Golovanov AP, Lian L-Y & Wilson SA (2008) . Proc Natl Acad Sci U S A, 105(13), 5154-5159. RIS download Bibtex download
  • Shiau CE, Lwigale PY, Das RM, Wilson SA & Bronner-Fraser M (2008) . NAT NEUROSCI, 11(3), 269-276. RIS download Bibtex download
  • Tintaru AM, Hautbergue GM, Hounslow AM, Hung M-L, Lian L-Y, Craven CJ & Wilson SA (2007) . EMBO Rep, 8(8), 756-762. RIS download Bibtex download
  • Tintaru AM, Hautbergue GM, Hounslow AM, Lian L-Y, Wilson SA & Craven CJ (2007) . J Biomol NMR, 38(2), 193. RIS download Bibtex download
  • Smith TG, Van Hateren N, Tickle C & Wilson SA (2007) . INT J DEV BIOL, 51(2), 173-176. RIS download Bibtex download
  • Manning L, Ohyama K, Saeger B, Hatano O, Wilson SA, Logan M & Placzek M (2006) . Dev Cell, 11(6), 873-885. RIS download Bibtex download
  • Hargous Y, Hautbergue GM, Tintaru AM, Skrisovska L, Golovanov AP, Stevenin J, Lian L-Y, Wilson SA & Allain FH-T (2006) . EMBO J, 25(21), 5126-5137. RIS download Bibtex download
  • Golovanov AP, Hautbergue GM, Tintaru AM, Lian L-Y & Wilson SA (2006) . RNA, 12(11), 1933-1948. RIS download Bibtex download
  • Das RM, Van Hateren NJ, Howell GR, Farrell ER, Bangs FK, Porteous VC, Manning EM, McGrew MJ, Ohyama K, Sacco MA , Halley PA et al (2006) . Dev Biol, 294(2), 554-563. RIS download Bibtex download
  • Golovanov AP, Hautbergue GM, Wilson SA & Lian L-Y (2006) . J Biomol NMR, 36 Suppl 1, 41. RIS download Bibtex download
  • Williams BJL, Boyne JR, Goodwin DJ, Roaden L, Hautbergue GM, Wilson SA & Whitehouse A (2005) . Biochem J, 387(Pt 2), 295-308. RIS download Bibtex download
  • Hillier LW, Miller W, Birney E, Warren W, Hardison RC, Ponting CP, Bork P, Burt DW, Groenen MAM, Delany ME , Dodgson JB et al (2005) . Nature, 433(7027), 777. RIS download Bibtex download
  • Hubbard SJ, Grafham DV, Beattie KJ, Overton IM, McLaren SR, Croning MDR, Boardman PE, Bonfield JK, Burnside J, Davies RM , Farrell ER et al (2005) . GENOME RES, 15(1), 174-183. RIS download Bibtex download
  • Hillier LW, Miller W, Birney E, Warren W, Hardison RC, Ponting CP, Bork P, Burt DW, Groenen MAM, Delany ME , Dodgson JB et al (2004) . NATURE, 432(7018), 695-716. RIS download Bibtex download
  • Wong GKS, Liu B, Wang J, Zhang Y, Yang X, Zhang ZJ, Meng QS, Zhou J, Li DW, Zhang JJ , Ni PX et al (2004) . NATURE, 432(7018), 717-722. RIS download Bibtex download
  • Golovanov AP, Hautbergue GM, Wilson SA & Lian L-Y (2004) . J Am Chem Soc, 126(29), 8933-8939. RIS download Bibtex download
  • Brown WRA, Hubbard SJ, Tickle C & Wilson SA (2003) The chicken as a model for large-scale analysis of vertebrate gene function. NAT REV GENET, 4(2), 87-98. RIS download Bibtex download
  • Boardman PE, Sanz-Ezquerro J, Overton IM, Burt DW, Bosch E, Fong WT, Tickle C, Brown WRA, Wilson SA & Hubbard SJ (2002) . Curr Biol, 12(22), 1965-1969. RIS download Bibtex download
  • Wilson HL, Wilson SA, Surprenant A & North RA (2002) . J Biol Chem, 277(37), 34017-34023. RIS download Bibtex download
  • Koffa MD, Clements JB, Izaurralde E, Wadd S, Wilson SA, Mattaj IW & Kuersten S (2001) Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway. EMBO J, 20(20), 5769-5778. RIS download Bibtex download
  • Yoon S, Kingsman SM, Kingsman AJ, Wilson SA & Mitrophanous KA (2000) . J Gen Virol, 81(Pt 9), 2189-2194. RIS download Bibtex download
  • O'Hara BP, Wilson SA, Lee AW, Roe SM, Siligardi G, Drew RE & Pearl LH (2000) . Protein Eng, 13(2), 129-132. RIS download Bibtex download
  • WILSON SA, SIEIRO-VAZQUEZ C, EDWARDS NJ, IOURIN O, BYLES ED, KOTSOPOULOU E, ADAMSON CS, KINGSMAN SM, KINGSMAN AJ & MARTIN-RENDON E (1999) . Biochemical Journal, 342(1), 97-103. RIS download Bibtex download
  • Wilson SA, Sieiro-Vazquez C, Edwards NJ, Iourin O, Byles ED, Kotsopoulou E, Adamson CS, Kingsman SM, Kingsman AJ & Martin-Rendon E (1999) Cloning and characterization of hIF2, a human homologue of bacterial translation initiation factor 2, and its interaction with HIV-1 matrix.. Biochem J, 342 ( Pt 1), 97-103. RIS download Bibtex download
  • Wilson SA, Brown EC, Kingsman AJ & Kingsman SM (1998) . Nucleic Acids Res, 26(15), 3460-3467. RIS download Bibtex download
  • Chamberlain D, O'Hara BP, Wilson SA, Pearl LH & Perkins SJ (1997) . Biochemistry, 36(26), 8020-8029. RIS download Bibtex download
  • Martin鈥怰endon E, Marfany G, Wilson S, Ferguson DJP, Kingsman SM & Kingsman AJ (1996) . Molecular Microbiology, 22(4), 667-679. RIS download Bibtex download
  • Wilson SA, Wachira SJM, Norman RA, Pearl LH & Drew RE (1996) . EMBO Journal, 15(21), 5907-5916. RIS download Bibtex download
  • WILSON SA, WILLIAMS RJ, PEARL LH & DREW RE (1995) IDENTIFICATION OF 2 NEW GENES IN THE PSEUDOMONAS-AERUGINOSA AMIDASE OPERON, ENCODING AN ATPASE (AMIB) AND A PUTATIVE INTEGRAL MEMBRANE-PROTEIN (AMIS). J BIOL CHEM, 270(32), 18818-18824. RIS download Bibtex download
  • Wilson SA & Drew RE (1995) . Journal of bacteriology, 177(11), 3052-3057. RIS download Bibtex download
  • Pearl L, O'Hara B, Drew R & Wilson S (1994) . The EMBO Journal, 13(24), 5810-5817. RIS download Bibtex download
  • O'Hara BP, Wilson SA, Wyborn NW, Jones CW & Pearl LH (1994) . Protein & Peptide Letters, 1(3), 202-205. RIS download Bibtex download
  • Wilson SA, Wachira SJ, Drew RE, Jones D & Pearl LH (1993) . The EMBO Journal, 12(9), 3637-3642. RIS download Bibtex download
  • Wilson SA, Chayen NE, Hemmings AM, Drew RE & Pearl LH (1991) . Journal of Molecular Biology, 222(4), 869-871. RIS download Bibtex download
  • Wilson S & Drew R (1991) . Journal of Bacteriology, 173(16), 4914-4921. RIS download Bibtex download
  • Siachisumo C, Luzzi S, Aldalaqan S, Hysenaj G, Dalgliesh C, Cheung K, Gazzara MR, Yonchev ID, James K, Kheirollahi Chadegani M , Ehrmann IE et al () . eLife, 12. RIS download Bibtex download
  • Siachisumo C, Luzzi S, Aldalaqan S, Hysenaj G, Dalgliesh C, Cheung K, Gazzara MR, Yonchev ID, James K, Kheirollahi Chadegani M , Ehrmann IE et al () . eLife, 12. RIS download Bibtex download
  • Baquero-P茅rez B, Yonchev ID, Delgado-Tejedor A, Medina R, Puig-Torrents M, Sudbery I, Begik O, Wilson SA, Novoa EM & D铆ez J () . Nature Communications, 15(1). RIS download Bibtex download
  • Manners O, Baquero-Perez B, Mottram TJ, Yonchev ID, Trevelyan CJ, Harper KL, Menezes S, Patterson MR, Macdonald A, Wilson SA , Aspden JL et al () . Viruses, 15(6), 1381-1381. RIS download Bibtex download

Chapters

  • Wilson SA, Van Hateren NJ & jones RS (2009) In Nakamura H (Ed.), Electroporation and Sonoporation in Developmental Biology (pp. 295-314). Springer Verlag RIS download Bibtex download
  • Wilson SA, van hateren NJ & das RM (2009) RNAi in chicken embryos In Doran DT & Helliwell C (Ed.), RNA interference: methods for plants and animals (pp. 183-204). CABI Publishing RIS download Bibtex download

Conference proceedings papers

  • Ohyama K, Wilson S, Briscoe J & Placzek M (2009) . Mechanisms of Development, Vol. 126 (pp S210-S210) RIS download Bibtex download

Preprints

  • Riley JJ, Alexandru-Crivac CN, Bryce-Smith S, Wilson SA & Sudbery IM (2024) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Baquero-Perez B, Yonchev ID, Delgado-Tejedor A, Medina R, Puig-Torrents M, Sudbery I, Begik O, Wilson SA, Maria Novoa E & D铆ez J (2023) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Siachisumo C, Luzzi S, Aldalaqan S, Hysenaj G, Dalgliesh C, Cheung K, Gazzara MR, Yonchev ID, James K, Chadegani MK , Ehrmann I et al (2023) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Manners O, Baquero-Perez B, Mottram TJ, Yonchev ID, Trevelyan CJ, Patterson MR, Macdonald A, Wilson SA, Aspden JL & Whitehouse A (2023) , Cold Spring Harbor Laboratory. RIS download Bibtex download
Research group

Graduate students

  • Joshua Zilate (2020-2024) BBSRC CASE student with Astrazenecadevelopment of improved biopharmaceutical expression systems for CHO cells.  

email: jzilate1@sheffield.ac.uk

  • Mikayla Fernholz (2021-2025) BBSRC CASE student with Astrazeneca 鈥 development of improved biopharmaceutical expression systems for CHO cells. 

email: mfernholz1@sheffield.ac.uk

  • Ashleigh Whelan (2022-2026) BBSRC 鈥 Analysis of the role of RNA binding proteins in the DNA damage response. 

email: agwhelan1@sheffield.ac.uk

Research staff

  • Dr Ang Li (2022-2025) BBSRC project on the role of RNA binding proteins in genome architecture and gene expression. 

email: ali15@sheffield.ac.uk

  • Dr Chiara Galloni (2021-2025) MRC project on synthetic mRNA untranslated regions.

email: c.galloni@sheffield.ac.uk

  • Dr Charlotte Vandermeulen (2021-2025) MRC project on synthetic mRNA untranslated regions.

email: c.vandermeulen@sheffield.ac.uk

  • Dr Daniel Williams (2023-2024) Lifearc project on the development of gene therapy approaches for the treatment of hnRNPU syndrome.

email: Daniel.willaims@sheffield.ac.uk

  • Dr AN Other 鈥 new BBSRC funded post to be advertised shortly鈥. 

Laboratory Manager

  • Vicky Porteous-Medley 

email: v.porteous@sheffield.ac.uk

Teaching activities
  • MBB325 The world of RNA (Module Coordinator)
  • MBB363 Genetics data handling
  • MBB361 Third year literature reviews
  • MBB380 Third year research projects
  • MBB402 Advanced literature review
  • MBB403/404 Advanced research projects